NHAC - BACSU - GREMLIN Contacts

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NHAC - Na(+)/H(+) antiporter NhaC

UniProt:	O07553	Sequences: MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVMLSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALSFIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGACFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAASTDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFVPYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIGLISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQRKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGFVKK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	453 (415)
Sequences:	2160 (1417)
Seq/√Len:	69.5

BACSU - NHAC MLEN
HALSA - Q9HNF7 Q9HS26 ARCD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
205_L	436_F	6.405	1.00
126_S	129_T	4.822	1.00
387_D	393_R	3.974	1.00
351_G	450_F	3.964	1.00
246_L	267_S	3.963	1.00
142_A	152_T	3.552	1.00
131_V	420_M	3.361	1.00
118_M	199_L	3.351	1.00
349_S	352_R	3.139	1.00
55_P	58_S	3.106	1.00
200_L	204_V	3.105	1.00
111_L	203_V	3.068	1.00
190_H	395_F	2.986	1.00
166_M	192_M	2.932	1.00
139_I	149_L	2.913	1.00
111_L	207_Y	2.898	1.00
201_I	440_I	2.820	1.00
357_T	386_Y	2.718	1.00
351_G	449_G	2.674	1.00
86_A	288_L	2.627	1.00
273_A	277_P	2.551	1.00
342_G	345_K	2.512	1.00
355_A	450_F	2.474	1.00
280_S	283_A	2.461	1.00
110_L	151_W	2.326	1.00
247_V	264_G	2.322	1.00
78_A	310_L	2.314	1.00
113_A	138_L	2.292	1.00
366_L	411_I	2.278	1.00
95_T	236_V	2.250	1.00
435_T	438_L	2.236	1.00
249_L	253_K	2.235	1.00
331_E	380_Q	2.220	1.00
360_S	382_F	2.194	1.00
65_D	332_K	2.192	1.00
49_A	59_I	2.191	1.00
358_V	403_G	2.180	1.00
365_N	407_I	2.171	1.00
114_L	199_L	2.151	1.00
269_G	284_F	2.117	1.00
155_A	206_F	2.099	1.00
391_I	395_F	2.053	1.00
86_A	265_I	2.043	1.00
358_V	446_I	2.039	1.00
436_F	440_I	2.038	1.00
181_E	393_R	2.029	1.00
89_Y	287_A	2.004	1.00
428_V	432_I	2.004	1.00
95_T	99_Y	2.003	1.00
198_A	440_I	1.990	1.00
264_G	268_S	1.983	1.00
182_I	393_R	1.956	1.00
204_V	208_F	1.953	1.00
230_I	236_V	1.948	1.00
201_I	444_I	1.941	1.00
62_G	332_K	1.916	1.00
235_N	238_P	1.898	1.00
202_T	206_F	1.882	1.00
273_A	276_V	1.876	1.00
207_Y	211_S	1.831	1.00
79_L	258_I	1.826	1.00
194_T	402_D	1.806	1.00
421_A	428_V	1.794	1.00
183_P	186_E	1.771	1.00
436_F	439_Y	1.760	1.00
92_A	243_S	1.759	1.00
443_M	447_L	1.744	1.00
95_T	241_L	1.737	1.00
289_Q	311_Q	1.732	1.00
25_S	30_L	1.690	1.00
250_L	263_A	1.671	0.99
147_V	152_T	1.631	0.99
337_S	341_E	1.628	0.99
151_W	209_L	1.618	0.99
314_M	318_S	1.611	0.99
362_I	407_I	1.607	0.99
70_G	324_F	1.595	0.99
