GREMLIN Database
NTDA - 3-oxo-glucose-6-phosphate:glutamate aminotransferase
UniProt: O07566 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 441 (358)
Sequences: 10339 (7717)
Seq/√Len: 407.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_I351_F3.7891.00
109_V304_L3.1511.00
183_E214_R3.0191.00
327_Q428_M2.8641.00
90_E102_Y2.6901.00
204_D207_H2.6691.00
209_R213_N2.6441.00
354_K409_Q2.5881.00
85_L89_T2.5791.00
113_Y311_S2.5211.00
405_K409_Q2.5131.00
323_R424_Q2.5041.00
209_R219_V2.4571.00
371_F430_G2.3821.00
323_R425_D2.3081.00
181_K184_E2.2941.00
182_I208_I2.1911.00
118_Y263_E2.1891.00
109_V308_K2.1731.00
202_H232_L2.1431.00
117_R261_D2.1401.00
180_D207_H2.1351.00
316_K319_F2.1121.00
366_K434_V2.1051.00
105_Q109_V2.0791.00
230_T345_D2.0771.00
371_F433_H2.0431.00
85_L93_P2.0071.00
82_E86_N1.9971.00
420_T423_E1.9781.00
178_D181_K1.9611.00
83_D308_K1.9601.00
426_R430_G1.9371.00
171_N174_T1.9361.00
218_K237_D1.9131.00
136_L218_K1.9111.00
385_M404_E1.9101.00
365_T369_E1.8921.00
359_D362_D1.8871.00
117_R263_E1.8821.00
168_V185_A1.8631.00
258_I269_C1.8521.00
327_Q425_D1.8351.00
263_E267_K1.8151.00
260_T266_A1.8131.00
296_D299_Q1.8021.00
102_Y304_L1.7961.00
181_K185_A1.7871.00
110_L257_A1.7821.00
132_G238_I1.7671.00
323_R421_L1.7671.00
128_A240_T1.7661.00
210_Q214_R1.7561.00
143_E190_T1.7521.00
206_Q231_D1.7381.00
193_I212_A1.7321.00
241_L259_A1.7201.00
243_F257_A1.7191.00
323_R327_Q1.7181.00
268_K288_N1.7171.00
89_T93_P1.7121.00
366_K369_E1.6891.00
111_S119_V1.6801.00
108_K112_T1.6681.00
120_I266_A1.6441.00
123_S127_D1.6181.00
150_S383_S1.6151.00
424_Q428_M1.6101.00
238_I265_L1.5911.00
367_L375_T1.5881.00
212_A219_V1.5601.00
363_I434_V1.5601.00
330_E432_F1.5511.00
252_C303_G1.5451.00
138_L163_G1.5441.00
143_E164_V1.5361.00
172_P402_H1.5131.00
142_D191_K1.5061.00
366_K371_F1.5031.00
187_T190_T1.5001.00
105_Q304_L1.4971.00
237_D262_N1.4881.00
318_L345_D1.4871.00
119_V257_A1.4751.00
226_G232_L1.4661.00
186_I211_I1.4631.00
110_L227_I1.4611.00
266_A270_I1.4531.00
322_D326_T1.4311.00
262_N265_L1.4281.00
213_N237_D1.4241.00
327_Q432_F1.4051.00
143_E187_T1.4041.00
335_G354_K1.4011.00
197_H205_M1.3821.00
207_H210_Q1.3741.00
373_V430_G1.3741.00
363_I411_L1.3631.00
148_A403_T1.3631.00
84_I305_E1.3591.00
146_M158_V1.3571.00
175_F406_A1.3481.00
172_P405_K1.3441.00
315_F319_F1.3281.00
316_K421_L1.3261.00
102_Y105_Q1.3201.00
74_R423_E1.3151.00
168_V181_K1.3151.00
305_E308_K1.3121.00
331_L432_F1.3031.00
83_D309_Y1.2921.00
201_K340_P1.2871.00
209_R235_Y1.2851.00
132_G220_I1.2831.00
364_M375_T1.2781.00
170_I406_A1.2751.00
363_I431_L1.2671.00
139_N142_D1.2661.00
83_D86_N1.2661.00
316_K320_L1.2641.00
109_V112_T1.2601.00
175_F354_K1.2511.00
278_E287_I1.2501.00
208_I219_V1.2491.00
328_L431_L1.2441.00
114_L259_A1.2401.00
87_T305_E1.2221.00
145_I168_V1.2141.00
106_F303_G1.2131.00
86_N89_T1.2081.00
143_E189_Y1.2071.00
