YHEI - BACSU - GREMLIN Contacts

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YHEI - Probable multidrug resistance ABC transporter ATP-binding/permease protein YheI

UniProt:	O07550	Sequences: MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAIDDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLLTMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWKLTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQETNDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLGELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEPGDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGEGSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAEAHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAKTEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWYREQYERQQLFTAEEGGAGA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	585 (561)
Sequences:	52445 (37187)
Seq/√Len:	1570.0

ECOLI - MDLA MSBA MDLB CYDC CYDD YOJI YDDA
BACSU - YHEI YHEH YGAD YKNU YWJA YFIC BMRA YFIB SUNT CYDD YKNV CYDC YVRA OPUAA OPUCA
HALSA - Q9HSQ7 Q9HMX3 BTUDA Q9HMW0
SULSO - Q97UJ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
454_E	464_L	4.550	1.00
365_Q	541_L	4.420	1.00
341_H	356_D	4.401	1.00
338_V	360_T	4.343	1.00
362_R	365_Q	4.333	1.00
426_R	430_E	4.026	1.00
340_S	394_S	3.944	1.00
541_L	553_R	3.930	1.00
556_H	566_Y	3.866	1.00
449_A	454_E	3.767	1.00
429_K	441_D	3.712	1.00
340_S	396_T	3.426	1.00
454_E	458_H	3.389	1.00
336_D	360_T	3.371	1.00
394_S	401_P	3.360	1.00
355_Q	549_V	3.097	1.00
339_F	342_V	3.084	1.00
429_K	465_E	3.026	1.00
429_K	433_L	2.987	1.00
440_T	443_E	2.947	1.00
448_I	464_L	2.893	1.00
563_N	567_R	2.893	1.00
381_I	529_L	2.870	1.00
567_R	571_E	2.806	1.00
352_D	355_Q	2.783	1.00
343_S	356_D	2.780	1.00
441_D	445_Q	2.750	1.00
381_I	497_I	2.736	1.00
413_W	494_E	2.632	1.00
552_E	562_N	2.500	1.00
338_V	396_T	2.498	1.00
432_I	448_I	2.496	1.00
446_Q	450_E	2.490	1.00
336_D	362_R	2.424	1.00
361_V	367_V	2.390	1.00
492_N	524_K	2.371	1.00
386_R	389_P	2.371	1.00
445_Q	454_E	2.368	1.00
415_G	493_P	2.358	1.00
345_T	352_D	2.332	1.00
543_L	553_R	2.318	1.00
45_D	276_G	2.311	1.00
552_E	564_G	2.304	1.00
555_T	558_E	2.303	1.00
436_K	443_E	2.290	1.00
429_K	444_V	2.288	1.00
406_P	409_R	2.288	1.00
343_S	352_D	2.207	1.00
462_S	466_T	2.204	1.00
359_F	543_L	2.203	1.00
366_T	539_A	2.176	1.00
343_S	392_E	2.154	1.00
445_Q	449_A	2.142	1.00
336_D	363_K	2.137	1.00
45_D	274_T	2.119	1.00
432_I	444_V	2.116	1.00
453_F	456_D	2.086	1.00
552_E	563_N	2.086	1.00
339_F	359_F	2.065	1.00
335_G	398_S	2.040	1.00
152_T	156_L	2.035	1.00
11_F	96_K	2.027	1.00
546_D	565_W	2.015	1.00
518_R	538_H	1.988	1.00
