GREMLIN Database
YHJB - Uncharacterized symporter YhjB
UniProt: O07556 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 489 (454)
Sequences: 11670 (7434)
Seq/√Len: 348.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
427_A469_V5.7531.00
358_T361_Q4.1651.00
416_V470_M3.9521.00
262_N265_V3.9111.00
17_F21_R3.6311.00
354_A361_Q3.5661.00
427_A465_L3.2901.00
168_T374_A3.2691.00
199_V203_I3.2241.00
424_G470_M3.1241.00
471_M475_L3.1051.00
350_Y357_T3.0311.00
423_A473_V3.0001.00
431_A465_L2.9841.00
469_V473_V2.9111.00
417_T477_T2.8821.00
211_D214_Q2.8751.00
473_V477_T2.8451.00
360_Q364_A2.8061.00
201_L289_A2.7821.00
419_Q477_T2.7751.00
155_T158_A2.7291.00
364_A368_F2.6851.00
111_T120_G2.6781.00
408_F470_M2.5731.00
420_G474_S2.5331.00
164_A378_V2.5181.00
368_F372_V2.3571.00
176_I259_S2.3251.00
40_F180_A2.2971.00
290_A305_S2.2811.00
10_G14_L2.2581.00
31_E38_R2.2271.00
261_E265_V2.1991.00
111_T117_P2.1501.00
211_D215_Q2.1171.00
118_L422_F2.0711.00
357_T361_Q2.0411.00
354_A357_T2.0391.00
417_T420_G2.0191.00
412_K416_V2.0151.00
423_A469_V2.0091.00
109_F409_S1.9931.00
161_W165_V1.9901.00
64_G303_D1.9671.00
405_A421_A1.9581.00
419_Q423_A1.9511.00
412_K415_M1.9421.00
32_Q37_G1.9421.00
265_V268_K1.9231.00
115_N118_L1.9231.00
375_L379_Y1.9191.00
114_Y416_V1.9171.00
214_Q218_T1.8911.00
350_Y354_A1.8821.00
347_K351_K1.8761.00
264_K268_K1.8711.00
13_L17_F1.8621.00
308_R312_Q1.8221.00
408_F467_I1.8221.00
195_L199_V1.8181.00
468_T472_A1.8141.00
193_V325_A1.7861.00
430_G434_Y1.7851.00
56_T141_G1.7771.00
35_V38_R1.7731.00
351_K362_V1.7721.00
264_K267_R1.7671.00
417_T474_S1.7591.00
415_M475_L1.7541.00
350_Y365_L1.7471.00
167_I334_G1.7411.00
420_G473_V1.7291.00
103_L112_K1.7201.00
11_V15_S1.7111.00
364_A367_K1.7091.00
220_K223_F1.6821.00
210_Q214_Q1.6721.00
42_T265_V1.6701.00
214_Q217_E1.6661.00
44_F184_V1.6531.00
174_S178_G1.6521.00
420_G424_G1.6501.00
412_K475_L1.6461.00
320_G324_A1.6431.00
225_T228_E1.6011.00
345_F349_V1.5871.00
361_Q364_A1.5751.00
294_V312_Q1.5581.00
345_F369_L1.5311.00
464_L468_T1.5201.00
412_K471_M1.5151.00
427_A431_A1.5101.00
18_L185_V1.5081.00
5_L9_F1.5051.00
206_Y212_M1.4781.00
423_A427_A1.4691.00
415_M478_R1.4531.00
143_G160_I1.4531.00
108_D348_N1.4511.00
165_V169_V1.4321.00
338_L374_A1.4231.00
222_G225_T1.4201.00
117_P121_I1.4191.00
47_L184_V1.4171.00
357_T362_V1.4101.00
144_L301_D1.3911.00
