GREMLIN Database
YHDT - UPF0053 protein YhdT
UniProt: O07589 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 461 (412)
Sequences: 6975 (4697)
Seq/√Len: 231.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_M330_L4.2201.00
400_D405_E3.9881.00
366_M429_I3.9141.00
408_R413_T3.4131.00
406_S413_T3.4041.00
406_S415_K3.3771.00
394_I427_I3.1571.00
255_D260_S3.0981.00
365_V417_L3.0031.00
235_T238_E2.9711.00
229_A254_T2.8371.00
286_T289_P2.8301.00
297_V306_L2.8281.00
255_D288_H2.8231.00
360_G363_H2.7731.00
269_H292_R2.7651.00
415_K430_K2.7391.00
131_K134_Q2.7361.00
234_M238_E2.7241.00
413_T430_K2.6401.00
253_V291_V2.6201.00
365_V426_Q2.5931.00
319_I330_L2.5611.00
114_F160_S2.4791.00
413_T432_E2.4341.00
144_R148_L2.4321.00
375_V379_L2.3101.00
232_T255_D2.3051.00
227_M327_T2.2681.00
301_I309_K2.2591.00
155_W159_G2.2471.00
35_I49_A2.2111.00
217_A306_L2.1891.00
393_L409_I2.1861.00
417_L428_D2.1671.00
359_L363_H2.1261.00
390_I427_I2.0891.00
319_I327_T2.0851.00
48_L144_R2.0201.00
363_H428_D1.9981.00
19_F142_P1.9811.00
418_K426_Q1.9671.00
229_A258_K1.9291.00
375_V429_I1.9251.00
17_T71_S1.9141.00
58_E151_F1.8971.00
220_I303_V1.8931.00
232_T288_H1.8841.00
163_L167_M1.8721.00
38_L137_L1.8681.00
230_V239_M1.8571.00
370_V375_V1.8561.00
306_L331_V1.8451.00
48_L141_G1.8391.00
363_H430_K1.8341.00
138_L142_P1.8101.00
356_I370_V1.7961.00
420_D425_K1.7921.00
51_R144_R1.7601.00
230_V253_V1.7531.00
232_T262_L1.7521.00
189_L206_V1.7441.00
264_L294_V1.7341.00
34_R133_E1.7201.00
241_E245_K1.7111.00
43_N137_L1.7041.00
418_K425_K1.7031.00
39_I50_R1.6951.00
370_V390_I1.6781.00
358_K364_Y1.6611.00
365_V428_D1.6591.00
317_M330_L1.6491.00
234_M239_M1.6491.00
233_E255_D1.6351.00
375_V390_I1.6281.00
48_L140_A1.6241.00
254_T261_V1.5951.00
415_K428_D1.5921.00
359_L365_V1.5741.00
334_E338_E1.5711.00
366_M390_I1.5701.00
259_D326_G1.5671.00
358_K361_D1.5671.00
220_I331_V1.5611.00
228_A242_V1.5601.00
249_T266_N1.5551.00
205_Y209_I1.5541.00
23_S139_I1.5491.00
359_L428_D1.5461.00
395_L424_I1.5461.00
414_I427_I1.5411.00
394_I414_I1.5331.00
205_Y340_I1.5081.00
17_T67_I1.5071.00
337_L341_V1.5041.00
411_S432_E1.4981.00
394_I416_V1.4941.00
376_N381_A1.4901.00
412_Y431_E1.4551.00
159_G163_L1.4461.00
134_Q138_L1.4401.00
366_M375_V1.4331.00
215_R219_E1.4301.00
408_R432_E1.4221.00
308_I311_Q1.4221.00
299_E328_S1.4091.00
36_D40_T1.3871.00
9_L77_L1.3851.00
7_L11_G1.3751.00
303_V336_I1.3751.00
264_L317_M1.3741.00
228_A248_Y1.3731.00
47_I51_R1.3621.00
257_D260_S1.3621.00
255_D262_L1.3601.00
409_I414_I1.3601.00
209_I340_I1.3521.00
36_D50_R1.3491.00
8_I12_V1.3471.00
