GREMLIN Database
YHJG - Uncharacterized aromatic compound monooxygenase YhjG
UniProt: O07561 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 499 (463)
Sequences: 7132 (5248)
Seq/√Len: 243.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
326_H330_H4.6881.00
19_L155_V4.0261.00
35_R124_E3.9491.00
8_V137_T3.9211.00
187_V255_D3.8421.00
6_E152_K3.7051.00
124_E140_K3.5891.00
273_R323_D3.5291.00
125_A137_T3.5151.00
271_R274_D3.4091.00
173_P270_K3.2831.00
64_R110_D3.2651.00
31_C120_F3.2551.00
171_E270_K3.1881.00
128_V154_A3.1781.00
15_V298_G3.1451.00
111_H114_S3.1111.00
136_Q150_T2.9961.00
6_E29_G2.9541.00
33_I139_F2.9181.00
5_Y31_C2.8641.00
137_T151_S2.7521.00
129_T136_Q2.7021.00
111_H115_L2.6911.00
127_A167_Q2.6591.00
170_I269_A2.6581.00
131_N136_Q2.6141.00
304_N308_K2.5861.00
127_A138_I2.5431.00
308_K324_S2.5051.00
139_F149_I2.4881.00
21_S111_H2.4611.00
131_N134_A2.4331.00
138_I148_T2.3821.00
109_E121_R2.3621.00
125_A128_V2.3111.00
170_I274_D2.2991.00
15_V280_A2.2681.00
22_E306_G2.2641.00
272_Y333_A2.2461.00
64_R114_S2.2141.00
126_L140_K2.1771.00
136_Q148_T2.1671.00
123_A139_F2.1641.00
271_R326_H2.1251.00
131_N150_T2.1211.00
39_P109_E2.1191.00
157_A280_A2.1181.00
134_A150_T2.1131.00
37_E122_G2.1021.00
240_K244_L2.0701.00
8_V33_I2.0621.00
163_T167_Q2.0451.00
137_T154_A2.0401.00
273_R319_S2.0371.00
268_Q330_H2.0321.00
168_A277_I1.9831.00
155_V280_A1.9751.00
31_C149_I1.9501.00
24_A117_T1.9361.00
330_H334_E1.9161.00
426_L463_L1.9101.00
52_T299_L1.9011.00
129_T138_I1.8981.00
273_R278_F1.8881.00
402_D414_R1.8761.00
8_V151_S1.8751.00
268_Q334_E1.8401.00
156_G164_V1.8371.00
63_E67_S1.8151.00
109_E113_R1.7991.00
10_I154_A1.7891.00
7_A23_L1.7421.00
311_A316_S1.7151.00
28_V313_I1.7121.00
317_A321_L1.6861.00
156_G279_L1.6851.00
120_F147_R1.6781.00
29_G118_E1.6501.00
135_V154_A1.6411.00
123_A147_R1.6381.00
235_T238_E1.6291.00
269_A279_L1.6221.00
28_V310_A1.6141.00
238_E241_A1.6031.00
69_G97_L1.5821.00
68_K103_K1.5811.00
241_A245_R1.5731.00
9_I30_T1.5661.00
113_R118_E1.5631.00
52_T296_N1.5611.00
18_M299_L1.5531.00
120_F123_A1.5531.00
19_L306_G1.5461.00
22_E59_R1.5401.00
106_K110_D1.5211.00
6_E28_V1.5191.00
128_V168_A1.5181.00
112_A117_T1.5051.00
237_E241_A1.4991.00
26_A310_A1.4941.00
130_Q274_D1.4891.00
312_A320_W1.4891.00
327_D388_R1.4851.00
126_L138_I1.4851.00
151_S154_A1.4681.00
21_S115_L1.4681.00
170_I279_L1.4631.00
153_F313_I1.4611.00
