GREMLIN Database
NHAC - Na(+)/H(+) antiporter NhaC
UniProt: O07553 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 453 (415)
Sequences: 2160 (1417)
Seq/√Len: 69.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
205_L436_F6.4051.00
126_S129_T4.8221.00
387_D393_R3.9741.00
351_G450_F3.9641.00
246_L267_S3.9631.00
142_A152_T3.5521.00
131_V420_M3.3611.00
118_M199_L3.3511.00
349_S352_R3.1391.00
55_P58_S3.1061.00
200_L204_V3.1051.00
111_L203_V3.0681.00
190_H395_F2.9861.00
166_M192_M2.9321.00
139_I149_L2.9131.00
111_L207_Y2.8981.00
201_I440_I2.8201.00
357_T386_Y2.7181.00
351_G449_G2.6741.00
86_A288_L2.6271.00
273_A277_P2.5511.00
342_G345_K2.5121.00
355_A450_F2.4741.00
280_S283_A2.4611.00
110_L151_W2.3261.00
247_V264_G2.3221.00
78_A310_L2.3141.00
113_A138_L2.2921.00
366_L411_I2.2781.00
95_T236_V2.2501.00
435_T438_L2.2361.00
249_L253_K2.2351.00
331_E380_Q2.2201.00
360_S382_F2.1941.00
65_D332_K2.1921.00
49_A59_I2.1911.00
358_V403_G2.1801.00
365_N407_I2.1711.00
114_L199_L2.1511.00
269_G284_F2.1171.00
155_A206_F2.0991.00
391_I395_F2.0531.00
86_A265_I2.0431.00
358_V446_I2.0391.00
436_F440_I2.0381.00
181_E393_R2.0291.00
89_Y287_A2.0041.00
428_V432_I2.0041.00
95_T99_Y2.0031.00
198_A440_I1.9901.00
264_G268_S1.9831.00
182_I393_R1.9561.00
204_V208_F1.9531.00
230_I236_V1.9481.00
201_I444_I1.9411.00
62_G332_K1.9161.00
235_N238_P1.8981.00
202_T206_F1.8821.00
273_A276_V1.8761.00
207_Y211_S1.8311.00
79_L258_I1.8261.00
194_T402_D1.8061.00
421_A428_V1.7941.00
183_P186_E1.7711.00
436_F439_Y1.7601.00
92_A243_S1.7591.00
443_M447_L1.7441.00
95_T241_L1.7371.00
289_Q311_Q1.7321.00
25_S30_L1.6901.00
250_L263_A1.6710.99
147_V152_T1.6310.99
337_S341_E1.6280.99
151_W209_L1.6180.99
314_M318_S1.6110.99
362_I407_I1.6070.99
70_G324_F1.5950.99
142_A149_L1.5930.99
43_V262_T1.5890.99
18_F44_M1.5770.99
49_A333_I1.5760.99
84_I132_S1.5700.99
65_D68_K1.5690.99
177_A182_I1.5630.99
447_L451_V1.5520.99
153_A424_L1.5380.99
361_S400_L1.5300.99
99_Y238_P1.5250.99
348_R352_R1.5060.99
355_A446_I1.5050.99
66_G328_G1.4980.99
158_C206_F1.4940.99
245_L249_L1.4920.99
186_E394_K1.4810.99
148_P213_V1.4790.99
399_S445_S1.4690.99
205_L209_L1.4630.99
179_I379_G1.4590.99
201_I205_L1.4580.99
435_T439_Y1.4560.99
354_V395_F1.4400.98
429_I432_I1.4330.98
419_F423_A1.4290.98
177_A181_E1.4190.98
209_L436_F1.4160.98
239_W271_L1.4150.98
358_V445_S1.4090.98
172_T375_I1.4070.98
157_I417_G1.3990.98
78_A314_M1.3720.98
115_F203_V1.3590.98
408_N416_S1.3570.98
85_G89_Y1.3560.98
152_T156_V1.3560.98
182_I186_E1.3500.98
165_K401_E1.3480.98
190_H394_K1.3460.98
86_A269_G1.3420.98
205_L440_I1.3370.98
99_Y241_L1.3300.97
