YHEH - BACSU - GREMLIN Contacts

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YHEH - Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH

UniProt:	O07549	Sequences: MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMIDDHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQAVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLLVFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTEAIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASYYNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNSLMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQFSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHISFTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGIVLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGSTLSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHRLSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	673 (557)
Sequences:	50694 (35547)
Seq/√Len:	1506.2

ECOLI - MSBA MDLB MDLA CYDD CYDC YOJI YDDA
BACSU - YHEH SUNT YFIC BMRA YKNV YGAD YWJA CYDD YFIB YHEI YKNU CYDC
HALSA - Q9HSQ7
SULSO - Q97UJ9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
546_E	556_I	4.457	1.00
431_E	452_T	4.406	1.00
454_Q	457_E	4.173	1.00
457_E	633_Q	4.134	1.00
633_Q	645_R	4.115	1.00
434_D	448_H	4.115	1.00
518_G	522_S	3.887	1.00
521_G	533_E	3.847	1.00
541_R	546_E	3.847	1.00
433_R	486_D	3.823	1.00
648_H	658_Y	3.574	1.00
429_R	452_T	3.569	1.00
433_R	488_L	3.547	1.00
546_E	550_K	3.473	1.00
486_D	493_S	3.240	1.00
447_K	641_E	3.108	1.00
521_G	557_N	3.041	1.00
655_E	659_Y	3.021	1.00
533_E	537_K	2.961	1.00
521_G	525_S	2.958	1.00
444_E	447_K	2.955	1.00
532_T	535_E	2.853	1.00
432_F	435_V	2.815	1.00
659_Y	663_E	2.786	1.00
540_L	556_I	2.776	1.00
436_S	448_H	2.721	1.00
644_E	654_L	2.628	1.00
505_H	586_A	2.599	1.00
473_L	621_I	2.582	1.00
431_E	488_L	2.566	1.00
473_L	589_I	2.531	1.00
538_N	542_Q	2.521	1.00
647_N	650_E	2.432	1.00
429_R	454_Q	2.416	1.00
537_K	546_E	2.407	1.00
438_A	444_E	2.403	1.00
635_L	645_R	2.401	1.00
243_T	247_L	2.369	1.00
498_S	501_E	2.334	1.00
554_K	558_E	2.332	1.00
436_S	444_E	2.321	1.00
584_D	616_R	2.312	1.00
436_S	484_K	2.298	1.00
453_A	459_V	2.289	1.00
521_G	536_I	2.277	1.00
478_R	481_D	2.275	1.00
524_V	540_L	2.261	1.00
528_D	535_E	2.187	1.00
507_G	585_P	2.165	1.00
644_E	656_G	2.154	1.00
644_E	655_E	2.135	1.00
429_R	455_K	2.131	1.00
458_T	631_A	2.114	1.00
108_G	111_T	2.107	1.00
451_F	635_L	2.056	1.00
537_K	541_R	2.039	1.00
610_D	630_N	2.014	1.00
638_D	657_Q	2.012	1.00
545_A	548_L	1.974	1.00
139_F	370_G	1.969	1.00
535_E	584_D	1.954	1.00
453_A	619_F	1.947	1.00
481_D	495_Y	1.933	1.00
524_V	536_I	1.928	1.00
438_A	483_Q	1.915	1.00
