GREMLIN Database
YHJP - Uncharacterized protein YhjP
UniProt: O07570 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 575 (448)
Sequences: 17862 (13176)
Seq/√Len: 622.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
287_N297_E4.0141.00
242_K248_E3.2061.00
363_S411_K3.1281.00
240_L248_E3.0421.00
199_K245_Y3.0371.00
418_T446_R3.0061.00
404_S407_E2.9841.00
243_G246_C2.8721.00
375_E379_R2.8351.00
215_A219_Q2.8191.00
508_G512_R2.8191.00
285_Q297_E2.6791.00
516_M521_S2.6321.00
357_G360_Q2.5831.00
133_V311_R2.5481.00
418_T448_T2.5371.00
215_A241_E2.5041.00
370_L404_S2.4221.00
420_V450_Q2.4071.00
184_G196_F2.3631.00
420_V448_T2.3621.00
373_S376_R2.3491.00
407_E411_K2.3261.00
186_E196_F2.3231.00
368_L440_C2.2531.00
505_I508_G2.2491.00
171_D176_E2.2191.00
192_Q248_E2.2111.00
240_L250_I2.2011.00
207_Q273_E2.1941.00
362_R366_K2.1331.00
209_L281_T2.1281.00
441_A446_R2.1081.00
363_S366_K2.1011.00
192_Q250_I2.0851.00
512_R525_I2.0801.00
521_S524_N2.0781.00
501_K536_E2.0781.00
168_F185_W2.0761.00
212_R241_E2.0521.00
295_V311_R2.0281.00
204_H299_N2.0231.00
194_R248_E2.0161.00
202_L301_R2.0081.00
202_L208_P1.9881.00
171_D178_K1.9851.00
518_D521_S1.9761.00
188_V191_K1.9731.00
187_E193_W1.9671.00
363_S408_L1.9641.00
133_V313_E1.9501.00
503_T536_E1.9151.00
237_K252_D1.9141.00
201_V209_L1.9051.00
165_D180_H1.8991.00
218_F249_L1.8711.00
196_F246_C1.8661.00
503_T532_Q1.8521.00
524_N528_D1.8461.00
212_R272_A1.8391.00
137_F328_I1.8361.00
489_S502_L1.8361.00
147_D220_R1.8271.00
237_K250_I1.7951.00
285_Q300_E1.7541.00
288_Q293_M1.7531.00
288_Q295_V1.7531.00
362_R536_E1.7371.00
183_H199_K1.7361.00
135_R313_E1.7221.00
210_T213_D1.7191.00
513_M526_L1.7141.00
389_V544_Q1.7031.00
506_C529_I1.7001.00
505_I528_D1.6961.00
509_M528_D1.6951.00
437_Q441_A1.6891.00
351_L540_I1.6811.00
489_S507_S1.6631.00
460_P465_M1.6611.00
214_V247_V1.6501.00
183_H196_F1.6261.00
410_K415_E1.6221.00
297_E311_R1.6161.00
505_I532_Q1.6121.00
371_L443_H1.6011.00
531_R535_Q1.6001.00
290_H293_M1.5901.00
212_R244_P1.5851.00
132_D310_D1.5841.00
173_D176_E1.5771.00
238_Q250_I1.5721.00
459_R463_V1.5721.00
513_M525_I1.5711.00
207_Q271_P1.5631.00
200_G208_P1.5571.00
212_R215_A1.5511.00
205_N271_P1.5431.00
504_Q508_G1.5421.00
188_V192_Q1.5351.00
502_L507_S1.5291.00
366_K404_S1.5261.00
213_D272_A1.5201.00
287_N311_R1.5191.00
366_K537_L1.5161.00
528_D531_R1.5131.00
330_E336_E1.5071.00
293_M313_E1.5061.00
284_F309_L1.5031.00
359_L419_I1.4971.00
331_K335_P1.4921.00
183_H198_R1.4901.00
401_E404_S1.4871.00
362_R535_Q1.4781.00
298_A310_D1.4771.00
525_I528_D1.4601.00
351_L468_I1.4581.00
331_K336_E1.4551.00
430_R434_E1.4531.00
211_S241_E1.4471.00
524_N527_R1.4461.00
210_T244_P1.4421.00
372_I436_I1.4341.00
354_K500_E1.4281.00
375_E388_P1.4071.00
194_R246_C1.4061.00
403_V406_S1.4061.00
509_M525_I1.3931.00
369_R537_L1.3861.00
523_I527_R1.3841.00