425_D429_E1.2041.00
130_M160_A1.2031.00
182_I211_I1.2031.00
86_N90_E1.2021.00
131_I269_C1.2011.00
271_Q288_N1.2001.00
323_R428_M1.1981.00
130_M293_S1.1941.00
173_Q338_E1.1901.00
148_A384_H1.1851.00
195_P219_V1.1801.00
197_H236_A1.1791.00
355_V363_I1.1751.00
131_I272_F1.1691.00
136_L238_I1.1671.00
364_M411_L1.1591.00
384_H404_E1.1541.00
177_I182_I1.1531.00
104_E108_K1.1391.00
402_H405_K1.1381.00
362_D366_K1.1351.00
101_P105_Q1.1331.00
183_E215_Y1.1301.00
130_M291_F1.1241.00
87_T308_K1.1231.00
136_L220_I1.1221.00
335_G356_R1.1191.00
319_F421_L1.1171.00
384_H400_L1.1171.00
352_P410_V1.1141.00
118_Y266_A1.1101.00
340_P343_S1.0911.00
145_I182_I1.0831.00
183_E207_H1.0821.00
227_I310_L1.0811.00
325_I339_L1.0781.00
285_K387_K1.0751.00
336_Y351_F1.0741.00
84_I302_I1.0741.00
320_L424_Q1.0721.00
99_S273_S1.0721.00
309_Y312_L1.0691.00
179_P211_I1.0611.00
121_A295_M1.0581.00
140_P162_G1.0561.00
183_E187_T1.0521.00
134_L161_S1.0461.00
130_M134_L1.0421.00
116_K234_K1.0371.00
109_V307_M1.0331.00
139_N163_G1.0331.00
320_L415_L1.0331.00
295_M300_A1.0291.00
430_G433_H1.0291.00
87_T90_E1.0291.00
159_L389_P1.0231.00
87_T102_Y1.0201.00
287_I387_K1.0191.00
81_V85_L1.0171.00
320_L419_F1.0121.00
171_N178_D1.0061.00
123_S293_S1.0051.00
133_L194_L1.0041.00
192_F218_K1.0011.00
209_R237_D0.9891.00
429_E433_H0.9891.00
356_R409_Q0.9891.00
148_A400_L0.9811.00
118_Y260_T0.9801.00
205_M235_Y0.9801.00
325_I336_Y0.9801.00
137_G268_K0.9771.00
168_V177_I0.9671.00
212_A217_L0.9641.00
146_M155_E0.9581.00
156_N275_H0.9571.00
81_V309_Y0.9551.00
81_V84_I0.9551.00
135_A269_C0.9551.00
120_I270_I0.9541.00
248_N349_H0.9511.00
421_L424_Q0.9421.00
352_P412_H0.9411.00
315_F318_L0.9401.00
155_E167_Y0.9401.00
422_E425_D0.9391.00
155_E383_S0.9381.00
421_L425_D0.9381.00
183_E211_I0.9371.00
362_D365_T0.9301.00
132_G240_T0.9291.00
133_L158_V0.9281.00
223_A232_L0.9261.00
318_L339_L0.9251.00
361_A365_T0.9221.00
116_K261_D0.9201.00
180_D183_E0.9161.00
138_L144_V0.9121.00
119_V259_A0.9121.00
260_T265_L0.9101.00
192_F220_I0.9101.00
122_T131_I0.9091.00
103_L300_A0.9081.00
145_I190_T0.9071.00
365_T368_N0.9061.00
364_M368_N0.9051.00
322_D325_I0.9041.00
125_G128_A0.8991.00
127_D293_S0.8991.00
175_F337_I0.8981.00
321_A348_W0.8981.00
398_L404_E0.8961.00
362_D434_V0.8871.00
110_L241_L0.8861.00
251_V255_A0.8851.00
211_I215_Y0.8841.00
201_K344_E0.8841.00
81_V93_P0.8841.00
147_P158_V0.8801.00
366_K430_G0.8801.00
405_K408_S0.8781.00
316_K418_S0.8761.00
371_F426_R0.8741.00
363_I367_L0.8731.00
138_L192_F0.8721.00
113_Y228_G0.8691.00
203_S208_I0.8631.00
312_L315_F0.8621.00
105_Q108_K0.8621.00
111_S114_L0.8531.00
143_E166_I0.8501.00
229_L347_V0.8501.00
108_K111_S0.8501.00
91_V301_A0.8481.00
312_L316_K0.8411.00
158_V165_P0.8381.00
333_N356_R0.8371.00
88_L298_L0.8351.00
210_Q213_N0.8311.00
324_Y427_V0.8311.00
314_N347_V0.8271.00
197_H221_E0.8271.00
426_R429_E0.8251.00
131_I273_S0.8231.00