62_A146_F1.3451.00
301_I306_L1.3431.00
49_A140_A1.3181.00
387_V396_K1.3161.00
231_S234_M1.3101.00
22_A135_L1.3011.00
411_S431_E1.2941.00
238_E241_E1.2891.00
417_L426_Q1.2801.00
394_I398_N1.2801.00
412_Y429_I1.2791.00
394_I407_I1.2781.00
38_L43_N1.2771.00
148_L151_F1.2711.00
359_L362_G1.2701.00
19_F139_I1.2701.00
142_P145_L1.2681.00
45_R137_L1.2641.00
250_R316_H1.2631.00
346_D349_D1.2631.00
50_R54_T1.2571.00
42_G46_A1.2561.00
362_G431_E1.2471.00
317_M332_T1.2461.00
78_G112_I1.2461.00
106_A110_G1.2401.00
100_S104_S1.2391.00
123_A164_L1.2371.00
225_K326_G1.2361.00
43_N46_A1.2301.00
397_E409_I1.2251.00
356_I378_L1.2251.00
372_I376_N1.2241.00
72_I75_G1.2201.00
45_R141_G1.2171.00
62_A154_I1.2121.00
141_G145_L1.2001.00
224_R259_D1.1991.00
139_I142_P1.1951.00
228_A246_E1.1771.00
49_A136_T1.1731.00
357_Q365_V1.1681.00
285_M289_P1.1501.00
309_K313_E1.1481.00
12_V16_L1.1461.00
127_V170_L1.1421.00
159_G162_R1.1371.00
20_F66_G1.1331.00
25_F28_V1.1301.00
261_V319_I1.1201.00
234_M242_V1.1141.00
355_L367_D1.1101.00
246_E251_W1.1091.00
20_F146_F1.0971.00
226_E423_L1.0961.00
39_I47_I1.0951.00
334_E344_I1.0931.00
231_S256_G1.0931.00
228_A251_W1.0911.00
35_I50_R1.0861.00
298_I301_I1.0791.00
5_D9_L1.0791.00
102_A106_A1.0781.00
151_F155_W1.0761.00
368_G390_I1.0751.00
67_I71_S1.0731.00
64_Q67_I1.0731.00
344_I349_D1.0681.00
376_N383_I1.0671.00
220_I336_I1.0651.00
379_L412_Y1.0641.00
414_I429_I1.0621.00
224_R326_G1.0571.00
71_S116_H1.0461.00
391_G395_L1.0371.00
407_I414_I1.0371.00
294_V319_I1.0371.00
265_V290_Y1.0341.00
30_V35_I1.0281.00
250_R334_E1.0241.00
259_D327_T1.0231.00
17_T21_V1.0231.00
229_A327_T1.0221.00
21_V25_F1.0151.00
262_L291_V1.0121.00
356_I366_M1.0061.00
217_A297_V1.0031.00
52_V59_Y1.0021.00
408_R411_S1.0001.00
356_I364_Y0.9941.00
120_G125_K0.9931.00
44_K47_I0.9921.00
398_N407_I0.9901.00
393_L414_I0.9881.00
192_S196_G0.9861.00
395_L401_I0.9811.00
163_L166_G0.9741.00
376_N382_S0.9741.00
367_D426_Q0.9711.00
230_V287_I0.9701.00
217_A320_L0.9691.00
193_L203_Y0.9691.00
30_V132_A0.9671.00
243_M251_W0.9591.00
232_T291_V0.9591.00
244_L276_F0.9531.00
322_D325_G0.9521.00
240_L244_L0.9511.00
231_S254_T0.9511.00
166_G171_K0.9441.00
256_G260_S0.9441.00
23_S143_L0.9401.00
14_I120_G0.9381.00
403_A418_K0.9361.00
104_S108_A0.9321.00
297_V318_A0.9221.00
180_H188_L0.9211.00
24_E125_K0.9181.00
10_I112_I0.9171.00
334_E349_D0.9161.00
171_K174_S0.9161.00
310_M318_A0.9131.00
121_E125_K0.9121.00
76_V109_Y0.9081.00
76_V79_E0.9081.00
371_R374_Q0.9071.00
156_I159_G0.9071.00
269_H348_F0.9051.00
285_M290_Y0.9000.99
301_I305_D0.8980.99
