GREMLIN Database
YHDH - Uncharacterized sodium-dependent transporter YhdH
UniProt: O07577 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 451 (428)
Sequences: 4607 (3089)
Seq/√Len: 149.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
151_L352_F5.3141.00
202_K206_V4.3401.00
158_V348_G4.2331.00
199_E202_K4.1101.00
208_H211_D3.6911.00
301_F304_L3.5611.00
70_N77_A3.1431.00
116_I307_I2.9621.00
148_A152_V2.9381.00
326_E340_R2.9211.00
72_T80_K2.8751.00
150_Q355_G2.8741.00
66_F77_A2.8041.00
339_K342_K2.7751.00
288_L313_F2.7631.00
244_K414_N2.7391.00
116_I311_V2.7311.00
201_V268_L2.6951.00
147_L356_I2.6301.00
157_T321_A2.6111.00
60_L235_M2.6101.00
205_L268_L2.5201.00
190_R193_T2.5061.00
192_L201_V2.4131.00
71_Q244_K2.3441.00
147_L359_C2.2011.00
31_K223_Q2.1421.00
190_R305_F2.1151.00
185_I189_L2.1021.00
6_P240_S2.0791.00
163_R171_R2.0371.00
181_F262_V2.0291.00
20_A258_M2.0181.00
404_S407_E2.0141.00
429_L433_I1.9971.00
28_A259_N1.9961.00
112_I314_L1.9941.00
185_I265_L1.9901.00
134_A138_S1.9791.00
22_S229_T1.9731.00
198_M201_V1.9641.00
204_L267_G1.9061.00
114_L118_K1.8901.00
188_V269_A1.8521.00
198_M202_K1.8451.00
151_L155_A1.8151.00
56_G228_L1.8091.00
114_L145_Q1.8041.00
57_Y256_V1.7971.00
119_T306_F1.7941.00
205_L264_L1.7931.00
72_T76_D1.7901.00
195_N279_F1.7531.00
13_I17_M1.7511.00
397_L402_K1.7441.00
116_I314_L1.7291.00
259_N263_T1.7191.00
146_T359_C1.7171.00
136_F140_I1.7071.00
51_F221_L1.7061.00
113_L314_L1.6961.00
159_L163_R1.6921.00
427_F431_R1.6851.00
380_D384_S1.6771.00
109_G317_A1.6761.00
8_Q71_Q1.6641.00
117_V149_A1.6551.00
73_N334_K1.6501.00
345_W349_L1.6431.00
354_V357_P1.6411.00
101_V383_V1.6271.00
120_A307_I1.6181.00
109_G153_F1.6061.00
204_L268_L1.6021.00
128_S131_Q1.5851.00
390_S442_F1.5831.00
338_K346_T1.5761.00
147_L352_F1.5731.00
237_T327_I1.5651.00
114_L149_A1.5631.00
149_A152_V1.5631.00
356_I360_L1.5541.00
14_G170_E1.5511.00
76_D335_G1.5501.00
131_Q134_A1.5441.00
158_V345_W1.5421.00
37_G281_P1.5391.00
188_V265_L1.5341.00
195_N276_S1.5331.00
178_P182_L1.5181.00
142_N147_L1.5161.00
190_R194_L1.5161.00
358_C375_F1.5131.00
133_G138_S1.5011.00
135_L138_S1.4991.00
338_K343_L1.4981.00
20_A24_I1.4951.00
106_S150_Q1.4941.00
61_V252_A1.4891.00
160_V318_L1.4781.00
428_Y432_F1.4751.00
184_F269_A1.4691.00
238_Y323_S1.4491.00
411_E414_N1.4461.00
22_S323_S1.4431.00
311_V315_F1.4241.00
64_F239_S1.4161.00
159_L162_A1.4071.00
154_M351_I1.4051.00
182_L186_L1.4041.00
47_I217_I1.4001.00
393_L439_I1.3991.00
133_G136_F1.3901.00
6_P334_K1.3771.00
133_G137_A1.3701.00
39_N215_E1.3671.00
124_L127_L1.3601.00
273_A295_V1.3591.00
204_L264_L1.3551.00
78_Y236_V1.3531.00
104_F380_D1.3491.00
61_V248_I1.3431.00
376_F380_D1.3311.00
