GREMLIN Database
YHDY - Uncharacterized MscS family protein YhdY
UniProt: O07594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (323)
Sequences: 6291 (4858)
Seq/√Len: 270.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_C149_S5.5521.00
265_P268_N4.2471.00
277_R281_L4.1711.00
214_E224_R3.5721.00
267_E332_E3.5281.00
297_T304_N3.2421.00
299_A304_N3.0611.00
259_H302_Y3.0311.00
331_I335_G2.9731.00
268_N271_R2.9171.00
205_E210_T2.8451.00
283_H325_D2.8341.00
333_I336_A2.7211.00
278_T282_E2.7031.00
329_K332_E2.6471.00
332_E336_A2.6031.00
268_N337_E2.5561.00
180_K184_S2.5381.00
49_P54_F2.4911.00
295_F303_Y2.4781.00
313_T318_E2.4711.00
333_I337_E2.4471.00
296_D306_F2.4101.00
279_M329_K2.3861.00
195_E219_R2.3691.00
309_F326_I2.3001.00
204_V213_V2.2841.00
267_E270_E2.1341.00
300_D304_N2.1081.00
262_Y298_F2.0481.00
268_N272_S2.0241.00
270_E328_Y2.0121.00
205_E244_T1.9951.00
269_L305_L1.9861.00
259_H304_N1.9701.00
273_I330_I1.9631.00
260_V269_L1.9511.00
267_E271_R1.9361.00
255_T306_F1.9211.00
215_D222_R1.8981.00
272_S333_I1.8961.00
257_S304_N1.8821.00
271_R278_T1.8811.00
221_T235_N1.8671.00
258_I330_I1.8661.00
257_S306_F1.8491.00
225_T231_V1.8381.00
261_S340_Q1.8371.00
334_L339_V1.8291.00
205_E208_T1.8161.00
203_W210_T1.7671.00
237_T241_E1.7641.00
270_E273_I1.7311.00
319_N323_R1.7301.00
265_P269_L1.7301.00
116_F120_K1.6861.00
259_H301_S1.6771.00
203_W212_S1.6761.00
214_E230_L1.6651.00
203_W226_A1.6601.00
323_R327_N1.6591.00
280_L307_F1.6461.00
205_E246_W1.6071.00
278_T281_L1.5991.00
300_D346_Q1.5971.00
97_S153_I1.5971.00
173_L176_A1.5651.00
272_S278_T1.5501.00
325_D329_K1.5441.00
199_T248_R1.5401.00
118_F121_V1.5331.00
163_G166_A1.5301.00
49_P55_K1.5281.00
260_V334_L1.5271.00
278_T333_I1.5211.00
211_G223_F1.5131.00
329_K333_I1.4971.00
259_H299_A1.4951.00
279_M333_I1.4691.00
283_H329_K1.4681.00
207_S241_E1.4571.00
311_T322_I1.4531.00
318_E321_N1.4181.00
181_D184_S1.4051.00
285_G318_E1.4011.00
170_L174_A1.3961.00
32_K36_R1.3881.00
259_H262_Y1.3631.00
285_G325_D1.3591.00
28_L32_K1.3511.00
343_Y347_M1.3411.00
182_T188_G1.3331.00
196_K199_T1.3161.00
334_L341_F1.3041.00
207_S242_A1.3031.00
170_L179_A1.3021.00
281_L288_N1.2971.00
272_S337_E1.2641.00
117_I121_V1.2531.00
178_A183_I1.2431.00
114_S117_I1.2201.00
260_V339_V1.2161.00
262_Y341_F1.2141.00
118_F122_N1.2121.00
66_R70_V1.2121.00
263_A340_Q1.2071.00
51_T54_F1.2061.00
269_L273_I1.1971.00
321_N325_D1.1941.00
262_Y343_Y1.1841.00
293_V307_F1.1791.00
36_R40_N1.1501.00
257_S297_T1.1501.00
209_V231_V1.1501.00
267_E272_S1.1461.00
259_H343_Y1.1381.00
272_S339_V1.1331.00
