GREMLIN Database
AAT3 - Putative aspartate aminotransferase YhdR
UniProt: O07587 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (344)
Sequences: 43102 (29851)
Seq/√Len: 1609.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
162_R199_E3.0401.00
60_I64_E2.9951.00
103_T109_A2.9691.00
351_Y387_S2.9211.00
123_E144_K2.8501.00
122_E170_K2.7881.00
305_K309_D2.7311.00
187_Q191_D2.7181.00
321_E334_K2.6691.00
310_L379_K2.6671.00
380_N384_I2.5721.00
346_H350_K2.5681.00
306_E375_I2.5561.00
82_K288_Q2.4941.00
118_V143_G2.4231.00
53_E57_R2.3481.00
257_L262_P2.3171.00
88_G94_D2.2691.00
78_A284_P2.2011.00
111_N115_K2.1671.00
339_D342_A2.1571.00
314_I382_R2.1291.00
252_L283_A2.0701.00
380_N383_D2.0521.00
186_S189_N2.0211.00
191_D195_A1.9821.00
57_R61_E1.9761.00
81_E85_Q1.9031.00
159_E192_D1.9001.00
138_I143_G1.8871.00
207_T234_R1.8641.00
151_T189_N1.8551.00
225_L229_F1.8481.00
313_D317_E1.8221.00
314_I317_E1.8091.00
42_F381_S1.8081.00
123_E146_V1.7981.00
162_R192_D1.7771.00
85_Q288_Q1.7591.00
199_E206_Q1.7571.00
226_A229_F1.7531.00
113_A236_I1.7381.00
155_E189_N1.7331.00
160_A164_S1.7281.00
171_G211_L1.7211.00
81_E97_A1.7101.00
312_V316_K1.6981.00
197_L210_V1.6971.00
314_I383_D1.6951.00
309_D313_D1.6911.00
316_K322_F1.6871.00
123_E169_T1.6681.00
211_L238_A1.6641.00
123_E166_T1.6611.00
157_D160_A1.6591.00
310_L314_I1.6581.00
215_P240_S1.6551.00
84_A97_A1.6541.00
312_V324_M1.6101.00
192_D195_A1.5911.00
113_A211_L1.5901.00
314_I386_I1.5801.00
106_A238_A1.5761.00
99_R259_S1.5741.00
77_L81_E1.5671.00
123_E168_Q1.5531.00
311_M331_V1.5521.00
128_A147_S1.5521.00
346_H388_L1.5341.00
124_V138_I1.5171.00
61_E285_V1.5161.00
355_I367_F1.5141.00
95_F256_G1.5131.00
160_A163_Q1.5071.00
374_P377_Q1.5001.00
114_L138_I1.4741.00
56_K60_I1.4731.00
83_V254_Y1.4711.00
135_K139_E1.4501.00
82_K85_Q1.4491.00
87_L256_G1.4431.00
340_E359_S1.4401.00
310_L375_I1.4371.00
78_A288_Q1.4361.00
158_I196_L1.4351.00
195_A199_E1.4311.00
197_L208_I1.4221.00
332_F358_S1.4151.00
255_I265_D1.4081.00
188_K191_D1.4051.00
98_E259_S1.3941.00
236_I257_L1.3811.00
383_D387_S1.3771.00
311_M382_R1.3711.00
312_V331_V1.3611.00
166_T169_T1.3571.00
165_I196_L1.3481.00
101_V262_P1.3431.00
342_A346_H1.3361.00
298_R302_S1.3361.00
128_A149_P1.3351.00
196_L206_Q1.3301.00
158_I192_D1.3121.00
83_V102_M1.3091.00
162_R206_Q1.3031.00
114_L173_I1.2981.00
317_E386_I1.2981.00
351_Y384_I1.2981.00
241_F283_A1.2971.00
59_L63_A1.2951.00
316_K324_M1.2811.00
149_P160_A1.2801.00
312_V322_F1.2781.00
342_A345_V1.2711.00
225_L228_P1.2621.00
82_K284_P1.2551.00
303_A306_E1.2381.00
379_K383_D1.2381.00
298_R301_A1.2311.00
76_L281_V1.2311.00
56_K64_E1.2291.00
303_A375_I1.2281.00
333_P369_L1.2241.00
108_G269_N1.2191.00
125_I169_T1.2191.00
314_I379_K1.2171.00