88_M307_R1.3300.97
24_I28_F1.3270.97
240_A271_L1.3250.97
379_G400_L1.3240.97
383_K387_D1.3230.97
408_N414_G1.3020.97
195_T441_S1.2870.97
86_A268_S1.2870.97
154_G158_C1.2870.97
191_M401_E1.2810.97
279_S287_A1.2700.97
406_L441_S1.2630.97
198_A441_S1.2540.96
64_V68_K1.2480.96
384_S388_K1.2390.96
110_L147_V1.2230.96
402_D445_S1.2210.96
432_I439_Y1.2120.96
135_G153_A1.2110.96
202_T440_I1.2090.96
361_S404_G1.2040.95
139_I153_A1.1990.95
165_K405_T1.1960.95
146_G149_L1.1960.95
138_L156_V1.1930.95
428_V431_Y1.1880.95
45_L329_L1.1790.95
82_I288_L1.1780.95
118_M162_F1.1770.95
401_E405_T1.1760.95
351_G446_I1.1730.95
203_V207_Y1.1700.95
14_G44_M1.1620.94
410_L439_Y1.1580.94
398_R402_D1.1530.94
311_Q315_G1.1450.94
385_L389_R1.1390.94
58_S61_K1.1310.94
274_I284_F1.1300.94
99_Y236_V1.1290.94
311_Q314_M1.1270.93
161_C420_M1.1270.93
181_E383_K1.1260.93
239_W242_L1.1200.93
173_T401_E1.1180.93
162_F401_E1.1140.93
238_P245_L1.1140.93
113_A155_A1.1090.93
439_Y443_M1.0970.93
385_L388_K1.0920.92
56_W259_P1.0910.92
161_C414_G1.0900.92
75_I258_I1.0890.92
353_L385_L1.0870.92
73_P372_Y1.0810.92
331_E337_S1.0790.92
63_I325_A1.0680.92
338_A342_G1.0580.91
192_M196_I1.0570.91
242_L271_L1.0550.91
444_I447_L1.0520.91
370_E374_S1.0380.90
350_K389_R1.0350.90
351_G355_A1.0330.90
139_I143_S1.0310.90
13_V17_I1.0300.90
187_H397_T1.0280.90
92_A240_A1.0260.90
104_I112_T1.0230.90
39_F82_I1.0200.90
242_L267_S1.0190.89
95_T240_A1.0170.89
440_I444_I1.0160.89
150_E430_D1.0050.89
237_T240_A1.0050.89
100_A234_A1.0020.89
34_P37_P1.0010.89
437_F441_S0.9980.88
18_F48_A0.9970.88
246_L249_L0.9960.88
198_A444_I0.9930.88
142_A146_G0.9900.88
308_G312_S0.9900.88
67_I75_I0.9840.88
139_I426_V0.9800.88
425_G428_V0.9790.88
250_L255_V0.9770.87
104_I108_H0.9740.87
349_S389_R0.9730.87
316_S416_S0.9710.87
110_L148_P0.9670.87
195_T401_E0.9650.87
180_G397_T0.9600.86
197_P444_I0.9590.86
79_L265_I0.9580.86
74_I320_I0.9550.86
61_K65_D0.9530.86
371_Q442_P0.9510.86
166_M196_I0.9500.86
406_L437_F0.9460.86
246_L263_A0.9450.86
57_K61_K0.9420.85
410_L435_T0.9410.85
116_S138_L0.9390.85
47_A51_W0.9390.85
347_I353_L0.9390.85
354_V449_G0.9350.85
62_G328_G0.9340.85
57_K115_F0.9310.85
384_S387_D0.9280.85
153_A426_V0.9270.84
74_I317_V0.9250.84
34_P415_V0.9210.84
117_C121_S0.9180.84
446_I450_F0.9170.84
86_A284_F0.9160.84
347_I356_A0.9130.84
175_F375_I0.9130.84
157_I368_T0.9120.84
197_P200_L0.9100.83
427_P430_D0.9100.83
165_K195_T0.9060.83
194_T398_R0.9040.83
347_I352_R0.8970.82
121_S130_T0.8950.82
448_I451_V0.8940.82
11_L51_W0.8840.82
282_Q286_T0.8820.81
117_C134_I0.8810.81
157_I420_M0.8780.81
187_H401_E0.8760.81
143_S149_L0.8730.81
