GREMLIN Database
LEPV - Signal peptidase I V
UniProt: O07560 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 168 (152)
Sequences: 6644 (4554)
Seq/√Len: 369.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_Q98_Q3.5861.00
136_Y157_E3.0341.00
84_T128_T3.0231.00
33_V36_N2.7591.00
83_E95_N2.7431.00
86_K128_T2.6371.00
135_K156_R2.5101.00
135_K154_P2.4391.00
136_Y160_I2.4011.00
59_R80_L2.3641.00
57_I77_V2.2171.00
63_V138_V2.2111.00
48_N51_S2.1711.00
84_T130_K2.1241.00
52_H57_I2.0761.00
36_N40_Q2.0311.00
59_R83_E1.9891.00
21_K26_I1.8191.00
59_R94_V1.8171.00
32_G41_E1.8101.00
67_G73_L1.7481.00
13_S17_A1.7271.00
77_V138_V1.7231.00
72_V161_V1.7061.00
47_V162_G1.6871.00
26_I49_K1.6781.00
48_N165_S1.6721.00
75_K146_S1.6521.00
34_S75_K1.6521.00
131_V154_P1.6471.00
74_I164_I1.6441.00
93_Y98_Q1.6121.00
92_L99_V1.6081.00
63_V160_I1.6041.00
156_R159_N1.6011.00
39_F74_I1.5791.00
29_K44_E1.5531.00
140_G146_S1.5501.00
81_P136_Y1.5141.00
47_V64_L1.4781.00
132_P154_P1.4691.00
80_L83_E1.3801.00
131_V135_K1.3691.00
88_K93_Y1.3441.00
147_F151_H1.3161.00
61_D163_V1.2991.00
87_Y92_L1.2841.00
33_V41_E1.2681.00
51_S55_K1.2671.00
134_G157_E1.2651.00
9_A13_S1.2641.00
86_K93_Y1.2421.00
67_G70_H1.2411.00
152_F155_I1.2391.00
52_H163_V1.2301.00
132_P135_K1.2251.00
84_T96_G1.2241.00
95_N99_V1.1831.00
65_F73_L1.1731.00
30_V39_F1.1531.00
36_N41_E1.1481.00
20_V25_F1.1381.00
81_P157_E1.1271.00
85_I94_V1.1171.00
66_K72_V1.1121.00
30_V45_L1.1121.00
45_L164_I1.0861.00
31_E41_E1.0841.00
65_F138_V1.0841.00
66_K161_V1.0831.00
25_F165_S1.0751.00
55_K61_D1.0531.00
35_M62_I1.0521.00
6_W9_A1.0351.00
88_K91_Q1.0301.00
129_S154_P1.0231.00
56_T157_E1.0231.00
20_V24_V1.0161.00
95_N98_Q1.0101.00
79_G85_I0.9961.00
101_E143_R0.9941.00
92_L139_V0.9861.00
83_E94_V0.9801.00
73_L152_F0.9641.00
63_V77_V0.9591.00
75_K140_G0.9581.00
157_E160_I0.9311.00
110_V150_R0.9261.00
25_F46_L0.9181.00
126_T129_S0.9141.00
50_F53_R0.9111.00
34_S146_S0.9061.00
137_F149_S0.9041.00
28_Y72_V0.8931.00
105_K108_K0.8831.00
39_F62_I0.8791.00
6_W10_G0.8751.00
90_D144_I0.8691.00
21_K27_D0.8671.00
68_P159_N0.8531.00
78_I92_L0.8501.00
7_F11_V0.8501.00
67_G152_F0.8501.00
77_V80_L0.8411.00
64_L72_V0.8391.00
101_E104_L0.8381.00
122_L125_V0.8361.00
27_D44_E0.8291.00
32_G152_F0.8221.00
32_G39_F0.8191.00
37_P40_Q0.8091.00
33_V145_Y0.8051.00
106_H109_S0.8041.00
81_P133_K0.7861.00
86_K96_G0.7831.00
34_S140_G0.7821.00
96_G99_V0.7811.00
24_V50_F0.7791.00
134_G156_R0.7721.00
62_I164_I0.7721.00
39_F164_I0.7711.00
28_Y47_V0.7681.00