423_T449_L1.3841.00
295_V313_E1.3471.00
153_L156_E1.3451.00
168_F195_F1.3391.00
287_N295_V1.3341.00
368_L445_I1.3281.00
406_S410_K1.3211.00
165_D281_T1.3181.00
516_M525_I1.3021.00
204_H285_Q1.3011.00
188_V194_R1.2991.00
185_W195_F1.2821.00
131_K310_D1.2781.00
208_P245_Y1.2741.00
512_R521_S1.2731.00
378_V388_P1.2691.00
165_D303_F1.2631.00
215_A239_V1.2521.00
521_S525_I1.2501.00
242_K246_C1.2491.00
532_Q536_E1.2471.00
249_L258_L1.2431.00
439_I442_Q1.2431.00
450_Q460_P1.2411.00
202_L299_N1.2381.00
135_R315_V1.2381.00
135_R329_Q1.2371.00
196_F245_Y1.2281.00
488_L511_E1.2261.00
508_G511_E1.2221.00
253_K515_S1.2181.00
423_T451_F1.2151.00
464_Q500_E1.2101.00
364_F409_L1.2101.00
241_E244_P1.2091.00
509_M532_Q1.2071.00
453_D456_D1.2061.00
205_N273_E1.1971.00
356_K467_D1.1931.00
421_L447_L1.1911.00
378_V386_R1.1901.00
520_C523_I1.1881.00
239_V247_V1.1861.00
350_S469_I1.1811.00
201_V281_T1.1811.00
435_W439_I1.1761.00
419_I468_I1.1661.00
337_Q553_K1.1621.00
366_K408_L1.1611.00
505_I509_M1.1531.00
438_N442_Q1.1511.00
364_F412_S1.1511.00
402_G443_H1.1451.00
512_R516_M1.1451.00
219_Q223_E1.1431.00
329_Q552_S1.1411.00
159_F296_L1.1401.00
408_L411_K1.1381.00
169_T180_H1.1381.00
181_L281_T1.1381.00
501_K506_C1.1331.00
296_L314_F1.1281.00
490_E507_S1.1271.00
419_I447_L1.1241.00
209_L269_I1.1211.00
454_A458_R1.1201.00
402_G406_S1.1141.00
293_M315_V1.1131.00
359_L368_L1.1091.00
169_T178_K1.0961.00
376_R439_I1.0921.00
235_G255_N1.0901.00
198_R303_F1.0881.00
371_L440_C1.0871.00
179_P185_W1.0781.00
407_E410_K1.0781.00
274_Q278_K1.0761.00
193_W258_L1.0661.00
204_H301_R1.0651.00
567_D570_S1.0641.00
437_Q449_L1.0631.00
217_T269_I1.0621.00
285_Q299_N1.0591.00
198_R201_V1.0591.00
362_R537_L1.0571.00
329_Q554_N1.0551.00
490_E502_L1.0511.00
440_C447_L1.0491.00
520_C524_N1.0491.00
568_L571_V1.0411.00
512_R528_D1.0401.00
298_A307_P1.0371.00
195_F249_L1.0371.00
216_F272_A1.0351.00
509_M512_R1.0331.00
181_L214_V1.0331.00
532_Q535_Q1.0321.00
509_M529_I1.0311.00
356_K360_Q1.0241.00
417_E445_I1.0241.00
340_V546_V1.0081.00
436_I440_C1.0041.00
404_S408_L1.0011.00
382_G543_Y1.0001.00
183_H245_Y0.9961.00
214_V269_I0.9961.00
130_A308_Y0.9931.00
219_Q222_L0.9921.00
437_Q447_L0.9901.00
387_I546_V0.9891.00
511_E515_S0.9891.00
181_L201_V0.9851.00
330_E333_T0.9831.00
297_E300_E0.9781.00
134_L309_L0.9771.00
479_S522_R0.9761.00
134_L555_V0.9751.00
213_D216_F0.9711.00
317_S328_I0.9701.00
377_L432_D0.9681.00
456_D460_P0.9641.00
193_W259_P0.9621.00
212_R216_F0.9571.00
506_C533_M0.9561.00
513_M529_I0.9541.00
431_E434_E0.9521.00
186_E194_R0.9491.00
363_S412_S0.9491.00
196_F199_K0.9481.00
366_K370_L0.9481.00
298_A306_R0.9471.00
339_T551_S0.9451.00
403_V407_E0.9441.00
304_K569_Y0.9431.00
378_V543_Y0.9411.00
211_S242_K0.9381.00
203_F213_D0.9361.00
420_V467_D0.9341.00
414_Y417_E0.9341.00
501_K538_N0.9301.00
199_K208_P0.9301.00
332_Q335_P0.9271.00
