GREMLIN Database
PLSC - 1-acyl-sn-glycerol-3-phosphate acyltransferase
UniProt: O07584 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (180)
Sequences: 11054 (7969)
Seq/√Len: 593.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_N162_E3.7441.00
22_Y159_I3.6321.00
140_A161_G3.5121.00
22_Y157_K3.2371.00
20_K157_K3.0431.00
63_K84_D2.9371.00
23_N26_N2.7621.00
182_T186_N2.7111.00
20_K155_K2.6661.00
180_A184_A2.2721.00
139_A160_I2.1331.00
33_F105_I2.0561.00
97_I101_K2.0051.00
135_P165_H1.9991.00
18_G155_K1.9961.00
57_I107_G1.9851.00
63_K67_Q1.9451.00
66_F82_P1.9431.00
142_Q157_K1.8911.00
98_K102_E1.8871.00
97_I131_M1.8551.00
33_F137_V1.8201.00
31_S135_P1.7931.00
73_S77_K1.7351.00
58_H104_E1.7131.00
179_A183_E1.7051.00
35_I137_V1.6841.00
97_I132_G1.6531.00
35_I105_I1.6501.00
176_E180_A1.6381.00
36_A125_A1.6211.00
37_C139_A1.5901.00
142_Q159_I1.5881.00
169_F180_A1.5761.00
51_G160_I1.5581.00
72_G76_K1.5551.00
96_P128_I1.5501.00
140_A185_L1.5191.00
183_E187_Q1.5181.00
66_F76_K1.5151.00
174_S178_L1.5121.00
62_K85_R1.4601.00
61_A65_L1.4421.00
91_S95_T1.4411.00
127_T131_M1.4351.00
178_L182_T1.4321.00
48_L139_A1.4301.00
62_K113_T1.3931.00
64_E85_R1.3861.00
137_V163_P1.3841.00
95_T98_K1.3391.00
95_T99_L1.3341.00
138_P161_G1.3321.00
140_A189_I1.3231.00
33_F135_P1.3071.00
115_T119_V1.3031.00
179_A182_T1.3021.00
100_L134_A1.2941.00
161_G188_R1.2591.00
184_A188_R1.2571.00
10_K14_S1.2481.00
60_M81_F1.2351.00
61_A66_F1.2181.00
177_R181_M1.2001.00
96_P106_V1.1871.00
85_R113_T1.1871.00
121_L186_N1.1811.00
68_N71_I1.1591.00
90_P94_K1.1401.00
21_V160_I1.1391.00
183_E186_N1.1381.00
121_L182_T1.1331.00
175_K179_A1.1241.00
99_L104_E1.1211.00
180_A183_E1.1211.00
159_I188_R1.1041.00
58_H99_L1.0971.00
184_A187_Q1.0931.00
123_R127_T1.0621.00
165_H169_F1.0581.00
37_C48_L1.0571.00
60_M83_V1.0571.00
61_A80_A1.0371.00
59_Y107_G1.0331.00
73_S76_K1.0321.00
40_S145_S1.0261.00
62_K65_L1.0251.00
181_M184_A1.0191.00
165_H168_D1.0191.00
32_G103_G1.0171.00
37_C109_F1.0061.00
98_K101_K0.9841.00
140_A188_R0.9821.00
138_P163_P0.9721.00
28_P31_S0.9661.00
181_M185_L0.9561.00
60_M92_S0.9531.00
40_S144_P0.9501.00
48_L109_F0.9321.00
45_V61_A0.9311.00
126_V181_M0.9211.00
31_S105_I0.9171.00
94_K98_K0.9121.00
100_L128_I0.9111.00
51_G158_L0.9101.00
32_G134_A0.9091.00
69_K72_G0.9071.00
147_G151_F0.9051.00
174_S182_T0.9011.00
129_A136_L0.8991.00
62_K114_R0.8821.00
40_S115_T0.8781.00
175_K178_L0.8771.00
55_Y105_I0.8741.00
89_G92_S0.8641.00
71_I75_L0.8591.00
174_S177_R0.8581.00
126_V178_L0.8581.00
34_V125_A0.8581.00
97_I128_I0.8571.00
161_G184_A0.8541.00
99_L106_V0.8531.00
48_L141_Y0.8511.00
148_K152_K0.8481.00
19_V47_T0.8441.00
178_L181_M0.8421.00
81_F99_L0.8411.00
121_L189_I0.8341.00
186_N189_I0.8311.00
16_R153_K0.8291.00
31_S165_H0.8271.00
37_C107_G0.8261.00
21_V24_K0.8231.00
127_T130_Q0.8221.00
81_F106_V0.8201.00
9_L13_L0.8191.00
133_K170_A0.8181.00
101_K132_G0.8111.00
94_K97_I0.8021.00
177_R182_T0.8011.00
65_L75_L0.7951.00
84_D87_N0.7931.00