128_L419_F0.8710.81
315_G318_S0.8710.81
426_V430_D0.8690.80
11_L52_F0.8670.80
82_I265_I0.8670.80
358_V449_G0.8670.80
350_K391_I0.8640.80
34_P38_L0.8630.80
417_G431_Y0.8610.80
386_Y396_L0.8600.80
367_A409_P0.8580.80
279_S283_A0.8580.80
118_M122_T0.8580.80
342_G346_G0.8580.80
421_A427_P0.8550.79
148_P434_F0.8480.79
283_A286_T0.8400.78
123_L248_V0.8380.78
198_A202_T0.8380.78
145_A152_T0.8370.78
190_H391_I0.8350.78
202_T205_L0.8350.78
344_M388_K0.8340.78
364_V378_P0.8320.77
362_I366_L0.8320.77
255_V263_A0.8310.77
165_K187_H0.8300.77
411_I414_G0.8280.77
358_V362_I0.8270.77
173_T176_A0.8250.77
85_G284_F0.8230.77
139_I156_V0.8210.77
45_L48_A0.8210.77
126_S371_Q0.8120.76
89_Y92_A0.8090.75
444_I448_I0.8090.75
15_L19_M0.8070.75
81_G313_M0.8040.75
355_A359_C0.8030.75
90_S271_L0.7990.75
172_T401_E0.7980.74
395_F449_G0.7960.74
375_I405_T0.7960.74
386_Y399_S0.7950.74
339_L348_R0.7930.74
76_V80_I0.7920.74
118_M121_S0.7920.74
129_T243_S0.7900.74
278_Y310_L0.7890.74
42_V322_I0.7850.73
202_T443_M0.7820.73
270_I275_F0.7770.73
157_I435_T0.7760.72
42_V46_S0.7760.72
182_I392_Q0.7710.72
54_F58_S0.7680.72
257_V304_I0.7650.71
15_L45_L0.7630.71
287_A310_L0.7590.71
307_R312_S0.7550.70
130_T160_A0.7520.70
208_F233_A0.7460.69
407_I438_L0.7420.69
165_K171_D0.7420.69
67_I321_M0.7410.69
42_V326_L0.7400.69
371_Q408_N0.7380.69
371_Q416_S0.7380.69
127_S172_T0.7370.68
166_M172_T0.7350.68
19_M437_F0.7320.68
46_S50_L0.7320.68
81_G309_G0.7310.68
310_L318_S0.7310.68
171_D176_A0.7280.68
370_E408_N0.7260.67
142_A145_A0.7240.67
164_D401_E0.7240.67
42_V63_I0.7240.67
374_S378_P0.7230.67
440_I443_M0.7220.67
181_E387_D0.7210.67
283_A287_A0.7210.67
289_Q315_G0.7190.67
46_S329_L0.7170.66
433_P436_F0.7160.66
251_A268_S0.7160.66
108_H111_L0.7150.66
395_F448_I0.7150.66
158_C435_T0.7120.66
187_H191_M0.7110.66
127_S160_A0.7100.66
161_C206_F0.7090.65
353_L357_T0.7080.65
18_F49_A0.7080.65
66_G324_F0.7070.65
209_L434_F0.7070.65
383_K393_R0.7060.65
176_A187_H0.7060.65
375_I400_L0.7040.65
378_P404_G0.7040.65
207_Y443_M0.7030.65
370_E415_V0.7020.65
111_L121_S0.7020.65
363_G367_A0.7020.65
406_L442_P0.7010.65
137_A321_M0.7000.64
180_G393_R0.6990.64
127_S171_D0.6980.64
46_S59_I0.6970.64
417_G421_A0.6960.64
172_T177_A0.6960.64
49_A250_L0.6950.64
19_M23_I0.6940.64
354_V399_S0.6940.64
73_P129_T0.6930.64
114_L129_T0.6920.64
395_F399_S0.6920.64
17_I249_L0.6920.64
237_T276_V0.6910.63
104_I127_S0.6910.63
145_A210_G0.6900.63
370_E414_G0.6890.63
263_A267_S0.6880.63
409_P438_L0.6870.63
267_S271_L0.6860.63
80_I131_V0.6860.63
126_S372_Y0.6830.63
49_A356_A0.6800.62
195_T402_D0.6790.62
132_S136_V0.6770.62