646_G	650_E	1.908	1.00
537_K	550_K	1.895	1.00
432_F	451_F	1.893	1.00
284_I	321_S	1.890	1.00
150_V	154_C	1.882	1.00
434_D	450_S	1.870	1.00
602_E	624_R	1.841	1.00
428_G	490_D	1.793	1.00
638_D	643_V	1.787	1.00
407_F	411_E	1.777	1.00
192_H	414_N	1.765	1.00
525_S	536_I	1.764	1.00
533_E	557_N	1.761	1.00
459_V	633_Q	1.736	1.00
459_V	635_L	1.734	1.00
472_I	637_L	1.711	1.00
418_A	498_S	1.701	1.00
538_N	541_R	1.699	1.00
307_H	310_E	1.683	1.00
544_G	604_V	1.682	1.00
525_S	533_E	1.674	1.00
635_L	642_I	1.663	1.00
539_A	543_V	1.663	1.00
542_Q	611_V	1.663	1.00
643_V	657_Q	1.659	1.00
139_F	368_S	1.656	1.00
458_T	620_V	1.652	1.00
603_A	607_K	1.644	1.00
457_E	632_D	1.633	1.00
430_V	619_F	1.629	1.00
249_D	361_L	1.617	1.00
111_T	114_D	1.613	1.00
460_A	631_A	1.605	1.00
154_C	158_G	1.564	1.00
535_E	538_N	1.561	1.00
493_S	496_N	1.560	1.00
427_L	490_D	1.553	1.00
461_L	635_L	1.544	1.00
561_I	566_T	1.543	1.00
560_V	567_L	1.539	1.00
216_D	405_R	1.538	1.00
650_E	654_L	1.536	1.00
429_R	490_D	1.535	1.00
597_I	605_I	1.527	1.00
112_V	115_G	1.526	1.00
644_E	659_Y	1.522	1.00
279_Q	404_G	1.518	1.00
652_M	662_Y	1.511	1.00
151_L	155_L	1.501	1.00
531_M	582_A	1.500	1.00
537_K	556_I	1.494	1.00
547_P	550_K	1.494	1.00
657_Q	660_Q	1.488	1.00
195_K	414_N	1.479	1.00
554_K	559_P	1.462	1.00
360_S	364_A	1.460	1.00
540_L	549_L	1.456	1.00
287_D	321_S	1.442	1.00
534_E	537_K	1.435	1.00
524_V	582_A	1.429	1.00
629_R	649_E	1.425	1.00
291_K	318_L	1.425	1.00
454_Q	633_Q	1.420	1.00
461_L	472_I	1.419	1.00
246_F	253_A	1.416	1.00
446_L	449_I	1.407	1.00
464_H	638_D	1.396	1.00
432_F	476_L	1.396	1.00
649_E	653_A	1.395	1.00
611_V	614_Q	1.390	1.00
280_K	325_F	1.377	1.00
437_F	471_S	1.373	1.00
540_L	546_E	1.366	1.00
517_S	559_P	1.363	1.00
246_F	250_V	1.363	1.00
657_Q	661_M	1.361	1.00
477_F	508_I	1.357	1.00
106_F	110_R	1.356	1.00
475_L	487_V	1.353	1.00
192_H	196_M	1.349	1.00
135_K	374_A	1.345	1.00
435_V	482_A	1.338	1.00
607_K	611_V	1.336	1.00
622_A	627_T	1.331	1.00
658_Y	661_M	1.311	1.00
284_I	325_F	1.309	1.00
284_I	287_D	1.308	1.00
548_L	571_E	1.298	1.00
533_E	536_I	1.297	1.00
426_A	490_D	1.291	1.00
448_H	641_E	1.289	1.00
111_T	115_G	1.284	1.00
507_G	580_A	1.282	1.00
273_Y	276_Y	1.279	1.00
525_S	531_M	1.278	1.00
535_E	582_A	1.275	1.00
460_A	628_I	1.274	1.00
534_E	538_N	1.274	1.00
111_T	188_D	1.271	1.00
428_G	455_K	1.266	1.00
110_R	113_S	1.264	1.00
552_L	558_E	1.263	1.00
437_F	480_Y	1.259	1.00
108_G	112_V	1.254	1.00
419_G	496_N	1.254	1.00
311_T	526_L	1.253	1.00
436_S	447_K	1.240	1.00
492_K	496_N	1.240	1.00
135_K	139_F	1.239	1.00
542_Q	581_L	1.233	1.00
433_R	450_S	1.232	1.00
437_F	475_L	1.229	1.00
613_K	618_T	1.223	1.00
