GREMLIN Database
YHDL - Probable anti-sigma-M factor YhdL
UniProt: O07581 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (293)
Sequences: 289 (244)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
222_D225_Y5.4011.00
123_N216_E4.9651.00
216_E351_G4.5051.00
148_K216_E4.4411.00
123_N351_G3.4680.99
285_F289_L3.2590.99
123_N148_K3.0780.98
316_Y320_N3.0360.98
234_F329_V2.9840.97
68_R71_Y2.9130.97
191_P220_S2.8770.97
329_V336_I2.8420.96
72_L296_E2.7610.96
215_S333_T2.5360.93
148_K351_G2.5220.93
226_P229_D2.5020.93
216_E331_G2.4620.92
332_P335_E2.4610.92
140_M164_M2.3240.90
119_L285_F2.2340.88
66_G220_S2.1890.87
151_G335_E2.0010.81
243_W248_T1.9710.80
99_M138_F1.8630.76
211_E334_K1.8620.76
148_K330_T1.8610.76
148_K218_Y1.8590.76
218_Y221_Y1.8580.76
331_G351_G1.8160.74
220_S328_V1.7990.73
82_T86_L1.7550.71
148_K331_G1.7420.71
83_L86_L1.7350.71
220_S247_E1.7350.71
221_Y327_S1.7220.70
76_V80_I1.7100.69
188_F218_Y1.6840.68
175_N343_K1.6780.68
84_M91_L1.6670.67
230_V327_S1.6630.67
247_E328_V1.6580.67
234_F272_A1.6540.67
97_Y209_L1.6430.66
208_T338_R1.6310.66
246_I336_I1.6130.65
223_R229_D1.6110.65
81_S341_K1.6010.64
83_L127_D1.5920.64
206_L228_K1.5770.63
168_K171_A1.5690.62
321_G325_Y1.5600.62
166_Y317_V1.5580.62
163_E294_K1.5400.61
326_G331_G1.5340.61
220_S346_K1.5320.61
334_K337_Q1.5270.60
188_F222_D1.5200.60
199_T346_K1.5190.60
221_Y225_Y1.5100.59
261_L289_L1.5100.59
188_F220_S1.5050.59
191_P346_K1.4810.58
77_L221_Y1.4790.58
81_S108_E1.4610.57
99_M212_G1.4560.57
286_I293_S1.4530.56
78_A341_K1.4430.56
263_Y266_K1.4350.55
214_V333_T1.4340.55
326_G336_I1.4120.54
221_Y348_A1.4110.54
233_K342_N1.4030.54
65_Y168_K1.3910.53
264_P289_L1.3890.53
218_Y245_A1.3650.52
148_K225_Y1.3630.51
216_E225_Y1.3560.51
220_S336_I1.3490.51
290_K298_W1.3450.50
193_N350_V1.3410.50
75_S85_I1.3370.50
65_Y94_Y1.3370.50
334_K345_V1.3240.49
150_I214_V1.3210.49
218_Y351_G1.3180.49
223_R233_K1.3130.49
83_L91_L1.3100.49
118_A288_A1.3050.48
178_D336_I1.2970.48
89_C244_N1.2970.48
92_G96_Y1.2950.48
220_S324_V1.2900.47
246_I322_V1.2780.47
149_Q240_S1.2690.46
246_I324_V1.2650.46
217_V289_L1.2460.45
314_L345_V1.2300.44
119_L289_L1.2290.44
67_K148_K1.2250.44
247_E336_I1.2180.44
123_N331_G1.2070.43
57_E83_L1.1950.42
245_A325_Y1.1830.42
207_S294_K1.1680.41
169_V327_S1.1630.41
201_K317_V1.1600.40
219_L254_K1.1470.40
216_E220_S1.1450.40
191_P324_V1.1390.39
58_K207_S1.1370.39
186_H344_S1.1330.39
200_A352_E1.1270.39
213_T350_V1.1260.39
67_K70_S1.1220.38
150_I262_G1.1160.38
214_V332_P1.1120.38
122_P243_W1.1090.38
190_H254_K1.1080.38
190_H325_Y1.1070.38
73_R304_K1.1010.37
61_A207_S1.0950.37
209_L325_Y1.0940.37
324_V346_K1.0940.37
316_Y321_G1.0880.37
85_I91_L1.0850.37
219_L329_V1.0850.37
260_P289_L1.0820.36
63_L220_S1.0800.36
69_K329_V1.0790.36
177_Y246_I1.0740.36
232_N283_D1.0660.36
203_E214_V1.0650.36
88_L329_V1.0640.36
268_S272_A1.0600.35
177_Y189_T1.0590.35
191_P243_W1.0570.35
192_S246_I1.0530.35
61_A283_D1.0470.35
61_A87_P1.0460.35
219_L238_D1.0450.35
56_P158_G1.0360.34
327_S331_G1.0250.34
151_G209_L1.0240.34
218_Y348_A1.0230.34
220_S325_Y1.0230.34
124_V330_T1.0230.34
142_T230_V1.0190.33
220_S351_G1.0170.33