51_S163_V0.7541.00
69_D147_F0.7501.00
60_F103_F0.7491.00
139_V143_R0.7451.00
18_I22_N0.7431.00
67_G72_V0.7421.00
36_N142_N0.7401.00
31_E43_N0.7331.00
37_P105_K0.7321.00
73_L147_F0.7261.00
40_Q43_N0.7261.00
28_Y64_L0.7261.00
8_L12_V0.7181.00
107_L110_V0.7131.00
131_V134_G0.7050.99
107_L111_S0.7040.99
5_F9_A0.7010.99
77_V136_Y0.6980.99
79_G83_E0.6960.99
142_N145_Y0.6950.99
19_Q23_A0.6940.99
48_N53_R0.6940.99
64_L164_I0.6900.99
66_K159_N0.6840.99
10_G14_V0.6830.99
51_S54_F0.6760.99
14_V18_I0.6750.99
48_N163_V0.6720.99
64_L161_V0.6670.99
123_K151_H0.6640.99
78_I139_V0.6630.99
73_L155_I0.6580.99
85_I137_F0.6560.99
137_F154_P0.6470.99
28_Y45_L0.6440.99
33_V40_Q0.6350.99
46_L165_S0.6330.99
138_V155_I0.6330.99
149_S153_G0.6320.99
123_K126_T0.6320.99
97_K133_K0.6290.99
30_V74_I0.6270.99
17_A21_K0.6250.99
55_K58_H0.6220.99
15_V18_I0.6190.99
31_E39_F0.6170.99
30_V41_E0.6170.99
45_L74_I0.6140.99
9_A12_V0.6140.99
38_T62_I0.6130.98
26_I72_V0.6100.98
16_L20_V0.6100.98
20_V23_A0.6070.98
108_K111_S0.6010.98
24_V27_D0.6010.98
33_V142_N0.6000.98
105_K109_S0.5970.98
147_F152_F0.5960.98
57_I160_I0.5950.98
67_G71_K0.5930.98
32_G43_N0.5920.98
65_F155_I0.5910.98
57_I80_L0.5890.98
21_K28_Y0.5850.98
79_G94_V0.5820.98
85_I131_V0.5790.98
12_V16_L0.5760.98
59_R79_G0.5750.98
150_R153_G0.5680.98
58_H133_K0.5630.97
52_H55_K0.5590.97
28_Y161_V0.5580.97
105_K142_N0.5550.97
65_F152_F0.5540.97
87_Y90_D0.5530.97
86_K127_G0.5470.97
94_V99_V0.5470.97
104_L108_K0.5390.97
9_A17_A0.5380.97
129_S137_F0.5340.96
83_E131_V0.5340.96
13_S16_L0.5320.96
85_I139_V0.5320.96
62_I75_K0.5290.96
16_L19_Q0.5280.96
50_F54_F0.5220.96
68_P152_F0.5210.96
8_L11_V0.5200.96
99_V103_F0.5200.96
103_F106_H0.5160.96
78_I99_V0.5160.96
60_F79_G0.5150.96
60_F83_E0.5140.96
27_D46_L0.5140.96
101_E105_K0.5140.96
86_K126_T0.5120.95
100_A103_F0.5120.95
5_F8_L0.5110.95
54_F157_E0.5100.95
145_Y151_H0.5100.95
11_V15_V0.5060.95
33_V42_G0.5050.95
51_S165_S0.5040.95
58_H163_V0.5010.95
125_V128_T0.5010.95
28_Y31_E0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1b12A 1 0.881 100 0.198 Contact Map
4nv4A 2 0.6845 100 0.216 Contact Map
4n31A 5 0.8095 100 0.266 Contact Map
4me8A 1 0.6726 100 0.293 Contact Map
4k8wA 2 0.6786 100 0.351 Contact Map
1umuA 2 0.6131 98.3 0.808 Contact Map
2hnfA 1 0.5952 98.2 0.816 Contact Map
1kcaA 6 0.5655 98.1 0.822 Contact Map
3bdnA 2 0.631 97.9 0.829 Contact Map
3k2zA 2 0.6607 97.6 0.839 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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