265_L	269_I	1.216	1.00
132_K	136_Q	1.204	1.00
320_E	324_Y	1.202	1.00
464_H	657_Q	1.198	1.00
451_F	472_I	1.198	1.00
429_R	491_G	1.197	1.00
295_S	311_T	1.185	1.00
465_T	601_T	1.183	1.00
655_E	663_E	1.178	1.00
476_L	619_F	1.177	1.00
545_A	549_L	1.176	1.00
187_Q	191_S	1.174	1.00
309_K	313_R	1.171	1.00
192_H	410_L	1.169	1.00
444_E	483_Q	1.165	1.00
427_L	455_K	1.162	1.00
459_V	619_F	1.155	1.00
455_K	586_A	1.154	1.00
361_L	366_I	1.151	1.00
313_R	317_E	1.143	1.00
551_K	571_E	1.142	1.00
368_S	371_V	1.141	1.00
550_K	555_G	1.140	1.00
245_L	375_F	1.135	1.00
287_D	318_L	1.133	1.00
449_I	472_I	1.133	1.00
354_W	360_S	1.127	1.00
540_L	545_A	1.122	1.00
528_D	531_M	1.122	1.00
520_I	575_I	1.120	1.00
131_E	378_Y	1.120	1.00
482_A	494_I	1.119	1.00
634_I	648_H	1.117	1.00
191_S	195_K	1.114	1.00
548_L	552_L	1.112	1.00
277_Y	328_R	1.109	1.00
119_I	166_F	1.108	1.00
561_I	564_G	1.106	1.00
252_L	375_F	1.103	1.00
499_R	503_R	1.103	1.00
573_Q	595_A	1.097	1.00
202_D	480_Y	1.096	1.00
492_K	497_M	1.091	1.00
418_A	499_R	1.085	1.00
537_K	540_L	1.084	1.00
501_E	504_S	1.083	1.00
539_A	581_L	1.079	1.00
189_V	409_L	1.078	1.00
298_G	514_Y	1.077	1.00
192_H	195_K	1.072	1.00
204_L	208_K	1.070	1.00
303_Q	308_Q	1.064	1.00
184_K	188_D	1.064	1.00
458_T	618_T	1.061	1.00
107_D	111_T	1.060	1.00
432_F	472_I	1.059	1.00
124_K	128_Y	1.058	1.00
544_G	607_K	1.056	1.00
544_G	601_T	1.055	1.00
648_H	652_M	1.052	1.00
509_V	580_A	1.044	1.00
532_T	582_A	1.043	1.00
620_V	631_A	1.043	1.00
567_L	575_I	1.039	1.00
107_D	411_E	1.036	1.00
317_E	321_S	1.036	1.00
208_K	286_S	1.035	1.00
432_F	487_V	1.034	1.00
176_M	180_R	1.034	1.00
434_D	484_K	1.033	1.00
205_P	208_K	1.032	1.00
547_P	551_K	1.031	1.00
269_I	273_Y	1.026	1.00
430_V	476_L	1.025	1.00
128_Y	240_G	1.022	1.00
656_G	659_Y	1.021	1.00
323_F	327_N	1.020	1.00
403_A	407_F	1.020	1.00
489_I	502_L	1.015	1.00
311_T	314_E	1.014	1.00
136_Q	140_Q	1.013	1.00
120_T	124_K	1.012	1.00
543_V	578_A	1.011	1.00
202_D	474_N	1.011	1.00
315_F	319_N	1.009	1.00
453_A	617_T	1.008	1.00
107_D	110_R	1.006	1.00
604_V	607_K	1.006	1.00
291_K	314_E	1.006	1.00
622_A	628_I	1.005	1.00
328_R	331_N	1.004	1.00
444_E	484_K	1.003	1.00
586_A	616_R	1.003	1.00
544_G	611_V	0.998	1.00
219_A	402_S	0.997	1.00
636_V	657_Q	0.993	1.00
538_N	584_D	0.991	1.00
475_L	482_A	0.983	1.00
544_G	608_A	0.983	1.00
251_K	366_I	0.982	1.00
439_Y	445_V	0.977	1.00
513_P	576_S	0.977	1.00
259_I	348_A	0.968	1.00
549_L	556_I	0.967	1.00
239_F	243_T	0.964	1.00
307_H	311_T	0.960	1.00
280_K	284_I	0.960	1.00
310_E	314_E	0.956	1.00
316_E	320_E	0.956	1.00
314_E	318_L	0.951	1.00
279_Q	283_S	0.949	1.00
254_F	258_A	0.947	1.00
539_A	582_A	0.945	1.00
106_F	111_T	0.944	1.00