64_R67_S1.4571.00
141_D147_R1.4481.00
19_L302_A1.4441.00
439_V442_L1.4401.00
435_D438_E1.4391.00
128_V277_I1.4341.00
65_F107_L1.4281.00
9_I19_L1.4261.00
23_L28_V1.3851.00
463_L471_A1.3851.00
33_I125_A1.3791.00
139_F147_R1.3771.00
396_N473_A1.3761.00
236_E259_M1.3761.00
476_A480_D1.3691.00
8_V31_C1.3651.00
244_L250_D1.3461.00
10_I164_V1.3381.00
241_A244_L1.3311.00
54_E399_R1.3261.00
25_I115_L1.3231.00
194_S197_L1.3211.00
189_L252_G1.3171.00
20_A32_V1.3111.00
236_E240_K1.3111.00
55_L303_M1.3081.00
128_V167_Q1.3061.00
12_G34_E1.3041.00
91_T94_P1.3001.00
125_A164_V1.2961.00
125_A163_T1.2941.00
153_F319_S1.2931.00
65_F104_T1.2901.00
12_G17_F1.2861.00
125_A167_Q1.2781.00
5_Y8_V1.2731.00
141_D145_S1.2701.00
56_L104_T1.2691.00
174_G267_R1.2611.00
334_E338_R1.2541.00
400_L454_E1.2451.00
33_I149_I1.2411.00
295_L299_L1.2341.00
437_I440_K1.2301.00
196_V199_L1.2301.00
278_F312_A1.2241.00
439_V443_R1.2231.00
58_M303_M1.2101.00
130_Q276_R1.2091.00
184_G239_L1.2041.00
10_I125_A1.2021.00
312_A317_A1.2011.00
5_Y29_G1.1971.00
30_T117_T1.1901.00
56_L299_L1.1831.00
25_I111_H1.1821.00
256_P259_M1.1801.00
189_L254_T1.1751.00
201_T204_G1.1751.00
187_V257_S1.1691.00
24_A30_T1.1631.00
404_K412_S1.1621.00
424_F428_S1.1531.00
172_F267_R1.1511.00
429_L432_E1.1481.00
311_A317_A1.1471.00
57_E417_S1.1291.00
91_T95_Y1.1231.00
152_K276_R1.1181.00
34_E121_R1.1181.00
462_I470_V1.1161.00
177_S341_E1.1141.00
39_P121_R1.1131.00
20_A30_T1.1121.00
61_I111_H1.0931.00
170_I270_K1.0901.00
272_Y330_H1.0861.00
310_A314_K1.0841.00
308_K321_L1.0831.00
197_L200_C1.0831.00
311_A424_F1.0811.00
394_R473_A1.0761.00
280_A325_Y1.0611.00
18_M56_L1.0561.00
272_Y326_H1.0551.00
237_E240_K1.0531.00
38_K121_R1.0471.00
135_V276_R1.0431.00
103_K106_K1.0421.00
31_C118_E1.0421.00
163_T166_K1.0421.00
57_E420_Q1.0411.00
85_D88_G1.0401.00
48_L295_L1.0391.00
7_A28_V1.0311.00
400_L464_I1.0281.00
154_A277_I1.0281.00
53_L62_L1.0251.00
312_A316_S1.0231.00
15_V302_A1.0201.00
402_D415_L1.0121.00
64_R111_H1.0091.00
110_D113_R1.0081.00
416_Y419_L1.0031.00
19_L157_A1.0011.00
400_L419_L1.0001.00
130_Q135_V1.0001.00
156_G163_T0.9971.00
18_M59_R0.9951.00
379_A384_Y0.9891.00
266_A341_E0.9871.00
236_E256_P0.9831.00
393_N473_A0.9731.00
92_S95_Y0.9721.00
280_A302_A0.9701.00
51_R54_E0.9651.00
304_N328_E0.9611.00
327_D331_P0.9611.00
168_A274_D0.9591.00
68_K106_K0.9571.00
5_Y149_I0.9551.00
268_Q333_A0.9541.00
194_S198_S0.9541.00