115_N418_K1.3901.00
350_Y361_Q1.3891.00
42_T46_F1.3871.00
90_L407_L1.3811.00
125_L349_V1.3771.00
217_E221_P1.3741.00
45_V48_L1.3711.00
280_L283_V1.3711.00
126_V429_V1.3681.00
223_F227_P1.3611.00
9_F13_L1.3291.00
45_V260_A1.3291.00
208_G211_D1.3281.00
122_L422_F1.3281.00
117_P352_V1.3221.00
108_D347_K1.3211.00
73_A77_I1.3171.00
158_A162_I1.3131.00
341_A373_I1.3021.00
158_A161_W1.2931.00
183_S256_A1.2891.00
209_F213_F1.2731.00
215_Q218_T1.2711.00
297_L300_A1.2661.00
417_T478_R1.2641.00
29_N32_Q1.2561.00
164_A374_A1.2531.00
287_G291_I1.2481.00
451_Q454_K1.2481.00
167_I331_L1.2471.00
363_S367_K1.2431.00
361_Q365_L1.2381.00
160_I378_V1.2301.00
14_L18_L1.2231.00
6_I10_G1.2221.00
223_F226_L1.2211.00
119_L422_F1.2201.00
34_T366_A1.2101.00
91_L95_W1.2081.00
105_S343_T1.2081.00
243_T246_G1.2021.00
119_L421_A1.1961.00
415_M479_K1.1911.00
111_T352_V1.1901.00
113_K409_S1.1891.00
207_G211_D1.1861.00
16_I19_G1.1831.00
345_F350_Y1.1791.00
142_L163_G1.1711.00
465_L469_V1.1671.00
109_F113_K1.1641.00
434_Y438_T1.1621.00
419_Q473_V1.1531.00
244_A250_W1.1521.00
246_G249_M1.1401.00
467_I471_M1.1391.00
14_L17_F1.1391.00
36_G40_F1.1381.00
182_I335_S1.1371.00
215_Q292_L1.1351.00
122_L425_I1.1341.00
183_S335_S1.1311.00
161_W378_V1.1281.00
424_G466_N1.1261.00
346_A366_A1.1191.00
286_V290_A1.1141.00
419_Q476_M1.1071.00
192_V196_F1.1061.00
84_Y88_Y1.1061.00
154_I159_A1.1051.00
188_I192_V1.1011.00
200_Y204_H1.0941.00
139_L164_A1.0901.00
15_S185_V1.0841.00
157_T382_F1.0831.00
135_L377_S1.0771.00
48_L336_M1.0761.00
120_G348_N1.0761.00
123_V425_I1.0751.00
405_A425_I1.0731.00
52_E336_M1.0701.00
246_G250_W1.0701.00
464_L467_I1.0681.00
147_S156_P1.0661.00
204_H293_Q1.0611.00
125_L129_A1.0571.00
418_K422_F1.0561.00
118_L122_L1.0511.00
459_G463_L1.0511.00
36_G176_I1.0491.00
301_D304_L1.0461.00
100_Q263_P1.0451.00
213_F217_E1.0421.00
27_D32_Q1.0411.00
226_L229_S1.0411.00
212_M216_I1.0351.00
452_A455_D1.0331.00
157_T161_W1.0281.00
365_L369_L1.0281.00
16_I20_I1.0271.00
50_A276_Y1.0271.00
46_F272_I1.0181.00
291_I295_P1.0161.00
469_V472_A1.0141.00
251_P340_S1.0121.00
431_A469_V1.0111.00
453_A456_L1.0101.00
239_T242_L1.0061.00
170_Y335_S1.0061.00
310_S322_I1.0041.00
92_P267_R1.0011.00
118_L418_K0.9971.00
128_I345_F0.9971.00
346_A365_L0.9961.00
14_L185_V0.9941.00
130_A398_L0.9931.00
235_W239_T0.9931.00
210_Q213_F0.9921.00
416_V474_S0.9921.00
139_L160_I0.9901.00