321_G324_N0.9251.00
366_K535_Q0.9231.00
166_T268_S0.9221.00
402_G442_Q0.9211.00
208_P244_P0.9201.00
191_K237_K0.9201.00
369_R540_I0.9201.00
298_A305_G0.9191.00
423_T433_A0.9181.00
452_C460_P0.9171.00
461_E469_I0.9161.00
519_R523_I0.9151.00
376_R380_E0.9081.00
337_Q551_S0.9081.00
379_R384_H0.9061.00
204_H279_N0.9051.00
196_F243_G0.9041.00
369_R374_S0.9031.00
166_T180_H0.9021.00
333_T336_E0.9001.00
433_A449_L0.8991.00
438_N441_A0.8971.00
142_S289_Q0.8951.00
331_K334_C0.8941.00
351_L368_L0.8901.00
189_G192_Q0.8901.00
191_K250_I0.8811.00
506_C510_T0.8801.00
129_G132_D0.8781.00
193_W251_L0.8771.00
168_F177_P0.8741.00
258_L262_L0.8731.00
361_H414_Y0.8721.00
235_G253_K0.8701.00
395_P398_F0.8701.00
168_F259_P0.8661.00
204_H286_M0.8621.00
194_R242_K0.8611.00
205_N279_N0.8541.00
215_A247_V0.8531.00
162_Q296_L0.8501.00
211_S247_V0.8441.00
364_F417_E0.8441.00
484_L488_L0.8431.00
163_I296_L0.8391.00
219_Q239_V0.8371.00
368_L419_I0.8361.00
251_L258_L0.8361.00
284_F307_P0.8351.00
512_R515_S0.8351.00
213_D217_T0.8351.00
165_D302_Y0.8341.00
132_D309_L0.8321.00
204_H280_G0.8301.00
374_S388_P0.8291.00
527_R531_R0.8221.00
350_S499_S0.8211.00
506_C532_Q0.8191.00
382_G386_R0.8171.00
241_E247_V0.8171.00
345_H474_T0.8141.00
190_K194_R0.8131.00
529_I532_Q0.8121.00
400_W442_Q0.8101.00
296_L312_V0.8101.00
163_I286_M0.8081.00
149_C221_F0.8071.00
172_S559_V0.8071.00
164_F280_G0.8031.00
181_L209_L0.8031.00
336_E553_K0.7971.00
349_L436_I0.7971.00
422_Y452_C0.7941.00
510_T529_I0.7921.00
320_A324_N0.7881.00
128_N308_Y0.7851.00
372_I377_L0.7841.00
148_P270_L0.7831.00
332_Q336_E0.7831.00
349_L468_I0.7801.00
405_P443_H0.7791.00
255_N261_A0.7761.00
168_F182_V0.7761.00
320_A323_M0.7751.00
187_E190_K0.7711.00
528_D532_Q0.7681.00
441_A445_I0.7671.00
171_D174_M0.7671.00
241_E248_E0.7661.00
342_D546_V0.7661.00
430_R451_F0.7651.00
373_S400_W0.7641.00
373_S439_I0.7631.00
217_T270_L0.7631.00
149_C220_R0.7611.00
370_L408_L0.7611.00
354_K464_Q0.7601.00
370_L400_W0.7601.00
426_E429_H0.7601.00
422_Y460_P0.7571.00
558_L571_V0.7551.00
409_L413_G0.7551.00
235_G252_D0.7541.00
236_V239_V0.7501.00
195_F259_P0.7491.00
298_A309_L0.7481.00
504_Q507_S0.7471.00
191_K253_K0.7461.00
422_Y466_A0.7451.00
142_S291_S0.7441.00
367_A409_L0.7431.00
289_Q294_L0.7431.00
488_L491_N0.7411.00
408_L412_S0.7411.00
409_L412_S0.7391.00
371_L402_G0.7391.00
330_E334_C0.7381.00
151_I160_V0.7381.00
203_F273_E0.7371.00
200_G245_Y0.7371.00
274_Q277_G0.7331.00
132_D308_Y0.7301.00
361_H412_S0.7291.00
364_F414_Y0.7271.00
335_P553_K0.7271.00
434_E437_Q0.7261.00
422_Y450_Q0.7211.00
456_D459_R0.7191.00
434_E449_L0.7191.00
182_V195_F0.7191.00
368_L540_I0.7191.00
236_V249_L0.7181.00
142_S316_F0.7161.00
185_W259_P0.7151.00
421_L433_A0.7141.00
377_L435_W0.7141.00
358_P417_E0.7121.00
191_K254_P0.7081.00
370_L399_E0.7071.00
137_F322_E0.7071.00
167_L182_V0.7061.00
201_V245_Y0.7051.00