97_S157_F1.1301.00
296_D304_N1.1281.00
324_E328_Y1.1261.00
295_F327_N1.1191.00
260_V305_L1.1171.00
282_E329_K1.1141.00
101_A105_W1.1011.00
73_G77_A1.0901.00
213_V223_F1.0871.00
237_T242_A1.0861.00
283_H326_I1.0791.00
259_H300_D1.0681.00
78_I82_P1.0671.00
154_A159_Y1.0661.00
263_A343_Y1.0601.00
37_Y41_L1.0561.00
343_Y346_Q1.0541.00
93_K96_R1.0451.00
27_F31_R1.0441.00
210_T226_A1.0411.00
265_P270_E1.0331.00
260_V264_T1.0291.00
230_L248_R1.0251.00
41_L45_L1.0251.00
271_R337_E1.0191.00
279_M326_I1.0101.00
294_N324_E1.0081.00
22_A25_L1.0071.00
269_L272_S1.0021.00
302_Y343_Y1.0011.00
266_I270_E1.0011.00
204_V223_F0.9991.00
299_A302_Y0.9981.00
301_S343_Y0.9951.00
33_L37_Y0.9941.00
90_V94_I0.9891.00
237_T240_M0.9871.00
100_V156_E0.9841.00
254_I323_R0.9831.00
262_Y300_D0.9811.00
280_L286_V0.9811.00
265_P272_S0.9801.00
263_A331_I0.9791.00
175_F183_I0.9711.00
253_Q308_N0.9681.00
64_P67_W0.9641.00
82_P85_D0.9631.00
92_S96_R0.9621.00
320_L324_E0.9611.00
197_P222_R0.9591.00
40_N43_F0.9571.00
119_H123_Q0.9541.00
225_T229_A0.9531.00
100_V149_S0.9521.00
254_I309_F0.9491.00
224_R228_G0.9471.00
74_L77_A0.9441.00
67_W71_A0.9431.00
40_N44_N0.9431.00
226_A308_N0.9401.00
60_A64_P0.9351.00
198_F221_T0.9271.00
266_I305_L0.9221.00
108_C146_I0.9211.00
259_H298_F0.9211.00
231_V244_T0.9151.00
256_F327_N0.9081.00
111_T145_I0.9061.00
252_R319_N0.9061.00
31_R35_T0.9061.00
266_I331_I0.9041.00
168_L171_G0.9041.00
297_T327_N0.9001.00
32_K35_T0.8991.00
279_M283_H0.8991.00
45_L48_R0.8931.00
21_L25_L0.8871.00
272_S334_L0.8821.00
171_G174_A0.8801.00
108_C142_R0.8781.00
340_Q347_M0.8751.00
70_V77_A0.8751.00
229_A244_T0.8721.00
114_S118_F0.8701.00
195_E220_S0.8651.00
307_F330_I0.8601.00
114_S121_V0.8501.00
270_E324_E0.8491.00
70_V73_G0.8491.00
227_Q253_Q0.8471.00
46_T49_P0.8421.00
175_F187_F0.8411.00
124_R127_L0.8411.00
228_G310_Y0.8340.99
261_S341_F0.8330.99
257_S296_D0.8330.99
44_N48_R0.8310.99
262_Y301_S0.8290.99
63_K67_W0.8260.99
303_Y331_I0.8260.99
187_F239_S0.8260.99
66_R78_I0.8240.99
180_K236_S0.8240.99
115_S118_F0.8230.99
19_I23_I0.8210.99
171_G175_F0.8170.99
165_V174_A0.8170.99
61_F64_P0.8150.99
301_S341_F0.8110.99
171_G178_A0.8100.99
181_D185_N0.8100.99
19_I22_A0.8090.99
78_I81_S0.8070.99
120_K124_R0.8020.99
298_F331_I0.8010.99
300_D344_P0.8000.99
285_G322_I0.7990.99
226_A246_W0.7950.99
262_Y303_Y0.7950.99
68_F72_L0.7940.99
300_D341_F0.7940.99
77_A81_S0.7940.99
298_F327_N0.7890.99
191_I239_S0.7840.99
104_C108_C0.7790.99
298_F303_Y0.7720.99
104_C145_I0.7690.99
301_S344_P0.7680.99
264_T269_L0.7670.99
207_S237_T0.7620.99