142_A	149_L	1.593	0.99
43_V	262_T	1.589	0.99
18_F	44_M	1.577	0.99
49_A	333_I	1.576	0.99
84_I	132_S	1.570	0.99
65_D	68_K	1.569	0.99
177_A	182_I	1.563	0.99
447_L	451_V	1.552	0.99
153_A	424_L	1.538	0.99
361_S	400_L	1.530	0.99
99_Y	238_P	1.525	0.99
348_R	352_R	1.506	0.99
355_A	446_I	1.505	0.99
66_G	328_G	1.498	0.99
158_C	206_F	1.494	0.99
245_L	249_L	1.492	0.99
186_E	394_K	1.481	0.99
148_P	213_V	1.479	0.99
399_S	445_S	1.469	0.99
205_L	209_L	1.463	0.99
179_I	379_G	1.459	0.99
201_I	205_L	1.458	0.99
435_T	439_Y	1.456	0.99
354_V	395_F	1.440	0.98
429_I	432_I	1.433	0.98
419_F	423_A	1.429	0.98
177_A	181_E	1.419	0.98
209_L	436_F	1.416	0.98
239_W	271_L	1.415	0.98
358_V	445_S	1.409	0.98
172_T	375_I	1.407	0.98
157_I	417_G	1.399	0.98
78_A	314_M	1.372	0.98
115_F	203_V	1.359	0.98
408_N	416_S	1.357	0.98
85_G	89_Y	1.356	0.98
152_T	156_V	1.356	0.98
182_I	186_E	1.350	0.98
165_K	401_E	1.348	0.98
190_H	394_K	1.346	0.98
86_A	269_G	1.342	0.98
205_L	440_I	1.337	0.98
99_Y	241_L	1.330	0.97
88_M	307_R	1.330	0.97
24_I	28_F	1.327	0.97
240_A	271_L	1.325	0.97
379_G	400_L	1.324	0.97
383_K	387_D	1.323	0.97
408_N	414_G	1.302	0.97
195_T	441_S	1.287	0.97
86_A	268_S	1.287	0.97
154_G	158_C	1.287	0.97
191_M	401_E	1.281	0.97
279_S	287_A	1.270	0.97
406_L	441_S	1.263	0.97
198_A	441_S	1.254	0.96
64_V	68_K	1.248	0.96
384_S	388_K	1.239	0.96
110_L	147_V	1.223	0.96
402_D	445_S	1.221	0.96
432_I	439_Y	1.212	0.96
135_G	153_A	1.211	0.96
202_T	440_I	1.209	0.96
361_S	404_G	1.204	0.95
139_I	153_A	1.199	0.95
165_K	405_T	1.196	0.95
146_G	149_L	1.196	0.95
138_L	156_V	1.193	0.95
428_V	431_Y	1.188	0.95
45_L	329_L	1.179	0.95
82_I	288_L	1.178	0.95
118_M	162_F	1.177	0.95
401_E	405_T	1.176	0.95
351_G	446_I	1.173	0.95
203_V	207_Y	1.170	0.95
14_G	44_M	1.162	0.94
410_L	439_Y	1.158	0.94
398_R	402_D	1.153	0.94
311_Q	315_G	1.145	0.94
385_L	389_R	1.139	0.94
58_S	61_K	1.131	0.94
274_I	284_F	1.130	0.94
99_Y	236_V	1.129	0.94
311_Q	314_M	1.127	0.93
161_C	420_M	1.127	0.93
181_E	383_K	1.126	0.93
239_W	242_L	1.120	0.93
173_T	401_E	1.118	0.93
162_F	401_E	1.114	0.93
238_P	245_L	1.114	0.93
113_A	155_A	1.109	0.93
439_Y	443_M	1.097	0.93
385_L	388_K	1.092	0.92
56_W	259_P	1.091	0.92
161_C	414_G	1.090	0.92
75_I	258_I	1.089	0.92
353_L	385_L	1.087	0.92
73_P	372_Y	1.081	0.92
331_E	337_S	1.079	0.92
63_I	325_A	1.068	0.92
338_A	342_G	1.058	0.91
192_M	196_I	1.057	0.91
242_L	271_L	1.055	0.91
444_I	447_L	1.052	0.91
370_E	374_S	1.038	0.90
350_K	389_R	1.035	0.90
351_G	355_A	1.033	0.90
139_I	143_S	1.031	0.90
13_V	17_I	1.030	0.90
187_H	397_T	1.028	0.90
92_A	240_A	1.026	0.90
104_I	112_T	1.023	0.90
39_F	82_I	1.020	0.90