416_Y420_Q0.9501.00
62_L66_V0.9491.00
18_M303_M0.9481.00
156_G168_A0.9471.00
21_S112_A0.9461.00
402_D416_Y0.9441.00
278_F305_L0.9441.00
268_Q272_Y0.9431.00
19_L305_L0.9431.00
161_G166_K0.9421.00
278_F322_L0.9411.00
185_D258_W0.9401.00
18_M22_E0.9371.00
19_L23_L0.9361.00
185_D217_R0.9321.00
78_S81_D0.9321.00
5_Y151_S0.9301.00
301_D329_R0.9231.00
440_K443_R0.9211.00
266_A337_L0.9191.00
395_L398_A0.9181.00
304_N324_S0.9171.00
335_G381_D0.9171.00
249_T252_G0.9151.00
22_E26_A0.9131.00
153_F278_F0.9101.00
24_A115_L0.9101.00
451_E454_E0.9091.00
55_L469_H0.9091.00
268_Q337_L0.9081.00
57_E414_R0.9071.00
133_E276_R0.9071.00
354_L358_S0.9041.00
384_Y387_D0.8991.00
109_E119_V0.8981.00
31_C147_R0.8961.00
366_F369_V0.8951.00
297_V333_A0.8941.00
28_V314_K0.8881.00
43_S185_D0.8881.00
187_V254_T0.8821.00
273_R326_H0.8811.00
398_A469_H0.8780.99
8_V149_I0.8750.99
242_D245_R0.8750.99
160_A286_I0.8740.99
65_F97_L0.8690.99
77_F81_D0.8680.99
378_S381_D0.8630.99
219_V224_Y0.8620.99
124_E142_R0.8570.99
128_V135_V0.8540.99
129_T148_T0.8540.99
229_P232_V0.8520.99
413_E417_S0.8520.99
428_S431_Q0.8510.99
99_L107_L0.8490.99
406_I412_S0.8470.99
247_C251_F0.8460.99
56_L61_I0.8450.99
287_H337_L0.8440.99
442_L445_V0.8430.99
77_F80_L0.8410.99
383_R398_A0.8400.99
297_V336_L0.8370.99
110_D114_S0.8350.99
10_I137_T0.8330.99
440_K444_T0.8330.99
153_F312_A0.8320.99
181_A205_G0.8320.99
243_L247_C0.8320.99
14_P295_L0.8310.99
217_R222_S0.8300.99
279_L284_A0.8270.99
425_V428_S0.8270.99
56_L65_F0.8260.99
33_I120_F0.8250.99
302_A306_G0.8240.99
222_S225_R0.8200.99
184_G256_P0.8190.99
307_W328_E0.8190.99
158_D164_V0.8170.99
122_G142_R0.8150.99
234_V238_E0.8110.99
244_L252_G0.8110.99
90_D95_Y0.8080.99
152_K313_I0.8080.99
65_F99_L0.8050.99
212_S215_R0.8040.99
462_I473_A0.8010.99
155_V306_G0.8000.99
438_E442_L0.7970.99
287_H340_T0.7970.99
341_E345_K0.7960.99
400_L462_I0.7940.99
435_D439_V0.7920.99
220_V223_P0.7870.99
300_Q332_A0.7850.99
387_D391_P0.7830.99
438_E441_G0.7800.99
76_H80_L0.7790.99
89_L94_P0.7780.99
244_L249_T0.7710.99
120_F149_I0.7680.99
380_L384_Y0.7650.99
154_A164_V0.7640.99
19_L280_A0.7610.99
445_V451_E0.7600.99
63_E66_V0.7550.98
68_K107_L0.7550.98
242_D246_I0.7540.98
5_Y118_E0.7540.98
125_A139_F0.7530.98
343_Q347_I0.7520.98
21_S59_R0.7520.98
361_S364_L0.7500.98
373_V376_Q0.7470.98
131_N276_R0.7450.98
330_H333_A0.7450.98
239_L259_M0.7450.98
45_A101_Q0.7440.98
439_V444_T0.7440.98
