GREMLIN Database
YHDG - Uncharacterized amino acid permease YhdG
UniProt: O07576 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 465 (414)
Sequences: 24632 (15731)
Seq/√Len: 773.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
172_T363_G4.4171.00
344_S357_V4.3041.00
69_A267_T3.2481.00
347_K357_V3.1131.00
391_V424_I3.0521.00
253_K257_K3.0401.00
349_H352_H2.9641.00
29_G249_K2.8811.00
399_V403_K2.8581.00
109_G335_M2.7461.00
93_Y338_D2.7441.00
248_T254_D2.7031.00
250_N253_K2.6891.00
336_S346_S2.5671.00
349_H356_Y2.5411.00
204_A276_I2.5281.00
165_F367_A2.5191.00
344_S347_K2.4931.00
34_T261_F2.4661.00
304_W308_I2.4441.00
246_E337_R2.4041.00
202_A206_V2.4021.00
81_E401_R2.3921.00
30_A261_F2.3441.00
97_Y105_A2.2681.00
333_F337_R2.1961.00
247_E330_R2.1861.00
360_W364_T2.1841.00
394_S423_A2.1691.00
169_M367_A2.1491.00
30_A254_D2.1411.00
421_G425_L2.1231.00
295_L298_Q2.1061.00
173_Y177_L2.1021.00
33_L248_T2.0821.00
172_T359_T2.0821.00
30_A34_T2.0731.00
164_A370_G2.0721.00
180_K184_R2.0561.00
176_Y356_Y2.0311.00
257_K261_F1.9861.00
78_S394_S1.9811.00
113_I362_F1.9641.00
100_L399_V1.9521.00
165_F370_G1.9341.00
191_I195_L1.9301.00
339_G343_G1.9301.00
24_L348_V1.9221.00
97_Y102_E1.9061.00
29_G32_D1.8921.00
295_L299_S1.8861.00
70_L74_F1.8691.00
285_Q299_S1.8681.00
53_G61_L1.8441.00
451_V455_L1.8431.00
418_V422_L1.8171.00
215_P218_P1.8131.00
345_L361_F1.8111.00
349_H354_T1.8011.00
282_P285_Q1.7971.00
100_L395_V1.7671.00
260_I264_L1.7611.00
175_L322_L1.7411.00
110_W449_G1.7311.00
425_L429_F1.7311.00
96_T108_I1.7161.00
169_M363_G1.7131.00
250_N254_D1.7101.00
34_T265_V1.7091.00
64_S227_A1.7091.00
32_D187_N1.7021.00
28_L32_D1.6821.00
168_V366_S1.6641.00
37_G262_S1.6581.00
443_L447_L1.6511.00
120_V366_S1.6461.00
289_V295_L1.6341.00
176_Y360_W1.6311.00
124_S321_M1.6281.00
352_H356_Y1.6211.00
101_G104_M1.6121.00
108_I392_L1.6001.00
60_G224_V1.5971.00
195_L199_L1.5911.00
131_F163_P1.5831.00
399_V402_K1.5761.00
445_W449_G1.5611.00
435_G438_T1.5601.00
214_Q218_P1.5331.00
244_A326_Y1.5221.00
264_L268_I1.5021.00
71_A426_F1.4921.00
250_N257_K1.4781.00
196_V312_G1.4721.00
177_L352_H1.4721.00
343_G347_K1.4701.00
70_L422_L1.4641.00
395_V424_I1.4591.00
74_F422_L1.4521.00
68_A231_V1.4511.00
124_S168_V1.4461.00
333_F348_V1.4451.00
209_K212_N1.4441.00
357_V361_F1.4431.00
165_F169_M1.4401.00
332_M358_A1.4321.00
343_G346_S1.4271.00
194_I198_L1.4251.00
25_K353_K1.4151.00
76_A263_L1.4111.00
283_F286_F1.4101.00
172_T360_W1.4001.00
32_D183_K1.3981.00
24_L333_F1.3941.00
328_Q362_F1.3881.00
168_V363_G1.3861.00
96_T392_L1.3721.00
89_S246_E1.3671.00
205_A276_I1.3601.00