145_L148_L0.8960.99
35_I53_I0.8920.99
383_I393_L0.8910.99
233_E288_H0.8900.99
241_E244_L0.8860.99
397_E407_I0.8860.99
295_I309_K0.8800.99
237_A241_E0.8760.99
55_D58_E0.8730.99
162_R166_G0.8700.99
393_L397_E0.8700.99
110_G114_F0.8700.99
16_L70_T0.8680.99
147_Y151_F0.8680.99
17_T116_H0.8660.99
236_M239_M0.8650.99
79_E108_A0.8610.99
345_R352_E0.8590.99
322_D328_S0.8560.99
391_G423_L0.8540.99
316_H337_L0.8510.99
185_L192_S0.8500.99
37_Q41_E0.8470.99
10_I74_L0.8460.99
68_T113_T0.8460.99
226_E369_K0.8460.99
182_E214_N0.8450.99
67_I121_E0.8440.99
10_I81_A0.8430.99
51_R55_D0.8410.99
45_R49_A0.8400.99
266_N269_H0.8400.99
217_A331_V0.8390.99
83_E104_S0.8370.99
48_L51_R0.8370.99
74_L112_I0.8350.99
368_G391_G0.8320.99
72_I109_Y0.8320.99
9_L12_V0.8310.99
218_K299_E0.8270.99
323_E392_G0.8230.99
230_V251_W0.8230.99
236_M285_M0.8200.99
78_G82_F0.8180.99
138_L141_G0.8180.99
22_A128_A0.8130.99
283_M286_T0.8110.99
384_Q387_V0.8110.99
67_I116_H0.8030.99
64_Q68_T0.8020.99
334_E347_E0.8010.99
52_V140_A0.8010.99
358_K362_G0.8010.99
338_E343_E0.8000.99
182_E210_F0.8000.99
68_T116_H0.7980.99
288_H291_V0.7950.99
17_T70_T0.7900.99
295_I318_A0.7880.99
75_G78_G0.7850.99
372_I383_I0.7840.99
165_C170_L0.7840.99
141_G144_R0.7820.99
252_P264_L0.7820.99
122_L157_L0.7810.99
297_V320_L0.7780.98
75_G79_E0.7750.98
185_L198_I0.7740.98
227_M258_K0.7720.98
32_R54_T0.7690.98
368_G424_I0.7680.98
15_A18_A0.7680.98
232_T239_M0.7660.98
18_A22_A0.7640.98
46_A137_L0.7610.98
334_E339_E0.7610.98
262_L288_H0.7590.98
103_V107_V0.7590.98
135_L139_I0.7590.98
39_I42_G0.7560.98
212_F336_I0.7550.98
64_Q71_S0.7520.98
387_V393_L0.7520.98
22_A26_A0.7510.98
72_I113_T0.7500.98
17_T68_T0.7490.98
9_L13_L0.7480.98
136_T140_A0.7470.98
367_D370_V0.7460.98
63_S143_L0.7460.98
230_V242_V0.7420.98
250_R266_N0.7380.98
74_L116_H0.7380.98
30_V49_A0.7350.98
34_R38_L0.7330.98
243_M270_L0.7310.98
334_E343_E0.7290.98
403_A419_M0.7280.98
212_F307_L0.7270.98
67_I122_L0.7270.98
218_K328_S0.7270.98
38_L41_E0.7260.98
282_R285_M0.7240.98
62_A147_Y0.7220.98
252_P319_I0.7220.98
253_V287_I0.7210.98
45_R138_L0.7210.98
205_Y212_F0.7210.98
243_M267_T0.7170.97
152_P156_I0.7160.97
182_E186_R0.7150.97
64_Q75_G0.7140.97
34_R37_Q0.7130.97
298_I323_E0.7120.97
57_D126_T0.7110.97
356_I375_V0.7100.97
21_V121_E0.7080.97
316_H334_E0.7050.97
372_I387_V0.7040.97
14_I17_T0.7040.97
67_I70_T0.7020.97
357_Q426_Q0.7020.97
68_T125_K0.7020.97
381_A412_Y0.7000.97
35_I46_A0.6990.97
250_R347_E0.6980.97
119_V164_L0.6970.97
39_I43_N0.6950.97
70_T113_T0.6930.97
242_V245_K0.6920.97
14_I115_L0.6910.97
338_E349_D0.6900.97