522_S	525_S	0.944	1.00
600_E	604_V	0.942	1.00
433_R	452_T	0.941	1.00
457_E	645_R	0.939	1.00
521_G	537_K	0.939	1.00
133_L	152_L	0.935	1.00
431_E	491_G	0.933	1.00
321_S	325_F	0.933	1.00
119_I	169_G	0.933	1.00
536_I	556_I	0.933	1.00
650_E	653_A	0.929	1.00
542_Q	612_V	0.927	1.00
250_V	254_F	0.926	1.00
197_P	415_T	0.925	1.00
467_S	637_L	0.924	1.00
580_A	588_L	0.923	1.00
200_Y	204_L	0.923	1.00
122_G	166_F	0.923	1.00
302_I	311_T	0.921	1.00
478_R	499_R	0.919	1.00
135_K	371_V	0.918	1.00
151_L	154_C	0.917	1.00
108_G	114_D	0.916	1.00
588_L	616_R	0.909	1.00
501_E	505_H	0.906	1.00
400_R	404_G	0.906	1.00
465_T	574_L	0.906	1.00
183_Q	187_Q	0.905	1.00
435_V	475_L	0.903	1.00
448_H	484_K	0.902	1.00
320_E	323_F	0.901	1.00
560_V	566_T	0.899	1.00
554_K	557_N	0.897	1.00
541_R	550_K	0.897	1.00
438_A	445_V	0.896	1.00
487_V	494_I	0.895	1.00
497_M	502_L	0.895	1.00
248_L	371_V	0.893	1.00
637_L	642_I	0.892	1.00
147_K	151_L	0.890	1.00
592_E	623_H	0.886	1.00
280_K	328_R	0.886	1.00
273_Y	332_L	0.883	1.00
460_A	622_A	0.881	1.00
281_I	326_Q	0.880	1.00
199_R	415_T	0.880	1.00
500_Q	504_S	0.879	1.00
482_A	495_Y	0.878	1.00
264_W	268_V	0.878	1.00
460_A	634_I	0.877	1.00
158_G	162_F	0.876	1.00
486_D	495_Y	0.875	1.00
431_E	450_S	0.874	1.00
189_V	213_I	0.874	1.00
108_G	115_G	0.872	1.00
318_L	321_S	0.872	1.00
458_T	610_D	0.872	1.00
212_R	408_E	0.871	1.00
310_E	313_R	0.871	1.00
531_M	535_E	0.869	1.00
116_K	174_L	0.868	1.00
199_R	203_N	0.868	1.00
536_I	582_A	0.866	1.00
642_I	645_R	0.858	1.00
216_D	402_S	0.858	1.00
477_F	506_M	0.858	1.00
440_Q	443_E	0.857	1.00
489_I	587_I	0.855	1.00
106_F	109_N	0.855	1.00
115_G	184_K	0.855	1.00
561_I	565_S	0.854	1.00
477_F	589_I	0.853	1.00
509_V	577_F	0.852	1.00
312_M	316_E	0.851	1.00
545_A	551_K	0.850	1.00
638_D	641_E	0.849	1.00
521_G	556_I	0.847	1.00
359_A	363_A	0.847	1.00
660_Q	663_E	0.845	1.00
277_Y	325_F	0.844	1.00
455_K	490_D	0.843	1.00
355_H	361_L	0.842	1.00
425_R	490_D	0.842	1.00
276_Y	280_K	0.839	1.00
413_K	417_E	0.838	1.00
438_A	442_G	0.836	1.00
458_T	613_K	0.836	1.00
416_E	481_D	0.836	1.00
309_K	312_M	0.835	1.00
550_K	556_I	0.835	1.00
423_K	497_M	0.835	1.00
245_L	253_A	0.833	1.00
482_A	487_V	0.831	1.00
119_I	173_L	0.825	1.00
188_D	192_H	0.825	1.00
140_Q	143_Q	0.824	1.00
148_G	151_L	0.823	1.00
658_Y	662_Y	0.823	1.00
361_L	364_A	0.820	1.00
142_Y	145_E	0.819	1.00
132_K	135_K	0.819	1.00
313_R	316_E	0.818	1.00
268_V	272_R	0.818	1.00
421_P	492_K	0.818	1.00
423_K	426_A	0.817	1.00
300_T	474_N	0.817	1.00
548_L	551_K	0.816	1.00
655_E	660_Q	0.815	1.00
542_Q	546_E	0.815	1.00
314_E	317_E	0.813	1.00
266_W	340_L	0.811	1.00
624_R	627_T	0.810	1.00
656_G	661_M	0.807	1.00
