GREMLIN Database
NHAX - Stress response protein NhaX
UniProt: O07552 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (138)
Sequences: 18187 (14507)
Seq/√Len: 1234.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_T110_D3.1421.00
6_R36_T2.6951.00
117_A153_K2.6661.00
8_I129_A2.5611.00
34_A108_D2.5541.00
23_T163_L2.5271.00
6_R34_A2.3671.00
131_M163_L2.3251.00
110_D123_H2.2671.00
123_H127_I2.0871.00
114_G119_S2.0571.00
134_T154_L2.0301.00
124_A132_I1.8911.00
152_E156_A1.8861.00
36_T108_D1.8811.00
22_L99_M1.8281.00
34_A106_D1.8051.00
97_R109_I1.8011.00
10_A134_T1.7911.00
132_I160_I1.7851.00
36_T127_I1.7841.00
112_L119_S1.7661.00
36_T129_A1.7361.00
36_T123_H1.6741.00
40_S119_S1.6711.00
9_V24_A1.6501.00
38_A123_H1.6361.00
10_A120_I1.5731.00
119_S122_E1.5411.00
97_R101_N1.5391.00
6_R130_D1.4891.00
86_E90_E1.4771.00
125_N159_D1.4651.00
33_A130_D1.4581.00
27_L31_V1.4541.00
124_A159_D1.3851.00
90_E94_A1.3751.00
112_L123_H1.3651.00
121_I157_K1.3541.00
39_H89_T1.3381.00
24_A28_A1.3341.00
132_I158_S1.3281.00
18_K99_M1.3201.00
153_K157_K1.3191.00
9_V21_L1.3061.00
132_I154_L1.2601.00
110_D127_I1.2501.00
158_S162_V1.2261.00
92_V96_A1.2081.00
82_P86_E1.1231.00
116_P150_V1.1181.00
38_A112_L1.1071.00
94_A97_R1.0981.00
123_H126_R1.0921.00
144_K152_E1.0901.00
136_S164_I1.0831.00
7_I131_M1.0821.00
142_L146_I1.0771.00
85_Y88_R1.0421.00
155_S164_I1.0291.00
38_A120_I0.9911.00
40_S116_P0.9911.00
23_T27_L0.9831.00
151_S164_I0.9831.00
17_S20_A0.9761.00
93_I109_I0.9741.00
21_L96_A0.9691.00
122_E126_R0.9681.00
21_L37_V0.9611.00
94_A98_M0.9571.00
11_F96_A0.9561.00
94_A109_I0.9551.00
23_T165_V0.9551.00
83_M87_D0.9541.00
26_D30_T0.9531.00
25_I100_L0.9491.00
23_T26_D0.9431.00
89_T93_I0.9381.00
6_R127_I0.9371.00
18_K95_E0.9321.00
112_L126_R0.9301.00
87_D91_E0.9251.00
11_F37_V0.9151.00
121_I124_A0.9061.00
37_V107_G0.9031.00
96_A99_M0.9001.00
77_V80_P0.8971.00
134_T151_S0.8901.00
124_A129_A0.8861.00
6_R129_A0.8851.00
96_A100_L0.8771.00
13_G39_H0.8731.00
99_M102_E0.8711.00
89_T111_I0.8701.00
84_I88_R0.8691.00
25_I105_A0.8691.00
124_A160_I0.8691.00
23_T161_P0.8631.00
99_M103_Q0.8591.00
14_S17_S0.8471.00
28_A35_I0.8431.00
11_F20_A0.8411.00
31_V130_D0.8381.00
92_V95_E0.8381.00
136_S151_S0.8371.00
88_R92_V0.8331.00
41_H111_I0.8321.00
24_A133_V0.8141.00
8_I38_A0.8141.00
95_E99_M0.8111.00
100_L107_G0.8111.00
121_I154_L0.8081.00
139_Q143_K0.7981.00
95_E98_M0.7961.00
21_L25_I0.7941.00
24_A35_I0.7941.00
89_T92_V0.7931.00
85_Y89_T0.7911.00
14_S138_D0.7891.00
8_I132_I0.7851.00
88_R91_E0.7831.00
121_I158_S0.7831.00
10_A135_G0.7791.00
28_A31_V0.7691.00
138_D147_F0.7681.00
37_V96_A0.7671.00
28_A33_A0.7661.00
79_S83_M0.7641.00
41_H113_E0.7641.00
11_F21_L0.7641.00
18_K22_L0.7611.00
87_D90_E0.7591.00
29_K104_Q0.7421.00
133_V163_L0.7401.00
26_D29_K0.7391.00
9_V35_I0.7381.00
39_H92_V0.7341.00
29_K103_Q0.7261.00
19_K22_L0.7251.00
141_R144_K0.7231.00
123_H129_A0.7181.00
11_F17_S0.7161.00
97_R107_G0.7141.00
108_D127_I0.7101.00
120_I154_L0.6981.00
115_D118_E0.6961.00
5_D33_A0.6931.00
98_M102_E0.6911.00
91_E95_E0.6891.00
84_I87_D0.6851.00
13_G92_V0.6791.00
142_L145_L0.6741.00
141_R145_L0.6701.00
80_P83_M0.6691.00
18_K96_A0.6651.00
134_T164_I0.6651.00
80_P84_I0.6571.00
90_E109_I0.6561.00
25_I103_Q0.6501.00
11_F18_K0.6491.00
8_I123_H0.6481.00
37_V100_L0.6331.00
98_M101_N0.6271.00
117_A154_L0.6221.00
83_M86_E0.6211.00
22_L103_Q0.6201.00
79_S82_P0.6191.00
38_A119_S0.6191.00
119_S123_H0.6071.00
9_V20_A0.6061.00
93_I97_R0.6051.00
117_A121_I0.6031.00
7_I28_A0.6031.00
43_M113_E0.6011.00
27_L133_V0.5961.00
138_D148_G0.5931.00
135_G165_V0.5931.00
27_L30_T0.5921.00
91_E94_A0.5851.00
136_S146_I0.5831.00
13_G96_A0.5811.00
100_L103_Q0.5811.00
147_F151_S0.5801.00
118_E122_E0.5771.00
20_A133_V0.5741.00
40_S114_G0.5701.00
128_S160_I0.5631.00
154_L162_V0.5581.00
47_Q51_D0.5561.00
25_I29_K0.5521.00
25_I99_M0.5521.00
15_E18_K0.5511.00
24_A33_A0.5491.00
5_D130_D0.5491.00
16_N19_K0.5481.00
6_R33_A0.5451.00
81_E85_Y0.5451.00
114_G122_E0.5441.00
7_I133_V0.5371.00
117_A157_K0.5371.00
78_T81_E0.5321.00
41_H89_T0.5281.00
27_L163_L0.5051.00
93_I111_I0.5041.00
138_D141_R0.5031.00
125_N160_I0.5021.00
117_A150_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5ahwA 4 0.8614 99.9 0.21 Contact Map
1mjhA 2 0.8434 99.9 0.225 Contact Map
2gm3A 2 0.7711 99.9 0.235 Contact Map
4wnyA 2 0.7711 99.9 0.237 Contact Map
3s3tA 4 0.8554 99.9 0.237 Contact Map
2dumA 2 0.8373 99.9 0.24 Contact Map
4r2kA 2 0.8675 99.9 0.248 Contact Map
3hgmA 2 0.8675 99.9 0.252 Contact Map
4wy2A 2 0.8675 99.9 0.253 Contact Map
3tnjA 2 0.759 99.9 0.255 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.