NTDA - BACSU - GREMLIN Contacts

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NTDA - 3-oxo-glucose-6-phosphate:glutamate aminotransferase

UniProt:	O07566	Sequences: MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQVLKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPYLEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLASGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLKVIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHGFEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNKGYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQDKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	441 (358)
Sequences:	10339 (7717)
Seq/√Len:	407.9

ECOLI - ARNB RFFA
BACSU - NTDA SPSC EPSN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
325_I	351_F	3.789	1.00
109_V	304_L	3.151	1.00
183_E	214_R	3.019	1.00
327_Q	428_M	2.864	1.00
90_E	102_Y	2.690	1.00
204_D	207_H	2.669	1.00
209_R	213_N	2.644	1.00
354_K	409_Q	2.588	1.00
85_L	89_T	2.579	1.00
113_Y	311_S	2.521	1.00
405_K	409_Q	2.513	1.00
323_R	424_Q	2.504	1.00
209_R	219_V	2.457	1.00
371_F	430_G	2.382	1.00
323_R	425_D	2.308	1.00
181_K	184_E	2.294	1.00
182_I	208_I	2.191	1.00
118_Y	263_E	2.189	1.00
109_V	308_K	2.173	1.00
202_H	232_L	2.143	1.00
117_R	261_D	2.140	1.00
180_D	207_H	2.135	1.00
316_K	319_F	2.112	1.00
366_K	434_V	2.105	1.00
105_Q	109_V	2.079	1.00
230_T	345_D	2.077	1.00
371_F	433_H	2.043	1.00
85_L	93_P	2.007	1.00
82_E	86_N	1.997	1.00
420_T	423_E	1.978	1.00
178_D	181_K	1.961	1.00
83_D	308_K	1.960	1.00
426_R	430_G	1.937	1.00
171_N	174_T	1.936	1.00
218_K	237_D	1.913	1.00
136_L	218_K	1.911	1.00
385_M	404_E	1.910	1.00
365_T	369_E	1.892	1.00
359_D	362_D	1.887	1.00
117_R	263_E	1.882	1.00
168_V	185_A	1.863	1.00
258_I	269_C	1.852	1.00
327_Q	425_D	1.835	1.00
263_E	267_K	1.815	1.00
260_T	266_A	1.813	1.00
296_D	299_Q	1.802	1.00
102_Y	304_L	1.796	1.00
181_K	185_A	1.787	1.00
110_L	257_A	1.782	1.00
132_G	238_I	1.767	1.00
323_R	421_L	1.767	1.00
128_A	240_T	1.766	1.00
210_Q	214_R	1.756	1.00
143_E	190_T	1.752	1.00
206_Q	231_D	1.738	1.00
193_I	212_A	1.732	1.00
241_L	259_A	1.720	1.00
243_F	257_A	1.719	1.00
323_R	327_Q	1.718	1.00
268_K	288_N	1.717	1.00
89_T	93_P	1.712	1.00
366_K	369_E	1.689	1.00
111_S	119_V	1.680	1.00
108_K	112_T	1.668	1.00
120_I	266_A	1.644	1.00
123_S	127_D	1.618	1.00
150_S	383_S	1.615	1.00
424_Q	428_M	1.610	1.00
238_I	265_L	1.591	1.00
367_L	375_T	1.588	1.00
212_A	219_V	1.560	1.00
363_I	434_V	1.560	1.00
330_E	432_F	1.551	1.00
252_C	303_G	1.545	1.00
138_L	163_G	1.544	1.00
143_E	164_V	1.536	1.00
172_P	402_H	1.513	1.00
142_D	191_K	1.506	1.00
366_K	371_F	1.503	1.00
187_T	190_T	1.500	1.00
105_Q	304_L	1.497	1.00
237_D	262_N	1.488	1.00
318_L	345_D	1.487	1.00
119_V	257_A	1.475	1.00
226_G	232_L	1.466	1.00
