GREMLIN Database
YHDJ - Uncharacterized N-acetyltransferase YhdJ
UniProt: O07579 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 142 (128)
Sequences: 5485 (4214)
Seq/√Len: 372.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E82_T2.9121.00
97_Y100_D2.7511.00
49_A56_I2.7361.00
99_S131_F2.5121.00
60_C98_A2.3321.00
119_K123_R2.3251.00
57_R85_C2.2721.00
48_F97_Y2.2421.00
5_K51_Y2.2071.00
50_L90_Y2.2041.00
74_L102_A2.0371.00
101_W104_K2.0271.00
15_E18_P1.9671.00
126_T133_I1.8901.00
92_K128_K1.8281.00
52_E85_C1.7841.00
101_W105_A1.7841.00
92_K129_M1.7801.00
114_S122_H1.7441.00
48_F101_W1.7031.00
100_D104_K1.6571.00
46_M105_A1.6391.00
95_L129_M1.6121.00
99_S110_V1.6031.00
52_E57_R1.5911.00
50_L58_A1.5871.00
85_C88_K1.5851.00
51_Y54_T1.5761.00
92_K96_D1.5631.00
10_K37_E1.5621.00
55_A82_T1.5611.00
52_E88_K1.5531.00
123_R126_T1.5451.00
28_D31_T1.5121.00
64_P107_L1.4901.00
62_A98_A1.4611.00
97_Y101_W1.4551.00
22_E83_A1.4341.00
51_Y56_I1.4081.00
18_P82_T1.4071.00
114_S118_R1.3821.00
58_A81_T1.3641.00
65_R75_W1.2881.00
60_C94_L1.2691.00
22_E80_V1.2341.00
64_P105_A1.2301.00
76_I95_L1.1761.00
71_G108_G1.1711.00
89_G92_K1.1591.00
57_R90_Y1.1501.00
15_E56_I1.1471.00
60_C76_I1.1471.00
55_A84_P1.1191.00
112_L131_F1.1091.00
23_L26_E1.0951.00
75_W113_S1.0931.00
46_M101_W1.0831.00
120_D123_R1.0631.00
82_T85_C1.0571.00
102_A107_L1.0571.00
15_E55_A1.0481.00
10_K40_V1.0431.00
114_S121_A1.0341.00
118_R122_H1.0321.00
32_Y35_R1.0101.00
73_H109_F1.0081.00
48_F62_A1.0071.00
93_M96_D1.0021.00
118_R121_A0.9971.00
5_K12_E0.9921.00
122_H126_T0.9921.00
75_W78_D0.9841.00
62_A101_W0.9811.00
29_I33_L0.9801.00
18_P22_E0.9781.00
14_A33_L0.9221.00
8_T16_S0.9101.00
74_L110_V0.9051.00
19_I56_I0.8981.00
96_D99_S0.8981.00
81_T90_Y0.8971.00
33_L37_E0.8951.00
44_S72_E0.8941.00
95_L131_F0.8921.00
46_M62_A0.8821.00
59_L80_V0.8761.00
100_D103_R0.8721.00
74_L98_A0.8661.00
37_E41_Q0.8371.00
121_A125_Y0.8371.00
8_T12_E0.8231.00
37_E40_V0.8181.00
17_Y21_S0.8171.00
87_S128_K0.8141.00
21_S25_T0.8121.00
116_L133_I0.8121.00
20_M61_G0.8101.00
30_E33_L0.8071.00
74_L107_L0.7971.00
34_Q37_E0.7931.00
36_L40_V0.7921.00
20_M59_L0.7921.00
20_M78_D0.7861.00
115_G118_R0.7841.00
31_T35_R0.7691.00
93_M97_Y0.7681.00
19_I80_V0.7671.00
8_T49_A0.7661.00
35_R38_A0.7651.00
110_V131_F0.7641.00
91_G124_F0.7611.00
15_E82_T0.7591.00
99_S103_R0.7591.00
55_A85_C0.7531.00
29_I32_Y0.7521.00
32_Y36_L0.7521.00
65_R73_H0.7511.00
16_S59_L0.7481.00
15_E19_I0.7421.00
72_E107_L0.7381.00
17_Y32_Y0.7361.00
58_A90_Y0.7351.00
112_L125_Y0.7221.00
62_A74_L0.7201.00
64_P74_L0.7020.99
42_K45_Y0.6990.99
123_R128_K0.6990.99
70_K108_G0.6800.99
102_A110_V0.6660.99
52_E55_A0.6660.99
58_A94_L0.6650.99
97_Y104_K0.6620.99
73_H111_S0.6600.99
76_I112_L0.6560.99
64_P101_W0.6550.99
87_S120_D0.6540.99
126_T132_T0.6530.99
35_R39_C0.6470.99
58_A91_G0.6450.99
34_Q38_A0.6420.99
96_D129_M0.6400.99
45_Y61_G0.6360.99
33_L36_L0.6340.99
10_K33_L0.6340.99
76_I110_V0.6320.99
38_A66_V0.6290.99
87_S91_G0.6270.99
9_S12_E0.6250.99
38_A41_Q0.6250.99
18_P21_S0.6170.99
119_K122_H0.6090.98
66_V72_E0.6090.98
81_T94_L0.6080.98
6_Q46_M0.6070.98
23_L80_V0.6010.98
24_R27_L0.5960.98
67_S78_D0.5930.98
50_L57_R0.5890.98
75_W111_S0.5850.98
83_A86_R0.5850.98
98_A110_V0.5820.98
19_I49_A0.5790.98
46_M64_P0.5780.98
109_F134_E0.5780.98
22_E84_P0.5740.98
14_A18_P0.5650.98
40_V43_E0.5650.98
63_L77_A0.5600.97
94_L97_Y0.5600.97
6_Q51_Y0.5520.97
52_E90_Y0.5480.97
9_S49_A0.5450.97
16_S20_M0.5380.97
71_G106_G0.5380.97
72_E105_A0.5360.97
13_W16_S0.5360.97
85_C90_Y0.5320.96
12_E51_Y0.5300.96
50_L94_L0.5260.96
64_P72_E0.5250.96
9_S14_A0.5220.96
77_A113_S0.5200.96
60_C79_L0.5170.96
76_I98_A0.5120.96
34_Q39_C0.5120.96
67_S73_H0.5110.96
76_I79_L0.5090.95
70_K109_F0.5090.95
17_Y33_L0.5070.95
13_W36_L0.5060.95
38_A72_E0.5060.95
59_L78_D0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s3zA 2 0.9859 99.9 0.315 Contact Map
3t9yA 2 0.9014 99.9 0.343 Contact Map
3fynA 2 0.9296 99.9 0.356 Contact Map
3dr6A 2 0.9789 99.9 0.358 Contact Map
1ufhA 3 0.9789 99.9 0.36 Contact Map
4yfjA 2 0.9859 99.9 0.363 Contact Map
1u6mA 1 0.9789 99.9 0.365 Contact Map
4evyA 2 0.9789 99.9 0.366 Contact Map
2j8mA 2 0.9789 99.9 0.37 Contact Map
3jvnA 2 0.7817 99.9 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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