153_F322_L0.7420.98
230_K233_P0.7420.98
22_E55_L0.7420.98
309_L313_I0.7410.98
287_H336_L0.7400.98
461_T472_W0.7390.98
357_R361_S0.7380.98
435_D444_T0.7370.98
162_S165_R0.7370.98
460_H474_V0.7360.98
371_R375_G0.7360.98
477_S480_D0.7360.98
285_H301_D0.7350.98
75_G78_S0.7330.98
99_L104_T0.7330.98
203_E245_R0.7310.98
196_V200_C0.7310.98
6_E314_K0.7300.98
123_A143_D0.7290.98
206_V211_L0.7280.98
424_F427_L0.7270.98
279_L283_A0.7250.98
184_G259_M0.7250.98
428_S461_T0.7250.98
215_R257_S0.7200.98
414_R418_F0.7170.98
385_E398_A0.7150.98
219_V222_S0.7150.98
419_L425_V0.7140.98
288_F344_T0.7140.98
48_L104_T0.7130.98
130_Q275_G0.7130.98
155_V309_L0.7130.98
308_K328_E0.7080.98
158_D162_S0.7080.98
339_N343_Q0.7070.98
290_A340_T0.7070.98
19_L156_G0.7050.98
172_F286_I0.7050.98
59_R306_G0.7050.98
435_D442_L0.7030.98
409_D412_S0.7020.98
61_I108_L0.7010.98
64_R68_K0.6970.97
124_E163_T0.6970.97
216_Y219_V0.6970.97
61_I107_L0.6960.97
275_G323_D0.6950.97
53_L66_V0.6930.97
177_S266_A0.6890.97
277_I280_A0.6880.97
383_R386_A0.6870.97
43_S258_W0.6870.97
53_L97_L0.6860.97
190_S193_P0.6850.97
46_L101_Q0.6850.97
217_R220_V0.6830.97
253_L256_P0.6820.97
113_R117_T0.6820.97
107_L110_D0.6800.97
68_K99_L0.6800.97
381_D384_Y0.6790.97
194_S199_L0.6780.97
23_L306_G0.6770.97
183_L262_F0.6770.97
441_G444_T0.6770.97
317_A324_S0.6750.97
26_A314_K0.6750.97
170_I271_R0.6740.97
18_M302_A0.6730.97
413_E418_F0.6710.97
36_L40_V0.6700.97
422_G425_V0.6700.97
461_T474_V0.6700.97
456_L462_I0.6700.97
429_L460_H0.6690.97
47_T96_T0.6690.97
312_A324_S0.6680.97
105_E121_R0.6660.97
66_V69_G0.6660.97
374_A378_S0.6650.97
218_V222_S0.6640.97
240_K252_G0.6640.97
135_V277_I0.6630.97
46_L209_V0.6620.96
17_F109_E0.6620.96
291_G343_Q0.6600.96
400_L470_V0.6590.96
6_E313_I0.6590.96
21_S24_A0.6580.96
47_T98_L0.6570.96
88_G92_S0.6570.96
183_L260_S0.6570.96
218_V223_P0.6540.96
49_H52_T0.6530.96
164_V167_Q0.6530.96
429_L462_I0.6530.96
400_L415_L0.6530.96
72_I75_G0.6520.96
360_M364_L0.6510.96
217_R224_Y0.6510.96
436_H440_K0.6500.96
304_N307_W0.6490.96
431_Q436_H0.6490.96
74_T78_S0.6490.96
8_V154_A0.6490.96
453_N456_L0.6490.96
433_A440_K0.6480.96
44_K101_Q0.6390.96
101_Q105_E0.6390.96
404_K414_R0.6390.96
354_L357_R0.6390.96
90_D93_C0.6390.96
370_N374_A0.6380.96
456_L459_V0.6380.96
100_P103_K0.6370.96
195_G198_S0.6370.96
195_G200_C0.6360.96
142_R145_S0.6360.96
312_A322_L0.6350.96
460_H475_D0.6350.96