389_P	403_Q	1.959	1.00
361_V	527_F	1.953	1.00
510_E	532_R	1.952	1.00
443_E	492_N	1.949	1.00
341_H	358_S	1.916	1.00
345_T	391_G	1.908	1.00
313_N	317_S	1.904	1.00
15_Y	92_I	1.901	1.00
445_Q	458_H	1.870	1.00
554_G	558_E	1.850	1.00
100_H	320_T	1.826	1.00
13_K	16_W	1.825	1.00
447_A	451_A	1.818	1.00
367_V	541_L	1.810	1.00
193_A	230_D	1.806	1.00
158_S	267_L	1.801	1.00
433_L	444_V	1.801	1.00
446_Q	449_A	1.759	1.00
511_A	515_K	1.727	1.00
58_L	62_G	1.721	1.00
433_L	441_D	1.707	1.00
380_I	545_M	1.705	1.00
367_V	543_L	1.703	1.00
505_V	513_I	1.682	1.00
334_P	398_S	1.682	1.00
543_L	550_I	1.681	1.00
368_G	539_A	1.676	1.00
337_I	527_F	1.653	1.00
551_A	565_W	1.652	1.00
452_H	512_A	1.638	1.00
216_Q	219_N	1.625	1.00
450_E	519_E	1.621	1.00
324_D	406_P	1.619	1.00
401_P	404_Q	1.609	1.00
62_G	66_V	1.604	1.00
365_Q	540_D	1.604	1.00
469_G	474_A	1.601	1.00
366_T	528_I	1.593	1.00
546_D	551_A	1.592	1.00
441_D	465_E	1.585	1.00
432_I	490_M	1.584	1.00
448_I	457_L	1.578	1.00
124_D	311_R	1.576	1.00
468_V	475_L	1.551	1.00
336_D	398_S	1.546	1.00
560_L	570_Y	1.542	1.00
552_E	567_R	1.539	1.00
328_P	331_L	1.531	1.00
188_T	310_D	1.529	1.00
443_E	446_Q	1.527	1.00
369_I	543_L	1.525	1.00
369_I	380_I	1.525	1.00
354_L	357_I	1.524	1.00
455_K	458_H	1.521	1.00
445_Q	464_L	1.517	1.00
439_A	490_M	1.516	1.00
558_E	562_N	1.495	1.00
266_F	270_R	1.491	1.00
537_E	557_Q	1.469	1.00
41_G	280_S	1.459	1.00
530_T	535_A	1.456	1.00
362_R	541_L	1.443	1.00
442_K	445_Q	1.442	1.00
103_T	320_T	1.434	1.00
344_F	379_T	1.425	1.00
100_H	104_M	1.419	1.00
448_I	454_E	1.416	1.00
196_A	230_D	1.406	1.00
385_L	416_Y	1.400	1.00
59_F	63_I	1.399	1.00
383_Q	395_I	1.397	1.00
262_G	266_F	1.388	1.00
356_D	549_V	1.384	1.00
462_S	467_M	1.381	1.00
37_P	284_Y	1.370	1.00
565_W	568_E	1.361	1.00
372_K	546_D	1.353	1.00
200_R	227_M	1.349	1.00
443_E	490_M	1.347	1.00
515_K	519_E	1.342	1.00
342_V	390_P	1.339	1.00
339_F	384_L	1.332	1.00
519_E	522_K	1.327	1.00
220_D	434_Y	1.325	1.00
344_F	383_Q	1.319	1.00
557_Q	561_A	1.317	1.00
456_D	479_Q	1.314	1.00
425_S	467_M	1.311	1.00
344_F	388_Y	1.301	1.00
335_G	363_K	1.300	1.00
415_G	488_A	1.290	1.00
460_L	466_T	1.281	1.00
154_G	158_S	1.280	1.00
189_E	234_K	1.277	1.00
368_G	536_V	1.276	1.00
428_V	483_I	1.275	1.00
441_D	444_V	1.273	1.00
433_L	439_A	1.270	1.00
340_S	358_S	1.251	1.00
100_H	316_L	1.244	1.00
182_K	185_E	1.244	1.00
372_K	565_W	1.242	1.00
25_L	74_M	1.240	1.00
193_A	234_K	1.238	1.00
14_A	92_I	1.217	1.00
193_A	196_A	1.216	1.00
373_T	509_T	1.216	1.00
469_G	472_G	1.215	1.00
174_I	178_L	1.209	1.00
442_K	446_Q	1.206	1.00
153_M	157_I	1.203	1.00
450_E	489_L	1.201	1.00
384_L	527_F	1.200	1.00
343_S	355_Q	1.196	1.00