66_R69_F0.7600.99
42_L46_T0.7570.99
294_N321_N0.7540.99
182_T239_S0.7500.99
311_T319_N0.7490.99
342_A346_Q0.7490.99
264_T303_Y0.7470.99
135_P215_D0.7430.99
140_L144_V0.7420.99
67_W70_V0.7370.99
114_S120_K0.7370.99
29_I32_K0.7370.99
32_K37_Y0.7330.99
341_F345_G0.7300.99
263_A335_G0.7300.99
143_F147_A0.7290.99
56_Q59_L0.7280.99
326_I330_I0.7280.99
36_R39_F0.7260.99
198_F243_I0.7250.99
262_Y302_Y0.7250.99
311_T314_T0.7250.99
135_P139_K0.7210.99
294_N320_L0.7200.99
222_R230_L0.7190.98
35_T39_F0.7190.98
37_Y40_N0.7180.98
273_I307_F0.7150.98
262_Y344_P0.7150.98
322_I325_D0.7120.98
325_D328_Y0.7110.98
74_L78_I0.7100.98
22_A26_V0.7100.98
292_M308_N0.7070.98
46_T55_K0.7070.98
210_T246_W0.6980.98
146_I150_V0.6980.98
173_L181_D0.6960.98
197_P243_I0.6960.98
263_A347_M0.6960.98
206_T233_V0.6950.98
88_M92_S0.6940.98
261_S342_A0.6940.98
38_F42_L0.6940.98
270_E332_E0.6920.98
64_P70_V0.6900.98
174_A179_A0.6880.98
184_S236_S0.6880.98
28_L35_T0.6850.98
24_L31_R0.6850.98
295_F305_L0.6840.98
89_P93_K0.6830.98
24_L27_F0.6820.98
101_A104_C0.6800.98
132_I193_I0.6800.98
93_K156_E0.6800.98
261_S345_G0.6790.98
167_G170_L0.6790.98
101_A153_I0.6780.98
225_T253_Q0.6780.98
41_L44_N0.6780.98
176_A180_K0.6770.98
79_R83_F0.6770.98
51_T55_K0.6750.98
153_I157_F0.6750.98
267_E328_Y0.6740.98
294_N308_N0.6740.98
62_D78_I0.6720.98
166_A169_G0.6710.98
179_A218_F0.6710.98
20_S30_L0.6690.98
320_L323_R0.6680.98
169_G184_S0.6660.98
69_F78_I0.6650.98
261_S343_Y0.6650.98
60_A69_F0.6640.97
184_S240_M0.6640.97
81_S85_D0.6590.97
203_W246_W0.6550.97
286_V309_F0.6540.97
72_L76_L0.6520.97
39_F46_T0.6510.97
123_Q127_L0.6440.97
331_I341_F0.6420.97
53_I57_V0.6400.97
31_R34_F0.6380.97
23_I80_Y0.6370.97
116_F119_H0.6370.97
301_S345_G0.6370.97
18_G21_L0.6360.97
36_R43_F0.6360.97
170_L173_L0.6350.97
194_T218_F0.6350.97
147_A151_S0.6340.97
115_S119_H0.6340.97
269_L303_Y0.6340.97
145_I149_S0.6320.97
46_T51_T0.6310.97
17_I21_L0.6310.97
60_A78_I0.6310.97
63_K75_F0.6290.97
70_V75_F0.6280.96
31_R36_R0.6260.96
209_V242_A0.6250.96
173_L179_A0.6250.96
64_P68_F0.6250.96
62_D70_V0.6240.96
255_T308_N0.6240.96
73_G78_I0.6240.96
64_P105_W0.6230.96
295_F331_I0.6200.96
298_F330_I0.6180.96
60_A63_K0.6150.96
46_T54_F0.6150.96
25_L30_L0.6140.96
204_V238_L0.6140.96
296_D323_R0.6130.96
192_I217_T0.6090.96
167_G172_G0.6080.96
187_F191_I0.6070.96
56_Q60_A0.6070.96
197_P220_S0.6050.96
342_A345_G0.6020.96
32_K41_L0.6000.95
149_S153_I0.6000.95
287_D312_K0.5990.95
36_R41_L0.5970.95
136_F139_K0.5960.95
280_L291_I0.5920.95
262_Y299_A0.5890.95
137_L141_L0.5880.95
60_A66_R0.5850.95