11_V331_L0.9891.00
461_V464_L0.9891.00
401_Q466_N0.9881.00
369_L372_V0.9881.00
114_Y409_S0.9881.00
186_K335_S0.9861.00
172_M371_P0.9841.00
417_T473_V0.9811.00
251_P255_S0.9761.00
43_V47_L0.9761.00
31_E102_K0.9751.00
289_A293_Q0.9741.00
196_F200_Y0.9731.00
243_T247_F0.9661.00
150_S154_I0.9641.00
17_F20_I0.9631.00
68_G302_G0.9631.00
167_I335_S0.9611.00
359_E362_V0.9591.00
287_G290_A0.9531.00
101_H112_K0.9531.00
85_I89_W0.9521.00
345_F373_I0.9471.00
391_L399_V0.9461.00
357_T365_L0.9421.00
12_L15_S0.9411.00
196_F318_F0.9401.00
82_L86_L0.9371.00
34_T343_T0.9351.00
409_S421_A0.9321.00
110_F123_V0.9301.00
379_Y383_K0.9291.00
308_R311_L0.9291.00
221_P224_L0.9261.00
416_V420_G0.9261.00
388_I392_L0.9191.00
339_M342_S0.9191.00
408_F416_V0.9161.00
235_W238_S0.9151.00
78_A82_L0.9151.00
89_W92_P0.9141.00
25_G177_H0.9121.00
161_W382_F0.9101.00
8_I12_L0.9091.00
170_Y331_L0.9091.00
136_V380_F0.9021.00
206_Y211_D0.8971.00
200_Y203_I0.8971.00
342_S346_A0.8961.00
350_Y353_I0.8951.00
296_D300_A0.8941.00
126_V425_I0.8891.00
284_L288_F0.8871.00
426_I430_G0.8861.00
65_W69_K0.8851.00
220_K227_P0.8851.00
424_G428_G0.8831.00
44_F180_A0.8831.00
408_F471_M0.8811.00
415_M480_A0.8801.00
392_L396_Y0.8791.00
285_F288_F0.8791.00
366_A370_V0.8741.00
353_I357_T0.8701.00
43_V46_F0.8671.00
110_F119_L0.8661.00
92_P263_P0.8651.00
465_L468_T0.8651.00
56_T330_A0.8651.00
203_I209_F0.8591.00
434_Y437_M0.8581.00
466_N470_M0.8581.00
221_P226_L0.8541.00
314_F318_F0.8521.00
183_S336_M0.8511.00
182_I186_K0.8511.00
351_K355_P0.8501.00
304_L308_R0.8471.00
286_V309_L0.8421.00
122_L426_I0.8421.00
11_V328_L0.8391.00
332_V335_S0.8301.00
232_S236_F0.8281.00
151_Y155_T0.8261.00
213_F216_I0.8251.00
128_I341_A0.8251.00
420_G423_A0.8251.00
52_E183_S0.8241.00
219_A222_G0.8201.00
147_S151_Y0.8151.00
27_D363_S0.8141.00
23_Q173_V0.8141.00
47_L187_D0.8141.00
42_T268_K0.8131.00
285_F289_A0.8121.00
48_L256_A0.8101.00
21_R25_G0.8081.00
181_W184_V0.8071.00
286_V289_A0.8031.00
6_I9_F0.8021.00
88_Y271_I0.8011.00
286_V291_I0.8001.00
368_F371_P0.8001.00
48_L52_E0.7981.00
260_A266_F0.7961.00
204_H313_A0.7931.00
224_L228_E0.7921.00
310_S319_V0.7911.00
114_Y470_M0.7911.00
160_I381_T0.7901.00
186_K328_L0.7891.00
154_I162_I0.7881.00
233_V236_F0.7881.00
405_A466_N0.7881.00
384_G387_T0.7861.00
288_F291_I0.7861.00
113_K412_K0.7831.00
388_I395_G0.7831.00
307_L310_S0.7831.00
458_V462_A0.7831.00