242_L	267_S	1.019	0.89
95_T	240_A	1.017	0.89
440_I	444_I	1.016	0.89
150_E	430_D	1.005	0.89
237_T	240_A	1.005	0.89
100_A	234_A	1.002	0.89
34_P	37_P	1.001	0.89
437_F	441_S	0.998	0.88
18_F	48_A	0.997	0.88
246_L	249_L	0.996	0.88
198_A	444_I	0.993	0.88
142_A	146_G	0.990	0.88
308_G	312_S	0.990	0.88
67_I	75_I	0.984	0.88
139_I	426_V	0.980	0.88
425_G	428_V	0.979	0.88
250_L	255_V	0.977	0.87
104_I	108_H	0.974	0.87
349_S	389_R	0.973	0.87
316_S	416_S	0.971	0.87
110_L	148_P	0.967	0.87
195_T	401_E	0.965	0.87
180_G	397_T	0.960	0.86
197_P	444_I	0.959	0.86
79_L	265_I	0.958	0.86
74_I	320_I	0.955	0.86
61_K	65_D	0.953	0.86
371_Q	442_P	0.951	0.86
166_M	196_I	0.950	0.86
406_L	437_F	0.946	0.86
246_L	263_A	0.945	0.86
57_K	61_K	0.942	0.85
410_L	435_T	0.941	0.85
116_S	138_L	0.939	0.85
47_A	51_W	0.939	0.85
347_I	353_L	0.939	0.85
354_V	449_G	0.935	0.85
62_G	328_G	0.934	0.85
57_K	115_F	0.931	0.85
384_S	387_D	0.928	0.85
153_A	426_V	0.927	0.84
74_I	317_V	0.925	0.84
34_P	415_V	0.921	0.84
117_C	121_S	0.918	0.84
446_I	450_F	0.917	0.84
86_A	284_F	0.916	0.84
347_I	356_A	0.913	0.84
175_F	375_I	0.913	0.84
157_I	368_T	0.912	0.84
197_P	200_L	0.910	0.83
427_P	430_D	0.910	0.83
165_K	195_T	0.906	0.83
194_T	398_R	0.904	0.83
347_I	352_R	0.897	0.82
121_S	130_T	0.895	0.82
448_I	451_V	0.894	0.82
11_L	51_W	0.884	0.82
282_Q	286_T	0.882	0.81
117_C	134_I	0.881	0.81
157_I	420_M	0.878	0.81
187_H	401_E	0.876	0.81
143_S	149_L	0.873	0.81
128_L	419_F	0.871	0.81
315_G	318_S	0.871	0.81
426_V	430_D	0.869	0.80
11_L	52_F	0.867	0.80
82_I	265_I	0.867	0.80
358_V	449_G	0.867	0.80
350_K	391_I	0.864	0.80
34_P	38_L	0.863	0.80
417_G	431_Y	0.861	0.80
386_Y	396_L	0.860	0.80
367_A	409_P	0.858	0.80
279_S	283_A	0.858	0.80
118_M	122_T	0.858	0.80
342_G	346_G	0.858	0.80
421_A	427_P	0.855	0.79
148_P	434_F	0.848	0.79
283_A	286_T	0.840	0.78
123_L	248_V	0.838	0.78
198_A	202_T	0.838	0.78
145_A	152_T	0.837	0.78
190_H	391_I	0.835	0.78
202_T	205_L	0.835	0.78
344_M	388_K	0.834	0.78
364_V	378_P	0.832	0.77
362_I	366_L	0.832	0.77
255_V	263_A	0.831	0.77
165_K	187_H	0.830	0.77
411_I	414_G	0.828	0.77
358_V	362_I	0.827	0.77
173_T	176_A	0.825	0.77
85_G	284_F	0.823	0.77
139_I	156_V	0.821	0.77
45_L	48_A	0.821	0.77
126_S	371_Q	0.812	0.76
89_Y	92_A	0.809	0.75
444_I	448_I	0.809	0.75
15_L	19_M	0.807	0.75
81_G	313_M	0.804	0.75
355_A	359_C	0.803	0.75
90_S	271_L	0.799	0.75
172_T	401_E	0.798	0.74
395_F	449_G	0.796	0.74
375_I	405_T	0.796	0.74
386_Y	399_S	0.795	0.74
339_L	348_R	0.793	0.74
76_V	80_I	0.792	0.74
118_M	121_S	0.792	0.74
129_T	243_S	0.790	0.74
278_Y	310_L	0.789	0.74
42_V	322_I	0.785	0.73
202_T	443_M	0.782	0.73
270_I	275_F	0.777	0.73