515_L	575_I	0.806	1.00
244_A	248_L	0.806	1.00
109_N	112_V	0.805	1.00
244_A	247_L	0.802	1.00
362_N	367_V	0.800	1.00
588_L	613_K	0.800	1.00
470_S	474_N	0.799	1.00
242_F	253_A	0.798	1.00
247_L	250_V	0.797	1.00
594_T	605_I	0.796	1.00
325_F	328_R	0.796	1.00
358_G	362_N	0.796	1.00
370_G	374_A	0.795	1.00
421_P	496_N	0.794	1.00
488_L	491_G	0.792	1.00
327_N	331_N	0.791	1.00
134_T	138_L	0.790	1.00
655_E	658_Y	0.790	1.00
438_A	441_E	0.790	1.00
585_P	616_R	0.789	1.00
430_V	489_I	0.789	1.00
301_I	305_F	0.788	1.00
273_Y	277_Y	0.788	1.00
449_I	642_I	0.787	1.00
136_Q	139_F	0.787	1.00
436_S	483_Q	0.787	1.00
524_V	575_I	0.787	1.00
552_L	567_L	0.786	1.00
545_A	575_I	0.784	1.00
525_S	530_R	0.779	1.00
406_V	410_L	0.777	1.00
602_E	606_Q	0.777	1.00
288_I	322_H	0.776	1.00
139_F	142_Y	0.775	1.00
515_L	572_R	0.775	1.00
504_S	583_F	0.770	1.00
428_G	617_T	0.766	1.00
362_N	372_L	0.764	1.00
494_I	502_L	0.762	1.00
425_R	586_A	0.761	1.00
255_V	355_H	0.761	1.00
569_S	574_L	0.760	1.00
128_Y	131_E	0.760	1.00
506_M	587_I	0.758	1.00
208_K	212_R	0.757	1.00
107_D	112_V	0.757	1.00
423_K	501_E	0.755	1.00
519_T	522_S	0.755	1.00
223_L	399_A	0.754	1.00
246_F	257_L	0.753	1.00
127_A	131_E	0.750	1.00
248_L	374_A	0.748	1.00
524_V	556_I	0.747	1.00
321_S	324_Y	0.744	1.00
193_I	201_F	0.744	1.00
577_F	590_L	0.743	1.00
209_V	409_L	0.742	1.00
497_M	501_E	0.742	1.00
512_D	572_R	0.741	1.00
544_G	547_P	0.740	1.00
234_S	388_G	0.739	1.00
196_M	412_E	0.739	1.00
219_A	398_L	0.738	1.00
189_V	406_V	0.738	1.00
251_K	254_F	0.738	1.00
152_L	155_L	0.737	1.00
543_V	574_L	0.736	1.00
299_M	303_Q	0.736	1.00
422_A	501_E	0.736	1.00
361_L	365_G	0.734	1.00
126_R	162_F	0.734	1.00
165_F	169_G	0.732	1.00
136_Q	152_L	0.732	1.00
251_K	361_L	0.731	1.00
241_I	381_R	0.730	1.00
192_H	413_K	0.728	1.00
525_S	529_E	0.728	1.00
124_K	127_A	0.727	1.00
280_K	283_S	0.727	1.00
359_A	362_N	0.727	1.00
284_I	318_L	0.726	1.00
125_S	129_A	0.724	1.00
462_V	636_V	0.723	1.00
438_A	443_E	0.723	1.00
116_K	177_S	0.723	1.00
188_D	191_S	0.723	1.00
126_R	166_F	0.722	1.00
588_L	618_T	0.722	1.00
447_K	639_K	0.722	1.00
528_D	584_D	0.721	1.00
458_T	630_N	0.719	1.00
258_A	261_P	0.719	1.00
340_L	344_I	0.717	1.00
657_Q	662_Y	0.717	1.00
443_E	447_K	0.717	1.00
253_A	375_F	0.716	1.00
112_V	184_K	0.714	1.00
324_Y	328_R	0.714	1.00
154_C	157_G	0.712	1.00
654_L	657_Q	0.711	1.00
272_R	276_Y	0.710	1.00
235_G	239_F	0.710	1.00
298_G	301_I	0.709	1.00
482_A	486_D	0.709	1.00
107_D	114_D	0.709	1.00
132_K	244_A	0.709	1.00
153_I	157_G	0.708	1.00
520_I	549_L	0.708	1.00
140_Q	148_G	0.706	1.00
430_V	587_I	0.705	1.00
422_A	498_S	0.704	1.00
404_G	408_E	0.703	1.00
168_Y	172_Y	0.701	1.00