48_L51_G0.7801.00
24_K28_M0.7791.00
452_A456_L0.7791.00
201_L204_H0.7761.00
91_L266_F0.7751.00
7_I320_G0.7751.00
225_T229_S0.7741.00
472_A475_L0.7731.00
392_L395_G0.7721.00
428_G466_N0.7701.00
108_D112_K0.7681.00
212_M215_Q0.7671.00
419_Q478_R0.7631.00
233_V237_S0.7621.00
362_V366_A0.7611.00
391_L395_G0.7601.00
435_I461_V0.7581.00
41_G265_V0.7571.00
378_V381_T0.7561.00
42_T272_I0.7561.00
51_G256_A0.7551.00
55_T134_Y0.7541.00
8_I327_L0.7541.00
375_L378_V0.7521.00
271_I275_L0.7491.00
238_S241_L0.7491.00
463_L467_I0.7481.00
22_A181_W0.7481.00
71_G288_F0.7481.00
450_P454_K0.7431.00
429_V433_T0.7431.00
243_T249_M0.7421.00
463_L466_N0.7421.00
179_S182_I0.7421.00
144_L147_S0.7401.00
449_L452_A0.7391.00
427_A473_V0.7391.00
247_F250_W0.7381.00
224_L227_P0.7371.00
428_G432_V0.7351.00
231_Q234_A0.7351.00
196_F199_V0.7341.00
197_L306_L0.7310.99
197_L201_L0.7310.99
202_P208_G0.7310.99
170_Y332_V0.7310.99
412_K474_S0.7310.99
20_I23_Q0.7300.99
107_S123_V0.7290.99
431_A435_I0.7260.99
191_L195_L0.7250.99
472_A476_M0.7240.99
19_G23_Q0.7240.99
350_Y355_P0.7220.99
467_I470_M0.7200.99
390_T394_M0.7200.99
408_F412_K0.7200.99
468_T471_M0.7200.99
24_K27_D0.7180.99
123_V402_L0.7170.99
243_T250_W0.7160.99
342_S370_V0.7160.99
290_A309_L0.7150.99
417_T479_K0.7120.99
66_A288_F0.7120.99
206_Y292_L0.7090.99
170_Y186_K0.7090.99
317_W321_I0.7080.99
179_S336_M0.7060.99
387_T390_T0.7030.99
243_T248_Y0.7020.99
372_V376_I0.7010.99
170_Y178_G0.7000.99
156_P160_I0.6980.99
20_I173_V0.6960.99
75_Y79_Y0.6950.99
143_G156_P0.6950.99
59_F194_V0.6950.99
239_T247_F0.6930.99
431_A434_Y0.6920.99
455_D459_G0.6920.99
93_A411_L0.6910.99
215_Q219_A0.6910.99
21_R24_K0.6910.99
234_A238_S0.6900.99
119_L418_K0.6890.99
462_A466_N0.6890.99
218_T221_P0.6890.99
55_T59_F0.6880.99
142_L330_A0.6880.99
412_K417_T0.6870.99
21_R181_W0.6870.99
138_Q333_P0.6870.99
240_V243_T0.6860.99
15_S19_G0.6860.99
121_I124_S0.6860.99
20_I24_K0.6850.99
42_T45_V0.6850.99
460_I464_L0.6800.99
457_N461_V0.6800.99
471_M474_S0.6760.99
83_A86_L0.6750.99
309_L313_A0.6740.99
242_L250_W0.6730.99
121_I349_V0.6720.99
345_F365_L0.6710.99
19_G22_A0.6700.99
449_L453_A0.6700.99
404_P467_I0.6670.99
33_W367_K0.6670.99
144_L303_D0.6660.99
286_V306_L0.6660.99
186_K333_P0.6660.99
117_P120_G0.6650.99
412_K420_G0.6650.99
416_V424_G0.6650.99
422_F426_I0.6650.99
396_Y399_V0.6640.99
171_V335_S0.6620.99
80_G274_P0.6600.99