209_K213_W1.3571.00
127_W314_V1.3521.00
395_V399_V1.3471.00
298_Q306_A1.3461.00
289_V292_P1.3451.00
405_P409_R1.3441.00
329_T359_T1.3441.00
347_K356_Y1.3351.00
201_I272_T1.3301.00
416_V420_P1.3271.00
307_G311_I1.3221.00
127_W167_I1.3191.00
86_V98_A1.3161.00
100_L104_M1.3111.00
251_P256_P1.3101.00
76_A259_I1.3021.00
99_T396_A1.2971.00
436_W439_I1.2961.00
291_H295_L1.2911.00
254_D257_K1.2801.00
28_L183_K1.2771.00
450_L454_F1.2751.00
268_I272_T1.2691.00
75_A394_S1.2651.00
48_V126_G1.2611.00
415_G419_I1.2531.00
88_V94_T1.2531.00
123_V320_V1.2531.00
77_L260_I1.2391.00
41_I266_C1.2371.00
30_A257_K1.2371.00
62_T275_A1.2361.00
208_V279_G1.2331.00
171_I321_M1.2321.00
428_L432_L1.2301.00
200_F204_A1.2281.00
204_A280_V1.2251.00
88_V98_A1.2231.00
28_L33_L1.2191.00
94_T98_A1.2101.00
31_F35_L1.2081.00
85_S409_R1.2041.00
435_G439_I1.2031.00
436_W440_V1.2011.00
332_M341_V1.2001.00
214_Q217_M1.1771.00
174_L185_V1.1751.00
103_L456_Y1.1711.00
298_Q303_N1.1691.00
79_Y92_V1.1631.00
78_S420_P1.1631.00
161_N165_F1.1551.00
249_K254_D1.1351.00
106_F110_W1.1331.00
33_L258_G1.1301.00
415_G418_V1.1251.00
162_L166_V1.1241.00
444_V448_I1.1211.00
186_N322_L1.1181.00
38_I265_V1.1171.00
429_F433_N1.1141.00
348_V353_K1.1121.00
96_T104_M1.1041.00
427_C430_L1.1001.00
37_G241_V1.0971.00
418_V421_G1.0931.00
444_V447_L1.0931.00
337_R346_S1.0911.00
36_L244_A1.0851.00
83_A95_F1.0851.00
452_I455_L1.0831.00
407_L410_A1.0801.00
185_V189_M1.0791.00
166_V170_A1.0771.00
93_Y334_A1.0771.00
357_V360_W1.0761.00
98_A404_Q1.0751.00
113_I332_M1.0721.00
398_I421_G1.0661.00
199_L203_V1.0651.00
27_E249_K1.0631.00
198_L202_A1.0581.00
420_P424_I1.0531.00
423_A427_C1.0521.00
128_S163_P1.0451.00
404_Q407_L1.0391.00
391_V428_L1.0371.00
441_R444_V1.0361.00
38_I266_C1.0361.00
420_P427_C1.0361.00
184_R188_I1.0331.00
449_G452_I1.0281.00
176_Y354_T1.0171.00
402_K417_P1.0091.00
194_I269_L1.0041.00
131_F314_V0.9941.00
172_T176_Y0.9911.00
60_G217_M0.9901.00
364_T368_L0.9901.00
429_F432_L0.9901.00
384_I442_F0.9891.00
417_P421_G0.9881.00
169_M173_Y0.9871.00
397_V420_P0.9851.00
81_E84_S0.9831.00
424_I428_L0.9811.00
189_M319_T0.9791.00
54_A61_L0.9761.00
66_V271_V0.9761.00
103_L450_L0.9751.00
437_V440_V0.9721.00
128_S160_F0.9721.00
437_V441_R0.9611.00
236_I386_T0.9601.00
179_I326_Y0.9561.00
440_V444_V0.9501.00
391_V395_V0.9501.00
217_M224_V0.9421.00
439_I442_F0.9401.00
245_A255_L0.9321.00
213_W278_T0.9281.00
239_D243_S0.9271.00
301_G305_V0.9261.00
431_I434_L0.9251.00
447_L451_V0.9251.00
85_S407_L0.9191.00
122_A379_A0.9191.00
170_A318_T0.9181.00
176_Y349_H0.9141.00
356_Y360_W0.9131.00
62_T278_T0.9111.00
345_L357_V0.9071.00