288_F341_E0.6340.96
10_I35_R0.6340.96
432_E437_I0.6330.95
10_I158_D0.6320.95
406_I409_D0.6320.95
236_E255_D0.6300.95
455_K460_H0.6290.95
379_A382_V0.6280.95
141_D144_G0.6270.95
86_F93_C0.6260.95
376_Q381_D0.6230.95
99_L103_K0.6220.95
195_G199_L0.6220.95
39_P106_K0.6210.95
156_G277_I0.6210.95
476_A479_P0.6200.95
9_I32_V0.6190.95
6_E30_T0.6190.95
415_L419_L0.6190.95
105_E109_E0.6180.95
125_A154_A0.6180.95
11_G16_G0.6180.95
375_G378_S0.6170.95
366_F372_Y0.6170.95
426_L461_T0.6170.95
231_D234_V0.6160.95
282_D285_H0.6150.95
273_R322_L0.6150.95
206_V210_P0.6140.95
176_D265_A0.6140.95
432_E435_D0.6140.95
33_I137_T0.6130.95
445_V454_E0.6130.95
266_A288_F0.6100.94
187_V214_D0.6100.94
445_V452_P0.6090.94
187_V215_R0.6080.94
232_V235_T0.6080.94
21_S117_T0.6080.94
358_S361_S0.6050.94
463_L472_W0.6040.94
437_I444_T0.6030.94
166_K169_K0.6030.94
282_D298_G0.6030.94
321_L324_S0.6030.94
112_A116_G0.6030.94
438_E444_T0.6030.94
303_M306_G0.6010.94
285_H329_R0.6000.94
90_D94_P0.5990.94
24_A29_G0.5990.94
250_D253_L0.5980.94
89_L92_S0.5980.94
417_S420_Q0.5960.94
428_S433_A0.5950.94
38_K41_P0.5940.94
244_L248_G0.5940.94
400_L427_L0.5940.94
266_A345_K0.5930.94
100_P212_S0.5930.94
33_I123_A0.5930.94
21_S61_I0.5930.94
156_G283_A0.5920.94
357_R360_M0.5910.94
180_T224_Y0.5910.94
403_M415_L0.5900.93
349_F353_G0.5900.93
400_L468_G0.5900.93
427_L464_I0.5890.93
306_G310_A0.5890.93
57_E62_L0.5870.93
428_S432_E0.5850.93
414_R417_S0.5840.93
308_K312_A0.5820.93
26_A30_T0.5820.93
326_H331_P0.5790.93
170_I326_H0.5790.93
217_R221_I0.5780.93
181_A344_T0.5770.93
438_E443_R0.5770.93
435_D441_G0.5760.93
375_G381_D0.5740.93
210_P213_P0.5740.93
55_L300_Q0.5720.92
406_I410_G0.5700.92
130_Q277_I0.5700.92
17_F105_E0.5680.92
430_R434_D0.5680.92
128_V163_T0.5670.92
179_V292_G0.5670.92
378_S383_R0.5670.92
316_S320_W0.5650.92
49_H300_Q0.5650.92
335_G338_R0.5640.92
165_R279_L0.5640.92
75_G80_L0.5630.92
312_A319_S0.5620.92
399_R416_Y0.5610.92
20_A117_T0.5610.92
298_G302_A0.5610.92
405_L415_L0.5600.92
419_L427_L0.5600.92
353_G356_L0.5590.92
269_A326_H0.5580.91
25_I59_R0.5570.91
7_A313_I0.5550.91
267_R286_I0.5550.91
425_V429_L0.5550.91
452_P456_L0.5550.91
333_A337_L0.5540.91
434_D458_N0.5530.91
55_L59_R0.5530.91
320_W323_D0.5520.91
43_S102_S0.5520.91
307_W321_L0.5510.91
265_A286_I0.5510.91
403_M434_D0.5510.91
64_R107_L0.5510.91
201_T205_G0.5510.91
436_H439_V0.5510.91
434_D437_I0.5490.91