57_R60_I1.2141.00
74_Q266_L1.2101.00
58_A285_V1.2101.00
195_A198_K1.2071.00
264_A267_L1.2041.00
269_N273_Y1.2001.00
83_V100_I1.1971.00
87_L254_Y1.1961.00
59_L282_N1.1911.00
302_S305_K1.1881.00
196_L208_I1.1841.00
189_N192_D1.1771.00
284_P288_Q1.1741.00
334_K366_H1.1691.00
126_I145_A1.1671.00
74_Q80_R1.1601.00
114_L118_V1.1521.00
37_D352_K1.1411.00
222_D326_K1.1371.00
125_I148_C1.1361.00
61_E65_K1.1341.00
308_R312_V1.1341.00
80_R84_A1.1331.00
116_S268_I1.1301.00
162_R196_L1.1291.00
239_S254_Y1.1261.00
344_C355_I1.1251.00
104_V108_G1.1241.00
135_K147_S1.1161.00
118_V124_V1.1111.00
302_S306_E1.1041.00
163_Q167_P1.0991.00
339_D364_S1.0961.00
191_D231_S1.0851.00
236_I255_I1.0831.00
78_A281_V1.0791.00
285_V288_Q1.0791.00
233_H258_D1.0781.00
334_K365_G1.0771.00
117_I171_G1.0761.00
96_S259_S1.0761.00
294_M298_R1.0731.00
84_A100_I1.0711.00
375_I379_K1.0691.00
138_I145_A1.0681.00
115_K141_Y1.0671.00
172_L208_I1.0641.00
303_A307_R1.0621.00
197_L206_Q1.0521.00
77_L97_A1.0501.00
162_R166_T1.0421.00
84_A96_S1.0421.00
78_A81_E1.0421.00
96_S99_R1.0411.00
188_K192_D1.0391.00
79_A102_M1.0341.00
53_E56_K1.0311.00
86_F294_M1.0291.00
263_D267_L1.0281.00
369_L381_S1.0141.00
77_L80_R1.0101.00
117_I209_Y1.0071.00
56_K63_A1.0041.00
116_S265_D1.0031.00
120_P142_G1.0011.00
373_V377_Q1.0011.00
109_A255_I0.9981.00
230_Q233_H0.9931.00
194_G210_V0.9921.00
112_V269_N0.9921.00
58_A61_E0.9921.00
148_C164_S0.9911.00
99_R262_P0.9881.00
343_F367_F0.9861.00
109_A238_A0.9851.00
130_Y175_N0.9831.00
119_N122_E0.9821.00
377_Q380_N0.9801.00
308_R371_F0.9781.00
209_Y236_I0.9761.00
198_K233_H0.9731.00
209_Y234_R0.9711.00
341_V359_S0.9691.00
194_G235_V0.9631.00
347_A385_F0.9621.00
309_D324_M0.9601.00
113_A265_D0.9481.00
216_Y330_F0.9461.00
100_I256_G0.9431.00
124_V171_G0.9411.00
220_I223_E0.9401.00
151_T157_D0.9371.00
313_D379_K0.9321.00
101_V265_D0.9271.00
307_R310_L0.9261.00
165_I208_I0.9221.00
156_I189_N0.9221.00
198_K232_Y0.9221.00
159_E163_Q0.9181.00
134_Y173_I0.9131.00
106_A215_P0.9121.00
108_G273_Y0.9101.00
313_D316_K0.8981.00
238_A255_I0.8961.00
320_F333_P0.8941.00
165_I169_T0.8931.00
353_L385_F0.8931.00
99_R232_Y0.8921.00
54_A292_A0.8901.00
209_Y261_M0.8881.00
310_L313_D0.8871.00
341_V345_V0.8851.00
86_F218_Q0.8851.00
340_E365_G0.8851.00
159_E162_R0.8841.00
158_I193_L0.8831.00
311_M378_I0.8771.00
38_Q352_K0.8711.00
58_A62_E0.8701.00
139_E145_A0.8701.00
47_P304_Y0.8651.00
295_D299_V0.8641.00
125_I164_S0.8611.00
107_G133_E0.8611.00
214_E237_L0.8601.00
106_A240_S0.8591.00
90_R294_M0.8581.00
299_V302_S0.8541.00
169_T208_I0.8521.00
311_M314_I0.8511.00
259_S263_D0.8501.00
42_F378_I0.8481.00
308_R325_P0.8471.00
346_H351_Y0.8431.00
310_L382_R0.8381.00
194_G231_S0.8381.00
158_I189_N0.8361.00
76_L284_P0.8311.00
262_P266_L0.8261.00