277_M282_R0.6880.97
401_I419_M0.6880.97
359_L418_K0.6870.97
224_R322_D0.6850.97
17_T64_Q0.6850.97
345_R351_D0.6840.97
333_T344_I0.6830.97
307_L336_I0.6820.97
344_I347_E0.6810.97
26_A136_T0.6810.97
75_G113_T0.6800.96
254_T257_D0.6790.96
19_F66_G0.6780.96
309_K312_R0.6770.96
402_E405_E0.6770.96
339_E343_E0.6760.96
21_V116_H0.6740.96
5_D8_I0.6730.96
171_K175_E0.6730.96
232_T235_T0.6730.96
250_R317_M0.6730.96
252_P261_V0.6710.96
294_V317_M0.6700.96
306_L336_I0.6700.96
287_I291_V0.6690.96
16_L20_F0.6680.96
398_N405_E0.6650.96
249_T268_K0.6640.96
266_N292_R0.6640.96
295_I313_E0.6640.96
14_I74_L0.6630.96
79_E83_E0.6620.96
72_I79_E0.6610.96
65_L153_F0.6600.96
56_L59_Y0.6560.96
217_A301_I0.6540.96
25_F128_A0.6540.96
204_K208_K0.6530.96
355_L370_V0.6520.96
212_F304_H0.6500.95
24_E121_E0.6500.95
145_L149_L0.6500.95
239_M243_M0.6470.95
334_E346_D0.6470.95
45_R48_L0.6470.95
76_V105_F0.6470.95
52_V147_Y0.6460.95
13_L73_G0.6460.95
82_F108_A0.6450.95
239_M287_I0.6430.95
75_G109_Y0.6410.95
261_V327_T0.6410.95
206_V210_F0.6390.95
38_L46_A0.6390.95
391_G424_I0.6370.95
47_I50_R0.6360.95
334_E348_F0.6330.95
254_T258_K0.6320.95
386_D396_K0.6300.95
67_I120_G0.6300.95
216_I219_E0.6270.94
382_S410_G0.6250.94
230_V234_M0.6220.94
358_K363_H0.6220.94
375_V378_L0.6210.94
70_T109_Y0.6200.94
41_E46_A0.6190.94
57_D162_R0.6180.94
25_F64_Q0.6140.94
239_M286_T0.6120.94
73_G105_F0.6120.94
222_I345_R0.6110.94
186_R207_N0.6090.94
39_I45_R0.6090.94
182_E213_D0.6080.94
261_V296_E0.6070.93
64_Q116_H0.6060.93
252_P388_D0.6040.93
68_T109_Y0.6030.93
393_L407_I0.6030.93
322_D326_G0.6030.93
153_F157_L0.6030.93
307_L333_T0.6020.93
275_L285_M0.6020.93
23_S27_I0.6020.93
362_G433_A0.5980.93
244_L272_S0.5980.93
71_S122_L0.5970.93
30_V59_Y0.5940.93
21_V71_S0.5940.93
295_I315_I0.5940.93
57_D61_S0.5930.93
218_K388_D0.5910.93
203_Y207_N0.5910.93
82_F110_G0.5890.92
60_L64_Q0.5880.92
24_E68_T0.5880.92
219_E388_D0.5880.92
132_A135_L0.5870.92
58_E147_Y0.5860.92
224_R323_E0.5850.92
45_R140_A0.5840.92
83_E101_H0.5840.92
333_T341_V0.5830.92
21_V67_I0.5830.92
157_L161_A0.5830.92
64_Q122_L0.5810.92
126_T129_I0.5800.92
238_E242_V0.5800.92
60_L120_G0.5790.92
341_V344_I0.5790.92
419_M422_R0.5790.92
344_I348_F0.5780.92
79_E117_V0.5770.92
72_I108_A0.5770.92
152_P155_W0.5750.92
6_S10_I0.5750.92
32_R50_R0.5750.92
338_E346_D0.5740.91
378_L381_A0.5720.91
105_F109_Y0.5710.91
76_V112_I0.5710.91
30_V133_E0.5700.91
219_E395_L0.5690.91
63_S70_T0.5680.91
384_Q397_E0.5680.91
73_G77_L0.5650.91
59_Y65_L0.5650.91
359_L425_K0.5640.91
397_E410_G0.5630.91
249_T346_D0.5630.91
28_V61_S0.5620.91
