GREMLIN Database
CUER - HTH-type transcriptional regulator CueR
UniProt: O07586 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (116)
Sequences: 12404 (8720)
Seq/√Len: 809.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
102_N112_F4.0831.00
50_D53_A3.1841.00
105_I109_L3.1111.00
98_I116_K3.0941.00
30_Y34_L2.7631.00
95_A119_D2.7221.00
26_R33_N2.4791.00
97_E100_H2.2371.00
25_K29_D2.0991.00
42_S48_Y1.9001.00
64_K70_L1.7511.00
105_I108_I1.7391.00
34_L74_K1.7371.00
98_I112_F1.6731.00
17_L54_L1.6671.00
15_S19_A1.6531.00
109_L112_F1.6051.00
61_V64_K1.5961.00
95_A123_L1.5831.00
98_I102_N1.5801.00
104_N107_G1.5721.00
17_L57_L1.5631.00
91_I95_A1.5591.00
69_A72_D1.5581.00
112_F116_K1.5571.00
103_Q107_G1.4971.00
102_N116_K1.4971.00
94_L119_D1.4281.00
98_I119_D1.4211.00
91_I123_L1.4011.00
56_R77_L1.3921.00
100_H104_N1.3771.00
16_E19_A1.3491.00
36_L60_I1.3481.00
14_I29_D1.3471.00
102_N105_I1.2931.00
56_R81_F1.2761.00
13_R16_E1.2631.00
72_D97_E1.2601.00
13_R48_Y1.2571.00
106_S109_L1.1931.00
21_A57_L1.1781.00
17_L53_A1.1581.00
24_T27_T1.1401.00
65_K107_G1.1381.00
108_I112_F1.0971.00
74_K78_E1.0911.00
16_E20_L1.0891.00
105_I112_F1.0641.00
20_L54_L1.0611.00
106_S110_H1.0561.00
99_D103_Q1.0401.00
28_V49_Y1.0161.00
60_I73_I1.0121.00
13_R46_Y1.0111.00
27_T30_Y1.0071.00
89_D92_G1.0001.00
101_M105_I0.9971.00
67_R104_N0.9941.00
117_P121_D0.9861.00
102_N106_S0.9831.00
34_L71_S0.9731.00
12_Y48_Y0.9721.00
61_V65_K0.9591.00
12_Y51_E0.9491.00
80_Q83_S0.9491.00
41_R44_S0.9491.00
28_V57_L0.9441.00
101_M108_I0.9271.00
31_Y57_L0.9251.00
104_N108_I0.9231.00
40_A53_A0.9161.00
21_A54_L0.9151.00
100_H103_Q0.9151.00
32_T38_T0.9081.00
103_Q106_S0.8881.00
30_Y70_L0.8831.00
18_A25_K0.8811.00
99_D102_N0.8801.00
92_G96_L0.8781.00
15_S25_K0.8691.00
72_D75_D0.8681.00
12_Y20_L0.8671.00
94_L115_L0.8591.00
40_A49_Y0.8431.00
82_P85_A0.8401.00
42_S46_Y0.8401.00
97_E104_N0.8341.00
71_S74_K0.8221.00
23_V57_L0.8191.00
32_T37_L0.8111.00
20_L58_I0.8071.00
51_E55_K0.8041.00
107_G110_H0.7841.00
66_Q111_R0.7771.00
37_L60_I0.7731.00
59_F63_C0.7691.00
37_L53_A0.7681.00
18_A28_V0.7631.00
93_N96_L0.7561.00
86_K89_D0.7391.00
40_A50_D0.7361.00
88_D126_K0.7331.00
101_M115_L0.7281.00
96_L100_H0.7211.00
14_I18_A0.7201.00
96_L99_D0.7201.00
32_T49_Y0.7181.00
20_L51_E0.7171.00
26_R30_Y0.7151.00
95_A98_I0.7131.00
72_D96_L0.7121.00
79_N83_S0.7011.00
121_D124_K0.6931.00
68_L76_R0.6891.00
54_L58_I0.6841.00
57_L64_K0.6821.00
109_L113_E0.6731.00
95_A99_D0.6661.00
91_I119_D0.6661.00
75_D78_E0.6641.00
113_E117_P0.6621.00
28_V32_T0.6601.00
35_G38_T0.6521.00
121_D125_S0.6491.00
72_D100_H0.6461.00
55_K58_I0.6381.00
58_I62_D0.6371.00
52_N55_K0.6341.00
92_G95_A0.6331.00
63_C68_L0.6281.00
23_V27_T0.6261.00
21_A28_V0.6261.00
23_V61_V0.6251.00
11_T48_Y0.6241.00
44_S48_Y0.6241.00
117_P120_R0.6231.00
42_S45_N0.6201.00
24_T30_Y0.6201.00
17_L37_L0.6131.00
75_D89_D0.6091.00
101_M111_R0.6081.00
79_N82_P0.6081.00
58_I61_V0.6011.00
53_A56_R0.5961.00
27_T64_K0.5931.00
90_E94_L0.5891.00
102_N109_L0.5881.00
30_Y33_N0.5811.00
68_L72_D0.5711.00
110_H113_E0.5661.00
116_K120_R0.5631.00
121_D126_K0.5541.00
34_L70_L0.5501.00
65_K114_R0.5441.00
88_D92_G0.5421.00
21_A25_K0.5371.00
90_E122_K0.5341.00
64_K73_I0.5321.00
32_T39_P0.5311.00
118_E121_D0.5251.00
26_R59_F0.5241.00
41_R47_R0.5221.00
17_L21_A0.5221.00
107_G111_R0.5211.00
123_L126_K0.5211.00
21_A61_V0.5161.00
93_N97_E0.5111.00
101_M112_F0.5071.00
11_T40_A0.5061.00
80_Q84_S0.5061.00
111_R114_R0.5031.00
63_C76_R0.5031.00
120_R123_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zhgA 2 0.8462 100 0.228 Contact Map
1q06A 2 0.8811 100 0.238 Contact Map
2dg6A 2 0.8462 100 0.24 Contact Map
3gp4A 4 0.9161 99.9 0.258 Contact Map
3hh0A 4 0.9021 99.9 0.259 Contact Map
4ua1A 2 0.8671 99.9 0.272 Contact Map
3gpvA 2 0.8042 99.9 0.28 Contact Map
3qaoA 2 0.8951 99.9 0.289 Contact Map
2vz4A 2 0.6923 99.9 0.319 Contact Map
1r8dA 2 0.7552 99.9 0.326 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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