229_T234_V1.3291.00
330_A334_K1.3241.00
349_L353_L1.3221.00
231_G392_A1.3151.00
101_V232_V1.3081.00
191_S273_A1.2961.00
45_F264_L1.2921.00
413_R416_S1.2921.00
83_P86_A1.2871.00
38_T215_E1.2861.00
102_L321_A1.2841.00
43_A209_F1.2771.00
189_L193_T1.2711.00
156_L318_L1.2701.00
142_N145_Q1.2641.00
406_S427_F1.2621.00
93_I391_G1.2601.00
150_Q154_M1.2551.00
373_K377_D1.2471.00
409_L427_F1.2471.00
74_A77_A1.2351.00
257_L261_I1.2291.00
333_G343_L1.2211.00
190_R300_P1.2181.00
69_R411_E1.2171.00
212_L216_S1.2121.00
133_G140_I1.2081.00
73_N76_D1.2031.00
400_P431_R1.1911.00
378_I382_T1.1901.00
358_C379_A1.1891.00
275_F281_P1.1801.00
113_L153_F1.1801.00
210_G213_T1.1771.00
64_F255_I1.1741.00
47_I212_L1.1741.00
173_S319_T1.1721.00
234_V324_M1.1651.00
21_G319_T1.1611.00
39_N216_S1.1591.00
406_S431_R1.1571.00
353_L357_P1.1491.00
95_V331_T1.1481.00
161_V329_V1.1481.00
288_L291_V1.1421.00
102_L351_I1.1401.00
9_W18_A1.1361.00
10_A13_I1.1341.00
62_G426_W1.1240.99
103_S358_C1.1240.99
103_S354_V1.1240.99
97_A387_L1.1120.99
35_V219_F1.1100.99
407_E410_A1.1050.99
393_L442_F1.1020.99
224_A259_N1.1000.99
286_T290_T1.0990.99
175_V179_I1.0960.99
74_A233_S1.0910.99
192_L197_A1.0890.99
403_I407_E1.0880.99
64_F235_M1.0850.99
54_L58_P1.0800.99
68_R411_E1.0720.99
187_L269_A1.0710.99
61_V65_I1.0700.99
413_R421_A1.0700.99
31_K35_V1.0700.99
307_I311_V1.0680.99
69_R410_A1.0630.99
319_T322_F1.0600.99
406_S410_A1.0490.99
224_A260_I1.0470.99
176_M315_F1.0460.99
428_Y433_I1.0430.99
424_Y427_F1.0420.99
440_I444_N1.0400.99
246_Q251_S1.0390.99
47_I216_S1.0370.99
425_T429_L1.0360.99
100_L383_V1.0350.99
113_L152_V1.0350.99
172_V176_M1.0340.99
249_P252_A1.0270.99
15_F19_A1.0250.99
186_L190_R1.0250.99
183_L308_G1.0220.99
39_N219_F1.0210.99
403_I411_E1.0120.99
8_Q243_P1.0120.99
342_K346_T1.0110.99
29_I316_A1.0080.99
16_V20_A1.0030.99
64_F252_A1.0010.99
65_I412_M0.9960.99
29_I313_F0.9960.99
373_K378_I0.9910.99
424_Y428_Y0.9860.99
185_I188_V0.9830.99
54_L221_L0.9830.99
127_L297_E0.9810.99
85_S398_F0.9800.99
52_T224_A0.9790.99
199_E279_F0.9780.99
155_A159_L0.9780.99
11_S14_G0.9770.99
126_G129_Q0.9760.99
329_V344_S0.9740.98
141_Q361_S0.9730.98
118_K135_L0.9670.98
102_L325_V0.9660.98
186_L305_F0.9630.98
157_T318_L0.9630.98
282_N286_T0.9530.98
82_A85_S0.9500.98
195_N200_G0.9490.98
109_G321_A0.9490.98
153_F321_A0.9420.98
108_I111_W0.9380.98
160_V172_V0.9380.98
117_V120_A0.9380.98
134_A137_A0.9380.98
188_V192_L0.9350.98
81_E399_I0.9340.98
374_T377_D0.9310.98
31_K380_D0.9260.98
425_T428_Y0.9240.98
35_V223_Q0.9240.98
101_V324_M0.9230.98
114_L139_I0.9190.98
162_A341_K0.9180.98
79_K86_A0.9170.98
197_A200_G0.9150.98
158_V344_S0.9120.98
260_I263_T0.9120.98
122_G125_S0.9090.98