21_V68_T0.5610.91
113_T117_V0.5610.91
150_L153_F0.5610.91
17_T113_T0.5610.91
307_L341_V0.5580.90
44_K141_G0.5570.90
366_M379_L0.5560.90
127_V131_K0.5550.90
55_D147_Y0.5540.90
70_T74_L0.5530.90
192_S198_I0.5520.90
98_S102_A0.5520.90
97_D101_H0.5510.90
424_I427_I0.5510.90
338_E344_I0.5500.90
63_S109_Y0.5500.90
68_T71_S0.5490.90
316_H344_I0.5490.90
60_L125_K0.5470.89
149_L152_P0.5470.89
130_Q170_L0.5470.89
51_R54_T0.5460.89
13_L70_T0.5450.89
237_A284_K0.5450.89
372_I390_I0.5440.89
292_R315_I0.5430.89
7_L81_A0.5430.89
372_I375_V0.5430.89
33_S187_M0.5430.89
334_E341_V0.5420.89
192_S197_E0.5420.89
29_R129_I0.5420.89
362_G430_K0.5410.89
71_S109_Y0.5410.89
25_F65_L0.5400.89
49_A53_I0.5390.89
338_E347_E0.5370.89
158_N161_A0.5370.89
224_R325_G0.5360.88
78_G104_S0.5350.88
364_Y379_L0.5340.88
213_D304_H0.5330.88
242_V246_E0.5330.88
267_T271_F0.5320.88
259_D323_E0.5310.88
65_L113_T0.5310.88
298_I321_S0.5310.88
34_R46_A0.5300.88
189_L198_I0.5300.88
208_K340_I0.5290.88
190_S207_N0.5290.88
103_V106_A0.5290.88
379_L429_I0.5280.88
296_E321_S0.5270.88
75_G80_P0.5250.87
228_A245_K0.5250.87
98_S101_H0.5250.87
210_F213_D0.5240.87
249_T347_E0.5240.87
27_I136_T0.5240.87
79_E113_T0.5230.87
299_E340_I0.5230.87
405_E424_I0.5230.87
308_I312_R0.5230.87
134_Q137_L0.5230.87
236_M240_L0.5230.87
366_M427_I0.5220.87
61_S68_T0.5210.87
364_Y378_L0.5210.87
291_V294_V0.5210.87
30_V38_L0.5200.87
376_N384_Q0.5200.87
56_L109_Y0.5190.87
76_V80_P0.5190.87
51_R148_L0.5190.87
72_I76_V0.5180.87
301_I320_L0.5170.87
289_P293_P0.5160.87
68_T122_L0.5150.86
370_V374_Q0.5140.86
395_L405_E0.5120.86
46_A136_T0.5120.86
68_T121_E0.5110.86
343_E346_D0.5110.86
373_D377_S0.5100.86
146_F150_L0.5090.86
241_E276_F0.5090.86
21_V63_S0.5080.86
224_R324_Y0.5070.86
249_T316_H0.5070.86
254_T262_L0.5070.86
358_K431_E0.5050.85
75_G117_V0.5050.85
109_Y116_H0.5050.85
425_K428_D0.5040.85
29_R59_Y0.5040.85
324_Y392_G0.5040.85
60_L121_E0.5040.85
186_R211_E0.5040.85
30_V137_L0.5030.85
374_Q378_L0.5010.85
189_L207_N0.5010.85
191_E198_I0.5010.85
337_L344_I0.5000.85
250_R346_D0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.4989 100 0.536 Contact Map
3lhhA 1 0.2711 100 0.775 Contact Map
3ocoA 2 0.2928 99.9 0.79 Contact Map
3oi8A 2 0.3384 99.9 0.793 Contact Map
3ocmA 5 0.3232 99.9 0.797 Contact Map
3kxrA 3 0.3492 99.9 0.801 Contact Map
2v8qE 1 0.5488 99.9 0.802 Contact Map
3lv9A 2 0.282 99.9 0.806 Contact Map
4iysA 2 0.308 99.9 0.813 Contact Map
3t4nC 1 0.5423 99.9 0.824 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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