400_V	404_Q	1.193	1.00
390_P	402_I	1.191	1.00
34_M	148_T	1.187	1.00
453_F	457_L	1.185	1.00
267_L	272_E	1.184	1.00
456_D	460_L	1.184	1.00
367_V	527_F	1.183	1.00
336_D	399_G	1.179	1.00
212_R	217_E	1.177	1.00
542_I	556_H	1.175	1.00
459_M	479_Q	1.173	1.00
436_K	439_A	1.171	1.00
521_R	526_T	1.170	1.00
448_I	453_F	1.166	1.00
363_K	494_E	1.161	1.00
481_Q	503_S	1.157	1.00
447_A	489_L	1.154	1.00
204_S	220_D	1.154	1.00
161_L	281_F	1.153	1.00
222_R	226_E	1.153	1.00
110_E	388_Y	1.152	1.00
325_P	404_Q	1.146	1.00
274_T	277_E	1.143	1.00
359_F	380_I	1.141	1.00
475_L	483_I	1.138	1.00
357_I	380_I	1.134	1.00
407_L	411_R	1.133	1.00
445_Q	448_I	1.131	1.00
218_T	222_R	1.130	1.00
97_L	315_T	1.125	1.00
207_G	422_L	1.124	1.00
95_T	99_G	1.123	1.00
400_V	405_I	1.122	1.00
452_H	509_T	1.119	1.00
440_T	490_M	1.113	1.00
334_P	363_K	1.110	1.00
155_F	159_W	1.108	1.00
229_A	233_Q	1.106	1.00
116_D	195_G	1.100	1.00
452_H	516_N	1.093	1.00
458_H	463_G	1.091	1.00
361_V	525_T	1.089	1.00
563_N	571_E	1.089	1.00
155_F	162_T	1.088	1.00
41_G	45_D	1.087	1.00
324_D	407_L	1.086	1.00
352_D	391_G	1.078	1.00
28_A	74_M	1.076	1.00
451_A	486_A	1.075	1.00
341_H	392_E	1.074	1.00
366_T	526_T	1.072	1.00
339_F	395_I	1.067	1.00
100_H	103_T	1.065	1.00
417_V	488_A	1.062	1.00
112_N	116_D	1.061	1.00
530_T	536_V	1.048	1.00
55_E	59_F	1.046	1.00
455_K	459_M	1.044	1.00
556_H	560_L	1.044	1.00
263_Y	267_L	1.042	1.00
186_R	237_K	1.042	1.00
309_L	313_N	1.038	1.00
383_Q	390_P	1.035	1.00
38_K	42_N	1.035	1.00
196_A	227_M	1.035	1.00
110_E	382_K	1.034	1.00
160_K	272_E	1.034	1.00
99_G	103_T	1.033	1.00
339_F	380_I	1.032	1.00
113_R	116_D	1.028	1.00
337_I	384_L	1.024	1.00
220_D	223_R	1.023	1.00
84_G	88_L	1.022	1.00
500_D	531_H	1.016	1.00
168_P	256_S	1.015	1.00
488_A	496_L	1.013	1.00
452_H	515_K	1.008	1.00
330_D	333_E	1.008	1.00
421_H	484_S	1.004	1.00
544_V	565_W	0.999	1.00
159_W	163_F	0.997	1.00
395_I	402_I	0.997	1.00
25_L	77_F	0.997	1.00
430_E	433_L	0.996	1.00
494_E	524_K	0.993	1.00
226_E	230_D	0.991	1.00
565_W	569_Q	0.990	1.00
365_Q	553_R	0.987	1.00
224_F	228_T	0.987	1.00
346_Y	353_N	0.984	1.00
373_T	482_R	0.983	1.00
397_F	410_L	0.983	1.00
409_R	412_G	0.982	1.00
39_L	60_Y	0.982	1.00
92_I	96_K	0.981	1.00
444_V	464_L	0.980	1.00
528_I	539_A	0.980	1.00
496_L	524_K	0.979	1.00
156_L	159_W	0.976	1.00
477_G	482_R	0.974	1.00
237_K	240_F	0.973	1.00
16_W	20_T	0.972	1.00
18_R	84_G	0.970	1.00
20_T	24_V	0.969	1.00
232_Y	236_M	0.969	1.00
211_I	220_D	0.967	1.00
347_P	351_S	0.966	1.00
457_L	464_L	0.964	1.00
447_A	490_M	0.963	1.00
127_A	308_S	0.962	1.00
22_A	82_L	0.959	1.00
462_S	465_E	0.958	1.00
200_R	223_R	0.958	1.00
368_G	530_T	0.958	1.00