10_A14_G0.9070.98
107_V359_C0.9060.98
371_F378_I0.9050.98
7_V166_Q0.9050.98
43_A212_L0.9030.98
411_E415_G0.9020.98
436_L440_I0.9010.97
137_A140_I0.8980.97
52_T260_I0.8940.97
339_K343_L0.8930.97
285_P288_L0.8920.97
130_A134_A0.8920.97
144_V148_A0.8910.97
50_L53_I0.8900.97
260_I264_L0.8880.97
233_S327_I0.8850.97
121_S124_L0.8810.97
332_I338_K0.8800.97
436_L439_I0.8790.97
253_A257_L0.8790.97
59_L438_I0.8760.97
422_F425_T0.8760.97
190_R299_L0.8750.97
132_Y136_F0.8680.97
194_L197_A0.8670.97
386_V446_I0.8660.97
215_E219_F0.8650.97
406_S409_L0.8630.97
113_L156_L0.8560.97
102_L324_M0.8540.97
135_L139_I0.8510.96
201_V205_L0.8510.96
299_L305_F0.8490.96
65_I408_L0.8490.96
282_N291_V0.8460.96
37_G275_F0.8450.96
20_A319_T0.8440.96
161_V344_S0.8420.96
68_R415_G0.8420.96
296_F306_F0.8380.96
343_L346_T0.8360.96
106_S153_F0.8350.96
14_G173_S0.8340.96
147_L151_L0.8330.96
160_V322_F0.8320.96
86_A335_G0.8290.96
145_Q149_A0.8290.96
232_V324_M0.8290.96
186_L189_L0.8270.96
400_P430_L0.8250.96
332_I343_L0.8250.96
99_F350_L0.8230.96
322_F326_E0.8230.96
98_C328_I0.8220.96
393_L397_L0.8200.96
36_A204_L0.8200.96
74_A94_G0.8200.96
412_M416_S0.8180.96
30_W34_Y0.8160.96
234_V323_S0.8160.96
35_V39_N0.8150.95
18_A238_Y0.8150.95
130_A133_G0.8090.95
76_D79_K0.8060.95
37_G274_V0.8020.95
19_A22_S0.8010.95
361_S376_F0.8000.95
127_L130_A0.8000.95
299_L302_G0.7990.95
410_A421_A0.7980.95
381_F386_V0.7980.95
112_I313_F0.7950.95
169_I322_F0.7950.95
186_L308_G0.7940.95
232_V388_M0.7930.95
390_S394_L0.7930.95
55_L437_A0.7930.95
62_G399_I0.7920.95
126_G130_A0.7920.95
18_A22_S0.7920.95
116_I120_A0.7890.95
90_T394_L0.7870.95
36_A267_G0.7870.95
79_K91_G0.7870.95
294_A298_Q0.7860.95
212_L217_I0.7830.94
152_V156_L0.7800.94
50_L54_L0.7800.94
376_F379_A0.7790.94
27_G31_K0.7790.94
241_Y326_E0.7770.94
89_L92_W0.7740.94
74_A236_V0.7740.94
278_G281_P0.7730.94
191_S272_P0.7720.94
434_V437_A0.7710.94
432_F436_L0.7700.94
137_A141_Q0.7680.94
37_G203_F0.7670.94
332_I336_D0.7640.94
49_V260_I0.7640.94
284_G287_L0.7600.93
82_A398_F0.7590.93
231_G388_M0.7590.93
176_M319_T0.7570.93
9_W15_F0.7570.93
60_L64_F0.7550.93
270_I293_P0.7520.93
102_L161_V0.7490.93
28_A48_F0.7490.93
201_V207_P0.7460.93
230_L234_V0.7460.93
93_I394_L0.7460.93
127_L131_Q0.7420.93
22_S234_V0.7420.93
243_P246_Q0.7380.92
117_V152_V0.7330.92
374_T378_I0.7330.92
75_I331_T0.7330.92
409_L413_R0.7320.92
98_C233_S0.7310.92
177_M319_T0.7300.92
152_V155_A0.7260.92
405_K427_F0.7230.92
357_P375_F0.7220.92
181_F185_I0.7210.92
396_S400_P0.7190.91
254_S258_M0.7190.91
104_F384_S0.7180.91
73_N330_A0.7160.91
16_V255_I0.7150.91
76_D80_K0.7140.91
30_W285_P0.7140.91
162_A344_S0.7130.91
435_P438_I0.7120.91
38_T219_F0.7080.91