157_I	435_T	0.776	0.72
42_V	46_S	0.776	0.72
182_I	392_Q	0.771	0.72
54_F	58_S	0.768	0.72
257_V	304_I	0.765	0.71
15_L	45_L	0.763	0.71
287_A	310_L	0.759	0.71
307_R	312_S	0.755	0.70
130_T	160_A	0.752	0.70
208_F	233_A	0.746	0.69
407_I	438_L	0.742	0.69
165_K	171_D	0.742	0.69
67_I	321_M	0.741	0.69
42_V	326_L	0.740	0.69
371_Q	408_N	0.738	0.69
371_Q	416_S	0.738	0.69
127_S	172_T	0.737	0.68
166_M	172_T	0.735	0.68
19_M	437_F	0.732	0.68
46_S	50_L	0.732	0.68
81_G	309_G	0.731	0.68
310_L	318_S	0.731	0.68
171_D	176_A	0.728	0.68
370_E	408_N	0.726	0.67
142_A	145_A	0.724	0.67
164_D	401_E	0.724	0.67
42_V	63_I	0.724	0.67
374_S	378_P	0.723	0.67
440_I	443_M	0.722	0.67
181_E	387_D	0.721	0.67
283_A	287_A	0.721	0.67
289_Q	315_G	0.719	0.67
46_S	329_L	0.717	0.66
433_P	436_F	0.716	0.66
251_A	268_S	0.716	0.66
108_H	111_L	0.715	0.66
395_F	448_I	0.715	0.66
158_C	435_T	0.712	0.66
187_H	191_M	0.711	0.66
127_S	160_A	0.710	0.66
161_C	206_F	0.709	0.65
353_L	357_T	0.708	0.65
18_F	49_A	0.708	0.65
66_G	324_F	0.707	0.65
209_L	434_F	0.707	0.65
383_K	393_R	0.706	0.65
176_A	187_H	0.706	0.65
375_I	400_L	0.704	0.65
378_P	404_G	0.704	0.65
207_Y	443_M	0.703	0.65
370_E	415_V	0.702	0.65
111_L	121_S	0.702	0.65
363_G	367_A	0.702	0.65
406_L	442_P	0.701	0.65
137_A	321_M	0.700	0.64
180_G	393_R	0.699	0.64
127_S	171_D	0.698	0.64
46_S	59_I	0.697	0.64
417_G	421_A	0.696	0.64
172_T	177_A	0.696	0.64
49_A	250_L	0.695	0.64
19_M	23_I	0.694	0.64
354_V	399_S	0.694	0.64
73_P	129_T	0.693	0.64
114_L	129_T	0.692	0.64
395_F	399_S	0.692	0.64
17_I	249_L	0.692	0.64
237_T	276_V	0.691	0.63
104_I	127_S	0.691	0.63
145_A	210_G	0.690	0.63
370_E	414_G	0.689	0.63
263_A	267_S	0.688	0.63
409_P	438_L	0.687	0.63
267_S	271_L	0.686	0.63
80_I	131_V	0.686	0.63
126_S	372_Y	0.683	0.63
49_A	356_A	0.680	0.62
195_T	402_D	0.679	0.62
132_S	136_V	0.677	0.62
74_I	321_M	0.675	0.62
110_L	142_A	0.673	0.61
90_S	391_I	0.673	0.61
174_N	178_G	0.670	0.61
409_P	420_M	0.669	0.61
173_T	188_I	0.667	0.61
274_I	281_L	0.667	0.61
50_L	59_I	0.666	0.61
361_S	378_P	0.665	0.61
421_A	431_Y	0.665	0.61
346_G	349_S	0.664	0.60
193_G	197_P	0.663	0.60
324_F	379_G	0.662	0.60
77_L	317_V	0.661	0.60
51_W	266_I	0.661	0.60
206_F	436_F	0.660	0.60
119_I	245_L	0.660	0.60
229_G	232_D	0.659	0.60
53_G	56_W	0.657	0.60
403_G	445_S	0.655	0.59
51_W	119_I	0.653	0.59
94_P	234_A	0.653	0.59
174_N	184_I	0.653	0.59
129_T	372_Y	0.652	0.59
130_T	372_Y	0.651	0.59
132_S	419_F	0.650	0.59
11_L	14_G	0.649	0.59
115_F	439_Y	0.649	0.59
74_I	93_I	0.648	0.59
161_C	407_I	0.647	0.58
443_M	446_I	0.644	0.58
205_L	208_F	0.643	0.58
249_L	252_M	0.642	0.58
161_C	438_L	0.642	0.58