178_L	182_K	0.956	1.00
378_T	382_K	0.956	1.00
338_V	399_G	0.956	1.00
452_H	519_E	0.956	1.00
352_D	392_E	0.952	1.00
265_A	269_F	0.952	1.00
41_G	277_E	0.951	1.00
216_Q	220_D	0.949	1.00
154_G	281_F	0.945	1.00
545_M	550_I	0.943	1.00
342_V	383_Q	0.939	1.00
105_S	321_D	0.938	1.00
345_T	353_N	0.937	1.00
450_E	520_N	0.937	1.00
163_F	167_I	0.936	1.00
446_Q	492_N	0.934	1.00
512_A	515_K	0.934	1.00
429_K	464_L	0.932	1.00
337_I	397_F	0.931	1.00
219_N	223_R	0.931	1.00
397_F	495_I	0.927	1.00
468_V	474_A	0.925	1.00
42_N	46_D	0.925	1.00
264_G	278_L	0.923	1.00
485_I	498_L	0.917	1.00
375_S	545_M	0.915	1.00
182_K	241_I	0.915	1.00
223_R	227_M	0.913	1.00
508_K	512_A	0.913	1.00
338_V	358_S	0.910	1.00
429_K	445_Q	0.908	1.00
189_E	193_A	0.907	1.00
306_N	310_D	0.906	1.00
356_D	392_E	0.904	1.00
158_S	162_T	0.903	1.00
25_L	81_Q	0.901	1.00
17_L	21_I	0.900	1.00
175_A	248_T	0.900	1.00
59_F	62_G	0.900	1.00
385_L	497_I	0.899	1.00
96_K	100_H	0.899	1.00
386_R	407_L	0.897	1.00
458_H	464_L	0.895	1.00
188_T	192_N	0.893	1.00
66_V	70_A	0.888	1.00
444_V	490_M	0.888	1.00
417_V	485_I	0.887	1.00
124_D	308_S	0.887	1.00
439_A	443_E	0.887	1.00
91_K	95_T	0.884	1.00
449_A	458_H	0.883	1.00
566_Y	569_Q	0.883	1.00
368_G	542_I	0.882	1.00
564_G	567_R	0.882	1.00
225_N	229_A	0.881	1.00
366_T	521_R	0.881	1.00
405_I	410_L	0.880	1.00
229_A	232_Y	0.879	1.00
108_F	112_N	0.879	1.00
390_P	395_I	0.875	1.00
432_I	483_I	0.873	1.00
469_G	473_V	0.872	1.00
230_D	234_K	0.871	1.00
409_R	413_W	0.868	1.00
10_W	13_K	0.867	1.00
558_E	561_A	0.865	1.00
120_R	314_E	0.863	1.00
390_P	403_Q	0.862	1.00
394_S	403_Q	0.859	1.00
453_F	459_M	0.859	1.00
532_R	535_A	0.856	1.00
189_E	237_K	0.854	1.00
107_P	321_D	0.851	1.00
268_V	273_L	0.851	1.00
363_K	398_S	0.849	1.00
97_L	121_G	0.849	1.00
15_Y	88_L	0.848	1.00
423_L	483_I	0.848	1.00
186_R	234_K	0.848	1.00
385_L	414_I	0.847	1.00
219_N	222_R	0.847	1.00
496_L	521_R	0.846	1.00
550_I	553_R	0.846	1.00
154_G	157_I	0.844	1.00
366_T	518_R	0.844	1.00
408_D	412_G	0.844	1.00
502_L	513_I	0.843	1.00
209_R	382_K	0.841	1.00
357_I	550_I	0.838	1.00
468_V	472_G	0.837	1.00
164_A	263_Y	0.833	1.00
451_A	482_R	0.831	1.00
493_P	524_K	0.831	1.00
423_L	480_K	0.830	1.00
345_T	348_S	0.830	1.00
190_A	235_N	0.830	1.00
22_A	85_G	0.830	1.00
154_G	162_T	0.827	1.00
322_V	389_P	0.826	1.00
402_I	410_L	0.825	1.00
453_F	483_I	0.823	1.00
32_I	74_M	0.822	1.00
546_D	549_V	0.822	1.00
182_K	186_R	0.821	1.00
32_I	70_A	0.818	1.00
340_S	360_T	0.816	1.00
345_T	349_S	0.813	1.00
223_R	226_E	0.811	1.00
157_I	277_E	0.811	1.00
325_P	328_P	0.811	1.00
222_R	225_N	0.810	1.00
185_E	189_E	0.809	1.00
319_E	323_T	0.806	1.00
568_E	571_E	0.806	1.00