36_A42_G0.7080.91
344_S348_G0.7030.91
15_F64_F0.7000.90
394_L397_L0.6990.90
223_Q227_T0.6990.90
239_S259_N0.6980.90
348_G352_F0.6970.90
160_V168_G0.6960.90
57_Y235_M0.6940.90
179_I183_L0.6930.90
33_P40_G0.6930.90
125_S128_S0.6930.90
225_F392_A0.6910.90
180_L316_A0.6900.90
277_F298_Q0.6890.90
423_F426_W0.6850.89
158_V162_A0.6820.89
36_A45_F0.6820.89
24_I28_A0.6790.89
12_K250_R0.6760.89
393_L396_S0.6760.89
371_F375_F0.6760.89
34_Y281_P0.6730.89
373_K381_F0.6720.88
74_A95_V0.6720.88
19_A255_I0.6710.88
171_R175_V0.6690.88
22_S101_V0.6680.88
324_M328_I0.6670.88
61_V412_M0.6660.88
131_Q135_L0.6660.88
35_V38_T0.6640.88
193_T196_G0.6630.88
276_S280_Q0.6620.88
133_G290_T0.6610.88
118_K145_Q0.6600.88
303_T307_I0.6570.87
325_V344_S0.6560.87
440_I443_L0.6550.87
114_L117_V0.6550.87
99_F351_I0.6550.87
95_V327_I0.6540.87
421_A424_Y0.6520.87
426_W430_L0.6520.87
328_I347_S0.6520.87
276_S298_Q0.6510.87
409_L412_M0.6510.87
125_S129_Q0.6500.87
60_L256_V0.6500.87
285_P290_T0.6480.87
81_E403_I0.6470.87
105_Y108_I0.6470.87
79_K335_G0.6470.87
123_S128_S0.6470.87
190_R195_N0.6470.87
25_G32_F0.6460.86
75_I91_G0.6450.86
24_I181_F0.6450.86
275_F278_G0.6450.86
113_L149_A0.6440.86
78_Y395_I0.6440.86
332_I350_L0.6420.86
106_S321_A0.6410.86
413_R423_F0.6400.86
163_R341_K0.6380.86
154_M348_G0.6380.86
222_G385_N0.6370.86
101_V384_S0.6370.86
51_F54_L0.6350.86
300_P372_G0.6350.86
13_I20_A0.6340.85
333_G340_R0.6340.85
103_S321_A0.6330.85
36_A212_L0.6320.85
60_L230_L0.6320.85
325_V347_S0.6300.85
98_C327_I0.6300.85
66_F81_E0.6290.85
336_D343_L0.6290.85
162_A345_W0.6280.85
401_L405_K0.6280.85
145_Q148_A0.6240.85
48_F227_T0.6240.85
439_I443_L0.6210.84
429_L434_V0.6200.84
77_A236_V0.6190.84
155_A345_W0.6180.84
229_T323_S0.6180.84
196_G200_G0.6170.84
154_M352_F0.6160.84
196_G199_E0.6160.84
247_N416_S0.6160.84
97_A391_G0.6160.84
49_V53_I0.6150.84
274_V279_F0.6110.83
109_G314_L0.6100.83
180_L312_A0.6100.83
43_A47_I0.6100.83
306_F310_L0.6100.83
401_L431_R0.6090.83
191_S271_F0.6090.83
252_A256_V0.6080.83
289_F309_F0.6080.83
165_V169_I0.6080.83
349_L399_I0.6070.83
411_E416_S0.6070.83
442_F446_I0.6070.83
99_F347_S0.6060.83
271_F276_S0.6040.83
377_D380_D0.6010.82
202_K205_L0.6010.82
61_V249_P0.6000.82
40_G44_F0.5970.82
179_I315_F0.5960.82
154_M157_T0.5950.82
191_S269_A0.5930.81
59_L396_S0.5930.81
274_V281_P0.5920.81
238_Y320_S0.5920.81
96_A100_L0.5920.81
17_M21_G0.5910.81
343_L347_S0.5910.81
175_V311_V0.5900.81
82_A86_A0.5900.81
384_S388_M0.5900.81
164_G293_P0.5870.81
63_E67_G0.5850.81
294_A297_E0.5830.80
250_R254_S0.5830.80
244_K411_E0.5820.80
85_S402_K0.5820.80
200_G305_F0.5800.80
89_L93_I0.5780.80
91_G104_F0.5780.80
61_V318_L0.5780.80
12_K251_S0.5780.80
34_Y285_P0.5770.80