131_V	261_L	0.641	0.58
209_L	213_V	0.638	0.57
42_V	438_L	0.637	0.57
36_I	377_I	0.636	0.57
41_S	45_L	0.634	0.57
376_L	411_I	0.634	0.57
27_L	34_P	0.634	0.57
204_V	350_K	0.632	0.57
183_P	189_R	0.631	0.57
77_L	161_C	0.630	0.56
191_M	339_L	0.630	0.56
129_T	371_Q	0.629	0.56
89_Y	279_S	0.628	0.56
14_G	236_V	0.628	0.56
190_H	398_R	0.628	0.56
83_L	261_L	0.628	0.56
108_H	112_T	0.627	0.56
77_L	80_I	0.627	0.56
122_T	171_D	0.625	0.56
151_W	158_C	0.624	0.56
93_I	323_A	0.623	0.56
323_A	327_G	0.622	0.55
256_S	259_P	0.621	0.55
161_C	409_P	0.620	0.55
365_N	408_N	0.618	0.55
241_L	268_S	0.618	0.55
271_L	276_V	0.615	0.55
357_T	399_S	0.615	0.55
374_S	425_G	0.614	0.55
27_L	261_L	0.614	0.55
314_M	317_V	0.613	0.54
21_C	233_A	0.612	0.54
399_S	403_G	0.611	0.54
21_C	49_A	0.611	0.54
16_F	63_I	0.610	0.54
200_L	249_L	0.610	0.54
113_A	117_C	0.609	0.54
264_G	376_L	0.609	0.54
173_T	187_H	0.608	0.54
142_A	147_V	0.608	0.54
330_M	333_I	0.608	0.54
80_I	261_L	0.607	0.54
369_G	408_N	0.607	0.54
344_M	347_I	0.601	0.53
115_F	231_K	0.601	0.53
118_M	203_V	0.600	0.53
15_L	335_L	0.598	0.53
96_M	171_D	0.598	0.53
138_L	418_A	0.598	0.53
157_I	414_G	0.597	0.52
199_L	437_F	0.597	0.52
324_F	365_N	0.596	0.52
54_F	332_K	0.595	0.52
130_T	144_A	0.595	0.52
240_A	244_P	0.594	0.52
139_I	148_P	0.593	0.52
38_L	77_L	0.592	0.52
98_V	102_S	0.591	0.52
39_F	322_I	0.591	0.52
426_V	432_I	0.589	0.52
164_D	170_S	0.589	0.52
341_E	388_K	0.589	0.52
174_N	378_P	0.588	0.51
199_L	203_V	0.588	0.51
232_D	270_I	0.587	0.51
206_F	435_T	0.587	0.51
55_P	196_I	0.587	0.51
347_I	382_F	0.586	0.51
204_V	207_Y	0.583	0.51
243_S	251_A	0.583	0.51
244_P	261_L	0.582	0.51
105_E	112_T	0.581	0.51
19_M	45_L	0.581	0.51
117_C	130_T	0.580	0.50
320_I	373_L	0.580	0.50
273_A	279_S	0.579	0.50
399_S	449_G	0.579	0.50
128_L	415_V	0.578	0.50
10_P	245_L	0.578	0.50
109_L	149_L	0.576	0.50
371_Q	437_F	0.575	0.50
195_T	405_T	0.575	0.50
34_P	315_G	0.575	0.50
10_P	15_L	0.574	0.50
47_A	50_L	0.574	0.50
167_S	309_G	0.574	0.50
250_L	260_V	0.573	0.50
139_I	423_A	0.571	0.49
365_N	371_Q	0.570	0.49
157_I	342_G	0.570	0.49
12_A	349_S	0.569	0.49
280_S	443_M	0.568	0.49
123_L	169_M	0.567	0.49
26_C	29_L	0.567	0.49
187_H	405_T	0.566	0.49
15_L	240_A	0.565	0.49
62_G	319_L	0.563	0.48
12_A	338_A	0.562	0.48
46_S	63_I	0.562	0.48
202_T	436_F	0.561	0.48
57_K	341_E	0.560	0.48
36_I	41_S	0.560	0.48
206_F	437_F	0.559	0.48
182_I	367_A	0.559	0.48
109_L	145_A	0.559	0.48
245_L	390_N	0.558	0.48
36_I	50_L	0.556	0.48
128_L	441_S	0.554	0.47
46_S	49_A	0.554	0.47
369_G	414_G	0.554	0.47
409_P	416_S	0.554	0.47
100_A	137_A	0.552	0.47
208_F	212_S	0.550	0.47
11_L	48_A	0.550	0.47