325_L363_G0.9071.00
84_S410_A0.9071.00
267_T271_V0.9061.00
35_L187_N0.9021.00
423_A426_F0.9001.00
103_L107_I0.9001.00
302_Q305_V0.8991.00
452_I456_Y0.8981.00
403_K406_D0.8951.00
112_L116_Y0.8941.00
24_L330_R0.8921.00
201_I276_I0.8921.00
225_F429_F0.8921.00
27_E180_K0.8921.00
282_P299_S0.8881.00
69_A235_F0.8871.00
128_S164_A0.8871.00
303_N307_G0.8861.00
440_V443_L0.8821.00
110_W341_V0.8811.00
442_F446_L0.8791.00
341_V345_L0.8781.00
394_S424_I0.8771.00
439_I443_L0.8761.00
97_Y338_D0.8711.00
131_F135_L0.8681.00
90_G93_Y0.8651.00
275_A279_G0.8641.00
261_F265_V0.8631.00
406_D409_R0.8631.00
201_I205_A0.8631.00
288_G292_P0.8541.00
32_D184_R0.8531.00
127_W318_T0.8531.00
220_G223_G0.8501.00
193_K316_G0.8471.00
90_G94_T0.8461.00
24_L247_E0.8451.00
31_F187_N0.8441.00
163_P166_V0.8431.00
171_I322_L0.8411.00
391_V427_C0.8401.00
127_W317_M0.8371.00
63_I224_V0.8351.00
73_L77_L0.8321.00
42_I45_G0.8281.00
122_A233_F0.8241.00
415_G420_P0.8231.00
449_G453_Y0.8211.00
240_A327_G0.8181.00
30_A258_G0.8161.00
420_P423_A0.8141.00
173_Y176_Y0.8131.00
104_M392_L0.8111.00
208_V276_I0.8061.00
363_G367_A0.8061.00
349_H353_K0.8021.00
210_P213_W0.8001.00
226_S230_L0.7971.00
171_I325_L0.7931.00
135_L138_L0.7921.00
200_F297_L0.7901.00
73_L260_I0.7871.00
288_G291_H0.7871.00
381_L385_G0.7831.00
205_A272_T0.7831.00
96_T396_A0.7821.00
85_S410_A0.7821.00
396_A400_L0.7811.00
398_I402_K0.7781.00
42_I193_K0.7761.00
161_N370_G0.7721.00
66_V70_L0.7691.00
74_F419_I0.7691.00
435_G440_V0.7681.00
411_F414_P0.7681.00
34_T258_G0.7671.00
438_T442_F0.7661.00
74_F78_S0.7631.00
436_W443_L0.7611.00
184_R187_N0.7601.00
427_C431_I0.7561.00
175_L359_T0.7541.00
177_L181_E0.7541.00
280_V296_V0.7541.00
292_P297_L0.7501.00
250_N256_P0.7481.00
165_F371_S0.7431.00
82_F95_F0.7431.00
236_I390_F0.7421.00
292_P296_V0.7421.00
445_W448_I0.7401.00
397_V401_R0.7391.00
101_G457_S0.7381.00
117_M365_M0.7351.00
297_L300_A0.7341.00
31_F184_R0.7341.00
82_F397_V0.7331.00
398_I420_P0.7311.00
53_G57_A0.7291.00
408_P412_K0.7281.00
46_I273_V0.7261.00
27_E179_I0.7221.00
168_V370_G0.7221.00
256_P259_I0.7211.00
41_I262_S0.7171.00
417_P420_P0.7171.00
448_I452_I0.7161.00
409_R412_K0.7151.00
42_I269_L0.7141.00
99_T400_L0.7121.00
213_W279_G0.7111.00
398_I417_P0.7031.00
443_L446_L0.7031.00
283_F287_A0.7031.00
261_F264_L0.7021.00
430_L434_L0.7021.00
424_I427_C0.7001.00
355_P358_A0.7001.00
385_G389_A0.7001.00
99_T399_V0.6991.00
325_L329_T0.6981.00
445_W452_I0.6971.00
62_T66_V0.6951.00
416_V419_I0.6951.00
448_I451_V0.6941.00
332_M361_F0.6941.00
161_N164_A0.6911.00
63_I67_V0.6901.00
93_Y97_Y0.6891.00
176_Y352_H0.6871.00