161_G185_L0.7881.00
7_N11_V0.7861.00
130_Q169_F0.7821.00
35_I139_A0.7821.00
135_P163_P0.7751.00
133_K166_Q0.7711.00
166_Q169_F0.7701.00
81_F92_S0.7671.00
141_Y144_P0.7631.00
7_N10_K0.7611.00
79_H104_E0.7561.00
68_N72_G0.7521.00
36_A181_M0.7511.00
148_K151_F0.7491.00
112_G124_G0.7481.00
91_S94_K0.7481.00
19_V50_V0.7481.00
49_G59_Y0.7421.00
40_S114_R0.7411.00
182_T189_I0.7401.00
35_I53_L0.7371.00
75_L80_A0.7351.00
121_L185_L0.7311.00
146_S154_G0.7301.00
27_L137_V0.7271.00
125_A136_L0.7261.00
94_K131_M0.7241.00
70_W73_S0.7081.00
114_R143_G0.7061.00
181_M186_N0.7011.00
182_T185_L0.7011.00
38_T121_L0.6881.00
32_G105_I0.6881.00
109_F141_Y0.6871.00
10_K13_L0.6861.00
178_L186_N0.6851.00
18_G153_K0.6821.00
135_P166_Q0.6811.00
8_A11_V0.6801.00
81_F96_P0.6791.00
27_L160_I0.6781.00
42_W45_V0.6731.00
133_K167_A0.6691.00
42_W65_L0.6671.00
99_L102_E0.6651.00
125_A129_A0.6641.00
182_T188_R0.6631.00
10_K50_V0.6611.00
28_P33_F0.6591.00
175_K182_T0.6511.00
133_K165_H0.6501.00
123_R175_K0.6491.00
108_I128_I0.6491.00
129_A132_G0.6491.00
162_E184_A0.6471.00
61_A75_L0.6351.00
76_K82_P0.6341.00
185_L189_I0.6331.00
30_D33_F0.6321.00
57_I105_I0.6311.00
113_T119_V0.6301.00
139_A158_L0.6231.00
54_P57_I0.6151.00
60_M96_P0.6141.00
9_L12_I0.6141.00
65_L71_I0.6111.00
33_F55_Y0.6111.00
178_L188_R0.6111.00
111_S115_T0.6111.00
118_D189_I0.6101.00
10_K54_P0.6091.00
45_V49_G0.6031.00
81_F95_T0.6031.00
11_V15_L0.6011.00
129_A166_Q0.5911.00
147_G152_K0.5881.00
180_A187_Q0.5851.00
75_L82_P0.5841.00
13_L50_V0.5841.00
60_M108_I0.5811.00
143_G146_S0.5791.00
35_I160_I0.5791.00
123_R178_L0.5781.00
49_G80_A0.5781.00
28_P137_V0.5761.00
59_Y109_F0.5761.00
111_S118_D0.5761.00
89_G97_I0.5751.00
166_Q170_A0.5741.00
42_W114_R0.5691.00
67_Q76_K0.5691.00
106_V134_A0.5681.00
38_T118_D0.5681.00
45_V109_F0.5661.00
118_D186_N0.5651.00
140_A159_I0.5651.00
174_S186_N0.5641.00
164_L180_A0.5641.00
11_V14_S0.5641.00
177_R180_A0.5621.00
47_T156_M0.5611.00
93_I96_P0.5560.99
17_G154_G0.5480.99
45_V65_L0.5480.99
83_V89_G0.5460.99
58_H79_H0.5450.99
85_R122_K0.5430.99
26_N160_I0.5390.99
44_D49_G0.5370.99
68_N75_L0.5370.99
89_G127_T0.5360.99
8_A13_L0.5330.99
114_R119_V0.5320.99
80_A96_P0.5310.99
31_S55_Y0.5310.99
126_V129_A0.5230.99
169_F184_A0.5190.99
13_L17_G0.5150.99
162_E188_R0.5120.99
165_H170_A0.5120.99
53_L160_I0.5100.99
130_Q170_A0.5090.99
23_N160_I0.5090.99
171_H174_S0.5090.99
48_L158_L0.5080.99
35_I107_G0.5040.99
111_S119_V0.5010.99
45_V59_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iuqA 1 0.9899 100 0.259 Contact Map
1jcuA 1 0.5327 13 0.944 Contact Map
1vr4A 3 0.3065 8.5 0.949 Contact Map
3uqsA 4 0.4322 7.8 0.949 Contact Map
2xwsA 2 0.5327 6.9 0.951 Contact Map
1k7jA 1 0.5377 6.6 0.951 Contact Map
4jenA 2 0.5528 6.6 0.951 Contact Map
1p8aA 1 0.6382 6.2 0.952 Contact Map
1jidA 1 0.4573 5.7 0.952 Contact Map
1f75A 2 0.4372 5.5 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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