186_I	211_I	1.463	1.00
110_L	227_I	1.461	1.00
266_A	270_I	1.453	1.00
322_D	326_T	1.431	1.00
262_N	265_L	1.428	1.00
213_N	237_D	1.424	1.00
327_Q	432_F	1.405	1.00
143_E	187_T	1.404	1.00
335_G	354_K	1.401	1.00
197_H	205_M	1.382	1.00
207_H	210_Q	1.374	1.00
373_V	430_G	1.374	1.00
363_I	411_L	1.363	1.00
148_A	403_T	1.363	1.00
84_I	305_E	1.359	1.00
146_M	158_V	1.357	1.00
175_F	406_A	1.348	1.00
172_P	405_K	1.344	1.00
315_F	319_F	1.328	1.00
316_K	421_L	1.326	1.00
102_Y	105_Q	1.320	1.00
74_R	423_E	1.315	1.00
168_V	181_K	1.315	1.00
305_E	308_K	1.312	1.00
331_L	432_F	1.303	1.00
83_D	309_Y	1.292	1.00
201_K	340_P	1.287	1.00
209_R	235_Y	1.285	1.00
132_G	220_I	1.283	1.00
364_M	375_T	1.278	1.00
170_I	406_A	1.275	1.00
363_I	431_L	1.267	1.00
139_N	142_D	1.266	1.00
83_D	86_N	1.266	1.00
316_K	320_L	1.264	1.00
109_V	112_T	1.260	1.00
175_F	354_K	1.251	1.00
278_E	287_I	1.250	1.00
208_I	219_V	1.249	1.00
328_L	431_L	1.244	1.00
114_L	259_A	1.240	1.00
87_T	305_E	1.222	1.00
145_I	168_V	1.214	1.00
106_F	303_G	1.213	1.00
86_N	89_T	1.208	1.00
143_E	189_Y	1.207	1.00
425_D	429_E	1.204	1.00
130_M	160_A	1.203	1.00
182_I	211_I	1.203	1.00
86_N	90_E	1.202	1.00
131_I	269_C	1.201	1.00
271_Q	288_N	1.200	1.00
323_R	428_M	1.198	1.00
130_M	293_S	1.194	1.00
173_Q	338_E	1.190	1.00
148_A	384_H	1.185	1.00
195_P	219_V	1.180	1.00
197_H	236_A	1.179	1.00
355_V	363_I	1.175	1.00
131_I	272_F	1.169	1.00
136_L	238_I	1.167	1.00
364_M	411_L	1.159	1.00
384_H	404_E	1.154	1.00
177_I	182_I	1.153	1.00
104_E	108_K	1.139	1.00
402_H	405_K	1.138	1.00
362_D	366_K	1.135	1.00
101_P	105_Q	1.133	1.00
183_E	215_Y	1.130	1.00
130_M	291_F	1.124	1.00
87_T	308_K	1.123	1.00
136_L	220_I	1.122	1.00
335_G	356_R	1.119	1.00
319_F	421_L	1.117	1.00
384_H	400_L	1.117	1.00
352_P	410_V	1.114	1.00
118_Y	266_A	1.110	1.00
340_P	343_S	1.091	1.00
145_I	182_I	1.083	1.00
183_E	207_H	1.082	1.00
227_I	310_L	1.081	1.00
325_I	339_L	1.078	1.00
285_K	387_K	1.075	1.00
336_Y	351_F	1.074	1.00
84_I	302_I	1.074	1.00
320_L	424_Q	1.072	1.00
99_S	273_S	1.072	1.00
309_Y	312_L	1.069	1.00
179_P	211_I	1.061	1.00
121_A	295_M	1.058	1.00
140_P	162_G	1.056	1.00
183_E	187_T	1.052	1.00
134_L	161_S	1.046	1.00
130_M	134_L	1.042	1.00
116_K	234_K	1.037	1.00
109_V	307_M	1.033	1.00
139_N	163_G	1.033	1.00
320_L	415_L	1.033	1.00
295_M	300_A	1.029	1.00
430_G	433_H	1.029	1.00
87_T	90_E	1.029	1.00
159_L	389_P	1.023	1.00
87_T	102_Y	1.020	1.00
287_I	387_K	1.019	1.00
81_V	85_L	1.017	1.00
320_L	419_F	1.012	1.00
171_N	178_D	1.006	1.00
123_S	293_S	1.005	1.00
133_L	194_L	1.004	1.00
192_F	218_K	1.001	1.00
209_R	237_D	0.989	1.00
429_E	433_H	0.989	1.00
356_R	409_Q	0.989	1.00
148_A	400_L	0.981	1.00
118_Y	260_T	0.980	1.00
205_M	235_Y	0.980	1.00
325_I	336_Y	0.980	1.00
137_G	268_K	0.977	1.00