133_L	159_L	0.700	1.00
249_D	253_A	0.699	1.00
502_L	506_M	0.698	1.00
139_F	143_Q	0.698	1.00
182_I	221_R	0.698	1.00
465_T	592_E	0.697	1.00
517_S	561_I	0.697	1.00
205_P	290_A	0.694	1.00
343_V	347_L	0.692	1.00
133_L	136_Q	0.691	1.00
191_S	312_M	0.691	1.00
141_F	145_E	0.691	1.00
155_L	158_G	0.690	1.00
240_G	243_T	0.690	1.00
560_V	564_G	0.690	1.00
188_D	410_L	0.689	1.00
346_N	350_V	0.687	1.00
488_L	493_S	0.687	1.00
574_L	601_T	0.686	1.00
542_Q	608_A	0.684	1.00
633_Q	647_N	0.684	1.00
660_Q	664_L	0.682	1.00
459_V	645_R	0.680	1.00
528_D	583_F	0.680	1.00
243_T	246_F	0.679	1.00
249_D	367_V	0.678	1.00
456_G	615_G	0.677	1.00
223_L	396_L	0.673	1.00
162_F	166_F	0.673	1.00
633_Q	650_E	0.672	1.00
439_Y	471_S	0.672	1.00
516_F	523_N	0.672	1.00
652_M	659_Y	0.671	1.00
265_L	268_V	0.670	1.00
148_G	152_L	0.669	1.00
545_A	556_I	0.668	1.00
277_Y	280_K	0.667	1.00
538_N	612_V	0.667	1.00
120_T	233_T	0.664	1.00
482_A	493_S	0.663	1.00
525_S	528_D	0.663	1.00
417_E	420_E	0.662	1.00
569_S	596_H	0.660	1.00
197_P	416_E	0.659	1.00
473_L	619_F	0.657	1.00
644_E	651_L	0.655	1.00
474_N	480_Y	0.655	1.00
116_K	120_T	0.654	1.00
416_E	478_R	0.654	1.00
108_G	188_D	0.653	1.00
241_I	382_L	0.653	1.00
126_R	159_L	0.653	1.00
441_E	483_Q	0.650	1.00
553_P	558_E	0.650	1.00
426_A	505_H	0.649	1.00
130_A	134_T	0.648	1.00
363_A	366_I	0.648	1.00
384_Q	388_G	0.643	1.00
446_L	637_L	0.641	1.00
115_G	180_R	0.640	1.00
189_V	410_L	0.639	1.00
649_E	652_M	0.639	1.00
489_I	494_I	0.639	1.00
110_R	114_D	0.637	1.00
249_D	252_L	0.637	1.00
539_A	578_A	0.637	1.00
535_E	539_A	0.636	1.00
150_V	153_I	0.635	1.00
135_K	138_L	0.635	1.00
286_S	405_R	0.635	1.00
605_I	608_A	0.633	1.00
421_P	424_E	0.632	1.00
133_L	155_L	0.632	1.00
185_M	217_T	0.632	1.00
256_C	379_L	0.629	1.00
644_E	657_Q	0.628	1.00
518_G	559_P	0.627	1.00
198_I	202_D	0.625	1.00
212_R	216_D	0.625	1.00
606_Q	630_N	0.624	1.00
180_R	183_Q	0.624	1.00
196_M	414_N	0.624	1.00
118_T	122_G	0.623	1.00
435_V	485_G	0.623	1.00
106_F	113_S	0.622	1.00
330_L	334_S	0.622	1.00
456_G	617_T	0.621	1.00
475_L	480_Y	0.621	1.00
189_V	217_T	0.621	1.00
602_E	627_T	0.619	1.00
594_T	602_E	0.618	1.00
109_N	113_S	0.617	1.00
282_R	285_N	0.617	1.00
533_E	556_I	0.614	1.00
141_F	144_P	0.613	1.00
461_L	619_F	0.613	1.00
211_A	289_N	0.612	1.00
490_D	586_A	0.611	1.00
645_R	650_E	0.611	1.00
182_I	186_R	0.611	1.00
138_L	373_Y	0.610	1.00
597_I	601_T	0.610	1.00
443_E	639_K	0.609	1.00
216_D	282_R	0.609	1.00
172_Y	176_M	0.608	1.00
269_I	272_R	0.608	1.00
577_F	581_L	0.608	1.00
328_R	332_L	0.608	1.00
427_L	617_T	0.607	1.00
606_Q	627_T	0.605	1.00
220_I	403_A	0.604	1.00
324_Y	327_N	0.604	1.00
573_Q	596_H	0.603	1.00
