GREMLIN Database
NTDB - Kanosamine-6-phosphate phosphatase
UniProt: O07565 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 282 (232)
Sequences: 11330 (9494)
Seq/√Len: 623.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
265_D274_N4.3461.00
38_Q268_Y3.2131.00
229_A243_V3.0691.00
20_Y226_R3.0331.00
266_S269_S2.8661.00
217_L227_A2.6441.00
240_L246_G2.6201.00
32_P39_K2.5861.00
24_C61_I2.5111.00
43_I270_K2.4891.00
45_E270_K2.4631.00
254_Q258_N2.4211.00
214_T242_T2.3881.00
241_Q259_L2.3721.00
32_P41_Q2.3541.00
65_T72_I2.3481.00
45_E277_K2.2141.00
224_T242_T2.1301.00
208_G238_R2.0311.00
234_G255_E1.9921.00
237_V256_A1.9321.00
234_G253_T1.8661.00
237_V259_L1.8021.00
19_Q228_I1.8001.00
223_N226_R1.7791.00
44_Y48_D1.7751.00
21_I62_G1.7571.00
106_Q111_W1.7561.00
52_Q56_D1.7481.00
23_F213_V1.7401.00
52_Q277_K1.7401.00
50_L61_I1.7381.00
246_G261_N1.7371.00
53_K59_L1.7261.00
247_Y275_T1.7091.00
98_Y101_E1.7031.00
248_L260_H1.7021.00
111_W114_R1.7011.00
214_T218_E1.6531.00
215_F219_K1.6491.00
47_E78_R1.6411.00
245_N261_N1.6311.00
265_D269_S1.6181.00
215_F218_E1.6181.00
52_Q57_G1.6141.00
229_A239_M1.6031.00
210_N242_T1.5981.00
245_N262_L1.5541.00
172_E176_E1.5441.00
211_E214_T1.5421.00
213_V239_M1.5221.00
23_F64_V1.5151.00
48_D52_Q1.5141.00
26_F31_F1.4971.00
60_I220_Y1.4941.00
254_Q257_K1.4931.00
19_Q59_L1.4921.00
256_A259_L1.4551.00
43_I46_L1.4371.00
24_C230_F1.4241.00
104_F111_W1.4111.00
262_L279_L1.3991.00
262_L275_T1.3931.00
230_F272_I1.3811.00
46_L270_K1.3711.00
45_E274_N1.3681.00
248_L252_A1.3571.00
230_F275_T1.3461.00
19_Q226_R1.3311.00
19_Q245_N1.3241.00
217_L224_T1.3051.00
225_E244_G1.2861.00
47_E51_E1.2821.00
237_V241_Q1.2791.00
183_N238_R1.2631.00
62_G87_F1.2631.00
247_Y264_T1.2601.00
49_Y273_T1.2441.00
224_T227_A1.2331.00
49_Y277_K1.2261.00
272_I276_L1.2191.00
257_K263_I1.2171.00
240_L256_A1.1921.00
185_N203_I1.1881.00
118_G121_K1.1831.00
51_E56_D1.1811.00
32_P268_Y1.1761.00
250_K266_S1.1761.00
255_E258_N1.1531.00
45_E49_Y1.1501.00
62_G216_M1.1491.00
114_R181_S1.1401.00
89_A212_I1.1391.00
264_T271_G1.1361.00
229_A240_L1.1241.00
208_G211_E1.1181.00
264_T275_T1.1031.00
87_F220_Y1.0991.00
94_T207_T1.0981.00
112_N116_N1.0971.00
227_A243_V1.0951.00
22_V276_L1.0931.00
32_P38_Q1.0901.00
262_L278_K1.0901.00
217_L242_T1.0811.00
228_I279_L1.0801.00
275_T279_L1.0691.00
21_I222_L1.0651.00
233_S253_T1.0561.00
111_W118_G1.0561.00
23_F227_A1.0441.00
275_T278_K1.0371.00
22_V59_L1.0341.00
21_I217_L1.0321.00
96_I215_F1.0241.00
216_M220_Y1.0201.00