168_V	177_I	0.967	1.00
212_A	217_L	0.964	1.00
146_M	155_E	0.958	1.00
156_N	275_H	0.957	1.00
81_V	309_Y	0.955	1.00
81_V	84_I	0.955	1.00
135_A	269_C	0.955	1.00
120_I	270_I	0.954	1.00
248_N	349_H	0.951	1.00
421_L	424_Q	0.942	1.00
352_P	412_H	0.941	1.00
315_F	318_L	0.940	1.00
155_E	167_Y	0.940	1.00
422_E	425_D	0.939	1.00
155_E	383_S	0.938	1.00
421_L	425_D	0.938	1.00
183_E	211_I	0.937	1.00
362_D	365_T	0.930	1.00
132_G	240_T	0.929	1.00
133_L	158_V	0.928	1.00
223_A	232_L	0.926	1.00
318_L	339_L	0.925	1.00
361_A	365_T	0.922	1.00
116_K	261_D	0.920	1.00
180_D	183_E	0.916	1.00
138_L	144_V	0.912	1.00
119_V	259_A	0.912	1.00
260_T	265_L	0.910	1.00
192_F	220_I	0.910	1.00
122_T	131_I	0.909	1.00
103_L	300_A	0.908	1.00
145_I	190_T	0.907	1.00
365_T	368_N	0.906	1.00
364_M	368_N	0.905	1.00
322_D	325_I	0.904	1.00
125_G	128_A	0.899	1.00
127_D	293_S	0.899	1.00
175_F	337_I	0.898	1.00
321_A	348_W	0.898	1.00
398_L	404_E	0.896	1.00
362_D	434_V	0.887	1.00
110_L	241_L	0.886	1.00
251_V	255_A	0.885	1.00
211_I	215_Y	0.884	1.00
201_K	344_E	0.884	1.00
81_V	93_P	0.884	1.00
147_P	158_V	0.880	1.00
366_K	430_G	0.880	1.00
405_K	408_S	0.878	1.00
316_K	418_S	0.876	1.00
371_F	426_R	0.874	1.00
363_I	367_L	0.873	1.00
138_L	192_F	0.872	1.00
113_Y	228_G	0.869	1.00
203_S	208_I	0.863	1.00
312_L	315_F	0.862	1.00
105_Q	108_K	0.862	1.00
111_S	114_L	0.853	1.00
143_E	166_I	0.850	1.00
229_L	347_V	0.850	1.00
108_K	111_S	0.850	1.00
91_V	301_A	0.848	1.00
312_L	316_K	0.841	1.00
158_V	165_P	0.838	1.00
333_N	356_R	0.837	1.00
88_L	298_L	0.835	1.00
210_Q	213_N	0.831	1.00
324_Y	427_V	0.831	1.00
314_N	347_V	0.827	1.00
197_H	221_E	0.827	1.00
426_R	429_E	0.825	1.00
131_I	273_S	0.823	1.00
419_F	427_V	0.821	1.00
122_T	258_I	0.819	1.00
400_L	403_T	0.819	1.00
325_I	348_W	0.818	1.00
101_P	104_E	0.814	1.00
327_Q	429_E	0.813	1.00
139_N	191_K	0.811	1.00
319_F	322_D	0.808	1.00
318_L	322_D	0.807	1.00
107_E	121_A	0.806	1.00
195_P	208_I	0.806	1.00
397_G	408_S	0.801	1.00
102_Y	297_N	0.800	1.00
110_L	307_M	0.798	1.00
271_Q	287_I	0.798	1.00
142_D	163_G	0.796	1.00
171_N	179_P	0.795	1.00
195_P	203_S	0.795	1.00
264_E	267_K	0.792	1.00
323_R	326_T	0.790	1.00
205_M	209_R	0.790	1.00
321_A	351_F	0.786	1.00
151_F	284_K	0.786	1.00
158_V	163_G	0.784	1.00
360_R	377_V	0.780	1.00
144_V	158_V	0.776	1.00
232_L	239_T	0.775	1.00
82_E	85_L	0.775	1.00
221_E	239_T	0.775	1.00
110_L	119_V	0.773	1.00
82_E	93_P	0.773	1.00
193_I	217_L	0.772	1.00
253_G	298_L	0.770	1.00
206_Q	210_Q	0.770	1.00
231_D	344_E	0.770	1.00
145_I	185_A	0.768	1.00
120_I	269_C	0.768	1.00
235_Y	239_T	0.766	1.00
228_G	314_N	0.766	1.00
238_I	258_I	0.766	1.00
88_L	92_L	0.764	1.00
311_S	315_F	0.762	1.00
428_M	432_F	0.760	1.00
319_F	323_R	0.759	1.00
114_L	234_K	0.759	1.00
88_L	302_I	0.758	1.00
138_L	191_K	0.758	1.00