249_E332_P1.0140.33
203_E249_E1.0130.33
245_A321_G1.0120.33
239_V340_L1.0110.33
239_V329_V1.0020.32
211_E217_V1.0010.32
76_V100_G0.9990.32
349_N352_E0.9930.32
178_D239_V0.9910.32
122_P345_V0.9880.32
246_I285_F0.9860.32
63_L160_E0.9830.32
55_S63_L0.9740.31
186_H247_E0.9720.31
97_Y264_P0.9640.31
138_F323_N0.9630.31
328_V351_G0.9620.31
289_L292_M0.9610.31
146_L176_Y0.9590.30
74_I196_E0.9590.30
154_T249_E0.9530.30
212_G332_P0.9490.30
245_A347_S0.9460.30
161_R177_Y0.9440.30
284_Q317_V0.9430.30
193_N219_L0.9420.30
136_K246_I0.9410.30
97_Y245_A0.9310.29
146_L165_F0.9260.29
64_A139_G0.9250.29
214_V330_T0.9250.29
166_Y206_L0.9240.29
212_G330_T0.9230.29
213_T247_E0.9070.28
85_I310_V0.9030.28
186_H199_T0.8990.28
55_S327_S0.8950.28
164_M177_Y0.8950.28
225_Y351_G0.8840.27
80_I279_K0.8830.27
93_S97_Y0.8820.27
212_G334_K0.8820.27
206_L213_T0.8820.27
61_A79_V0.8800.27
166_Y334_K0.8790.27
146_L158_G0.8730.27
166_Y327_S0.8670.26
150_I330_T0.8670.26
67_K71_Y0.8650.26
214_V350_V0.8630.26
73_R294_K0.8630.26
92_G338_R0.8610.26
67_K96_Y0.8560.26
99_M140_M0.8540.26
321_G337_Q0.8490.26
186_H201_K0.8480.26
65_Y74_I0.8440.25
112_T138_F0.8390.25
65_Y134_Q0.8380.25
186_H346_K0.8360.25
226_P283_D0.8330.25
238_D340_L0.8240.25
220_S326_G0.8240.25
204_K329_V0.8230.25
82_T343_K0.8210.24
119_L218_Y0.8180.24
310_V314_L0.8180.24
74_I175_N0.8170.24
256_A259_E0.8170.24
123_N225_Y0.8170.24
287_N350_V0.8140.24
57_E65_Y0.8130.24
298_W303_S0.8070.24
135_V141_N0.8060.24
119_L237_Y0.8060.24
148_K328_V0.8060.24
307_D311_D0.8050.24
258_T261_L0.8030.24
190_H220_S0.8010.24
67_K216_E0.8000.24
249_E313_R0.7980.24
118_A183_K0.7960.23
248_T322_V0.7960.23
66_G299_A0.7920.23
151_G349_N0.7860.23
218_Y317_V0.7800.23
195_S199_T0.7800.23
213_T332_P0.7740.23
136_K140_M0.7730.23
298_W302_I0.7730.23
178_D330_T0.7710.22
151_G332_P0.7670.22
69_K317_V0.7670.22
220_S331_G0.7650.22
186_H329_V0.7640.22
64_A208_T0.7620.22
140_M339_M0.7580.22
152_T184_T0.7570.22
188_F225_Y0.7510.22
119_L244_N0.7490.22
193_N205_T0.7480.22
239_V303_S0.7470.22
245_A250_K0.7430.21
220_S339_M0.7420.21
97_Y218_Y0.7420.21
96_Y295_H0.7400.21
292_M296_E0.7390.21
207_S210_P0.7310.21
123_N328_V0.7290.21
73_R78_A0.7280.21
119_L155_A0.7260.21
63_L322_V0.7260.21
148_K245_A0.7240.21
155_A226_P0.7220.21
220_S286_I0.7090.20
140_M235_K0.7050.20
292_M321_G0.7040.20
168_K175_N0.7020.20
195_S202_A0.7010.20
84_M316_Y0.6960.20
219_L289_L0.6940.20
155_A202_A0.6930.20
148_K262_G0.6910.20
255_T263_Y0.6890.20
141_N206_L0.6890.20
292_M322_V0.6870.19
221_Y285_F0.6870.19
82_T85_I0.6860.19
262_G351_G0.6850.19
234_F336_I0.6830.19
64_A162_V0.6820.19
189_T235_K0.6800.19
148_K209_L0.6780.19
135_V263_Y0.6780.19
53_S200_A0.6760.19
322_V328_V0.6740.19
76_V219_L0.6720.19
97_Y318_E0.6680.19
99_M155_A0.6670.19
120_T336_I0.6640.19
123_N218_Y0.6580.18
63_L336_I0.6570.18
119_L292_M0.6560.18
178_D185_G0.6550.18
218_Y328_V0.6550.18
245_A328_V0.6540.18
64_A78_A0.6540.18
148_K220_S0.6520.18
94_Y279_K0.6490.18
69_K201_K0.6480.18
158_G178_D0.6480.18
155_A184_T0.6440.18
260_P348_A0.6430.18
200_A349_N0.6420.18
210_P296_E0.6420.18
75_S82_T0.6420.18
202_A232_N0.6400.18
186_H350_V0.6390.18
71_Y322_V0.6380.18