648_H	662_Y	0.603	1.00
540_L	543_V	0.602	1.00
644_E	660_Q	0.602	1.00
644_E	652_M	0.602	1.00
399_A	402_S	0.601	1.00
599_T	602_E	0.600	1.00
197_P	200_Y	0.600	1.00
419_G	498_S	0.600	1.00
241_I	378_Y	0.600	1.00
451_F	642_I	0.599	1.00
519_T	557_N	0.599	1.00
577_F	605_I	0.598	1.00
161_V	165_F	0.597	1.00
132_K	248_L	0.597	1.00
345_R	349_F	0.597	1.00
607_K	610_D	0.597	1.00
203_N	440_Q	0.597	1.00
367_V	371_V	0.597	1.00
453_A	457_E	0.597	1.00
106_F	112_V	0.597	1.00
543_V	577_F	0.596	1.00
123_D	127_A	0.595	1.00
124_K	131_E	0.594	1.00
517_S	566_T	0.593	1.00
192_H	412_E	0.593	1.00
107_D	113_S	0.593	1.00
251_K	355_H	0.593	1.00
608_A	611_V	0.592	1.00
183_Q	319_N	0.591	1.00
282_R	401_V	0.591	1.00
284_I	322_H	0.590	1.00
544_G	605_I	0.590	1.00
358_G	361_L	0.589	1.00
222_D	226_T	0.589	1.00
628_I	631_A	0.589	1.00
131_E	135_K	0.587	1.00
589_I	619_F	0.587	1.00
270_Y	336_M	0.587	1.00
238_M	242_F	0.587	1.00
648_H	651_L	0.586	1.00
128_Y	132_K	0.585	1.00
107_D	407_F	0.583	1.00
231_F	235_G	0.583	1.00
261_P	265_L	0.582	1.00
175_Q	226_T	0.582	1.00
512_D	563_K	0.581	1.00
643_V	655_E	0.581	1.00
587_I	617_T	0.581	1.00
111_T	184_K	0.580	1.00
291_K	311_T	0.580	1.00
120_T	128_Y	0.578	1.00
222_D	395_K	0.578	1.00
277_Y	329_M	0.577	1.00
283_S	287_D	0.577	1.00
280_K	321_S	0.575	1.00
659_Y	662_Y	0.575	1.00
278_N	329_M	0.574	1.00
473_L	508_I	0.574	1.00
435_V	450_S	0.574	1.00
449_I	637_L	0.574	1.00
543_V	581_L	0.573	1.00
546_E	549_L	0.573	1.00
417_E	498_S	0.573	1.00
301_I	304_A	0.573	1.00
449_I	635_L	0.572	1.00
606_Q	622_A	0.571	1.00
536_I	540_L	0.571	1.00
525_S	540_L	0.569	1.00
499_R	502_L	0.568	1.00
175_Q	179_N	0.568	1.00
507_G	583_F	0.568	1.00
178_A	225_V	0.568	1.00
528_D	582_A	0.567	1.00
541_R	547_P	0.567	1.00
636_V	644_E	0.567	1.00
438_A	484_K	0.566	1.00
211_A	285_N	0.565	1.00
435_V	487_V	0.563	1.00
634_I	647_N	0.562	1.00
537_K	549_L	0.561	1.00
442_G	445_V	0.560	1.00
230_T	388_G	0.560	1.00
652_M	663_E	0.560	1.00
452_T	645_R	0.559	1.00
568_S	571_E	0.559	1.00
613_K	616_R	0.559	1.00
200_Y	209_V	0.559	1.00
264_W	267_S	0.557	1.00
123_D	167_Q	0.557	1.00
602_E	626_S	0.557	1.00
629_R	648_H	0.557	1.00
515_L	560_V	0.557	1.00
655_E	661_M	0.556	1.00
349_F	352_L	0.556	1.00
107_D	115_G	0.556	1.00
654_L	659_Y	0.554	1.00
347_L	351_C	0.554	1.00
342_N	387_T	0.554	1.00
122_G	126_R	0.554	1.00
570_G	598_D	0.552	1.00
164_V	168_Y	0.552	1.00
291_K	295_S	0.551	1.00
533_E	540_L	0.551	1.00
262_I	265_L	0.551	1.00
105_S	108_G	0.550	1.00
155_L	159_L	0.550	1.00
124_K	236_I	0.549	1.00
510_L	513_P	0.549	1.00
574_L	597_I	0.548	1.00
190_F	194_Q	0.547	1.00
120_T	170_Q	0.546	1.00
185_M	220_I	0.546	1.00
639_K	643_V	0.545	1.00