409_L414_Y0.7041.00
134_L312_V0.7031.00
391_S530_D0.7011.00
222_L252_D0.7001.00
195_F262_L0.7001.00
201_V303_F0.6971.00
286_M294_L0.6961.00
372_I440_C0.6941.00
297_E310_D0.6941.00
207_Q213_D0.6921.00
163_I280_G0.6911.00
223_E226_D0.6911.00
427_T431_E0.6901.00
180_H303_F0.6861.00
392_F541_P0.6831.00
347_Q429_H0.6831.00
351_L359_L0.6831.00
159_F294_L0.6821.00
218_F262_L0.6811.00
497_H500_E0.6811.00
424_F429_H0.6801.00
440_C445_I0.6801.00
421_L470_H0.6801.00
361_H364_F0.6801.00
525_I529_I0.6791.00
209_L217_T0.6791.00
197_L209_L0.6781.00
488_L510_T0.6781.00
211_S215_A0.6781.00
353_L538_N0.6771.00
457_L469_I0.6741.00
256_A522_R0.6721.00
203_F269_I0.6721.00
481_F485_H0.6711.00
162_Q312_V0.6711.00
210_T245_Y0.6701.00
353_L499_S0.6701.00
432_D436_I0.6691.00
215_A240_L0.6681.00
511_E514_F0.6681.00
423_T430_R0.6601.00
368_L468_I0.6591.00
137_F317_S0.6591.00
440_C468_I0.6581.00
271_P279_N0.6581.00
552_S555_V0.6571.00
409_L445_I0.6531.00
372_I540_I0.6531.00
285_Q301_R0.6521.00
157_G265_E0.6501.00
151_I156_E0.6501.00
203_F280_G0.6491.00
476_Y482_G0.6491.00
230_K234_H0.6481.00
300_E310_D0.6471.00
436_I447_L0.6461.00
286_M289_Q0.6451.00
551_S558_L0.6441.00
441_A447_L0.6441.00
239_V249_L0.6411.00
164_F278_K0.6391.00
481_F514_F0.6391.00
409_L443_H0.6391.00
340_V385_R0.6381.00
312_V568_L0.6351.00
179_P184_G0.6331.00
375_E378_V0.6331.00
340_V548_Q0.6321.00
349_L542_L0.6321.00
197_L245_Y0.6321.00
144_S153_L0.6311.00
432_D543_Y0.6311.00
371_L400_W0.6301.00
538_N541_P0.6301.00
183_H186_E0.6281.00
284_F311_R0.6261.00
452_C456_D0.6241.00
304_K307_P0.6241.00
203_F281_T0.6231.00
131_K308_Y0.6231.00
489_S511_E0.6231.00
170_F177_P0.6221.00
187_E259_P0.6221.00
167_L214_V0.6211.00
506_C509_M0.6161.00
337_Q552_S0.6151.00
170_F263_C0.6131.00
501_K532_Q0.6111.00
454_A471_D0.6101.00
372_I542_L0.6091.00
480_E484_L0.6061.00
414_Y445_I0.6051.00
473_A476_Y0.6031.00
209_L245_Y0.6031.00
507_S511_E0.6021.00
326_F552_S0.6011.00
136_L568_L0.6011.00
378_V382_G0.6011.00
253_K511_E0.6011.00
359_L468_I0.6001.00
203_F210_T0.5991.00
185_W196_F0.5971.00
425_S430_R0.5971.00
210_T272_A0.5961.00
190_K517_P0.5951.00
424_F457_L0.5941.00
412_S416_G0.5941.00
219_Q238_Q0.5941.00
309_L555_V0.5921.00
406_S443_H0.5911.00
522_R526_L0.5901.00
452_C457_L0.5891.00
427_T430_R0.5891.00
356_K359_L0.5891.00
458_R462_I0.5891.00
412_S415_E0.5871.00
165_D304_K0.5861.00
354_K360_Q0.5851.00
409_L417_E0.5851.00
477_Q481_F0.5851.00
211_S245_Y0.5831.00
233_L267_L0.5831.00
257_L479_S0.5811.00
361_H413_G0.5801.00
203_F207_Q0.5801.00
164_F274_Q0.5801.00
513_M522_R0.5801.00
294_L316_F0.5801.00
385_R548_Q0.5791.00
370_L401_E0.5781.00
440_C443_H0.5781.00
192_Q240_L0.5781.00
315_V327_T0.5771.00
169_T304_K0.5771.00
163_I278_K0.5751.00
434_E438_N0.5741.00
309_L312_V0.5731.00
351_L369_R0.5711.00
128_N132_D0.5711.00
145_S150_Q0.5701.00
527_R530_D0.5701.00