75_S78_A0.6380.18
260_P285_F0.6380.18
247_E324_V0.6360.18
153_K186_H0.6360.18
64_A207_S0.6360.18
117_V146_L0.6350.18
203_E349_N0.6340.18
72_L80_I0.6310.18
98_G101_G0.6290.18
239_V290_K0.6290.18
151_G240_S0.6280.18
140_M347_S0.6260.17
184_T218_Y0.6250.17
202_A245_A0.6250.17
146_L335_E0.6230.17
140_M245_A0.6210.17
184_T332_P0.6210.17
77_L152_T0.6190.17
75_S89_C0.6170.17
314_L321_G0.6170.17
140_M148_K0.6160.17
164_M202_A0.6160.17
239_V262_G0.6110.17
127_D246_I0.6110.17
97_Y140_M0.6070.17
230_V274_L0.6050.17
249_E325_Y0.6040.17
151_G166_Y0.6010.17
279_K294_K0.6000.17
203_E215_S0.5990.17
79_V311_D0.5960.17
211_E333_T0.5960.17
84_M160_E0.5930.16
245_A332_P0.5930.16
188_F326_G0.5920.16
230_V324_V0.5920.16
56_P83_L0.5920.16
99_M351_G0.5910.16
58_K340_L0.5900.16
228_K297_K0.5890.16
135_V286_I0.5880.16
115_V118_A0.5880.16
58_K211_E0.5870.16
74_I83_L0.5860.16
138_F302_I0.5860.16
253_N293_S0.5820.16
101_G294_K0.5820.16
268_S277_K0.5810.16
215_S250_K0.5800.16
56_P150_I0.5800.16
246_I257_S0.5770.16
209_L352_E0.5770.16
69_K91_L0.5740.16
230_V328_V0.5730.16
139_G166_Y0.5700.16
158_G328_V0.5680.16
79_V279_K0.5670.16
56_P88_L0.5660.16
209_L217_V0.5640.16
111_E217_V0.5640.16
114_A293_S0.5630.16
169_V318_E0.5630.16
171_A283_D0.5620.16
69_K86_L0.5620.16
311_D315_D0.5590.15
221_Y271_L0.5580.15
320_N338_R0.5580.15
97_Y289_L0.5580.15
96_Y299_A0.5570.15
213_T337_Q0.5570.15
238_D302_I0.5550.15
168_K173_A0.5520.15
332_P352_E0.5520.15
52_L184_T0.5510.15
234_F241_F0.5510.15
156_A277_K0.5500.15
90_T119_L0.5490.15
128_T251_N0.5480.15
166_Y284_Q0.5470.15
151_G190_H0.5460.15
177_Y226_P0.5450.15
122_P180_E0.5440.15
118_A289_L0.5430.15
123_N188_F0.5420.15
216_E328_V0.5390.15
259_E303_S0.5390.15
186_H348_A0.5370.15
194_K323_N0.5370.15
267_D318_E0.5370.15
70_S180_E0.5370.15
78_A256_A0.5370.15
228_K251_N0.5360.15
264_P267_D0.5360.15
190_H346_K0.5350.15
288_A321_G0.5340.15
148_K184_T0.5340.15
221_Y245_A0.5340.15
177_Y235_K0.5330.15
202_A221_Y0.5330.15
135_V325_Y0.5290.15
93_S96_Y0.5290.15
192_S289_L0.5280.15
141_N186_H0.5280.15
62_I211_E0.5260.15
210_P262_G0.5260.15
97_Y100_G0.5260.15
240_S244_N0.5240.14
147_Q235_K0.5190.14
294_K320_N0.5190.14
235_K339_M0.5180.14
227_T282_G0.5170.14
300_Q323_N0.5170.14
88_L170_K0.5140.14
242_L263_Y0.5130.14
63_L329_V0.5120.14
215_S332_P0.5120.14
243_W345_V0.5100.14
95_L158_G0.5100.14
219_L327_S0.5100.14
238_D317_V0.5090.14
153_K247_E0.5080.14
177_Y203_E0.5070.14
242_L324_V0.5070.14
230_V322_V0.5070.14
83_L118_A0.5060.14
317_V321_G0.5040.14
227_T287_N0.5040.14
80_I255_T0.5030.14
74_I291_F0.5030.14
207_S337_Q0.5030.14
171_A345_V0.5020.14
203_E217_V0.5000.14
69_K217_V0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hugB 2 0.1425 96.4 0.927 Contact Map
4nqwB 1 0.1788 93.9 0.938 Contact Map
2kogA 1 0.1872 89.1 0.946 Contact Map
3hd7A 1 0.2235 64 0.957 Contact Map
2m8rA 1 0.2598 50.9 0.96 Contact Map
2q1zB 1 0.4888 49.2 0.961 Contact Map
4kqtA 1 0.3212 32.4 0.965 Contact Map
1u2mA 3 0.2765 24.7 0.967 Contact Map
4jioA 1 0.3073 20.4 0.968 Contact Map
3p0jA 1 0.1704 20.4 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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