334_L337_E0.5850.95
220_S232_T0.5840.95
181_D236_S0.5840.95
220_S247_T0.5830.95
292_M317_A0.5830.95
283_H286_V0.5810.95
66_R79_R0.5810.95
189_G244_T0.5800.95
99_I103_L0.5800.95
161_V166_A0.5800.95
70_V78_I0.5800.95
202_D248_R0.5770.94
277_R280_L0.5760.94
179_A187_F0.5750.94
191_I219_R0.5730.94
249_M252_R0.5720.94
35_T38_F0.5720.94
138_S142_R0.5700.94
27_F33_L0.5680.94
341_F347_M0.5680.94
57_V60_A0.5670.94
105_W109_N0.5660.94
63_K109_N0.5650.94
281_L290_I0.5640.94
285_G321_N0.5630.94
300_D343_Y0.5630.94
120_K123_Q0.5620.94
151_S161_V0.5620.94
18_G22_A0.5620.94
39_F53_I0.5590.93
195_E232_T0.5590.93
212_S226_A0.5570.93
277_R321_N0.5570.93
166_A170_L0.5540.93
95_Y144_V0.5540.93
39_F44_N0.5540.93
266_I303_Y0.5520.93
81_S84_L0.5520.93
205_E225_T0.5520.93
87_Q90_V0.5470.93
29_I33_L0.5460.93
200_I216_I0.5450.93
258_I295_F0.5440.92
177_L182_T0.5440.92
266_I328_Y0.5440.92
181_D240_M0.5430.92
192_I320_L0.5430.92
115_S138_S0.5420.92
258_I273_I0.5380.92
19_I36_R0.5380.92
194_T197_P0.5380.92
105_W108_C0.5370.92
198_F235_N0.5360.92
22_A29_I0.5350.92
280_L309_F0.5350.92
178_A187_F0.5310.92
185_N236_S0.5300.92
69_F76_L0.5300.92
162_N166_A0.5290.91
139_K143_F0.5290.91
54_F57_V0.5290.91
185_N234_P0.5290.91
236_S239_S0.5280.91
295_F298_F0.5280.91
178_A219_R0.5270.91
227_Q255_T0.5270.91
212_S224_R0.5270.91
168_L218_F0.5270.91
270_E277_R0.5260.91
155_Q160_D0.5260.91
121_V124_R0.5250.91
236_S240_M0.5230.91
67_W74_L0.5230.91
76_L80_Y0.5210.91
308_N320_L0.5210.91
198_F238_L0.5210.91
52_E85_D0.5210.91
203_W244_T0.5200.91
270_E293_V0.5190.91
63_K66_R0.5190.91
23_I40_N0.5170.90
258_I305_L0.5170.90
55_K58_V0.5160.90
203_W252_R0.5160.90
206_T238_L0.5150.90
61_F81_S0.5150.90
167_G230_L0.5130.90
277_R291_I0.5130.90
265_P271_R0.5130.90
264_T268_N0.5130.90
93_K97_S0.5120.90
64_P69_F0.5100.90
313_T317_A0.5090.90
299_A303_Y0.5080.90
20_S23_I0.5060.90
251_K289_E0.5060.90
26_V30_L0.5040.89
273_I334_L0.5030.89
117_I120_K0.5010.89
224_R230_L0.5010.89
268_N273_I0.5010.89
287_D314_T0.5010.89
213_V241_E0.5000.89
182_T219_R0.5000.89
253_Q310_Y0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hw9A 3 0.6792 100 0.302 Contact Map
5ajiA 3 0.7062 100 0.316 Contact Map
3udcA 3 0.6981 100 0.329 Contact Map
3j9pD 4 0.7332 33 0.954 Contact Map
4mt1A 3 0.8787 19.1 0.959 Contact Map
1nz9A 1 0.1294 18.9 0.959 Contact Map
2aalA 3 0.3019 18 0.959 Contact Map
3ne5A 3 0.8976 17.1 0.96 Contact Map
2lt1A 1 0.1698 15.4 0.961 Contact Map
2e6zA 1 0.1375 15.1 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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