299_V303_A0.8251.00
281_V284_P0.8241.00
38_Q380_N0.8231.00
166_T206_Q0.8221.00
355_I369_L0.8211.00
347_A355_I0.8161.00
125_I172_L0.8161.00
61_E64_E0.8141.00
114_L171_G0.8111.00
49_V303_A0.8111.00
340_E364_S0.8081.00
125_I161_V0.8021.00
103_T255_I0.8001.00
146_V166_T0.8001.00
107_G131_F0.7991.00
86_F245_L0.7981.00
79_A83_V0.7971.00
198_K234_R0.7931.00
296_D300_D0.7921.00
118_V171_G0.7891.00
57_R64_E0.7891.00
105_G251_R0.7841.00
86_F91_F0.7801.00
124_V143_G0.7791.00
127_L148_C0.7771.00
221_Y305_K0.7761.00
218_Q244_D0.7741.00
54_A285_V0.7731.00
222_D308_R0.7731.00
158_I162_R0.7721.00
345_V350_K0.7701.00
353_L384_I0.7681.00
41_D46_N0.7631.00
336_P365_G0.7631.00
241_F254_Y0.7591.00
341_V357_P0.7571.00
306_E309_D0.7551.00
343_F388_L0.7541.00
161_V172_L0.7531.00
311_M371_F0.7511.00
118_V122_E0.7491.00
376_E379_K0.7461.00
236_I261_M0.7411.00
126_I138_I0.7391.00
150_L178_H0.7381.00
60_I63_A0.7361.00
295_D298_R0.7341.00
86_F90_R0.7331.00
296_D299_V0.7321.00
54_A57_R0.7311.00
353_L381_S0.7311.00
198_K230_Q0.7311.00
179_N216_Y0.7271.00
128_A362_G0.7261.00
340_E357_P0.7261.00
127_L156_I0.7251.00
339_D343_F0.7241.00
50_E56_K0.7231.00
244_D293_R0.7221.00
351_Y388_L0.7211.00
108_G112_V0.7211.00
101_V255_I0.7171.00
75_G80_R0.7141.00
300_D304_Y0.7141.00
321_E336_P0.7121.00
127_L178_H0.7111.00
54_A293_R0.7101.00
157_D189_N0.7081.00
257_L265_D0.7081.00
85_Q88_G0.7071.00
36_E352_K0.7061.00
146_V169_T0.7011.00
173_I211_L0.6981.00
67_S281_V0.6961.00
90_R218_Q0.6951.00
36_E39_V0.6951.00
151_T155_E0.6951.00
245_L294_M0.6901.00
340_E344_C0.6901.00
52_P55_F0.6891.00
38_Q377_Q0.6881.00
62_E282_N0.6881.00
335_S367_F0.6871.00
232_Y235_V0.6861.00
228_P235_V0.6841.00
344_C357_P0.6831.00
114_L143_G0.6831.00
80_R97_A0.6831.00
82_K287_M0.6821.00
153_R186_S0.6821.00
123_E170_K0.6801.00
252_L279_G0.6781.00
344_C367_F0.6771.00
178_H181_T0.6761.00
76_L280_F0.6761.00
307_R374_P0.6741.00
148_C160_A0.6741.00
309_D312_V0.6741.00
113_A238_A0.6731.00
51_P55_F0.6721.00
59_L278_L0.6711.00
358_S366_H0.6701.00
121_G144_K0.6701.00
310_L378_I0.6691.00
333_P366_H0.6631.00
134_Y138_I0.6631.00
40_F380_N0.6621.00
110_L137_Y0.6621.00
84_A95_F0.6611.00
233_H260_R0.6601.00
172_L197_L0.6581.00
311_M369_L0.6581.00
314_I318_A0.6581.00
112_V268_I0.6571.00
293_R296_D0.6561.00
153_R189_N0.6541.00
91_F217_S0.6541.00
136_L139_E0.6531.00
51_P54_A0.6511.00
198_K231_S0.6511.00
155_E186_S0.6461.00
161_V196_L0.6461.00
102_M252_L0.6441.00
212_F237_L0.6431.00
306_E310_L0.6411.00
320_F335_S0.6371.00
112_V265_D0.6361.00
257_L261_M0.6341.00
197_L207_T0.6331.00
221_Y371_F0.6331.00
176_T214_E0.6301.00
231_S235_V0.6281.00
114_L141_Y0.6251.00
297_L301_A0.6241.00
45_G216_Y0.6241.00
219_L301_A0.6231.00
317_E379_K0.6231.00
111_N141_Y0.6231.00