514_I	530_T	0.805	1.00
267_L	270_R	0.805	1.00
210_V	214_Y	0.802	1.00
150_F	162_T	0.802	1.00
104_M	318_Y	0.800	1.00
405_I	409_R	0.800	1.00
117_L	315_T	0.798	1.00
427_T	430_E	0.798	1.00
432_I	464_L	0.797	1.00
424_F	431_N	0.796	1.00
173_A	177_S	0.796	1.00
450_E	454_E	0.796	1.00
221_V	225_N	0.796	1.00
335_G	525_T	0.794	1.00
345_T	351_S	0.791	1.00
396_T	399_G	0.791	1.00
100_H	319_E	0.790	1.00
343_S	391_G	0.789	1.00
337_I	495_I	0.788	1.00
227_M	230_D	0.787	1.00
116_D	120_R	0.786	1.00
461_P	466_T	0.785	1.00
9_G	13_K	0.785	1.00
97_L	312_V	0.785	1.00
158_S	273_L	0.782	1.00
333_E	398_S	0.782	1.00
496_L	526_T	0.781	1.00
39_L	67_L	0.781	1.00
218_T	221_V	0.776	1.00
268_V	278_L	0.775	1.00
348_S	351_S	0.770	1.00
510_E	514_I	0.770	1.00
177_S	181_S	0.769	1.00
9_G	12_F	0.764	1.00
276_G	280_S	0.763	1.00
73_I	77_F	0.762	1.00
32_I	67_L	0.762	1.00
42_N	60_Y	0.762	1.00
236_M	240_F	0.762	1.00
312_V	316_L	0.761	1.00
414_I	495_I	0.761	1.00
456_D	459_M	0.760	1.00
56_G	59_F	0.760	1.00
433_L	438_D	0.757	1.00
234_K	237_K	0.755	1.00
160_K	267_L	0.752	1.00
38_K	41_G	0.752	1.00
61_I	65_F	0.750	1.00
120_R	124_D	0.749	1.00
208_V	212_R	0.749	1.00
433_L	437_Q	0.748	1.00
107_P	111_K	0.747	1.00
420_D	480_K	0.747	1.00
514_I	535_A	0.746	1.00
460_L	475_L	0.746	1.00
332_K	398_S	0.746	1.00
412_G	491_A	0.745	1.00
39_L	63_I	0.744	1.00
127_A	304_R	0.743	1.00
143_T	147_M	0.742	1.00
160_K	163_F	0.740	1.00
556_H	570_Y	0.740	1.00
370_A	544_V	0.740	1.00
433_L	436_K	0.740	1.00
76_Y	80_H	0.738	1.00
207_G	210_V	0.738	1.00
267_L	271_N	0.737	1.00
264_G	268_V	0.737	1.00
42_N	45_D	0.736	1.00
153_M	156_L	0.736	1.00
193_A	227_M	0.736	1.00
131_T	305_G	0.732	1.00
560_L	567_R	0.731	1.00
101_L	109_Y	0.730	1.00
233_Q	237_K	0.730	1.00
197_L	231_V	0.729	1.00
62_G	65_F	0.728	1.00
105_S	322_V	0.728	1.00
329_A	332_K	0.728	1.00
230_D	233_Q	0.724	1.00
330_D	409_R	0.724	1.00
481_Q	504_A	0.724	1.00
31_V	35_F	0.723	1.00
28_A	70_A	0.722	1.00
373_T	500_D	0.721	1.00
477_G	504_A	0.719	1.00
162_T	281_F	0.716	1.00
63_I	66_V	0.716	1.00
355_Q	547_G	0.715	1.00
26_L	141_D	0.713	1.00
44_I	279_V	0.713	1.00
189_E	192_N	0.712	1.00
167_I	170_P	0.711	1.00
251_L	255_A	0.711	1.00
60_Y	63_I	0.710	1.00
131_T	302_M	0.709	1.00
45_D	48_K	0.709	1.00
24_V	28_A	0.709	1.00
390_P	394_S	0.709	1.00
453_F	464_L	0.708	1.00
364_G	523_G	0.707	1.00
502_L	510_E	0.706	1.00
364_G	525_T	0.704	1.00
174_I	177_S	0.703	1.00
46_D	56_G	0.700	1.00
18_R	88_L	0.700	1.00
450_E	516_N	0.700	1.00
513_I	516_N	0.699	1.00
181_S	185_E	0.699	1.00
521_R	524_K	0.698	1.00
310_D	314_E	0.697	1.00
447_A	486_A	0.697	1.00
482_R	509_T	0.695	1.00
436_K	492_N	0.695	1.00
30_N	144_M	0.693	1.00