415_L427_L0.5480.91
75_G79_M0.5470.91
420_Q426_L0.5470.91
324_S327_D0.5470.91
374_A379_A0.5470.91
179_V290_A0.5450.90
174_G265_A0.5430.90
101_Q217_R0.5420.90
429_L454_E0.5420.90
233_P238_E0.5410.90
163_T168_A0.5410.90
385_E388_R0.5410.90
207_M211_L0.5400.90
221_I224_Y0.5400.90
436_H443_R0.5390.90
10_I128_V0.5390.90
434_D438_E0.5390.90
89_L93_C0.5390.90
104_T107_L0.5380.90
251_F254_T0.5380.90
373_V377_I0.5370.90
73_P78_S0.5370.90
368_D372_Y0.5350.90
376_Q379_A0.5330.89
43_S46_L0.5330.89
334_E337_L0.5320.89
420_Q425_V0.5320.89
437_I441_G0.5300.89
162_S283_A0.5290.89
238_E242_D0.5290.89
53_L69_G0.5280.89
128_V164_V0.5280.89
218_V221_I0.5270.89
22_E303_M0.5270.89
357_R364_L0.5270.89
372_Y376_Q0.5270.89
358_S362_E0.5270.89
353_G358_S0.5270.89
54_E57_E0.5260.89
40_V44_K0.5260.89
459_V476_A0.5260.89
313_I316_S0.5250.89
295_L298_G0.5240.89
180_T230_K0.5230.89
43_S104_T0.5220.89
394_R401_P0.5210.88
455_K459_V0.5200.88
230_K234_V0.5200.88
312_A318_P0.5200.88
156_G167_Q0.5200.88
434_D440_K0.5200.88
264_N287_H0.5190.88
22_E25_I0.5180.88
177_S263_G0.5180.88
12_G19_L0.5160.88
266_A287_H0.5160.88
87_S90_D0.5160.88
430_R433_A0.5160.88
312_A315_G0.5150.88
359_M362_E0.5150.88
125_A277_I0.5150.88
293_Q336_L0.5140.88
377_I380_L0.5130.88
475_D478_A0.5130.88
453_N457_R0.5120.88
287_H297_V0.5120.88
51_R332_A0.5120.88
186_V218_V0.5110.87
130_Q134_A0.5110.87
311_A321_L0.5110.87
21_S25_I0.5100.87
17_F119_V0.5100.87
211_L215_R0.5080.87
199_L208_I0.5080.87
304_N331_P0.5080.87
112_A115_L0.5080.87
355_H359_M0.5070.87
107_L111_H0.5070.87
385_E395_L0.5070.87
339_N376_Q0.5060.87
51_R300_Q0.5050.87
408_S433_A0.5050.87
297_V340_T0.5050.87
216_Y221_I0.5040.87
188_L191_P0.5030.87
382_V386_A0.5030.87
304_N325_Y0.5030.87
332_A382_V0.5030.87
394_R398_A0.5030.87
164_V277_I0.5020.87
445_V456_L0.5010.86
459_V475_D0.5010.86
86_F95_Y0.5010.86
433_A438_E0.5010.86
74_T80_L0.5010.86
88_G95_Y0.5010.86
46_L98_L0.5010.86
47_T292_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qa1A 2 0.9639 100 0.219 Contact Map
2qa2A 2 0.9679 100 0.222 Contact Map
4k5sA 2 0.9719 100 0.236 Contact Map
4k2xA 2 0.9579 100 0.247 Contact Map
1pn0A 3 0.984 100 0.266 Contact Map
4cy8A 3 0.9178 100 0.274 Contact Map
3ihgA 3 0.9579 100 0.274 Contact Map
2dkhA 2 0.9299 100 0.278 Contact Map
2r0cA 1 0.9299 100 0.298 Contact Map
4n9xA 5 0.7134 100 0.472 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0145 seconds.