GREMLIN Database
NTDC - Glucose-6-phosphate 3-dehydrogenase
UniProt: O07564 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 350 (314)
Sequences: 25394 (18863)
Seq/√Len: 1064.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_D79_Q3.1511.00
74_K102_I2.9611.00
78_L106_T2.8221.00
121_R183_D2.8151.00
82_G106_T2.7381.00
197_S225_Q2.6901.00
36_Q40_E2.6741.00
3_K27_E2.6461.00
140_N254_H2.6341.00
101_S325_F2.6131.00
128_I131_S2.6041.00
68_S76_H2.5051.00
74_K99_E2.4631.00
78_L82_G2.4621.00
5_G57_L2.4511.00
196_E227_K2.4051.00
78_L102_I2.4021.00
86_H113_R2.3901.00
130_K134_I2.3581.00
222_I334_F2.2801.00
336_E340_N2.1871.00
81_L112_V2.1791.00
30_G51_F2.1711.00
72_C76_H2.1631.00
131_S135_N2.1211.00
53_N56_E2.1071.00
309_A313_N2.0861.00
49_K60_A2.0521.00
74_K78_L2.0381.00
128_I132_L2.0271.00
105_D109_R2.0231.00
14_R45_T1.9911.00
77_A89_C1.9901.00
63_G307_W1.9551.00
108_E322_S1.9191.00
75_E79_Q1.8721.00
81_L107_A1.8621.00
68_S72_C1.8611.00
106_T110_L1.8441.00
25_N312_Q1.8271.00
86_H112_V1.7941.00
101_S105_D1.7851.00
82_G110_L1.7801.00
40_E44_K1.7741.00
101_S329_E1.7681.00
35_N38_N1.7671.00
138_L253_G1.7661.00
226_L232_V1.7451.00
97_L332_E1.7411.00
64_L80_A1.7361.00
4_I63_G1.7341.00
26_A308_I1.7031.00
77_A103_M1.6901.00
20_L65_I1.6791.00
23_I305_I1.6641.00
96_S99_E1.6561.00
52_E56_E1.5961.00
130_K187_Y1.5891.00
202_M338_D1.5881.00
132_L137_E1.5831.00
58_I80_A1.5831.00
59_D83_K1.5821.00
114_A321_F1.5811.00
117_G303_E1.5521.00
54_V79_Q1.5331.00
106_T109_R1.5151.00
196_E225_Q1.5131.00
104_K321_F1.5061.00
104_K325_F1.5061.00
82_G109_R1.4821.00
326_R329_E1.4671.00
129_L258_F1.4651.00
51_F60_A1.4621.00
56_E59_D1.4531.00
36_Q52_E1.4531.00
95_I99_E1.4521.00
113_R314_D1.4461.00
41_S45_T1.4311.00
74_K103_M1.4191.00
142_L254_H1.4131.00
164_D168_K1.4081.00
145_K250_E1.3931.00
55_D59_D1.3871.00
189_F230_V1.3851.00
94_A100_A1.3791.00
250_E259_K1.3751.00
94_A103_M1.3721.00
39_A50_S1.3701.00
79_Q82_G1.3691.00
51_F57_L1.3641.00
81_L110_L1.3561.00
100_A325_F1.3501.00
186_W326_R1.3491.00
61_S85_K1.3491.00
97_L101_S1.3431.00
97_L329_E1.3431.00
191_S227_K1.3351.00
309_A315_W1.3321.00
9_A31_V1.3071.00
32_Y54_V1.2791.00
3_K29_V1.2771.00
201_K225_Q1.2771.00
79_Q83_K1.2751.00
138_L256_K1.2711.00
3_K62_E1.2611.00
306_N310_S1.2531.00
145_K235_I1.2381.00
56_E60_A1.2341.00
66_V77_A1.2321.00
191_S228_N1.2321.00
84_H110_L1.2191.00
104_K322_S1.2151.00
186_W226_L1.2021.00
102_I105_D1.2011.00
32_Y57_L1.1931.00
66_V76_H1.1931.00