379_A383_V0.5770.80
35_V216_S0.5760.80
326_E333_G0.5760.80
333_G338_K0.5760.80
111_W115_Y0.5740.79
231_G327_I0.5740.79
161_V322_F0.5740.79
216_S223_Q0.5740.79
59_L434_V0.5720.79
346_T350_L0.5720.79
229_T324_M0.5710.79
309_F326_E0.5700.79
398_F402_K0.5690.79
69_R407_E0.5690.79
72_T79_K0.5690.79
57_Y252_A0.5680.79
214_P217_I0.5670.78
13_I16_V0.5670.78
409_L423_F0.5650.78
241_Y330_A0.5630.78
423_F427_F0.5630.78
51_F224_A0.5630.78
373_K376_F0.5620.78
74_A331_T0.5620.78
270_I292_L0.5610.78
195_N198_M0.5610.78
161_V325_V0.5590.78
106_S154_M0.5590.78
320_S323_S0.5570.77
427_F432_F0.5570.77
118_K123_S0.5570.77
142_N356_I0.5560.77
27_G30_W0.5550.77
150_Q359_C0.5550.77
98_C234_V0.5530.77
31_K384_S0.5520.77
211_D216_S0.5520.77
332_I347_S0.5510.76
103_S379_A0.5510.76
28_A52_T0.5510.76
296_F299_L0.5490.76
316_A319_T0.5480.76
64_F248_I0.5470.76
45_F204_L0.5440.76
31_K108_I0.5440.76
30_W284_G0.5410.75
9_W426_W0.5410.75
420_K423_F0.5390.75
59_L224_A0.5380.75
240_S334_K0.5360.75
19_A60_L0.5360.75
300_P303_T0.5360.75
196_G276_S0.5360.75
94_G391_G0.5360.75
270_I287_L0.5350.74
19_A235_M0.5350.74
176_M322_F0.5340.74
62_G65_I0.5340.74
107_V150_Q0.5340.74
177_M180_L0.5330.74
377_D381_F0.5330.74
90_T398_F0.5320.74
397_L401_L0.5320.74
150_Q157_T0.5310.74
9_W56_G0.5300.74
62_G430_L0.5290.74
237_T323_S0.5290.74
350_L354_V0.5280.73
15_F242_L0.5280.73
28_A263_T0.5280.73
46_L212_L0.5270.73
242_L246_Q0.5260.73
205_L209_F0.5250.73
345_W348_G0.5250.73
28_A260_I0.5240.73
69_R414_N0.5240.73
95_V328_I0.5220.73
328_I349_L0.5220.73
227_T259_N0.5220.73
405_K409_L0.5220.73
236_V395_I0.5200.72
179_I182_L0.5200.72
276_S279_F0.5200.72
117_V121_S0.5200.72
305_F308_G0.5190.72
272_P276_S0.5180.72
194_L200_G0.5180.72
408_L411_E0.5180.72
30_W33_P0.5170.72
122_G303_T0.5170.72
74_A234_V0.5170.72
15_F426_W0.5160.72
197_A201_V0.5160.72
16_V254_S0.5160.72
216_S219_F0.5160.72
28_A227_T0.5150.72
66_F395_I0.5140.71
120_A123_S0.5120.71
189_L192_L0.5110.71
104_F232_V0.5100.71
271_F275_F0.5090.71
186_L192_L0.5090.71
228_L260_I0.5090.71
110_G150_Q0.5080.71
262_V271_F0.5080.71
428_Y436_L0.5070.70
80_K436_L0.5060.70
30_W40_G0.5030.70
42_G59_L0.5010.70
89_L173_S0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xp4A 1 0.9623 100 0.031 Contact Map
4us3A 1 0.9734 100 0.037 Contact Map
2a65A 2 0.9468 100 0.089 Contact Map
3giaA 1 0.8492 98.7 0.901 Contact Map
3l1lA 2 0.8248 98.2 0.916 Contact Map
4djkA 2 0.8603 98.1 0.918 Contact Map
2jlnA 1 0.8492 97.6 0.926 Contact Map
4wgvA 2 0.8004 93.3 0.949 Contact Map
3dh4A 3 0.8337 86.7 0.956 Contact Map
2xq2A 2 0.8514 85.6 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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