GREMLIN Database
YHJE - Uncharacterized membrane protein YhjE
UniProt: O07559 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (175)
Sequences: 9992 (7287)
Seq/√Len: 550.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_I137_T4.0541.00
136_G139_P2.8531.00
61_F153_F2.6891.00
184_Y188_K2.6751.00
56_G59_E2.5061.00
183_W187_K2.4091.00
69_T145_A2.4031.00
84_Q101_M2.3431.00
73_I141_I2.2771.00
109_F143_A2.2751.00
65_W149_L2.1051.00
171_R175_A2.1001.00
185_V189_V2.0971.00
29_A51_N2.0631.00
113_F146_S2.0611.00
107_H110_G1.9561.00
56_G60_G1.9401.00
30_V63_L1.9311.00
109_F139_P1.9191.00
34_L74_L1.8381.00
101_M105_E1.7561.00
52_T159_G1.7241.00
98_R102_L1.7141.00
77_L81_Q1.6891.00
64_S152_I1.6811.00
183_W186_G1.6471.00
30_V67_G1.6441.00
26_P63_L1.6411.00
189_V193_L1.6141.00
61_F156_S1.6101.00
83_G86_K1.6041.00
57_L61_F1.6001.00
69_T141_I1.5911.00
77_L137_T1.5741.00
137_T141_I1.5721.00
174_I178_V1.5701.00
80_R134_R1.5621.00
170_I174_I1.5621.00
157_F161_D1.5331.00
186_G190_E1.4971.00
57_L157_F1.4961.00
30_V66_A1.4861.00
79_V132_L1.4851.00
72_S144_A1.4801.00
34_L70_A1.4281.00
171_R174_I1.3831.00
138_R142_L1.3701.00
79_V131_G1.3701.00
17_L21_Y1.3671.00
187_K191_R1.3591.00
173_V177_L1.3251.00
180_T183_W1.3251.00
96_S99_K1.2991.00
51_N60_G1.2811.00
59_E62_I1.2771.00
73_I77_L1.2731.00
30_V34_L1.2621.00
58_W62_I1.2591.00
58_W61_F1.2491.00
186_G189_V1.2451.00
60_G156_S1.2221.00
26_P59_E1.2151.00
59_E63_L1.2111.00
48_V64_S1.2021.00
188_K191_R1.1871.00
182_L186_G1.1871.00
18_F25_G1.1861.00
184_Y187_K1.1671.00
64_S156_S1.1591.00
112_M143_A1.1591.00
25_G55_F1.1591.00
98_R101_M1.1231.00
188_K192_Y1.1201.00
165_L169_P1.1061.00
84_Q88_L1.1021.00
29_A64_S1.1021.00
187_K190_E1.1011.00
165_L168_Q1.0991.00
101_M134_R1.0991.00
101_M133_S1.0971.00
104_V130_A1.0961.00
150_V153_F1.0951.00
55_F60_G1.0911.00
172_T176_V1.0911.00
63_L67_G1.0871.00
65_W145_A1.0761.00
115_L126_V1.0681.00
26_P56_G1.0561.00
123_S151_M1.0541.00
86_K90_F1.0411.00
116_L144_A1.0401.00
30_V70_A1.0351.00
48_V156_S1.0221.00
61_F65_W1.0111.00
180_T184_Y0.9911.00
141_I145_A0.9681.00
75_V128_V0.9651.00
52_T156_S0.9641.00
61_F157_F0.9591.00
110_G114_L0.9531.00
175_A179_I0.9421.00
81_Q85_R0.9421.00
117_C150_V0.9361.00
176_V180_T0.9321.00
146_S149_L0.9261.00
172_T175_A0.9231.00
24_F28_I0.9171.00
179_I183_W0.9161.00
103_W111_P0.9091.00
138_R141_I0.9081.00
95_P99_K0.9001.00
17_L20_S0.8961.00
116_L127_N0.8941.00
48_V52_T0.8891.00
144_A148_K0.8881.00
65_W152_I0.8861.00
62_I66_A0.8821.00
92_R96_S0.8801.00
51_N55_F0.8781.00
139_P143_A0.8721.00
102_L106_R0.8691.00
33_P37_A0.8681.00
113_F143_A0.8661.00
112_M135_I0.8611.00
33_P67_G0.8601.00
123_S148_K0.8541.00
33_P48_V0.8501.00
170_I173_V0.8501.00
113_F150_V0.8481.00
58_W157_F0.8421.00
52_T60_G0.8421.00
127_N144_A0.8391.00
69_T148_K0.8371.00
109_F142_L0.8301.00
178_V182_L0.8281.00
76_F137_T0.8241.00
152_I156_S0.8221.00
68_S148_K0.8221.00