248_S259_K1.1901.00
182_I330_V1.1881.00
80_A87_V1.1871.00
54_V76_H1.1851.00
306_N318_I1.1831.00
43_V50_S1.1801.00
81_L106_T1.1801.00
308_I312_Q1.1781.00
41_S44_K1.1771.00
37_Q40_E1.1751.00
141_I251_V1.1611.00
320_S323_D1.1591.00
22_T301_R1.1501.00
199_R223_Y1.1481.00
305_I309_A1.1371.00
4_I26_A1.1351.00
332_E336_E1.1291.00
93_M100_A1.1251.00
88_L117_G1.1231.00
30_G57_L1.1191.00
104_K108_E1.1131.00
100_A328_Q1.1101.00
336_E339_S1.1051.00
88_L303_E1.0981.00
105_D108_E1.0931.00
54_V58_I1.0921.00
69_P72_C1.0871.00
58_I79_Q1.0841.00
126_V187_Y1.0841.00
333_M336_E1.0801.00
102_I106_T1.0731.00
186_W323_D1.0681.00
144_I232_V1.0601.00
192_D227_K1.0451.00
86_H314_D1.0351.00
186_W192_D1.0291.00
138_L258_F1.0281.00
7_I76_H1.0201.00
132_L135_N1.0151.00
94_A99_E1.0151.00
99_E102_I1.0131.00
185_V232_V1.0131.00
39_A52_E1.0091.00
25_N305_I1.0071.00
98_E101_S0.9971.00
78_L103_M0.9961.00
89_C114_A0.9961.00
127_N318_I0.9941.00
306_N315_W0.9931.00
144_I189_F0.9891.00
16_H65_I0.9881.00
306_N309_A0.9841.00
131_S134_I0.9771.00
18_T22_T0.9741.00
58_I83_K0.9731.00
86_H311_T0.9681.00
121_R323_D0.9681.00
39_A43_V0.9671.00
316_V320_S0.9621.00
141_I253_G0.9601.00
122_Y306_N0.9581.00
302_S305_I0.9561.00
97_L325_F0.9521.00
129_L260_Y0.9431.00
138_L141_I0.9411.00
38_N41_S0.9411.00
301_R305_I0.9391.00
98_E102_I0.9381.00
93_M321_F0.9371.00
161_W164_D0.9351.00
37_Q41_S0.9341.00
51_F56_E0.9321.00
9_A33_D0.9271.00
309_A314_D0.9231.00
93_M114_A0.9211.00
76_H79_Q0.9181.00
5_G30_G0.9151.00
77_A87_V0.9091.00
322_S326_R0.9081.00
103_M114_A0.9051.00
74_K94_A0.9041.00
141_I189_F0.9041.00
267_V270_L0.9021.00
119_N299_S0.9001.00
335_F339_S0.8961.00
95_I170_T0.8941.00
40_E50_S0.8941.00
60_A85_K0.8921.00
25_N309_A0.8891.00
18_T45_T0.8831.00
2_K311_T0.8831.00
72_C75_E0.8811.00
36_Q39_A0.8811.00
333_M337_K0.8801.00
101_S104_K0.8751.00
29_V49_K0.8741.00
191_S326_R0.8711.00
329_E333_M0.8691.00
33_D39_A0.8671.00
65_I304_L0.8671.00
107_A110_L0.8671.00
81_L87_V0.8661.00
221_E233_N0.8591.00
31_V42_F0.8571.00
115_S307_W0.8521.00
40_E43_V0.8471.00
107_A114_A0.8461.00
250_E257_E0.8451.00
14_R41_S0.8441.00
4_I20_L0.8401.00
20_L304_L0.8391.00
147_H248_S0.8391.00
16_H304_L0.8341.00
139_G256_K0.8341.00
201_K231_F0.8311.00
77_A81_L0.8291.00
66_V80_A0.8291.00
165_A215_L0.8261.00
159_F163_D0.8231.00
113_R310_S0.8191.00
161_W165_A0.8141.00
192_D326_R0.8131.00
145_K233_N0.8131.00
71_F169_K0.8111.00
33_D38_N0.8061.00
268_Y272_D0.8041.00
144_I251_V0.8031.00
186_W327_S0.7991.00