69_I90_S1.0171.00
111_W116_N1.0111.00
23_F62_G1.0091.00
169_L172_E1.0081.00
22_V53_K1.0071.00
104_F107_Q1.0061.00
251_N267_E1.0051.00
114_R117_E1.0051.00
273_T277_K0.9991.00
224_T244_G0.9951.00
274_N278_K0.9921.00
210_N238_R0.9921.00
183_N206_G0.9851.00
26_F75_K0.9831.00
169_L173_K0.9791.00
181_S205_I0.9711.00
214_T224_T0.9701.00
228_I275_T0.9661.00
252_A257_K0.9651.00
137_I140_N0.9631.00
173_K176_E0.9491.00
204_P207_T0.9461.00
65_T90_S0.9461.00
44_Y47_E0.9461.00
82_R86_H0.9451.00
249_L271_G0.9411.00
116_N120_S0.9391.00
170_A173_K0.9391.00
21_I227_A0.9151.00
253_T256_A0.9151.00
248_L256_A0.9131.00
265_D271_G0.9111.00
117_E121_K0.9081.00
228_I247_Y0.9011.00
243_V246_G0.8971.00
250_K257_K0.8931.00
87_F216_M0.8851.00
228_I245_N0.8831.00
96_I212_I0.8791.00
51_E80_K0.8791.00
64_V89_A0.8741.00
24_C272_I0.8731.00
68_S91_D0.8721.00
30_Y46_L0.8711.00
30_Y50_L0.8661.00
46_L273_T0.8651.00
247_Y262_L0.8641.00
234_G237_V0.8531.00
250_K265_D0.8521.00
213_V243_V0.8511.00
183_N208_G0.8451.00
118_G122_E0.8441.00
274_N277_K0.8361.00
217_L222_L0.8321.00
22_V228_I0.8281.00
249_L264_T0.8191.00
46_L49_Y0.8181.00
89_A216_M0.8171.00
60_I87_F0.8161.00
217_L244_G0.8161.00
87_F98_Y0.8141.00
108_D215_F0.8121.00
38_Q267_E0.8121.00
90_S95_E0.8091.00
53_K61_I0.8021.00
138_L141_P0.7971.00
170_A174_I0.7951.00
106_Q215_F0.7911.00
203_I208_G0.7911.00
53_K276_L0.7821.00
45_E273_T0.7751.00
227_A244_G0.7741.00
69_I97_T0.7701.00
66_G235_N0.7691.00
90_S97_T0.7661.00
59_L228_I0.7611.00
106_Q110_K0.7561.00
48_D51_E0.7551.00
244_G261_N0.7541.00
30_Y42_D0.7541.00
255_E259_L0.7541.00
49_Y52_Q0.7531.00
213_V229_A0.7501.00
24_C30_Y0.7501.00
26_F63_W0.7461.00
73_L77_G0.7381.00
117_E181_S0.7381.00
250_K269_S0.7381.00
111_W120_S0.7281.00
87_F99_F0.7281.00
184_I200_V0.7281.00
240_L259_L0.7271.00
184_I202_F0.7211.00
128_V131_L0.7201.00
265_D278_K0.7201.00
129_K132_H0.7201.00
19_Q60_I0.7191.00
91_D201_D0.7181.00
92_L201_D0.7171.00
169_L186_R0.7171.00
227_A242_T0.7151.00
104_F110_K0.7121.00
46_L50_L0.7111.00
210_N214_T0.7011.00
60_I86_H0.7001.00
32_P43_I0.7001.00
126_K129_K0.6991.00
63_W72_I0.6981.00
249_L252_A0.6971.00
113_S117_E0.6971.00
153_N156_Y0.6971.00
211_E215_F0.6971.00
264_T274_N0.6911.00
136_N139_L0.6831.00
168_L172_E0.6821.00
127_L131_L0.6801.00
135_H138_L0.6801.00
111_W115_I0.6761.00
252_A256_A0.6741.00
45_E48_D0.6731.00
188_N198_Y0.6731.00
151_K201_D0.6711.00
118_G181_S0.6701.00
127_L130_Q0.6671.00
64_V239_M0.6611.00
172_E186_R0.6601.00
207_T211_E0.6591.00
145_L148_S0.6581.00
