GREMLIN Database
YHDW - Putative glycerophosphoryl diester phosphodiesterase YhdW
UniProt: O07592 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 243 (228)
Sequences: 9370 (6926)
Seq/√Len: 458.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
198_N224_D2.8511.00
19_A86_E2.7371.00
96_K128_F2.6311.00
23_L26_K2.6051.00
92_E124_L2.4771.00
22_D97_R2.4541.00
21_F34_L2.4011.00
11_G230_Y2.3941.00
66_T69_E2.3911.00
105_L137_Q2.2941.00
67_L71_Q2.2681.00
215_A234_I2.2531.00
67_L90_T2.2211.00
71_Q93_A2.1591.00
18_I89_P2.0841.00
12_Y232_D2.0201.00
47_I62_V2.0051.00
38_L120_E1.9161.00
210_N229_D1.9021.00
43_Q67_L1.8991.00
92_E127_Q1.8681.00
34_L94_V1.8641.00
52_V73_L1.8491.00
39_T45_V1.8211.00
4_I31_M1.8101.00
92_E128_F1.8101.00
17_T75_A1.8041.00
230_Y233_F1.7931.00
157_A181_Y1.7801.00
40_K66_T1.7771.00
22_D26_K1.7601.00
56_T75_A1.7391.00
34_L46_V1.7361.00
120_E123_Q1.7241.00
31_M103_G1.7211.00
61_F64_D1.7201.00
13_A23_L1.7141.00
25_V102_I1.7091.00
58_G73_L1.6811.00
205_F225_G1.6571.00
211_N214_T1.6511.00
52_V65_F1.6321.00
43_Q90_T1.6151.00
45_V67_L1.6041.00
46_V94_V1.5991.00
47_I55_T1.5951.00
90_T93_A1.5791.00
186_H214_T1.5251.00
10_S20_A1.5211.00
91_L106_I1.5081.00
206_A223_V1.5061.00
119_E150_L1.4911.00
15_E54_R1.4871.00
23_L27_M1.4851.00
7_R15_E1.4691.00
126_G151_Y1.4661.00
39_T43_Q1.4481.00
60_G65_F1.4421.00
214_T217_K1.4421.00
184_I206_A1.4301.00
45_V62_V1.4281.00
21_F94_V1.4281.00
136_V147_F1.4261.00
5_A20_A1.4221.00
118_E143_S1.4091.00
122_G151_Y1.4041.00
146_R150_L1.3831.00
53_D59_S1.3751.00
137_Q227_V1.3571.00
124_L128_F1.3551.00
217_K221_M1.3261.00
123_Q127_Q1.3181.00
38_L44_I1.3141.00
43_Q92_E1.3101.00
92_E96_K1.2911.00
18_I97_R1.2871.00
42_R120_E1.2811.00
65_F69_E1.2711.00
119_E123_Q1.2551.00
36_V44_I1.2501.00
148_R156_T1.2391.00
49_D54_R1.2381.00
146_R149_E1.2341.00
136_V154_I1.2321.00
9_A12_Y1.2281.00
216_A220_A1.2271.00
70_L88_I1.2151.00
39_T70_L1.2141.00
148_R180_N1.2001.00
9_A23_L1.1791.00
122_G147_F1.1771.00
125_L136_V1.1721.00
65_F70_L1.1681.00
58_G65_F1.1661.00
118_E146_R1.1541.00
39_T67_L1.1491.00
191_R195_G1.1431.00
197_I204_I1.1361.00
194_I204_I1.1291.00
203_N224_D1.1271.00
137_Q183_N1.1251.00
95_L104_L1.1231.00
4_I225_G1.1151.00
108_L121_V1.1101.00
53_D60_G1.1071.00
33_E48_H1.1021.00
9_A27_M1.1011.00
47_I88_I1.0961.00
44_I121_V1.0921.00
195_G199_K1.0851.00
19_A23_L1.0851.00
212_Q216_A1.0811.00
69_E72_K1.0761.00
95_L125_L1.0751.00
25_V97_R1.0741.00