219_A291_I0.6570.99
423_A426_I0.6570.99
337_I340_S0.6560.99
198_G282_F0.6560.99
36_G259_S0.6560.99
393_L397_S0.6560.99
30_L34_T0.6530.99
176_I180_A0.6520.99
140_K144_L0.6520.99
43_V184_V0.6510.99
67_Y296_D0.6510.99
186_K331_L0.6490.99
212_M289_A0.6490.99
456_L459_G0.6490.99
476_M479_K0.6480.99
353_I356_R0.6460.99
7_I317_W0.6460.99
118_L121_I0.6460.99
377_S381_T0.6460.99
245_L249_M0.6460.99
114_Y408_F0.6450.99
74_F77_I0.6450.99
53_I396_Y0.6440.99
15_S23_Q0.6440.99
346_A362_V0.6420.99
271_I274_P0.6410.99
351_K359_E0.6400.99
388_I400_T0.6390.99
104_M108_D0.6390.99
415_M419_Q0.6380.99
33_W370_V0.6380.99
237_S241_L0.6370.99
186_K332_V0.6370.99
59_F322_I0.6370.99
241_L245_L0.6360.99
219_A223_F0.6360.99
285_F290_A0.6360.99
161_W164_A0.6360.99
16_I169_V0.6300.98
159_A163_G0.6300.98
370_V374_A0.6290.98
221_P225_T0.6290.98
206_Y210_Q0.6290.98
428_G431_A0.6280.98
67_Y305_S0.6240.98
394_M436_T0.6230.98
242_L246_G0.6230.98
338_L370_V0.6210.98
46_F50_A0.6210.98
304_L307_L0.6210.98
73_A78_A0.6210.98
477_T480_A0.6200.98
51_G186_K0.6200.98
333_P337_I0.6200.98
48_L180_A0.6200.98
454_K457_N0.6190.98
430_G433_T0.6160.98
85_I244_A0.6160.98
260_A265_V0.6150.98
457_N460_I0.6150.98
65_W68_G0.6140.98
92_P95_W0.6140.98
431_A462_A0.6130.98
151_Y154_I0.6130.98
395_G399_V0.6120.98
134_Y337_I0.6120.98
28_M32_Q0.6120.98
285_F291_I0.6110.98
394_M433_T0.6100.98
89_W93_A0.6090.98
43_V48_L0.6080.98
197_L322_I0.6050.98
45_V49_M0.6040.98
10_G17_F0.6040.98
168_T371_P0.6020.98
392_L399_V0.6010.98
388_I396_Y0.6010.98
475_L478_R0.6000.98
210_Q215_Q0.6000.98
268_K272_I0.5990.98
433_T437_M0.5990.98
94_V254_F0.5980.98
314_F322_I0.5980.98
453_A461_V0.5980.98
195_L198_G0.5980.98
241_L250_W0.5980.98
342_S366_A0.5970.98
395_G398_L0.5950.98
257_S270_A0.5930.98
127_G344_L0.5930.98
415_M418_K0.5920.98
138_Q334_G0.5910.98
161_W375_L0.5900.98
144_L148_E0.5890.98
121_I125_L0.5890.98
40_F45_V0.5880.98
11_V19_G0.5880.98
436_T458_V0.5860.98
346_A350_Y0.5860.98
245_L250_W0.5850.98
146_V159_A0.5840.98
74_F78_A0.5830.97
451_Q455_D0.5810.97
460_I463_L0.5790.97
284_L287_G0.5790.97
41_G44_F0.5740.97
302_G305_S0.5740.97
311_L319_V0.5730.97
237_S240_V0.5720.97
18_L22_A0.5720.97
114_Y421_A0.5710.97
160_I164_A0.5710.97
105_S348_N0.5700.97
235_W242_L0.5690.97
177_H181_W0.5690.97
48_L183_S0.5690.97
50_A187_D0.5670.97
423_A472_A0.5660.97
78_A81_C0.5660.97
231_Q236_F0.5640.97