21_I216_M0.6541.00
183_N205_I0.6541.00
180_V205_I0.6531.00
88_I99_F0.6441.00
214_T217_L0.6431.00
128_V132_H0.6411.00
28_E249_L0.6391.00
117_E120_S0.6371.00
154_F157_Q0.6331.00
26_F30_Y0.6331.00
20_Y59_L0.6321.00
265_D275_T0.6311.00
151_K156_Y0.6291.00
232_D252_A0.6231.00
32_P267_E0.6231.00
72_I88_I0.6221.00
251_N266_S0.6181.00
94_T204_P0.6141.00
112_N118_G0.6121.00
69_I73_L0.6091.00
72_I90_S0.6071.00
127_L132_H0.6051.00
151_K154_F0.6051.00
149_R154_F0.6041.00
30_Y267_E0.6041.00
226_R244_G0.6031.00
108_D204_P0.6021.00
232_D249_L0.6001.00
95_E104_F0.5991.00
115_I122_E0.5961.00
245_N275_T0.5941.00
262_L265_D0.5931.00
152_H156_Y0.5901.00
39_K268_Y0.5891.00
234_G256_A0.5871.00
246_G256_A0.5861.00
173_K177_E0.5851.00
183_N203_I0.5851.00
125_E128_V0.5841.00
256_A260_H0.5811.00
123_K129_K0.5801.00
91_D199_D0.5801.00
238_R241_Q0.5801.00
42_D47_E0.5801.00
186_R189_P0.5801.00
230_F247_Y0.5791.00
246_G260_H0.5781.00
167_N170_A0.5781.00
126_K130_Q0.5761.00
171_I175_C0.5751.00
22_V230_F0.5741.00
145_L149_R0.5731.00
95_E150_Y0.5731.00
137_I141_P0.5711.00
111_W121_K0.5671.00
174_I177_E0.5651.00
125_E132_H0.5631.00
30_Y63_W0.5631.00
237_V240_L0.5621.00
76_M88_I0.5581.00
188_N233_S0.5581.00
26_F72_I0.5571.00
240_L260_H0.5571.00
110_K113_S0.5541.00
124_V128_V0.5481.00
249_L267_E0.5471.00
98_Y104_F0.5461.00
91_D94_T0.5461.00
121_K125_E0.5450.99
222_L227_A0.5440.99
92_L187_C0.5440.99
96_I216_M0.5430.99
30_Y272_I0.5410.99
262_L274_N0.5400.99
42_D46_L0.5380.99
59_L226_R0.5380.99
251_N257_K0.5360.99
150_Y153_N0.5350.99
68_S71_S0.5340.99
270_K273_T0.5340.99
63_W76_M0.5320.99
124_V132_H0.5310.99
156_Y159_Q0.5300.99
248_L259_L0.5270.99
229_A246_G0.5260.99
107_Q215_F0.5250.99
73_L76_M0.5250.99
81_F86_H0.5240.99
230_F264_T0.5210.99
69_I91_D0.5210.99
156_Y160_D0.5200.99
19_Q22_V0.5180.99
206_G211_E0.5170.99
115_I119_F0.5120.99
91_D95_E0.5080.99
31_F267_E0.5070.99
32_P270_K0.5060.99
115_I118_G0.5050.99
132_H138_L0.5040.99
24_C53_K0.5030.99
96_I219_K0.5020.99
113_S120_S0.5010.99
114_R182_V0.5010.99
153_N201_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nrwA 1 0.8404 100 0.266 Contact Map
2b30A 2 0.9007 100 0.289 Contact Map
3l7yA 1 0.844 100 0.295 Contact Map
3pgvA 3 0.8546 100 0.296 Contact Map
4qjbA 1 0.9149 100 0.301 Contact Map
3dnpA 2 0.8475 100 0.304 Contact Map
1rkqA 1 0.8723 100 0.305 Contact Map
1nf2A 4 0.8475 100 0.312 Contact Map
1rlmA 1 0.8475 100 0.313 Contact Map
3daoA 1 0.8723 100 0.316 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0093 seconds.