74_D85_G1.0721.00
18_I22_D1.0571.00
21_F32_I1.0531.00
124_L127_Q1.0521.00
37_Q50_D1.0461.00
209_V215_A1.0391.00
105_L205_F1.0141.00
5_A10_S1.0131.00
4_I105_L1.0091.00
144_V156_T0.9941.00
71_Q87_R0.9891.00
74_D87_R0.9861.00
95_L128_F0.9811.00
194_I198_N0.9791.00
5_A29_A0.9791.00
56_T60_G0.9771.00
98_Y104_L0.9751.00
51_R61_F0.9721.00
52_V58_G0.9711.00
131_S151_Y0.9711.00
207_W227_V0.9711.00
197_I202_L0.9641.00
16_N21_F0.9621.00
193_M197_I0.9581.00
10_S229_D0.9501.00
130_F134_N0.9491.00
137_Q157_A0.9471.00
44_I120_E0.9471.00
105_L227_V0.9451.00
36_V106_I0.9441.00
130_F133_N0.9401.00
9_A232_D0.9391.00
36_V91_L0.9371.00
44_I124_L0.9341.00
21_F46_V0.9281.00
108_L143_S0.9261.00
12_Y27_M0.9211.00
122_G126_G0.9181.00
91_L95_L0.9141.00
51_R54_R0.9131.00
40_K64_D0.9071.00
36_V121_V0.9001.00
5_A9_A0.8971.00
107_E139_F0.8921.00
126_G131_S0.8891.00
151_Y154_I0.8891.00
119_E146_R0.8861.00
183_N205_F0.8841.00
65_F73_L0.8841.00
16_N89_P0.8791.00
53_D57_N0.8781.00
3_I235_I0.8681.00
215_A226_I0.8651.00
181_Y203_N0.8621.00
34_L104_L0.8621.00
89_P94_V0.8611.00
57_N60_G0.8591.00
196_S200_N0.8581.00
105_L135_I0.8571.00
228_T234_I0.8531.00
13_A19_A0.8511.00
22_D98_Y0.8481.00
6_H48_H0.8411.00
196_S199_K0.8341.00
71_Q90_T0.8321.00
195_G198_N0.8301.00
45_V70_L0.8201.00
8_G21_F0.8161.00
209_V218_L0.8131.00
137_Q159_I0.8071.00
139_F159_I0.8041.00
120_E124_L0.8021.00
198_N204_I0.8011.00
212_Q236_K0.7981.00
181_Y205_F0.7911.00
35_D48_H0.7911.00
9_A231_P0.7901.00
74_D78_W0.7871.00
194_I221_M0.7771.00
122_G150_L0.7741.00
206_A218_L0.7681.00
140_Q143_S0.7671.00
107_E138_S0.7671.00
29_A231_P0.7661.00
57_N61_F0.7621.00
38_L42_R0.7511.00
219_Q234_I0.7511.00
172_M175_F0.7471.00
44_I117_I0.7441.00
141_F158_V0.7411.00
37_Q63_K0.7381.00
210_N228_T0.7371.00
70_L73_L0.7351.00
215_A233_F0.7341.00
38_L117_I0.7281.00
76_G79_Y0.7271.00
68_E72_K0.7261.00
105_L183_N0.7241.00
121_V125_L0.7231.00
12_Y23_L0.7221.00
43_Q120_E0.7141.00
141_F145_Q0.7081.00
155_P180_N0.7071.00
212_Q233_F0.7071.00
4_I227_V0.7031.00
126_G153_S0.7031.00
52_V60_G0.7021.00
94_V104_L0.6981.00
118_E122_G0.6971.00
3_I234_I0.6971.00
56_T73_L0.6891.00
99_H130_F0.6891.00
52_V70_L0.6861.00
51_R59_S0.6831.00
12_Y230_Y0.6821.00
157_A205_F0.6801.00
214_T218_L0.6771.00
74_D77_S0.6771.00
6_H33_E0.6771.00
94_V98_Y0.6761.00
47_I56_T0.6751.00
131_S134_N0.6701.00
93_A96_K0.6661.00
157_A183_N0.6621.00
37_Q62_V0.6611.00
25_V101_K0.6601.00
9_A13_A0.6591.00