489_I	497_M	0.544	1.00
437_F	445_V	0.543	1.00
453_A	458_T	0.543	1.00
350_V	354_W	0.543	1.00
367_V	372_L	0.542	1.00
128_Y	135_K	0.542	1.00
351_C	355_H	0.542	1.00
322_H	326_Q	0.541	1.00
462_V	628_I	0.540	1.00
247_L	251_K	0.540	1.00
461_L	637_L	0.539	1.00
454_Q	459_V	0.539	1.00
281_I	329_M	0.539	1.00
594_T	597_I	0.538	1.00
206_A	210_V	0.536	1.00
198_I	479_F	0.536	1.00
465_T	622_A	0.536	1.00
474_N	508_I	0.536	1.00
233_T	237_Y	0.536	1.00
211_A	286_S	0.535	1.00
465_T	597_I	0.534	1.00
348_A	351_C	0.534	1.00
520_I	560_V	0.534	1.00
126_R	130_A	0.534	1.00
145_E	148_G	0.532	1.00
555_G	558_E	0.531	1.00
250_V	253_A	0.530	1.00
619_F	635_L	0.529	1.00
541_R	556_I	0.528	1.00
432_F	449_I	0.527	1.00
509_V	590_L	0.526	1.00
234_S	238_M	0.526	1.00
470_S	473_L	0.526	1.00
182_I	217_T	0.525	1.00
402_S	405_R	0.524	1.00
217_T	406_V	0.524	1.00
169_G	173_L	0.523	1.00
581_L	612_V	0.522	1.00
138_L	141_F	0.522	1.00
447_K	450_S	0.521	1.00
179_N	182_I	0.520	1.00
581_L	608_A	0.520	1.00
428_G	586_A	0.520	1.00
498_S	502_L	0.519	1.00
523_N	575_I	0.519	1.00
426_A	455_K	0.519	1.00
207_G	290_A	0.518	1.00
645_R	654_L	0.518	1.00
129_A	132_K	0.518	1.00
122_G	162_F	0.516	1.00
117_L	120_T	0.516	1.00
171_H	175_Q	0.514	1.00
344_I	348_A	0.514	1.00
453_A	635_L	0.514	1.00
525_S	582_A	0.514	1.00
355_H	360_S	0.514	1.00
419_G	501_E	0.512	1.00
524_V	527_D	0.512	1.00
285_N	289_N	0.511	1.00
197_P	412_E	0.511	1.00
132_K	378_Y	0.510	1.00
180_R	184_K	0.510	1.00
511_Q	569_S	0.510	1.00
128_Y	136_Q	0.509	1.00
132_K	374_A	0.509	1.00
601_T	604_V	0.509	1.00
277_Y	332_L	0.508	1.00
656_G	660_Q	0.508	1.00
339_N	342_N	0.508	1.00
375_F	379_L	0.508	1.00
287_D	290_A	0.507	1.00
444_E	448_H	0.506	1.00
452_T	455_K	0.506	1.00
256_C	382_L	0.505	1.00
208_K	405_R	0.505	1.00
358_G	372_L	0.505	1.00
317_E	320_E	0.504	1.00
436_S	446_L	0.504	1.00
213_I	217_T	0.503	1.00
620_V	628_I	0.503	1.00
461_L	621_I	0.503	1.00
360_S	363_A	0.503	1.00
540_L	578_A	0.503	1.00
129_A	159_L	0.503	1.00
179_N	183_Q	0.502	1.00
587_I	619_F	0.502	1.00
593_A	622_A	0.502	1.00
218_E	221_R	0.502	1.00
421_P	425_R	0.501	1.00
346_N	349_F	0.501	1.00
342_N	349_F	0.501	1.00
201_F	204_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ry2A	2	0.9599	100	0.169	Contact Map
4a82A	2	0.838	100	0.19	Contact Map
4f4cA	1	0.9272	100	0.223	Contact Map
4q4hB	1	0.8588	100	0.223	Contact Map
4q9hA	1	0.8425	100	0.231	Contact Map
3b60A	2	0.841	100	0.234	Contact Map
3b5xA	2	0.841	100	0.235	Contact Map
3wmgA	1	0.8425	100	0.242	Contact Map
3zdqA	2	0.8232	100	0.243	Contact Map
4mrsA	2	0.8588	100	0.243	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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