70_N176_D0.7981.00
162_R165_A0.7961.00
20_L26_A0.7951.00
127_N131_S0.7941.00
173_S236_T0.7911.00
5_G32_Y0.7911.00
248_S261_H0.7871.00
89_C93_M0.7861.00
146_V249_I0.7821.00
23_I26_A0.7811.00
133_I253_G0.7801.00
146_V181_L0.7791.00
144_I185_V0.7781.00
107_A112_V0.7771.00
200_A334_F0.7771.00
182_I331_L0.7771.00
118_F179_I0.7751.00
107_A321_F0.7751.00
7_I68_S0.7741.00
134_I190_E0.7731.00
113_R311_T0.7721.00
36_Q50_S0.7681.00
81_L114_A0.7671.00
100_A104_K0.7661.00
12_I16_H0.7631.00
199_R337_K0.7611.00
13_A67_A0.7601.00
29_V60_A0.7531.00
197_S201_K0.7481.00
89_C103_M0.7471.00
2_K63_G0.7461.00
42_F45_T0.7451.00
193_F226_L0.7441.00
310_S317_E0.7431.00
224_G232_V0.7431.00
310_S313_N0.7421.00
7_I54_V0.7411.00
159_F164_D0.7391.00
63_G86_H0.7381.00
310_S315_W0.7311.00
325_F329_E0.7291.00
115_S310_S0.7281.00
17_A28_L0.7261.00
93_M116_M0.7251.00
6_I17_A0.7241.00
5_G64_L0.7221.00
12_I300_F0.7211.00
179_I327_S0.7211.00
178_G236_T0.7201.00
172_G217_D0.7191.00
7_I32_Y0.7191.00
116_M324_G0.7171.00
149_K235_I0.7171.00
139_G253_G0.7121.00
140_N228_N0.7111.00
307_W311_T0.7071.00
127_N302_S0.7071.00
174_L331_L0.7061.00
165_A339_S0.7061.00
2_K312_Q0.7051.00
185_V226_L0.7041.00
12_I67_A0.7031.00
147_H235_I0.7031.00
189_F226_L0.7021.00
218_D239_C0.7021.00
270_L273_G0.7021.00
203_N225_Q0.6991.00
193_F224_G0.6991.00
201_K223_Y0.6961.00
171_S175_G0.6941.00
223_Y231_F0.6901.00
143_S231_F0.6901.00
13_A18_T0.6851.00
73_H89_C0.6851.00
120_Y123_L0.6841.00
306_N317_E0.6831.00
126_V184_M0.6821.00
164_D215_L0.6811.00
328_Q332_E0.6781.00
9_A39_A0.6721.00
121_R187_Y0.6701.00
323_D326_R0.6691.00
225_Q231_F0.6681.00
25_N308_I0.6661.00
78_L81_L0.6641.00
74_K106_T0.6641.00
84_H112_V0.6621.00
226_L230_V0.6601.00
321_F324_G0.6581.00
14_R18_T0.6581.00
85_K112_V0.6551.00
4_I308_I0.6491.00
113_R316_V0.6491.00
91_K180_H0.6481.00
81_L103_M0.6441.00
140_N255_K0.6441.00
174_L220_A0.6431.00
252_V257_E0.6421.00
300_F303_E0.6401.00
89_C116_M0.6391.00
160_T163_D0.6391.00
88_L115_S0.6381.00
217_D335_F0.6381.00
178_G181_L0.6351.00
222_I234_I0.6351.00
35_N40_E0.6351.00
30_G49_K0.6341.00
186_W330_V0.6341.00
118_F327_S0.6331.00
272_D275_N0.6301.00
133_I251_V0.6281.00
200_A222_I0.6281.00
193_F330_V0.6261.00
75_E102_I0.6261.00
51_F61_S0.6251.00
42_F46_F0.6221.00
57_L60_A0.6221.00
77_A114_A0.6211.00
188_L251_V0.6201.00
119_N300_F0.6191.00
183_D327_S0.6161.00
176_D238_K0.6151.00
4_I65_I0.6131.00
146_V185_V0.6111.00
32_Y51_F0.6101.00
148_F177_L0.6091.00