419_F427_V0.8211.00
122_T258_I0.8191.00
400_L403_T0.8191.00
325_I348_W0.8181.00
101_P104_E0.8141.00
327_Q429_E0.8131.00
139_N191_K0.8111.00
319_F322_D0.8081.00
318_L322_D0.8071.00
107_E121_A0.8061.00
195_P208_I0.8061.00
397_G408_S0.8011.00
102_Y297_N0.8001.00
110_L307_M0.7981.00
271_Q287_I0.7981.00
142_D163_G0.7961.00
171_N179_P0.7951.00
195_P203_S0.7951.00
264_E267_K0.7921.00
323_R326_T0.7901.00
205_M209_R0.7901.00
321_A351_F0.7861.00
151_F284_K0.7861.00
158_V163_G0.7841.00
360_R377_V0.7801.00
144_V158_V0.7761.00
232_L239_T0.7751.00
82_E85_L0.7751.00
221_E239_T0.7751.00
110_L119_V0.7731.00
82_E93_P0.7731.00
193_I217_L0.7721.00
253_G298_L0.7701.00
206_Q210_Q0.7701.00
231_D344_E0.7701.00
145_I185_A0.7681.00
120_I269_C0.7681.00
235_Y239_T0.7661.00
228_G314_N0.7661.00
238_I258_I0.7661.00
88_L92_L0.7641.00
311_S315_F0.7621.00
428_M432_F0.7601.00
319_F323_R0.7591.00
114_L234_K0.7591.00
88_L302_I0.7581.00
138_L191_K0.7581.00
267_K278_E0.7551.00
133_L220_I0.7531.00
179_P203_S0.7521.00
425_D428_M0.7501.00
179_P208_I0.7481.00
156_N389_P0.7441.00
285_K381_I0.7381.00
207_H231_D0.7351.00
326_T329_A0.7321.00
80_E84_I0.7321.00
103_L295_M0.7311.00
130_M161_S0.7311.00
135_A238_I0.7301.00
144_V192_F0.7301.00
159_L165_P0.7291.00
133_L138_L0.7261.00
423_E426_R0.7251.00
248_N314_N0.7231.00
402_H406_A0.7221.00
134_L160_A0.7191.00
90_E94_T0.7181.00
363_I435_I0.7161.00
132_G258_I0.7151.00
114_L119_V0.7151.00
103_L121_A0.7141.00
378_Y412_H0.7141.00
221_E236_A0.7101.00
83_D305_E0.7101.00
160_A291_F0.7081.00
154_T157_A0.7041.00
255_A295_M0.7041.00
149_N378_Y0.7021.00
279_V285_K0.7011.00
116_K259_A0.7001.00
327_Q330_E0.6971.00
231_D343_S0.6961.00
195_P205_M0.6951.00
125_G240_T0.6941.00
186_I217_L0.6931.00
321_A415_L0.6931.00
289_F388_T0.6891.00
171_N204_D0.6871.00
157_A194_L0.6871.00
328_L432_F0.6851.00
201_K339_L0.6831.00
87_T301_A0.6821.00
83_D87_T0.6760.99
404_E408_S0.6730.99
150_S154_T0.6710.99
84_I309_Y0.6710.99
202_H229_L0.6700.99
236_A239_T0.6700.99
212_A215_Y0.6700.99
209_R236_A0.6630.99
234_K261_D0.6620.99
157_A161_S0.6580.99
169_D402_H0.6570.99
148_A167_Y0.6560.99
396_A399_Q0.6530.99
124_S127_D0.6530.99
158_V194_L0.6490.99
320_L324_Y0.6480.99
318_L348_W0.6480.99
159_L388_T0.6460.99
231_D235_Y0.6460.99
159_L289_F0.6450.99
74_R418_S0.6440.99
202_H231_D0.6430.99
311_S345_D0.6430.99
134_L291_F0.6420.99
354_K410_V0.6410.99
128_A258_I0.6390.99
368_N375_T0.6380.99
124_S292_N0.6380.99
334_K353_I0.6370.99
182_I193_I0.6370.99
321_A325_I0.6350.99
340_P344_E0.6350.99
320_L323_R0.6350.99
223_A239_T0.6340.99
139_N161_S0.6330.99
357_T409_Q0.6320.99
90_E105_Q0.6300.99
275_H294_K0.6270.99
314_N318_L0.6260.99
132_G136_L0.6250.99
122_T128_A0.6240.99
325_I338_E0.6230.99
238_I260_T0.6190.99
144_V194_L0.6180.99
116_K239_T0.6180.99
309_Y313_N0.6170.99
205_M219_V0.6160.99
173_Q335_G0.6160.99
154_T194_L0.6160.99
385_M398_L0.6150.99