209_F212_M0.5630.97
135_L334_G0.5620.97
230_G234_A0.5610.97
183_S332_V0.5600.97
234_A241_L0.5600.97
168_T172_M0.5590.97
120_G124_S0.5570.97
58_T280_L0.5570.97
473_V476_M0.5560.97
278_L282_F0.5560.97
404_P470_M0.5540.97
121_I352_V0.5540.97
147_S155_T0.5520.97
238_S242_L0.5520.97
239_T249_M0.5500.96
268_K271_I0.5490.96
212_M288_F0.5490.96
113_K413_H0.5480.96
12_L16_I0.5470.96
148_E304_L0.5460.96
62_G66_A0.5450.96
115_N119_L0.5450.96
220_K224_L0.5440.96
256_A336_M0.5440.96
52_E171_V0.5440.96
77_I81_C0.5430.96
192_V195_L0.5420.96
244_A248_Y0.5410.96
29_N37_G0.5410.96
139_L178_G0.5410.96
51_G187_D0.5410.96
244_A247_F0.5400.96
316_P319_V0.5390.96
394_M397_S0.5380.96
6_I13_L0.5370.96
202_P209_F0.5360.96
44_F181_W0.5340.96
279_V283_V0.5330.96
202_P285_F0.5320.96
164_A381_T0.5300.96
342_S369_L0.5300.96
120_G352_V0.5290.96
241_L247_F0.5290.96
52_E256_A0.5290.96
459_G466_N0.5280.96
90_L94_V0.5280.96
288_F292_L0.5260.95
217_E220_K0.5260.95
32_Q177_H0.5260.95
216_I288_F0.5240.95
179_S339_M0.5230.95
41_G45_V0.5220.95
337_I402_L0.5220.95
119_L425_I0.5220.95
354_A359_E0.5210.95
12_L19_G0.5210.95
233_V241_L0.5210.95
16_I23_Q0.5210.95
371_P375_L0.5200.95
261_E264_K0.5190.95
65_W389_V0.5180.95
454_K461_V0.5170.95
73_A76_I0.5170.95
148_E308_R0.5160.95
389_V395_G0.5160.95
42_T48_L0.5150.95
134_Y252_H0.5140.95
346_A369_L0.5130.95
138_Q141_G0.5130.95
11_V186_K0.5130.95
179_S256_A0.5120.95
146_V150_S0.5120.95
119_L123_V0.5110.95
231_Q237_S0.5110.95
30_L33_W0.5090.95
40_F259_S0.5090.95
376_I379_Y0.5090.95
84_Y271_I0.5090.95
256_A332_V0.5080.95
387_T395_G0.5080.95
331_L335_S0.5080.95
104_M347_K0.5070.94
425_I428_G0.5060.94
30_L362_V0.5050.94
110_F405_A0.5040.94
53_I277_Q0.5040.94
415_M471_M0.5030.94
25_G28_M0.5030.94
57_F141_G0.5010.94
367_K370_V0.5010.94
59_F64_G0.5010.94
194_V282_F0.5000.94
269_N273_M0.5000.94
419_Q422_F0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xq2A 2 0.9162 100 0.227 Contact Map
3dh4A 3 0.8712 100 0.254 Contact Map
3l1lA 2 0.8344 99.3 0.847 Contact Map
3giaA 1 0.8589 99.2 0.858 Contact Map
4wgvA 2 0.7566 99.1 0.866 Contact Map
4djkA 2 0.8262 98.7 0.883 Contact Map
2jlnA 1 0.8487 98.5 0.89 Contact Map
2wswA 3 0.7935 95 0.934 Contact Map
4us3A 1 0.7955 95 0.934 Contact Map
4c7rA 3 0.8691 94.5 0.935 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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