17_A42_F0.6061.00
268_Y271_I0.6061.00
130_K188_L0.6051.00
186_W191_S0.6031.00
14_R38_N0.6031.00
31_V50_S0.6001.00
180_H183_D0.6001.00
237_S240_S0.5981.00
115_S306_N0.5961.00
193_F196_E0.5951.00
13_A42_F0.5931.00
63_G311_T0.5921.00
199_R225_Q0.5911.00
158_K162_R0.5891.00
55_D75_E0.5881.00
118_F183_D0.5881.00
200_A220_A0.5871.00
143_S252_V0.5871.00
164_D169_K0.5871.00
174_L222_I0.5861.00
23_I301_R0.5851.00
64_L85_K0.5851.00
75_E78_L0.5841.00
183_D187_Y0.5841.00
26_A63_G0.5821.00
14_R46_F0.5811.00
12_I90_E0.5791.00
57_L61_S0.5771.00
23_I308_I0.5771.00
141_I230_V0.5761.00
182_I334_F0.5761.00
9_A42_F0.5751.00
66_V73_H0.5711.00
14_R42_F0.5701.00
309_A312_Q0.5691.00
270_L275_N0.5671.00
54_V80_A0.5661.00
205_N218_D0.5661.00
267_V271_I0.5661.00
264_N267_V0.5631.00
34_I68_S0.5631.00
90_E117_G0.5591.00
18_T21_S0.5591.00
297_A301_R0.5561.00
219_Y237_S0.5561.00
202_M220_A0.5561.00
11_G15_A0.5551.00
104_K107_A0.5551.00
327_S331_L0.5531.00
265_P268_Y0.5521.00
185_V234_I0.5511.00
55_D83_K0.5511.00
298_D301_R0.5471.00
150_K177_L0.5471.00
175_G332_E0.5461.00
129_L188_L0.5451.00
223_Y233_N0.5421.00
127_N187_Y0.5411.00
71_F95_I0.5411.00
65_I88_L0.5401.00
291_N294_Y0.5391.00
115_S303_E0.5391.00
136_N140_N0.5381.00
224_G234_I0.5371.00
220_A236_T0.5361.00
197_S200_A0.5361.00
67_A90_E0.5351.00
259_K269_K0.5331.00
91_K176_D0.5331.00
93_M103_M0.5281.00
77_A107_A0.5251.00
120_Y183_D0.5251.00
68_S73_H0.5241.00
10_G67_A0.5231.00
124_S302_S0.5221.00
136_N253_G0.5211.00
82_G102_I0.5201.00
221_E235_I0.5191.00
38_N42_F0.5191.00
6_I65_I0.5191.00
133_I188_L0.5191.00
113_R317_E0.5191.00
266_H270_L0.5181.00
16_H67_A0.5171.00
10_G13_A0.5161.00
30_G60_A0.5141.00
219_Y235_I0.5141.00
253_G258_F0.5131.00
2_K26_A0.5131.00
130_K190_E0.5131.00
159_F162_R0.5091.00
137_E140_N0.5081.00
62_E312_Q0.5081.00
122_Y319_P0.5061.00
170_T216_V0.5031.00
127_N130_K0.5031.00
16_H20_L0.5021.00
7_I64_L0.5021.00
143_S235_I0.5011.00
31_V39_A0.5001.00
6_I28_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h6dA 8 0.9514 100 0.199 Contact Map
3dtyA 4 0.94 100 0.207 Contact Map
3v5nA 4 0.9143 100 0.211 Contact Map
2nvwA 3 0.9371 100 0.214 Contact Map
3db2A 2 0.96 100 0.221 Contact Map
1zh8A 2 0.9 100 0.222 Contact Map
4gqaA 4 0.9829 100 0.222 Contact Map
3euwA 4 0.9429 100 0.228 Contact Map
3q2iA 4 0.9429 100 0.23 Contact Map
3btvA 2 0.9343 100 0.231 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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