231_W234_H0.5691.00
166_T281_T0.5671.00
145_S275_G0.5661.00
537_L540_I0.5661.00
346_V389_V0.5661.00
216_F220_R0.5661.00
330_E335_P0.5651.00
164_F281_T0.5651.00
286_M296_L0.5651.00
284_F298_A0.5631.00
347_Q432_D0.5631.00
466_A469_I0.5631.00
211_S243_G0.5621.00
347_Q545_N0.5611.00
349_L421_L0.5601.00
519_R522_R0.5601.00
138_I314_F0.5591.00
402_G409_L0.5591.00
219_Q272_A0.5591.00
203_F209_L0.5591.00
410_K414_Y0.5581.00
425_S451_F0.5581.00
359_L364_F0.5571.00
419_I467_D0.5571.00
485_H489_S0.5551.00
503_T506_C0.5551.00
207_Q272_A0.5541.00
473_A486_L0.5541.00
488_L492_S0.5531.00
435_W438_N0.5531.00
146_L294_L0.5521.00
216_F273_E0.5521.00
160_V164_F0.5511.00
343_E547_L0.5501.00
358_P467_D0.5491.00
143_V294_L0.5481.00
159_F314_F0.5481.00
377_L381_A0.5471.00
377_L436_I0.5460.99
516_M522_R0.5440.99
133_V295_V0.5440.99
162_Q314_F0.5430.99
481_F526_L0.5420.99
477_Q482_G0.5420.99
216_F270_L0.5410.99
144_S156_E0.5410.99
381_A435_W0.5400.99
515_S525_I0.5380.99
433_A470_H0.5370.99
131_K311_R0.5370.99
534_I537_L0.5370.99
509_M513_M0.5370.99
187_E192_Q0.5370.99
276_G291_S0.5360.99
375_E399_E0.5360.99
567_D571_V0.5330.99
517_P521_S0.5320.99
275_G278_K0.5320.99
377_L542_L0.5310.99
349_L470_H0.5300.99
219_Q241_E0.5290.99
134_L571_V0.5290.99
353_L356_K0.5280.99
476_Y483_F0.5280.99
128_N131_K0.5270.99
333_T337_Q0.5260.99
551_S555_V0.5260.99
177_P259_P0.5250.99
353_L360_Q0.5250.99
239_V242_K0.5240.99
143_V146_L0.5240.99
505_I536_E0.5240.99
447_L468_I0.5240.99
154_R474_T0.5240.99
289_Q316_F0.5230.99
395_P544_Q0.5230.99
179_P182_V0.5220.99
342_D387_I0.5210.99
348_Y539_A0.5200.99
337_Q556_K0.5190.99
142_S292_G0.5180.99
363_S407_E0.5170.99
204_H281_T0.5160.99
119_F122_V0.5150.99
149_C217_T0.5150.99
222_L236_V0.5150.99
213_D273_E0.5150.99
348_Y471_D0.5150.99
211_S244_P0.5140.99
487_L539_A0.5140.99
154_R158_H0.5130.99
209_L214_V0.5130.99
534_I541_P0.5120.99
197_L214_V0.5110.99
499_S539_A0.5100.99
413_G416_G0.5100.99
153_L454_A0.5090.99
404_S411_K0.5080.99
229_Y232_L0.5080.99
376_R435_W0.5080.99
135_R328_I0.5080.99
484_L514_F0.5070.99
130_A310_D0.5070.99
168_F263_C0.5050.99
215_A242_K0.5050.99
138_I143_V0.5050.99
168_F262_L0.5050.99
535_Q538_N0.5040.99
454_A457_L0.5040.99
146_L289_Q0.5040.99
401_E407_E0.5030.99
549_V558_L0.5030.99
429_H472_S0.5020.99
429_H470_H0.5020.99
278_K286_M0.5010.99
309_L571_V0.5000.99
530_D534_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zs6A 1 0.7687 100 0.357 Contact Map
4tozA 1 0.7826 100 0.361 Contact Map
1xocA 2 0.7704 100 0.361 Contact Map
1jetA 1 0.7826 100 0.363 Contact Map
3m8uA 1 0.7687 100 0.364 Contact Map
4qflA 1 0.767 100 0.368 Contact Map
1dpeA 1 0.7652 100 0.37 Contact Map
4gl8A 1 0.7635 100 0.371 Contact Map
3tpaA 1 0.767 100 0.371 Contact Map
1uqwA 1 0.7687 100 0.373 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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