33_P36_E0.8201.00
139_P142_L0.8191.00
65_W69_T0.8181.00
21_Y28_I0.8161.00
84_Q87_L0.8121.00
90_F93_S0.8101.00
45_I123_S0.8081.00
57_L156_S0.8051.00
33_P47_F0.8001.00
153_F157_F0.7911.00
51_N64_S0.7831.00
102_L105_E0.7761.00
50_A53_N0.7701.00
175_A178_V0.7681.00
45_I155_I0.7581.00
62_I65_W0.7531.00
42_L124_A0.7521.00
36_E124_A0.7491.00
36_E44_L0.7471.00
48_V152_I0.7411.00
181_V185_V0.7361.00
143_A147_G0.7311.00
177_L180_T0.7291.00
72_S116_L0.7291.00
71_G75_V0.7291.00
76_F140_F0.7251.00
77_L80_R0.7241.00
48_V68_S0.7211.00
76_F80_R0.7181.00
79_V128_V0.7171.00
27_L31_L0.7071.00
189_V192_Y0.7071.00
190_E193_L0.7041.00
103_W106_R0.7021.00
186_G193_L0.7001.00
35_I40_P0.6961.00
86_K89_G0.6961.00
72_S137_T0.6911.00
87_L97_V0.6911.00
177_L181_V0.6901.00
46_V50_A0.6821.00
50_A54_S0.6821.00
142_L146_S0.6821.00
170_I188_K0.6821.00
63_L66_A0.6751.00
162_L165_L0.6741.00
158_I162_L0.6681.00
114_L118_F0.6631.00
37_A116_L0.6591.00
179_I186_G0.6581.00
37_A71_G0.6541.00
162_L166_I0.6531.00
75_V124_A0.6431.00
17_L25_G0.6421.00
72_S127_N0.6381.00
22_R25_G0.6361.00
99_K103_W0.6341.00
34_L67_G0.6331.00
78_I82_Y0.6311.00
85_R88_L0.6281.00
36_E71_G0.6281.00
40_P124_A0.6271.00
146_S150_V0.6261.00
95_P98_R0.6261.00
148_K151_M0.6241.00
104_V108_G0.6221.00
145_A149_L0.6211.00
57_L153_F0.6191.00
174_I177_L0.6161.00
23_A27_L0.6121.00
70_A74_L0.6111.00
154_M157_F0.6021.00
86_K91_I0.5951.00
116_L148_K0.5951.00
21_Y25_G0.5951.00
65_W148_K0.5951.00
171_R178_V0.5931.00
96_S100_L0.5911.00
115_L130_A0.5901.00
112_M130_A0.5891.00
24_F27_L0.5871.00
126_V130_A0.5871.00
171_R183_W0.5841.00
88_L93_S0.5831.00
82_Y85_R0.5821.00
170_I187_K0.5770.99
68_S116_L0.5770.99
87_L91_I0.5740.99
172_T187_K0.5730.99
160_Y163_H0.5720.99
142_L145_A0.5700.99
124_A127_N0.5640.99
153_F156_S0.5630.99
35_I39_L0.5600.99
29_A60_G0.5570.99
180_T187_K0.5520.99
158_I161_D0.5500.99
88_L98_R0.5490.99
185_V188_K0.5480.99
181_V184_Y0.5450.99
91_I97_V0.5420.99
170_I182_L0.5400.99
25_G28_I0.5380.99
97_V101_M0.5370.99
69_T144_A0.5360.99
118_F121_T0.5350.99
41_F124_A0.5340.99
171_R186_G0.5300.99
93_S98_R0.5280.99
39_L44_L0.5240.99
172_T179_I0.5230.99
130_A135_I0.5230.99
160_Y164_A0.5230.99
67_G71_G0.5200.99
44_L151_M0.5180.99
149_L153_F0.5180.99
33_P44_L0.5180.99
85_R89_G0.5120.99
154_M158_I0.5080.99
170_I185_V0.5060.99
61_F149_L0.5050.99
113_F147_G0.5020.99
72_S140_F0.5010.99
171_R179_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rp9A 2 0.9179 70.7 0.906 Contact Map
3w9iA 3 0.8261 62.6 0.911 Contact Map
4dx5A 3 0.8551 60.9 0.912 Contact Map
3b60A 2 0.8744 56.8 0.914 Contact Map
3b5xA 2 0.8792 53.3 0.916 Contact Map
3zdqA 2 0.8841 48.1 0.919 Contact Map
3zuxA 1 0.9082 48 0.919 Contact Map
3rlbA 1 0.686 41.7 0.922 Contact Map
4xnjA 1 0.9082 41.5 0.922 Contact Map
4q65A 1 0.8696 40.7 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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