GREMLIN Database
CRCB1 - Putative fluoride ion transporter CrcB 1
UniProt: O07590 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 118 (112)
Sequences: 2859 (2162)
Seq/√Len: 204.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_G74_T4.5571.00
43_L73_F4.0281.00
7_F11_G3.5391.00
10_G14_A3.3831.00
48_L66_G3.1221.00
98_Y102_T2.6251.00
42_I109_A2.5941.00
9_G64_I2.5511.00
16_L69_F2.3181.00
11_G72_A2.2211.00
12_L64_I2.0851.00
45_A106_S1.9311.00
42_I105_G1.8951.00
38_L101_L1.8271.00
40_V73_F1.7901.00
83_T99_I1.7131.00
53_G114_W1.6481.00
48_L70_F1.5761.00
20_L40_V1.5651.00
51_F65_I1.5591.00
47_G70_F1.5471.00
83_T95_S1.5441.00
48_L110_F1.5261.00
39_T43_L1.5141.00
12_L69_F1.4411.00
14_A72_A1.4041.00
91_R94_E1.3971.00
16_L73_F1.3891.00
15_M19_W1.3741.00
83_T98_Y1.3741.00
51_F66_G1.3581.00
46_L116_I1.3351.00
30_G35_I1.3331.00
24_I36_G1.3061.00
64_I69_F1.3051.00
48_L72_A1.2961.00
63_L67_T1.2841.00
96_I100_V1.2251.00
18_F22_N1.2141.00
50_I54_L1.2051.00
111_W115_T1.1661.00
84_I114_W1.1541.00
46_L109_A1.1441.00
85_Q88_M1.1351.00
78_T82_E1.1331.00
7_F15_M1.1201.00
52_T81_V1.1191.00
84_I110_F1.1021.00
19_W23_V1.0961.00
53_G57_A1.0901.00
52_T56_V1.0351.00
82_E85_Q1.0191.00
101_L105_G1.0141.00
93_K96_I1.0131.00
87_L95_S1.0051.00
52_T66_G0.9831.00
80_S110_F0.9610.99
36_G40_V0.9580.99
19_W22_N0.9470.99
38_L42_I0.9350.99
21_G40_V0.9220.99
38_L105_G0.9180.99
14_A70_F0.9080.99
6_I63_L0.9030.99
102_T106_S0.8890.99
24_I39_T0.8840.99
40_V43_L0.8800.99
11_G15_M0.8760.99
3_L15_M0.8740.99
93_K97_L0.8610.99
21_G82_E0.8390.99
112_C115_T0.8380.99
4_A8_I0.8270.98
46_L113_G0.8210.98
69_F73_F0.8080.98
5_G60_S0.7940.98
3_L63_L0.7940.98
46_L53_G0.7880.98
105_G109_A0.7860.98
109_A112_C0.7830.98
62_S66_G0.7760.98
24_I29_K0.7750.98
108_F112_C0.7750.98
3_L52_T0.7740.98
29_K32_S0.7540.97
21_G25_T0.7460.97
20_L24_I0.7450.97
35_I39_T0.7420.97
33_L86_L0.7380.97
80_S103_L0.7260.97
95_S103_L0.7170.96
9_G79_F0.7110.96
63_L66_G0.7090.96
104_C108_F0.7000.96
61_V64_I0.6990.96
45_A70_F0.6900.95
33_L38_L0.6840.95
47_G65_I0.6760.95
17_R68_G0.6760.95
94_E98_Y0.6680.94
92_V96_I0.6680.94
79_F106_S0.6610.94
79_F103_L0.6540.94
54_L58_N0.6530.94
61_V65_I0.6500.94
53_G56_V0.6490.94
55_H58_N0.6490.94
49_G76_F0.6470.93
50_I113_G0.6430.93
66_G78_T0.6410.93
24_I28_T0.6330.93
100_V104_C0.6290.93
20_L43_L0.6250.92
67_T78_T0.6250.92
6_I90_K0.6220.92
29_K35_I0.6220.92
34_P86_L0.6210.92
47_G51_F0.6200.92
38_L106_S0.6160.92
25_T36_G0.6140.92
55_H66_G0.6090.91
50_I53_G0.6090.91
51_F55_H0.6090.91
37_I41_N0.6000.91
111_W114_W0.5990.91
25_T28_T0.5940.90
20_L39_T0.5930.90
10_G98_Y0.5930.90
110_F113_G0.5900.90
101_L104_C0.5860.90
72_A79_F0.5840.89
38_L102_T0.5840.89
16_L19_W0.5830.89
96_I107_L0.5830.89
45_A110_F0.5830.89
37_I82_E0.5820.89
45_A107_L0.5790.89
49_G64_I0.5750.89
23_V87_L0.5710.88
107_L110_F0.5690.88
79_F99_I0.5670.88
23_V28_T0.5610.88
108_F111_W0.5610.88
80_S84_I0.5600.87
72_A76_F0.5590.87
32_S91_R0.5550.87
37_I75_T0.5550.87
81_V85_Q0.5530.87
88_M114_W0.5500.87
6_I9_G0.5480.86
25_T29_K0.5470.86
20_L73_F0.5460.86
42_I46_L0.5460.86
97_L101_L0.5430.86
81_V110_F0.5420.86
89_A92_V0.5360.85
56_V114_W0.5290.84
24_I40_V0.5280.84
86_L98_Y0.5220.84
45_A80_S0.5190.83
98_Y106_S0.5170.83
49_G110_F0.5100.82
60_S63_L0.5090.82
5_G64_I0.5090.82
66_G81_V0.5090.82
90_K95_S0.5020.81
22_N25_T0.5010.81
87_L92_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q65A 1 0.9831 11.3 0.915 Contact Map
4uvmA 1 0.9831 9.3 0.918 Contact Map
4j05A 3 0.9576 7.8 0.921 Contact Map
4tphA 2 0.9661 7.2 0.922 Contact Map
4ikvA 1 0.9831 6.5 0.923 Contact Map
4xnjA 1 0.9831 4.7 0.928 Contact Map
4pypA 1 0.9831 4.7 0.928 Contact Map
2cfqA 1 0.9576 4.4 0.929 Contact Map
4xp4A 1 0.9831 4.3 0.93 Contact Map
4oh3A 2 0.9831 4.2 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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