267_K	278_E	0.755	1.00
133_L	220_I	0.753	1.00
179_P	203_S	0.752	1.00
425_D	428_M	0.750	1.00
179_P	208_I	0.748	1.00
156_N	389_P	0.744	1.00
285_K	381_I	0.738	1.00
207_H	231_D	0.735	1.00
326_T	329_A	0.732	1.00
80_E	84_I	0.732	1.00
103_L	295_M	0.731	1.00
130_M	161_S	0.731	1.00
135_A	238_I	0.730	1.00
144_V	192_F	0.730	1.00
159_L	165_P	0.729	1.00
133_L	138_L	0.726	1.00
423_E	426_R	0.725	1.00
248_N	314_N	0.723	1.00
402_H	406_A	0.722	1.00
134_L	160_A	0.719	1.00
90_E	94_T	0.718	1.00
363_I	435_I	0.716	1.00
132_G	258_I	0.715	1.00
114_L	119_V	0.715	1.00
103_L	121_A	0.714	1.00
378_Y	412_H	0.714	1.00
221_E	236_A	0.710	1.00
83_D	305_E	0.710	1.00
160_A	291_F	0.708	1.00
154_T	157_A	0.704	1.00
255_A	295_M	0.704	1.00
149_N	378_Y	0.702	1.00
279_V	285_K	0.701	1.00
116_K	259_A	0.700	1.00
327_Q	330_E	0.697	1.00
231_D	343_S	0.696	1.00
195_P	205_M	0.695	1.00
125_G	240_T	0.694	1.00
186_I	217_L	0.693	1.00
321_A	415_L	0.693	1.00
289_F	388_T	0.689	1.00
171_N	204_D	0.687	1.00
157_A	194_L	0.687	1.00
328_L	432_F	0.685	1.00
201_K	339_L	0.683	1.00
87_T	301_A	0.682	1.00
83_D	87_T	0.676	0.99
404_E	408_S	0.673	0.99
150_S	154_T	0.671	0.99
84_I	309_Y	0.671	0.99
202_H	229_L	0.670	0.99
236_A	239_T	0.670	0.99
212_A	215_Y	0.670	0.99
209_R	236_A	0.663	0.99
234_K	261_D	0.662	0.99
157_A	161_S	0.658	0.99
169_D	402_H	0.657	0.99
148_A	167_Y	0.656	0.99
396_A	399_Q	0.653	0.99
124_S	127_D	0.653	0.99
158_V	194_L	0.649	0.99
320_L	324_Y	0.648	0.99
318_L	348_W	0.648	0.99
159_L	388_T	0.646	0.99
231_D	235_Y	0.646	0.99
159_L	289_F	0.645	0.99
74_R	418_S	0.644	0.99
202_H	231_D	0.643	0.99
311_S	345_D	0.643	0.99
134_L	291_F	0.642	0.99
354_K	410_V	0.641	0.99
128_A	258_I	0.639	0.99
368_N	375_T	0.638	0.99
124_S	292_N	0.638	0.99
334_K	353_I	0.637	0.99
182_I	193_I	0.637	0.99
321_A	325_I	0.635	0.99
340_P	344_E	0.635	0.99
320_L	323_R	0.635	0.99
223_A	239_T	0.634	0.99
139_N	161_S	0.633	0.99
357_T	409_Q	0.632	0.99
90_E	105_Q	0.630	0.99
275_H	294_K	0.627	0.99
314_N	318_L	0.626	0.99
132_G	136_L	0.625	0.99
122_T	128_A	0.624	0.99
325_I	338_E	0.623	0.99
238_I	260_T	0.619	0.99
144_V	194_L	0.618	0.99
116_K	239_T	0.618	0.99
309_Y	313_N	0.617	0.99
205_M	219_V	0.616	0.99
173_Q	335_G	0.616	0.99
154_T	194_L	0.616	0.99
385_M	398_L	0.615	0.99
91_V	102_Y	0.613	0.99
385_M	408_S	0.611	0.99
133_L	161_S	0.609	0.99
416_Y	419_F	0.606	0.99
170_I	403_T	0.605	0.99
147_P	196_V	0.605	0.99
399_Q	404_E	0.600	0.99
207_H	211_I	0.600	0.99
401_V	404_E	0.600	0.99
268_K	272_F	0.600	0.99
239_T	259_A	0.600	0.99
134_L	272_F	0.598	0.99
361_A	364_M	0.596	0.99
154_T	196_V	0.594	0.99
197_H	203_S	0.593	0.99
267_K	271_Q	0.591	0.99
198_L	225_Q	0.590	0.99
355_V	359_D	0.590	0.99
85_L	92_L	0.589	0.99
355_V	435_I	0.587	0.99
170_I	402_H	0.585	0.99
111_S	118_Y	0.585	0.99
