GREMLIN Database
CRCB2 - Putative fluoride ion transporter CrcB 2
UniProt: O07591 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 131 (115)
Sequences: 4171 (3207)
Seq/√Len: 299.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
40_A73_F4.1961.00
41_G74_T4.0711.00
11_G15_A3.1191.00
45_L66_G3.1181.00
8_F12_A2.8871.00
39_A108_F2.5651.00
97_Y101_S2.5501.00
47_I116_G2.2971.00
10_G64_F2.2931.00
12_A72_G2.2751.00
39_A104_S2.0491.00
17_L69_F2.0411.00
21_L37_E1.9531.00
83_T98_V1.9191.00
43_L115_V1.8791.00
83_T97_Y1.8191.00
83_T94_A1.7661.00
13_L69_F1.7571.00
13_L64_F1.6631.00
42_S105_G1.6601.00
48_L65_L1.6581.00
25_I33_A1.5871.00
50_G113_V1.5551.00
37_E73_F1.5351.00
36_L40_A1.5321.00
17_L73_F1.4951.00
45_L109_A1.4411.00
20_G24_W1.4191.00
43_L112_G1.4171.00
35_W100_A1.4111.00
45_L70_C1.4001.00
8_F16_C1.3271.00
90_Q93_L1.3261.00
16_C20_G1.3251.00
85_M88_Q1.3091.00
44_L70_C1.3001.00
12_A16_C1.2781.00
19_Y23_L1.2761.00
48_L66_G1.2721.00
34_T82_E1.2641.00
4_Y16_C1.2491.00
50_G116_G1.2201.00
95_L99_A1.1741.00
15_A72_G1.1611.00
110_L114_F1.1521.00
22_N37_E1.1271.00
45_L72_G1.0951.00
78_T82_E1.0841.00
87_L94_A1.0741.00
35_W104_S1.0551.00
30_F35_W1.0551.00
64_F69_F1.0541.00
112_G116_G1.0511.00
50_G54_I1.0301.00
43_L108_F1.0221.00
49_T81_K1.0071.00
63_A67_T0.9891.00
92_S95_L0.9811.00
100_A104_S0.9801.00
35_W39_A0.9561.00
87_L91_P0.9321.00
47_I50_G0.9211.00
91_P95_L0.8931.00
7_V63_A0.8901.00
111_I114_F0.8841.00
49_T66_G0.8751.00
84_V113_V0.8621.00
84_V109_A0.8551.00
114_F117_R0.8481.00
9_I12_A0.8441.00
69_F72_G0.8421.00
20_G23_L0.8361.00
92_S96_L0.8251.00
25_I36_L0.8171.00
59_P63_A0.8131.00
6_A60_L0.8111.00
84_V110_L0.8041.00
80_S84_V0.7870.99
22_N26_H0.7860.99
33_A37_E0.7840.99
31_P86_L0.7780.99
101_S105_G0.7740.99
22_N82_E0.7700.99
62_S66_G0.7690.99
79_F105_G0.7650.99
61_L64_F0.7510.99
57_K61_L0.7490.99
108_F111_I0.7460.99
110_L113_V0.7460.99
22_N34_T0.7440.99
96_L100_A0.7330.99
82_E85_M0.7290.99
43_L50_G0.7290.99
32_A36_L0.7100.99
100_A103_I0.7060.99
94_A102_L0.7050.99
113_V117_R0.7040.99
51_F116_G0.7040.99
106_I109_A0.6920.99
52_F55_G0.6920.99
9_I64_F0.6900.99
17_L20_G0.6880.99
23_L27_T0.6880.99
114_F118_R0.6880.99
99_A103_I0.6850.99
6_A64_F0.6800.98
37_E40_A0.6790.98
79_F98_V0.6790.98
21_L36_L0.6770.98
52_F57_K0.6680.98
76_M80_S0.6640.98
104_S108_F0.6640.98
4_Y63_A0.6600.98
29_Q96_L0.6570.98
60_L63_A0.6540.98
50_G53_M0.6540.98
69_F73_F0.6500.98
17_L21_L0.6470.98
47_I115_V0.6430.98
15_A70_C0.6420.98
63_A66_G0.6390.98
86_L97_Y0.6360.98
35_W101_S0.6360.98
29_Q93_L0.6350.98
81_K85_M0.6330.98
48_L52_F0.6270.97
51_F55_G0.6220.97
58_R61_L0.6150.97
13_L16_C0.6140.97
26_H33_A0.6070.97
54_I117_R0.6040.97
10_G79_F0.6010.97
80_S102_L0.6010.97
48_L57_K0.5970.97
7_V10_G0.5940.96
21_L25_I0.5930.96
10_G69_F0.5900.96
34_T75_T0.5900.96
80_S83_T0.5890.96
107_I111_I0.5870.96
21_L33_A0.5830.96
28_G32_A0.5820.96
30_F86_L0.5790.96
28_G93_L0.5780.96
21_L73_F0.5710.96
29_Q95_L0.5690.95
4_Y49_T0.5680.95
46_G109_A0.5660.95
42_S109_A0.5650.95
44_L65_L0.5590.95
80_S109_A0.5560.95
60_L64_F0.5550.95
93_L96_L0.5540.95
35_W93_L0.5470.94
98_V102_L0.5460.94
4_Y20_G0.5410.94
49_T113_V0.5380.94
42_S45_L0.5350.94
47_I51_F0.5300.93
45_L49_T0.5290.93
49_T53_M0.5290.93
61_L65_L0.5230.93
84_V88_Q0.5230.93
72_G76_M0.5170.93
59_P62_S0.5150.92
21_L40_A0.5140.92
66_G78_T0.5140.92
72_G79_F0.5100.92
42_S70_C0.5050.92
108_F116_G0.5050.92
53_M113_V0.5020.91
7_V89_G0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pypA 1 0.9313 28 0.909 Contact Map
4p6vD 1 0.8321 27.4 0.909 Contact Map
4j05A 3 0.9771 20.3 0.914 Contact Map
3rlbA 1 0.9618 14.7 0.92 Contact Map
4eneA 2 0.9313 9.5 0.926 Contact Map
3j1zP 8 0.8779 9.3 0.927 Contact Map
2b2hA 3 1 8.5 0.928 Contact Map
4w6vA 1 0.9084 7.8 0.929 Contact Map
3effK 4 0.8015 7.7 0.929 Contact Map
2kluA 1 0.3282 7.4 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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