72_C238_F0.6841.00
119_A123_V0.6821.00
407_L412_K0.6791.00
203_V302_Q0.6791.00
130_Y313_A0.6781.00
221_F224_V0.6781.00
364_T367_A0.6781.00
329_T358_A0.6771.00
89_S333_F0.6741.00
344_S361_F0.6731.00
183_K187_N0.6721.00
272_T276_I0.6711.00
203_V207_Y0.6711.00
103_L453_Y0.6701.00
63_I66_V0.6691.00
125_V378_L0.6671.00
345_L358_A0.6661.00
297_L302_Q0.6661.00
40_A323_V0.6631.00
34_T37_G0.6631.00
451_V454_F0.6621.00
59_P278_T0.6621.00
291_H294_S0.6601.00
61_L274_S0.6591.00
175_L326_Y0.6591.00
176_Y359_T0.6581.00
201_I273_V0.6581.00
115_E386_T0.6571.00
179_I244_A0.6571.00
49_L379_A0.6521.00
79_Y393_I0.6521.00
293_V297_L0.6521.00
119_A122_A0.6501.00
83_A242_S0.6491.00
223_G226_S0.6481.00
438_T441_R0.6481.00
119_A382_V0.6481.00
101_G105_A0.6471.00
85_S405_P0.6471.00
423_A434_L0.6471.00
116_Y324_M0.6471.00
192_L312_G0.6471.00
132_Q160_F0.6471.00
336_S345_L0.6451.00
246_E333_F0.6431.00
330_R333_F0.6421.00
273_V277_M0.6411.00
304_W307_G0.6411.00
134_F311_I0.6401.00
171_I318_T0.6381.00
131_F167_I0.6371.00
446_L450_L0.6361.00
169_M172_T0.6361.00
316_G319_T0.6351.00
242_S259_I0.6351.00
39_G190_V0.6351.00
425_L428_L0.6341.00
413_C419_I0.6331.00
208_V280_V0.6331.00
76_A238_F0.6321.00
441_R445_W0.6321.00
438_T445_W0.6271.00
118_L381_L0.6271.00
420_P434_L0.6261.00
81_E414_P0.6261.00
121_S378_L0.6261.00
167_I321_M0.6241.00
37_G41_I0.6231.00
93_Y109_G0.6221.00
100_L396_A0.6221.00
65_F234_A0.6221.00
111_D389_A0.6221.00
121_S369_L0.6221.00
46_I49_L0.6211.00
183_K322_L0.6201.00
27_E31_F0.6201.00
56_T226_S0.6191.00
181_E184_R0.6191.00
40_A324_M0.6171.00
426_F430_L0.6171.00
221_F225_F0.6161.00
43_G270_Y0.6151.00
38_I190_V0.6151.00
442_F445_W0.6141.00
78_S423_A0.6141.00
134_F310_D0.6121.00
454_F457_S0.6121.00
351_K356_Y0.6121.00
24_L27_E0.6121.00
133_S310_D0.6101.00
265_V269_L0.6101.00
255_L259_I0.6091.00
50_T274_S0.6091.00
219_M222_G0.6081.00
128_S131_F0.6081.00
376_D379_A0.6081.00
53_G231_V0.6051.00
248_T255_L0.6051.00
236_I239_D0.6041.00
436_W445_W0.6031.00
92_V239_D0.6021.00
92_V243_S0.5991.00
252_A410_A0.5981.00
75_A427_C0.5981.00
123_V321_M0.5981.00
62_T271_V0.5941.00
181_E185_V0.5931.00
124_S128_S0.5891.00
276_I279_G0.5881.00
328_Q332_M0.5871.00
83_A255_L0.5861.00
391_V431_I0.5851.00
420_P431_I0.5851.00
243_S327_G0.5851.00
76_A80_A0.5811.00
80_A84_S0.5811.00
126_G130_Y0.5801.00
442_F449_G0.5801.00
31_F34_T0.5791.00
453_Y456_Y0.5791.00
93_Y105_A0.5791.00
67_V228_A0.5791.00
170_A174_L0.5791.00
400_L409_R0.5791.00
247_E355_P0.5791.00
401_R405_P0.5781.00
192_L196_V0.5771.00
420_P433_N0.5741.00
410_A414_P0.5741.00
82_F99_T0.5721.00
430_L433_N0.5711.00
401_R416_V0.5701.00