22_I	37_P	0.550	0.47
280_S	284_F	0.549	0.47
110_L	155_A	0.549	0.47
59_I	333_I	0.549	0.47
124_V	130_T	0.548	0.47
355_A	358_V	0.546	0.46
282_Q	436_F	0.546	0.46
236_V	240_A	0.545	0.46
85_G	240_A	0.545	0.46
165_K	173_T	0.545	0.46
358_V	399_S	0.543	0.46
178_G	442_P	0.542	0.46
316_S	330_M	0.542	0.46
280_S	287_A	0.542	0.46
73_P	415_V	0.541	0.46
64_V	71_V	0.540	0.46
44_M	267_S	0.539	0.45
89_Y	284_F	0.539	0.45
92_A	244_P	0.538	0.45
231_K	266_I	0.538	0.45
172_T	176_A	0.537	0.45
17_I	200_L	0.536	0.45
229_G	254_R	0.535	0.45
128_L	408_N	0.535	0.45
147_V	213_V	0.535	0.45
128_L	416_S	0.535	0.45
121_S	168_P	0.532	0.45
192_M	205_L	0.532	0.45
235_N	239_W	0.530	0.44
341_E	443_M	0.530	0.44
162_F	166_M	0.530	0.44
100_A	168_P	0.529	0.44
166_M	188_I	0.529	0.44
118_M	285_M	0.529	0.44
304_I	391_I	0.529	0.44
274_I	346_G	0.528	0.44
90_S	241_L	0.528	0.44
29_L	376_L	0.527	0.44
71_V	321_M	0.527	0.44
253_K	266_I	0.526	0.44
51_W	242_L	0.526	0.44
39_F	324_F	0.526	0.44
46_S	132_S	0.526	0.44
240_A	276_V	0.525	0.44
53_G	200_L	0.525	0.44
184_I	418_A	0.524	0.44
49_A	335_L	0.523	0.44
366_L	369_G	0.523	0.44
206_F	209_L	0.523	0.44
150_E	429_I	0.523	0.44
155_A	202_T	0.521	0.43
75_I	93_I	0.521	0.43
121_S	285_M	0.519	0.43
216_D	246_L	0.519	0.43
41_S	440_I	0.519	0.43
155_A	198_A	0.518	0.43
350_K	399_S	0.517	0.43
397_T	405_T	0.516	0.43
211_S	242_L	0.516	0.43
354_V	357_T	0.514	0.42
60_E	93_I	0.514	0.42
360_S	397_T	0.513	0.42
365_N	374_S	0.513	0.42
65_D	246_L	0.512	0.42
242_L	341_E	0.512	0.42
93_I	264_G	0.510	0.42
194_T	445_S	0.510	0.42
77_L	178_G	0.509	0.42
244_P	251_A	0.509	0.42
421_A	433_P	0.509	0.42
318_S	381_S	0.509	0.42
242_L	275_F	0.508	0.42
120_I	261_L	0.507	0.42
187_H	398_R	0.507	0.42
253_K	387_D	0.507	0.42
57_K	60_E	0.505	0.41
93_I	97_T	0.505	0.41
29_L	249_L	0.505	0.41
154_G	377_I	0.504	0.41
274_I	429_I	0.504	0.41
56_W	60_E	0.503	0.41
363_G	388_K	0.503	0.41
121_S	162_F	0.503	0.41
165_K	172_T	0.502	0.41
77_L	370_E	0.501	0.41
330_M	335_L	0.501	0.41
217_A	242_L	0.501	0.41
235_N	276_V	0.501	0.41
141_V	234_A	0.501	0.41
166_M	191_M	0.500	0.41
129_T	373_L	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4f35D	2	0.872	99.9	0.811	Contact Map
4r1iA	2	0.9404	99.8	0.836	Contact Map
4r0cA	3	0.4746	99.7	0.864	Contact Map
4pd6A	3	0.426	46.6	0.972	Contact Map
4bwzA	2	0.6468	17.8	0.977	Contact Map
2m67A	1	0.1457	13.7	0.978	Contact Map
3nd0A	2	0.6821	11.5	0.979	Contact Map
3l1lA	2	0.1347	8.7	0.98	Contact Map
2l9xA	1	0.064	7	0.981	Contact Map
4njnA	4	0.1236	4.7	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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