70_A	74_M	0.693	1.00
346_Y	379_T	0.691	1.00
126_Q	129_S	0.689	1.00
428_V	457_L	0.687	1.00
96_K	99_G	0.686	1.00
557_Q	560_L	0.685	1.00
21_I	81_Q	0.685	1.00
142_S	294_A	0.683	1.00
452_H	455_K	0.681	1.00
396_T	401_P	0.681	1.00
361_V	365_Q	0.680	1.00
104_M	320_T	0.679	1.00
191_Q	194_F	0.674	1.00
46_D	49_A	0.674	1.00
382_K	388_Y	0.673	1.00
334_P	525_T	0.672	1.00
367_V	553_R	0.669	1.00
552_E	565_W	0.668	1.00
305_G	308_S	0.667	1.00
410_L	414_I	0.666	1.00
141_D	145_F	0.664	1.00
445_Q	457_L	0.661	1.00
99_G	221_V	0.661	1.00
516_N	519_E	0.660	1.00
381_I	527_F	0.660	1.00
541_L	555_T	0.659	1.00
436_K	491_A	0.658	1.00
443_E	447_A	0.658	1.00
97_L	316_L	0.657	1.00
119_A	198_N	0.657	1.00
383_Q	388_Y	0.657	1.00
562_N	565_W	0.655	1.00
552_E	559_L	0.654	1.00
425_S	469_G	0.652	1.00
497_I	527_F	0.651	1.00
29_V	75_S	0.651	1.00
124_D	128_V	0.648	1.00
149_I	287_M	0.646	1.00
113_R	199_D	0.646	1.00
96_K	316_L	0.645	1.00
366_T	538_H	0.645	1.00
420_D	471_K	0.644	1.00
18_R	81_Q	0.642	1.00
426_R	467_M	0.642	1.00
329_A	400_V	0.642	1.00
10_W	96_K	0.642	1.00
15_Y	18_R	0.641	1.00
354_L	545_M	0.641	1.00
13_K	17_L	0.640	1.00
369_I	527_F	0.640	1.00
116_D	311_R	0.640	1.00
485_I	489_L	0.640	1.00
93_L	125_L	0.640	1.00
328_P	333_E	0.638	1.00
339_F	357_I	0.638	1.00
34_M	37_P	0.637	1.00
433_L	448_I	0.637	1.00
26_L	78_W	0.637	1.00
344_F	353_N	0.637	1.00
263_Y	266_F	0.637	1.00
153_M	158_S	0.635	1.00
536_V	539_A	0.635	1.00
97_L	125_L	0.635	1.00
186_R	189_E	0.634	1.00
423_L	468_V	0.631	1.00
90_E	94_R	0.630	1.00
90_E	129_S	0.630	1.00
155_F	166_I	0.630	1.00
323_T	326_K	0.630	1.00
476_S	479_Q	0.629	1.00
100_H	318_Y	0.629	1.00
397_F	402_I	0.629	1.00
463_G	466_T	0.628	1.00
69_A	73_I	0.626	1.00
187_F	238_V	0.626	1.00
541_L	558_E	0.625	1.00
510_E	535_A	0.625	1.00
552_E	560_L	0.624	1.00
106_P	110_E	0.623	1.00
448_I	451_A	0.623	1.00
485_I	513_I	0.623	1.00
250_K	293_F	0.622	1.00
552_E	568_E	0.620	1.00
56_G	60_Y	0.620	1.00
149_I	288_M	0.619	1.00
142_S	146_M	0.619	1.00
161_L	267_L	0.619	1.00
427_T	465_E	0.619	1.00
425_S	474_A	0.617	1.00
556_H	559_L	0.617	1.00
124_D	191_Q	0.617	1.00
88_L	91_K	0.617	1.00
446_Q	520_N	0.616	1.00
331_L	405_I	0.615	1.00
563_N	568_E	0.614	1.00
239_A	243_S	0.613	1.00
381_I	416_Y	0.613	1.00
157_I	280_S	0.613	1.00
441_D	464_L	0.611	1.00
335_G	494_E	0.611	1.00
290_W	294_A	0.611	1.00
195_G	311_R	0.611	1.00
255_A	259_I	0.610	1.00
144_M	148_T	0.609	1.00
329_A	333_E	0.609	1.00
83_F	134_F	0.608	1.00
451_A	485_I	0.608	1.00
145_F	149_I	0.607	1.00
139_L	143_T	0.607	1.00
507_A	510_E	0.606	1.00
342_V	393_G	0.606	1.00
349_S	352_D	0.606	1.00
398_S	494_E	0.604	1.00
128_V	309_L	0.603	1.00