74_I321_M0.6750.62
110_L142_A0.6730.61
90_S391_I0.6730.61
174_N178_G0.6700.61
409_P420_M0.6690.61
173_T188_I0.6670.61
274_I281_L0.6670.61
50_L59_I0.6660.61
361_S378_P0.6650.61
421_A431_Y0.6650.61
346_G349_S0.6640.60
193_G197_P0.6630.60
324_F379_G0.6620.60
77_L317_V0.6610.60
51_W266_I0.6610.60
206_F436_F0.6600.60
119_I245_L0.6600.60
229_G232_D0.6590.60
53_G56_W0.6570.60
403_G445_S0.6550.59
51_W119_I0.6530.59
94_P234_A0.6530.59
174_N184_I0.6530.59
129_T372_Y0.6520.59
130_T372_Y0.6510.59
132_S419_F0.6500.59
11_L14_G0.6490.59
115_F439_Y0.6490.59
74_I93_I0.6480.59
161_C407_I0.6470.58
443_M446_I0.6440.58
205_L208_F0.6430.58
249_L252_M0.6420.58
161_C438_L0.6420.58
131_V261_L0.6410.58
209_L213_V0.6380.57
42_V438_L0.6370.57
36_I377_I0.6360.57
41_S45_L0.6340.57
376_L411_I0.6340.57
27_L34_P0.6340.57
204_V350_K0.6320.57
183_P189_R0.6310.57
77_L161_C0.6300.56
191_M339_L0.6300.56
129_T371_Q0.6290.56
89_Y279_S0.6280.56
14_G236_V0.6280.56
190_H398_R0.6280.56
83_L261_L0.6280.56
108_H112_T0.6270.56
77_L80_I0.6270.56
122_T171_D0.6250.56
151_W158_C0.6240.56
93_I323_A0.6230.56
323_A327_G0.6220.55
256_S259_P0.6210.55
161_C409_P0.6200.55
365_N408_N0.6180.55
241_L268_S0.6180.55
271_L276_V0.6150.55
357_T399_S0.6150.55
374_S425_G0.6140.55
27_L261_L0.6140.55
314_M317_V0.6130.54
21_C233_A0.6120.54
399_S403_G0.6110.54
21_C49_A0.6110.54
16_F63_I0.6100.54
200_L249_L0.6100.54
113_A117_C0.6090.54
264_G376_L0.6090.54
173_T187_H0.6080.54
142_A147_V0.6080.54
330_M333_I0.6080.54
80_I261_L0.6070.54
369_G408_N0.6070.54
344_M347_I0.6010.53
115_F231_K0.6010.53
118_M203_V0.6000.53
15_L335_L0.5980.53
96_M171_D0.5980.53
138_L418_A0.5980.53
157_I414_G0.5970.52
199_L437_F0.5970.52
324_F365_N0.5960.52
54_F332_K0.5950.52
130_T144_A0.5950.52
240_A244_P0.5940.52
139_I148_P0.5930.52
38_L77_L0.5920.52
98_V102_S0.5910.52
39_F322_I0.5910.52
426_V432_I0.5890.52
164_D170_S0.5890.52
341_E388_K0.5890.52
174_N378_P0.5880.51
199_L203_V0.5880.51
232_D270_I0.5870.51
206_F435_T0.5870.51
55_P196_I0.5870.51
347_I382_F0.5860.51
204_V207_Y0.5830.51
243_S251_A0.5830.51
244_P261_L0.5820.51
105_E112_T0.5810.51
19_M45_L0.5810.51
117_C130_T0.5800.50
320_I373_L0.5800.50
273_A279_S0.5790.50
399_S449_G0.5790.50
128_L415_V0.5780.50
10_P245_L0.5780.50
109_L149_L0.5760.50
371_Q437_F0.5750.50
195_T405_T0.5750.50
34_P315_G0.5750.50
10_P15_L0.5740.50
47_A50_L0.5740.50
167_S309_G0.5740.50
250_L260_V0.5730.50
139_I423_A0.5710.49
365_N371_Q0.5700.49
157_I342_G0.5700.49
12_A349_S0.5690.49
280_S443_M0.5680.49
123_L169_M0.5670.49
26_C29_L0.5670.49
187_H405_T0.5660.49
15_L240_A0.5650.49
62_G319_L0.5630.48
12_A338_A0.5620.48