125_L134_N0.6591.00
180_N183_N0.6591.00
100_K133_N0.6581.00
155_P203_N0.6561.00
24_A29_A0.6561.00
213_K216_A0.6551.00
189_L206_A0.6451.00
171_Q174_A0.6370.99
125_L131_S0.6360.99
75_A89_P0.6360.99
218_L221_M0.6340.99
185_K188_R0.6330.99
161_R185_K0.6320.99
147_F156_T0.6320.99
95_L124_L0.6290.99
191_R221_M0.6280.99
45_V90_T0.6250.99
34_L106_I0.6180.99
3_I29_A0.6170.99
32_I102_I0.6140.99
27_M235_I0.6130.99
27_M232_D0.6130.99
145_Q149_E0.6120.99
139_F207_W0.6100.99
40_K69_E0.6090.99
32_I98_Y0.6090.99
107_E159_I0.6080.99
206_A209_V0.6080.99
121_V136_V0.6040.99
108_L117_I0.6040.99
226_I234_I0.5950.99
9_A29_A0.5940.99
4_I205_F0.5930.99
19_A22_D0.5890.99
147_F154_I0.5870.99
109_K139_F0.5870.99
162_P188_R0.5840.99
27_M231_P0.5830.99
33_E49_D0.5800.99
181_Y184_I0.5800.99
17_T20_A0.5780.99
37_Q110_G0.5770.99
145_Q176_R0.5770.99
135_I181_Y0.5760.99
211_N215_A0.5760.99
215_A219_Q0.5750.99
142_R145_Q0.5730.99
160_T182_V0.5720.99
53_D58_G0.5720.99
173_K200_N0.5700.99
193_M196_S0.5690.99
138_S144_V0.5690.99
205_F227_V0.5680.99
118_E121_V0.5670.99
68_E71_Q0.5640.99
103_G155_P0.5640.99
55_T75_A0.5630.99
91_L124_L0.5590.99
168_S171_Q0.5570.99
61_F65_F0.5560.99
91_L121_V0.5550.99
53_D56_T0.5510.99
10_S231_P0.5480.98
31_M105_L0.5470.98
40_K65_F0.5440.98
18_I21_F0.5430.98
217_K220_A0.5430.98
74_D79_Y0.5410.98
169_R172_M0.5390.98
56_T59_S0.5390.98
144_V148_R0.5380.98
33_E109_K0.5380.98
14_P55_T0.5380.98
169_R196_S0.5370.98
3_I231_P0.5340.98
99_H133_N0.5340.98
31_M135_I0.5320.98
31_M137_Q0.5280.98
51_R55_T0.5270.98
208_T228_T0.5260.98
25_V32_I0.5260.98
28_N235_I0.5250.98
24_A32_I0.5220.98
47_I89_P0.5220.98
55_T58_G0.5170.98
182_V197_I0.5170.98
39_T62_V0.5150.98
21_F97_R0.5150.98
22_D86_E0.5150.98
103_G133_N0.5100.98
48_H109_K0.5080.98
31_M102_I0.5070.97
20_A24_A0.5060.97
107_E137_Q0.5030.97
33_E107_E0.5030.97
233_F236_K0.5030.97
125_L130_F0.5020.97
29_A102_I0.5020.97
170_N173_K0.5000.97
189_L221_M0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r7oA 4 0.9877 100 0.074 Contact Map
2pz0A 2 0.9835 100 0.092 Contact Map
2oogA 4 0.9877 100 0.103 Contact Map
2otdA 1 0.9712 100 0.111 Contact Map
1zccA 5 0.963 100 0.114 Contact Map
3l12A 2 0.9753 100 0.119 Contact Map
3qvqA 4 0.9835 100 0.12 Contact Map
3ks6A 1 0.9794 100 0.122 Contact Map
2o55A 1 0.9547 100 0.123 Contact Map
3ch0A 1 0.9671 100 0.124 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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