177_P327_G0.6221.00
269_N276_R0.6211.00
221_Y308_R0.6191.00
358_S361_F0.6191.00
174_L190_I0.6191.00
282_N285_V0.6181.00
126_I135_K0.6181.00
55_F247_I0.6151.00
332_F366_H0.6141.00
146_V164_S0.6131.00
169_T172_L0.6121.00
222_D305_K0.6091.00
54_A296_D0.6081.00
244_D297_L0.6081.00
51_P296_D0.6041.00
102_M280_F0.6031.00
152_S160_A0.6021.00
260_R263_D0.6001.00
383_D386_I0.6001.00
280_F284_P0.5991.00
65_K285_V0.5981.00
359_S364_S0.5971.00
86_F217_S0.5971.00
58_A282_N0.5951.00
87_L237_L0.5951.00
183_T326_K0.5901.00
111_N137_Y0.5891.00
101_V257_L0.5881.00
48_I307_R0.5861.00
122_E168_Q0.5831.00
308_R324_M0.5831.00
101_V266_L0.5811.00
340_E343_F0.5771.00
156_I161_V0.5731.00
165_I206_Q0.5721.00
258_D261_M0.5711.00
185_L189_N0.5701.00
266_L269_N0.5691.00
322_F331_V0.5681.00
126_I147_S0.5681.00
315_L333_P0.5681.00
242_S251_R0.5661.00
339_D359_S0.5661.00
231_S234_R0.5661.00
149_P164_S0.5641.00
294_M297_L0.5631.00
384_I387_S0.5621.00
185_L190_I0.5621.00
332_F368_R0.5621.00
176_T184_V0.5621.00
190_I212_F0.5601.00
51_P56_K0.5561.00
316_K321_E0.5561.00
318_A386_I0.5551.00
307_R375_I0.5551.00
163_Q166_T0.5531.00
194_G197_L0.5531.00
263_D266_L0.5501.00
113_A171_G0.5491.00
55_F286_M0.5491.00
81_E288_Q0.5471.00
40_F384_I0.5471.00
99_R257_L0.5471.00
88_G92_E0.5461.00
71_I76_L0.5461.00
217_S239_S0.5451.00
115_K268_I0.5451.00
161_V193_L0.5451.00
179_N368_R0.5441.00
156_I172_L0.5391.00
221_Y325_P0.5391.00
281_V285_V0.5391.00
380_N387_S0.5371.00
194_G230_Q0.5371.00
149_P157_D0.5341.00
301_A305_K0.5331.00
343_F347_A0.5331.00
305_K308_R0.5311.00
137_Y141_Y0.5311.00
119_N170_K0.5311.00
95_F99_R0.5301.00
43_S354_L0.5291.00
81_E84_A0.5291.00
340_E367_F0.5271.00
72_Q77_L0.5241.00
304_Y329_F0.5201.00
104_V275_N0.5191.00
114_L137_Y0.5191.00
80_R266_L0.5191.00
80_R98_E0.5181.00
344_C348_A0.5171.00
62_E65_K0.5171.00
314_I378_I0.5171.00
41_D44_L0.5151.00
45_G330_F0.5151.00
348_A354_L0.5141.00
307_R377_Q0.5131.00
382_R386_I0.5131.00
139_E144_K0.5121.00
79_A283_A0.5121.00
39_V354_L0.5121.00
54_A295_D0.5111.00
124_V173_I0.5111.00
255_I262_P0.5111.00
219_L304_Y0.5111.00
125_I165_I0.5111.00
52_P293_R0.5111.00
172_L210_V0.5081.00
42_F369_L0.5051.00
104_V277_T0.5041.00
111_N272_V0.5031.00
50_E55_F0.5001.00
105_G253_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dydA 2 0.9109 100 0.314 Contact Map
3h14A 2 0.9186 100 0.315 Contact Map
1b5pA 2 0.9567 100 0.321 Contact Map
3piuA 2 0.9364 100 0.322 Contact Map
1yizA 2 0.9517 100 0.322 Contact Map
3eleA 2 0.9695 100 0.323 Contact Map
3jtxA 2 0.944 100 0.324 Contact Map
1o4sA 2 0.9542 100 0.324 Contact Map
1j32A 2 0.9593 100 0.326 Contact Map
2x5dA 3 0.9262 100 0.327 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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