482_R	505_V	0.602	1.00
553_R	558_E	0.601	1.00
237_K	241_I	0.601	1.00
373_T	530_T	0.601	1.00
348_S	391_G	0.601	1.00
265_A	268_V	0.600	1.00
357_I	545_M	0.600	1.00
108_F	117_L	0.599	1.00
28_A	32_I	0.599	1.00
54_A	58_L	0.599	1.00
505_V	509_T	0.598	1.00
361_V	366_T	0.598	1.00
146_M	150_F	0.597	1.00
45_D	49_A	0.597	1.00
452_H	513_I	0.596	1.00
441_D	448_I	0.595	1.00
390_P	401_P	0.595	1.00
359_F	550_I	0.595	1.00
444_V	448_I	0.594	1.00
345_T	392_E	0.594	1.00
91_K	228_T	0.592	1.00
451_A	489_L	0.592	1.00
566_Y	570_Y	0.591	1.00
38_K	153_M	0.591	1.00
436_K	440_T	0.591	1.00
495_I	525_T	0.590	1.00
38_K	157_I	0.589	1.00
191_Q	307_A	0.589	1.00
478_G	506_D	0.588	1.00
325_P	406_P	0.587	1.00
210_V	213_A	0.586	1.00
93_L	128_V	0.586	1.00
362_R	367_V	0.586	1.00
35_F	67_L	0.584	1.00
156_L	160_K	0.584	1.00
128_V	312_V	0.584	1.00
342_V	358_S	0.584	1.00
510_E	534_S	0.584	1.00
193_A	231_V	0.584	1.00
562_N	567_R	0.584	1.00
119_A	195_G	0.583	1.00
454_E	457_L	0.582	1.00
328_P	406_P	0.581	1.00
125_L	129_S	0.580	1.00
417_V	498_L	0.580	1.00
415_G	491_A	0.580	1.00
397_F	405_I	0.580	1.00
328_P	332_K	0.579	1.00
308_S	311_R	0.578	1.00
179_Y	245_F	0.578	1.00
189_E	230_D	0.576	1.00
506_D	509_T	0.576	1.00
514_I	528_I	0.576	1.00
273_L	277_E	0.575	1.00
547_G	551_A	0.574	1.00
327_Q	404_Q	0.574	1.00
175_A	252_L	0.573	1.00
322_V	386_R	0.573	1.00
83_F	87_N	0.573	1.00
41_G	276_G	0.572	1.00
86_A	133_G	0.572	1.00
273_L	278_L	0.571	1.00
165_A	285_L	0.569	1.00
352_D	356_D	0.569	1.00
233_Q	236_M	0.567	1.00
147_M	152_T	0.567	1.00
130_L	301_V	0.567	1.00
200_R	204_S	0.567	1.00
119_A	194_F	0.567	1.00
17_L	20_T	0.567	1.00
98_M	102_L	0.566	1.00
436_K	490_M	0.565	1.00
537_E	556_H	0.564	1.00
428_V	468_V	0.563	1.00
170_P	174_I	0.563	1.00
20_T	23_I	0.562	1.00
178_L	181_S	0.562	1.00
449_A	455_K	0.562	1.00
407_L	410_L	0.562	1.00
357_I	543_L	0.561	1.00
55_E	58_L	0.561	1.00
58_L	61_I	0.560	1.00
342_V	395_I	0.559	1.00
152_T	155_F	0.559	1.00
433_L	490_M	0.558	1.00
80_H	84_G	0.558	1.00
542_I	555_T	0.556	1.00
105_S	108_F	0.556	1.00
125_L	312_V	0.556	1.00
515_K	518_R	0.556	1.00
130_L	134_F	0.555	1.00
192_N	196_A	0.555	1.00
544_V	552_E	0.555	1.00
173_A	176_I	0.553	1.00
87_N	90_E	0.553	1.00
512_A	516_N	0.552	1.00
15_Y	89_M	0.552	1.00
160_K	263_Y	0.552	1.00
431_N	483_I	0.551	1.00
115_G	199_D	0.549	1.00
29_V	74_M	0.548	1.00
418_P	421_H	0.548	1.00
119_A	123_N	0.547	1.00
515_K	538_H	0.547	1.00
15_Y	85_G	0.547	1.00
382_K	416_Y	0.543	1.00
14_A	96_K	0.543	1.00
501_S	530_T	0.543	1.00
106_P	387_Q	0.542	1.00
38_K	280_S	0.542	1.00
449_A	464_L	0.542	1.00
111_K	347_P	0.541	1.00
171_V	174_I	0.541	1.00
355_Q	358_S	0.538	1.00
243_S	247_P	0.538	1.00