46_S63_I0.5620.48
202_T436_F0.5610.48
57_K341_E0.5600.48
36_I41_S0.5600.48
206_F437_F0.5590.48
182_I367_A0.5590.48
109_L145_A0.5590.48
245_L390_N0.5580.48
36_I50_L0.5560.48
128_L441_S0.5540.47
46_S49_A0.5540.47
369_G414_G0.5540.47
409_P416_S0.5540.47
100_A137_A0.5520.47
208_F212_S0.5500.47
11_L48_A0.5500.47
22_I37_P0.5500.47
280_S284_F0.5490.47
110_L155_A0.5490.47
59_I333_I0.5490.47
124_V130_T0.5480.47
355_A358_V0.5460.46
282_Q436_F0.5460.46
236_V240_A0.5450.46
85_G240_A0.5450.46
165_K173_T0.5450.46
358_V399_S0.5430.46
178_G442_P0.5420.46
316_S330_M0.5420.46
280_S287_A0.5420.46
73_P415_V0.5410.46
64_V71_V0.5400.46
44_M267_S0.5390.45
89_Y284_F0.5390.45
92_A244_P0.5380.45
231_K266_I0.5380.45
172_T176_A0.5370.45
17_I200_L0.5360.45
229_G254_R0.5350.45
128_L408_N0.5350.45
147_V213_V0.5350.45
128_L416_S0.5350.45
121_S168_P0.5320.45
192_M205_L0.5320.45
235_N239_W0.5300.44
341_E443_M0.5300.44
162_F166_M0.5300.44
100_A168_P0.5290.44
166_M188_I0.5290.44
118_M285_M0.5290.44
304_I391_I0.5290.44
274_I346_G0.5280.44
90_S241_L0.5280.44
29_L376_L0.5270.44
71_V321_M0.5270.44
253_K266_I0.5260.44
51_W242_L0.5260.44
39_F324_F0.5260.44
46_S132_S0.5260.44
240_A276_V0.5250.44
53_G200_L0.5250.44
184_I418_A0.5240.44
49_A335_L0.5230.44
366_L369_G0.5230.44
206_F209_L0.5230.44
150_E429_I0.5230.44
155_A202_T0.5210.43
75_I93_I0.5210.43
121_S285_M0.5190.43
216_D246_L0.5190.43
41_S440_I0.5190.43
155_A198_A0.5180.43
350_K399_S0.5170.43
397_T405_T0.5160.43
211_S242_L0.5160.43
354_V357_T0.5140.42
60_E93_I0.5140.42
360_S397_T0.5130.42
365_N374_S0.5130.42
65_D246_L0.5120.42
242_L341_E0.5120.42
93_I264_G0.5100.42
194_T445_S0.5100.42
77_L178_G0.5090.42
244_P251_A0.5090.42
421_A433_P0.5090.42
318_S381_S0.5090.42
242_L275_F0.5080.42
120_I261_L0.5070.42
187_H398_R0.5070.42
253_K387_D0.5070.42
57_K60_E0.5050.41
93_I97_T0.5050.41
29_L249_L0.5050.41
154_G377_I0.5040.41
274_I429_I0.5040.41
56_W60_E0.5030.41
363_G388_K0.5030.41
121_S162_F0.5030.41
165_K172_T0.5020.41
77_L370_E0.5010.41
330_M335_L0.5010.41
217_A242_L0.5010.41
235_N276_V0.5010.41
141_V234_A0.5010.41
166_M191_M0.5000.41
129_T373_L0.5000.41
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.872 99.9 0.811 Contact Map
4r1iA 2 0.9404 99.8 0.836 Contact Map
4r0cA 3 0.4746 99.7 0.864 Contact Map
4pd6A 3 0.426 46.6 0.972 Contact Map
4bwzA 2 0.6468 17.8 0.977 Contact Map
2m67A 1 0.1457 13.7 0.978 Contact Map
3nd0A 2 0.6821 11.5 0.979 Contact Map
3l1lA 2 0.1347 8.7 0.98 Contact Map
2l9xA 1 0.064 7 0.981 Contact Map
4njnA 4 0.1236 4.7 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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