265_V268_I0.5701.00
116_Y327_G0.5671.00
273_V293_V0.5671.00
46_I50_T0.5661.00
59_P283_F0.5651.00
182_S326_Y0.5651.00
178_G181_E0.5641.00
82_F400_L0.5641.00
172_T325_L0.5641.00
56_T59_P0.5641.00
252_A408_P0.5621.00
117_M369_L0.5611.00
130_Y294_S0.5601.00
52_T376_D0.5581.00
440_V445_W0.5561.00
53_G227_A0.5551.00
77_L419_I0.5541.00
288_G295_L0.5541.00
435_G442_F0.5541.00
57_A64_S0.5531.00
431_I439_I0.5521.00
187_N191_I0.5511.00
225_F433_N0.5501.00
371_S374_P0.5501.00
38_I41_I0.5491.00
59_P62_T0.5491.00
253_K256_P0.5481.00
23_S26_R0.5481.00
78_S413_C0.5461.00
118_L382_V0.5461.00
344_S348_V0.5451.00
74_F423_A0.5451.00
294_S298_Q0.5451.00
50_T53_G0.5431.00
121_S124_S0.5421.00
427_C434_L0.5421.00
111_D388_S0.5411.00
422_L425_L0.5401.00
68_A232_F0.5391.00
29_G180_K0.5391.00
121_S366_S0.5391.00
251_P254_D0.5371.00
284_A287_A0.5361.00
356_Y359_T0.5361.00
186_N319_T0.5351.00
361_F365_M0.5351.00
96_T105_A0.5351.00
117_M362_F0.5351.00
68_A235_F0.5341.00
252_A257_K0.5341.00
77_L414_P0.5341.00
168_V367_A0.5331.00
24_L89_S0.5331.00
40_A240_A0.5331.00
265_V272_T0.5331.00
375_L379_A0.5321.00
192_L315_L0.5311.00
33_L254_D0.5311.00
311_I315_L0.5301.00
52_T56_T0.5281.00
239_D390_F0.5271.00
419_I423_A0.5251.00
134_F314_V0.5251.00
447_L450_L0.5231.00
186_N193_K0.5231.00
28_L179_I0.5221.00
108_I389_A0.5211.00
166_V169_M0.5211.00
436_W442_F0.5201.00
413_C416_V0.5201.00
169_M360_W0.5191.00
81_E411_F0.5171.00
81_E85_S0.5171.00
297_L305_V0.5151.00
308_I312_G0.5141.00
64_S231_V0.5141.00
330_R348_V0.5141.00
62_T65_F0.5131.00
421_G424_I0.5131.00
27_E353_K0.5121.00
75_A239_D0.5121.00
426_F429_F0.5121.00
420_P430_L0.5111.00
442_F447_L0.5111.00
414_P418_V0.5101.00
435_G445_W0.5101.00
188_I192_L0.5101.00
386_T389_A0.5101.00
65_F274_S0.5091.00
56_T227_A0.5091.00
332_M336_S0.5081.00
247_E348_V0.5081.00
123_V126_G0.5071.00
167_I318_T0.5071.00
206_V209_K0.5071.00
409_R413_C0.5061.00
80_A259_I0.5061.00
50_T54_A0.5051.00
348_V352_H0.5041.00
167_I171_I0.5041.00
420_P426_F0.5041.00
405_P408_P0.5031.00
196_V308_I0.5021.00
248_T258_G0.5011.00
419_I433_N0.5011.00
241_V255_L0.5001.00
270_Y274_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8839 100 0.299 Contact Map
3giaA 1 0.9011 100 0.349 Contact Map
4djkA 2 0.8731 100 0.369 Contact Map
3dh4A 3 0.871 98.9 0.857 Contact Map
2jlnA 1 0.886 98.9 0.859 Contact Map
2xq2A 2 0.8839 98.7 0.868 Contact Map
2a65A 2 0.9183 97.3 0.908 Contact Map
4wgvA 2 0.7806 97.2 0.909 Contact Map
4us3A 1 0.8645 96.9 0.913 Contact Map
4xp4A 1 0.9183 96.7 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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