327_Q	424_Q	0.584	0.99
387_K	390_L	0.584	0.99
149_N	410_V	0.583	0.98
69_F	374_Q	0.581	0.98
366_K	433_H	0.580	0.98
354_K	405_K	0.580	0.98
237_D	261_D	0.579	0.98
201_K	346_H	0.576	0.98
310_L	314_N	0.576	0.98
353_I	413_L	0.576	0.98
186_I	190_T	0.576	0.98
125_G	224_C	0.573	0.98
202_H	344_E	0.572	0.98
353_I	411_L	0.571	0.98
325_I	329_A	0.571	0.98
94_T	101_P	0.570	0.98
69_F	372_G	0.570	0.98
339_L	348_W	0.570	0.98
363_I	366_K	0.569	0.98
151_F	277_F	0.569	0.98
155_E	389_P	0.567	0.98
84_I	88_L	0.564	0.98
221_E	233_G	0.564	0.98
191_K	218_K	0.563	0.98
138_L	142_D	0.563	0.98
91_V	94_T	0.563	0.98
144_V	163_G	0.561	0.98
121_A	257_A	0.559	0.98
208_I	211_I	0.556	0.98
271_Q	278_E	0.555	0.98
84_I	306_R	0.555	0.98
81_V	89_T	0.555	0.98
238_I	269_C	0.554	0.98
177_I	195_P	0.553	0.98
176_C	202_H	0.551	0.98
74_R	416_Y	0.550	0.98
243_F	303_G	0.550	0.98
366_K	435_I	0.550	0.98
228_G	310_L	0.550	0.98
103_L	297_N	0.545	0.98
253_G	299_Q	0.543	0.98
178_D	207_H	0.541	0.98
179_P	204_D	0.539	0.98
354_K	406_A	0.539	0.98
359_D	434_V	0.539	0.98
179_P	207_H	0.537	0.97
76_I	81_V	0.537	0.97
133_L	144_V	0.536	0.97
353_I	431_L	0.535	0.97
199_Y	378_Y	0.535	0.97
295_M	299_Q	0.534	0.97
76_I	418_S	0.534	0.97
85_L	88_L	0.532	0.97
89_T	92_L	0.531	0.97
74_R	95_G	0.531	0.97
270_I	273_S	0.529	0.97
333_N	435_I	0.528	0.97
118_Y	270_I	0.526	0.97
367_L	430_G	0.526	0.97
80_E	313_N	0.525	0.97
186_I	215_Y	0.525	0.97
261_D	265_L	0.525	0.97
213_N	216_K	0.524	0.97
194_L	220_I	0.522	0.97
304_L	308_K	0.518	0.97
224_C	247_K	0.518	0.97
234_K	239_T	0.518	0.97
146_M	154_T	0.517	0.97
99_S	297_N	0.517	0.97
229_L	232_L	0.517	0.97
311_S	314_N	0.517	0.97
120_I	260_T	0.516	0.97
248_N	347_V	0.515	0.97
356_R	359_D	0.514	0.97
149_N	198_L	0.514	0.97
87_T	91_V	0.513	0.97
111_S	116_K	0.513	0.97
197_H	232_L	0.512	0.97
152_S	277_F	0.511	0.97
130_M	157_A	0.510	0.97
324_Y	424_Q	0.510	0.97
257_A	303_G	0.509	0.97
350_L	412_H	0.509	0.97
381_I	407_H	0.509	0.97
172_P	335_G	0.508	0.96
218_K	262_N	0.508	0.96
142_D	189_Y	0.507	0.96
133_L	157_A	0.506	0.96
205_M	221_E	0.506	0.96
199_Y	352_P	0.505	0.96
233_G	241_L	0.505	0.96
137_G	163_G	0.504	0.96
240_T	258_I	0.502	0.96
131_I	293_S	0.502	0.96
339_L	346_H	0.501	0.96
305_E	309_Y	0.500	0.96
192_F	195_P	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4zwvA	2	0.805	100	0.532	Contact Map
3bb8A	2	0.898	100	0.55	Contact Map
3frkA	2	0.8163	100	0.56	Contact Map
3b8xA	2	0.8118	100	0.564	Contact Map
2fnuA	2	0.8254	100	0.571	Contact Map
1o69A	2	0.78	100	0.572	Contact Map
2c81A	2	0.8209	100	0.573	Contact Map
4lc3A	2	0.8322	100	0.578	Contact Map
3nytA	2	0.805	100	0.581	Contact Map
1b9hA	2	0.8299	100	0.583	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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