91_V102_Y0.6130.99
385_M408_S0.6110.99
133_L161_S0.6090.99
416_Y419_F0.6060.99
170_I403_T0.6050.99
147_P196_V0.6050.99
399_Q404_E0.6000.99
207_H211_I0.6000.99
401_V404_E0.6000.99
268_K272_F0.6000.99
239_T259_A0.6000.99
134_L272_F0.5980.99
361_A364_M0.5960.99
154_T196_V0.5940.99
197_H203_S0.5930.99
267_K271_Q0.5910.99
198_L225_Q0.5900.99
355_V359_D0.5900.99
85_L92_L0.5890.99
355_V435_I0.5870.99
170_I402_H0.5850.99
111_S118_Y0.5850.99
327_Q424_Q0.5840.99
387_K390_L0.5840.99
149_N410_V0.5830.98
69_F374_Q0.5810.98
366_K433_H0.5800.98
354_K405_K0.5800.98
237_D261_D0.5790.98
201_K346_H0.5760.98
310_L314_N0.5760.98
353_I413_L0.5760.98
186_I190_T0.5760.98
125_G224_C0.5730.98
202_H344_E0.5720.98
353_I411_L0.5710.98
325_I329_A0.5710.98
94_T101_P0.5700.98
69_F372_G0.5700.98
339_L348_W0.5700.98
363_I366_K0.5690.98
151_F277_F0.5690.98
155_E389_P0.5670.98
84_I88_L0.5640.98
221_E233_G0.5640.98
191_K218_K0.5630.98
138_L142_D0.5630.98
91_V94_T0.5630.98
144_V163_G0.5610.98
121_A257_A0.5590.98
208_I211_I0.5560.98
271_Q278_E0.5550.98
84_I306_R0.5550.98
81_V89_T0.5550.98
238_I269_C0.5540.98
177_I195_P0.5530.98
176_C202_H0.5510.98
74_R416_Y0.5500.98
243_F303_G0.5500.98
366_K435_I0.5500.98
228_G310_L0.5500.98
103_L297_N0.5450.98
253_G299_Q0.5430.98
178_D207_H0.5410.98
179_P204_D0.5390.98
354_K406_A0.5390.98
359_D434_V0.5390.98
179_P207_H0.5370.97
76_I81_V0.5370.97
133_L144_V0.5360.97
353_I431_L0.5350.97
199_Y378_Y0.5350.97
295_M299_Q0.5340.97
76_I418_S0.5340.97
85_L88_L0.5320.97
89_T92_L0.5310.97
74_R95_G0.5310.97
270_I273_S0.5290.97
333_N435_I0.5280.97
118_Y270_I0.5260.97
367_L430_G0.5260.97
80_E313_N0.5250.97
186_I215_Y0.5250.97
261_D265_L0.5250.97
213_N216_K0.5240.97
194_L220_I0.5220.97
304_L308_K0.5180.97
224_C247_K0.5180.97
234_K239_T0.5180.97
146_M154_T0.5170.97
99_S297_N0.5170.97
229_L232_L0.5170.97
311_S314_N0.5170.97
120_I260_T0.5160.97
248_N347_V0.5150.97
356_R359_D0.5140.97
149_N198_L0.5140.97
87_T91_V0.5130.97
111_S116_K0.5130.97
197_H232_L0.5120.97
152_S277_F0.5110.97
130_M157_A0.5100.97
324_Y424_Q0.5100.97
257_A303_G0.5090.97
350_L412_H0.5090.97
381_I407_H0.5090.97
172_P335_G0.5080.96
218_K262_N0.5080.96
142_D189_Y0.5070.96
133_L157_A0.5060.96
205_M221_E0.5060.96
199_Y352_P0.5050.96
233_G241_L0.5050.96
137_G163_G0.5040.96
240_T258_I0.5020.96
131_I293_S0.5020.96
339_L346_H0.5010.96
305_E309_Y0.5000.96
192_F195_P0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4zwvA 2 0.805 100 0.532 Contact Map
3bb8A 2 0.898 100 0.55 Contact Map
3frkA 2 0.8163 100 0.56 Contact Map
3b8xA 2 0.8118 100 0.564 Contact Map
2fnuA 2 0.8254 100 0.571 Contact Map
1o69A 2 0.78 100 0.572 Contact Map
2c81A 2 0.8209 100 0.573 Contact Map
4lc3A 2 0.8322 100 0.578 Contact Map
3nytA 2 0.805 100 0.581 Contact Map
1b9hA 2 0.8299 100 0.583 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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