GREMLIN Database
NSRR - HTH-type transcriptional regulator NsrR
UniProt: O07573 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (134)
Sequences: 5890 (4074)
Seq/√Len: 351.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
77_G124_D3.8691.00
72_E129_R3.0191.00
92_C106_C2.8951.00
56_E66_R2.8571.00
16_F34_T2.8301.00
10_S83_T2.7021.00
129_R133_K2.6601.00
14_L54_Y2.6001.00
114_E122_V2.4961.00
52_L82_K2.3841.00
69_M78_E2.3761.00
81_R124_D2.2621.00
14_L128_L2.2371.00
77_G81_R2.1601.00
13_V46_I2.0641.00
25_L66_R2.0401.00
18_A132_V2.0221.00
92_C100_C1.9211.00
118_A122_V1.9091.00
17_L55_V1.8811.00
29_K39_K1.8351.00
100_C106_C1.7731.00
118_A121_A1.7471.00
16_F26_S1.6591.00
70_D73_D1.6471.00
29_K33_E1.6131.00
69_M73_D1.6021.00
58_I66_R1.5921.00
114_E126_Y1.5751.00
50_G57_T1.5091.00
75_N127_T1.5001.00
7_T80_V1.4971.00
47_Y51_Q1.4761.00
20_E24_E1.4521.00
37_I42_L1.4381.00
115_A119_Y1.4321.00
13_V42_L1.3971.00
75_N78_E1.3241.00
28_I46_I1.3111.00
122_V125_K1.3101.00
120_L124_D1.2941.00
81_R120_L1.2831.00
116_L120_L1.2521.00
111_V126_Y1.2031.00
16_F20_E1.1801.00
69_M74_I1.1781.00
7_T84_E1.1651.00
13_V31_I1.1611.00
56_E68_G1.1431.00
117_L121_A1.1081.00
16_F35_Y1.1041.00
47_Y50_G1.0981.00
27_N30_Q1.0951.00
114_E134_N1.0921.00
21_R24_E1.0771.00
115_A123_L1.0741.00
6_Y44_K1.0721.00
54_Y74_I1.0681.00
121_A125_K1.0661.00
20_E26_S1.0511.00
9_Y37_I1.0351.00
25_L58_I1.0291.00
80_V123_L1.0211.00
46_I65_I1.0151.00
15_I132_V0.9971.00
8_D12_R0.9861.00
14_L79_V0.9841.00
54_Y82_K0.9781.00
113_N117_L0.9731.00
24_E30_Q0.9511.00
78_E124_D0.9441.00
33_E39_K0.9401.00
11_L76_I0.9161.00
30_Q34_T0.9001.00
110_H134_N0.8961.00
40_N43_M0.8931.00
19_A132_V0.8901.00
115_A118_A0.8871.00
14_L49_L0.8831.00
5_N41_H0.8741.00
17_L26_S0.8731.00
6_Y48_R0.8721.00
28_I43_M0.8711.00
30_Q33_E0.8701.00
77_G120_L0.8601.00
67_L71_P0.8531.00
89_I116_L0.8521.00
46_I55_V0.8471.00
122_V126_Y0.8411.00
48_R52_L0.8331.00
57_T65_I0.8321.00
76_I111_V0.8191.00
127_T130_D0.8191.00
114_E118_A0.8161.00
50_G55_V0.8161.00
47_Y65_I0.8111.00
43_M65_I0.8101.00
87_F120_L0.8081.00
6_Y10_S0.8041.00
47_Y57_T0.8031.00
78_E81_R0.8011.00
21_R71_P0.8001.00
98_N103_S0.7991.00
28_I39_K0.7941.00
6_Y41_H0.7931.00
70_D129_R0.7851.00
114_E125_K0.7841.00
76_I131_L0.7811.00
109_K113_N0.7741.00
68_G74_I0.7721.00
96_N99_L0.7721.00
10_S45_V0.7681.00
54_Y78_E0.7591.00
43_M50_G0.7531.00
16_F31_I0.7471.00
3_L112_L0.7421.00
130_D133_K0.7381.00
81_R86_D0.7220.99
113_N116_L0.7180.99
3_L80_V0.7180.99
39_K43_M0.7080.99
78_E82_K0.7070.99
41_H45_V0.7050.99
9_Y45_V0.7050.99
74_I79_V0.7040.99
80_V84_E0.6990.99
16_F30_Q0.6850.99
38_S41_H0.6770.99
7_T83_T0.6760.99
121_A124_D0.6640.99
111_V114_E0.6520.99
32_A37_I0.6460.99
115_A122_V0.6430.99
74_I128_L0.6400.99
53_G68_G0.6390.99
40_N44_K0.6370.99
112_L119_Y0.6360.99
79_V128_L0.6290.99
79_V82_K0.6280.98
4_T7_T0.6210.98
31_I46_I0.6210.98
54_Y69_M0.6210.98
75_N125_K0.6200.98
71_P132_V0.6170.98
114_E117_L0.6150.98
108_L112_L0.6140.98
75_N124_D0.6080.98
15_I131_L0.6050.98
48_R51_Q0.6040.98
4_T84_E0.6010.98
41_H59_R0.6010.98
52_L78_E0.5980.98
9_Y41_H0.5970.98
44_K47_Y0.5960.98
3_L7_T0.5880.98
72_E133_K0.5860.98
4_T41_H0.5840.98
91_E94_D0.5820.98
92_C109_K0.5810.98
106_C109_K0.5800.97
55_V59_R0.5790.97
129_R132_V0.5790.97
17_L46_I0.5760.97
27_N62_G0.5760.97
50_G65_I0.5750.97
5_N91_E0.5740.97
118_A123_L0.5730.97
8_D108_L0.5660.97
59_R112_L0.5650.97
94_D98_N0.5620.97
19_A34_T0.5580.97
12_R35_Y0.5530.97
68_G71_P0.5520.97
22_P70_D0.5500.97
94_D97_K0.5470.96
72_E130_D0.5460.96
20_E34_T0.5430.96
71_P74_I0.5430.96
88_N94_D0.5430.96
101_V105_V0.5360.96
69_M72_E0.5340.96
19_A107_G0.5330.96
5_N36_S0.5320.96
71_P128_L0.5280.96
103_S109_K0.5240.95
101_V104_P0.5240.95
31_I35_Y0.5210.95
9_Y35_Y0.5210.95
117_L120_L0.5170.95
27_N59_R0.5170.95
36_S101_V0.5160.95
126_Y131_L0.5130.95
21_R70_D0.5100.95
44_K48_R0.5090.95
28_I65_I0.5080.95
111_V122_V0.5060.95
57_T85_D0.5050.94
6_Y43_M0.5040.94
89_I106_C0.5020.94
13_V45_V0.5000.94
102_I105_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hf1A 2 0.9384 100 0.2 Contact Map
1xd7A 2 0.7808 100 0.239 Contact Map
4hf0A 3 0.8356 100 0.252 Contact Map
3k69A 2 0.9452 100 0.275 Contact Map
1ylfA 5 0.8219 100 0.276 Contact Map
3lwfA 5 0.9452 100 0.282 Contact Map
4cicA 2 0.9041 100 0.283 Contact Map
3t8rA 2 0.8288 100 0.326 Contact Map
2y75A 5 0.8767 99.9 0.359 Contact Map
2jscA 2 0.6027 98.4 0.749 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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