400_V	409_R	0.537	1.00
489_L	520_N	0.537	1.00
348_S	352_D	0.536	1.00
138_T	294_A	0.534	1.00
65_F	69_A	0.534	1.00
327_Q	406_P	0.534	1.00
63_I	67_L	0.533	1.00
72_Y	76_Y	0.533	1.00
74_M	77_F	0.532	1.00
448_I	486_A	0.531	1.00
254_G	258_L	0.531	1.00
33_E	71_V	0.531	1.00
419_Q	477_G	0.530	1.00
120_R	311_R	0.529	1.00
444_V	447_A	0.528	1.00
362_R	525_T	0.528	1.00
551_A	563_N	0.528	1.00
560_L	571_E	0.526	1.00
379_T	388_Y	0.526	1.00
373_T	505_V	0.526	1.00
495_I	527_F	0.526	1.00
90_E	125_L	0.525	1.00
370_A	536_V	0.525	1.00
328_P	400_V	0.525	1.00
30_N	34_M	0.524	1.00
432_I	435_G	0.524	1.00
417_V	501_S	0.524	1.00
186_R	238_V	0.523	1.00
509_T	513_I	0.523	1.00
149_I	284_Y	0.521	1.00
190_A	238_V	0.519	1.00
77_F	81_Q	0.518	1.00
102_L	105_S	0.518	1.00
155_F	158_S	0.518	1.00
159_W	162_T	0.517	1.00
284_Y	291_P	0.517	1.00
527_F	543_L	0.517	1.00
378_T	381_I	0.517	1.00
264_G	267_L	0.516	1.00
514_I	538_H	0.515	1.00
200_R	220_D	0.515	1.00
134_F	138_T	0.515	1.00
369_I	545_M	0.515	1.00
123_N	191_Q	0.515	1.00
560_L	563_N	0.515	1.00
166_I	170_P	0.515	1.00
148_T	152_T	0.515	1.00
366_T	523_G	0.514	1.00
158_S	161_L	0.514	1.00
530_T	534_S	0.513	1.00
109_Y	112_N	0.512	1.00
361_V	543_L	0.512	1.00
194_F	198_N	0.512	1.00
165_A	288_M	0.512	1.00
427_T	467_M	0.512	1.00
478_G	482_R	0.511	1.00
11_F	93_L	0.511	1.00
428_V	453_F	0.511	1.00
565_W	570_Y	0.509	1.00
564_G	569_Q	0.509	1.00
406_P	410_L	0.508	1.00
321_D	411_R	0.508	1.00
369_I	529_L	0.508	1.00
528_I	536_V	0.507	1.00
502_L	505_V	0.507	1.00
379_T	383_Q	0.507	1.00
544_V	551_A	0.506	1.00
501_S	528_I	0.506	1.00
39_L	64_F	0.506	1.00
386_R	402_I	0.506	1.00
52_F	56_G	0.506	1.00
114_T	118_M	0.505	1.00
338_V	394_S	0.505	1.00
520_N	523_G	0.504	1.00
343_S	354_L	0.504	1.00
30_N	33_E	0.504	1.00
39_L	42_N	0.504	1.00
121_G	125_L	0.504	1.00
269_F	272_E	0.504	1.00
370_A	533_L	0.503	1.00
442_K	449_A	0.503	1.00
207_G	424_F	0.503	1.00
482_R	504_A	0.503	1.00
507_A	534_S	0.503	1.00
349_S	353_N	0.503	1.00
171_V	175_A	0.502	1.00
231_V	235_N	0.502	1.00
80_H	83_F	0.502	1.00
516_N	520_N	0.502	1.00
360_T	553_R	0.501	1.00
498_L	501_S	0.501	1.00
196_A	199_D	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ry2A	2	0.959	100	0.093	Contact Map
4a82A	2	0.9761	100	0.12	Contact Map
4q4hB	1	0.9778	100	0.149	Contact Map
3b60A	2	0.9761	100	0.156	Contact Map
3b5xA	2	0.9761	100	0.156	Contact Map
4f4cA	1	0.9607	100	0.159	Contact Map
4q4hA	1	0.9744	100	0.169	Contact Map
4mrsA	2	0.9966	100	0.169	Contact Map
3zdqA	2	0.959	100	0.172	Contact Map
4q9hA	1	0.9795	100	0.178	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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