GREMLIN Database
YHEG - Uncharacterized protein YheG
UniProt: O07548 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 206 (189)
Sequences: 52717 (35059)
Seq/√Len: 2550.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A30_A2.9641.00
19_Q186_D2.4041.00
77_D81_T2.3861.00
66_I192_L2.3371.00
19_Q189_Y2.3111.00
101_I188_L2.2651.00
31_L49_G2.2041.00
58_K92_E2.1311.00
153_P188_L2.0881.00
97_R147_D2.0461.00
49_G56_D1.9561.00
29_F45_R1.9541.00
68_I192_L1.9291.00
29_F47_V1.9121.00
141_L148_W1.8901.00
29_F64_A1.8861.00
151_I191_E1.8821.00
84_A140_M1.8791.00
69_S100_T1.8291.00
53_R56_D1.7991.00
119_E122_E1.7961.00
58_K89_V1.7701.00
135_A139_E1.7391.00
186_D190_R1.7161.00
83_M137_V1.7091.00
19_Q24_E1.6671.00
4_A64_A1.6571.00
16_F70_C1.6541.00
189_Y193_V1.6491.00
6_L69_S1.6451.00
54_L88_S1.6021.00
16_F185_A1.6001.00
81_T84_A1.5991.00
5_L17_L1.5881.00
190_R194_T1.5561.00
70_C101_I1.5431.00
84_A88_S1.5241.00
24_E189_Y1.5211.00
16_F68_I1.5131.00
58_K93_Q1.4901.00
54_L58_K1.4831.00
102_G106_I1.4691.00
76_D136_K1.4661.00
19_Q185_A1.4491.00
12_V156_L1.4431.00
3_I26_F1.4251.00
56_D59_K1.4181.00
54_L85_H1.4161.00
97_R149_T1.4131.00
91_E144_S1.4001.00
52_R77_D1.3891.00
67_V90_M1.3501.00
124_K135_A1.3481.00
8_A17_L1.3471.00
24_E193_V1.3461.00
153_P184_T1.3271.00
27_D45_R1.3161.00
17_L30_A1.3121.00
51_A82_A1.3111.00
65_E96_K1.3061.00
19_Q22_A1.3041.00
101_I153_P1.3001.00
62_E93_Q1.2941.00
4_A31_L1.2791.00
100_T137_V1.2781.00
132_K136_K1.2751.00
179_I184_T1.2671.00
26_F193_V1.2621.00
118_F122_E1.2471.00
139_E142_K1.2421.00
34_S46_T1.2411.00
30_A44_D1.2341.00
142_K150_I1.2201.00
130_A134_H1.2171.00
15_A182_G1.2131.00
68_I188_L1.2071.00
100_T150_I1.1941.00
6_L86_I1.1931.00
19_Q182_G1.1871.00
51_A71_L1.1851.00
140_M143_E1.1711.00
115_K119_E1.1701.00
18_T160_T1.1691.00
90_M98_L1.1691.00
157_P180_S1.1671.00
99_I151_I1.1531.00
100_T141_L1.1491.00
3_I66_I1.1411.00
9_S32_I1.1341.00
73_T78_T1.1311.00
89_V92_E1.1301.00
88_S91_E1.1271.00
21_A44_D1.1211.00
69_S83_M1.1121.00
57_V89_V1.1111.00
20_A189_Y1.1091.00
156_L184_T1.1031.00
80_S136_K1.1011.00
85_H88_S1.0851.00
81_T85_H1.0801.00
115_K122_E1.0731.00
67_V86_I1.0721.00
21_A43_K1.0711.00
88_S92_E1.0561.00
79_L133_E1.0501.00
151_I188_L1.0441.00
87_L98_L1.0251.00
86_I98_L1.0251.00
78_T82_A1.0221.00
15_A181_V1.0181.00
3_I20_A1.0151.00
90_M95_I1.0091.00
31_L56_D1.0061.00
34_S37_A1.0051.00
149_T191_E1.0031.00
70_C188_L1.0021.00
18_T22_A0.9951.00
87_L141_L0.9931.00
76_D80_S0.9891.00
138_Y152_C0.9871.00
181_V185_A0.9871.00
98_L141_L0.9831.00
35_Q48_M0.9701.00
104_A154_T0.9691.00
61_M64_A0.9671.00
91_E146_L0.9631.00
186_D189_Y0.9601.00
76_D81_T0.9591.00
89_V93_Q0.9581.00
11_R158_D0.9511.00
11_R181_V0.9511.00
61_M67_V0.9441.00
59_K62_E0.9391.00
180_S183_D0.9351.00
15_A18_T0.9321.00
142_K148_W0.9271.00
54_L92_E0.9221.00
32_I46_T0.9191.00
58_K62_E0.9171.00
61_M89_V0.9121.00
3_I68_I0.9091.00
190_R193_V0.9001.00
15_A19_Q0.8931.00
17_L28_I0.8891.00
61_M93_Q0.8881.00
132_K143_E0.8841.00
34_S48_M0.8821.00
56_D60_I0.8781.00
16_F20_A0.8751.00
116_Y122_E0.8701.00
29_F63_N0.8661.00
66_I97_R0.8551.00
14_Q160_T0.8421.00
31_L60_I0.8401.00
83_M141_L0.8361.00
91_E145_S0.8351.00
165_Y168_E0.8251.00
47_V60_I0.8221.00
55_E58_K0.8161.00
31_L57_V0.8161.00
33_R50_N0.8111.00
136_K139_E0.8071.00
128_T131_A0.8041.00
185_A189_Y0.7991.00
16_F188_L0.7971.00
52_R78_T0.7971.00
85_H89_V0.7911.00
113_P116_Y0.7901.00
55_E59_K0.7891.00
96_K147_D0.7851.00
139_E143_E0.7781.00
102_G138_Y0.7761.00
3_I192_L0.7761.00
136_K140_M0.7721.00
69_S86_I0.7681.00
115_K118_F0.7391.00
132_K139_E0.7301.00
161_A166_R0.7291.00
54_L89_V0.7261.00
67_V98_L0.7251.00
164_V167_T0.7241.00
4_A61_M0.7241.00
129_R132_K0.7231.00
34_S39_L0.7231.00
159_G180_S0.7221.00
97_R195_G0.7161.00
26_F65_E0.7121.00
151_I187_F0.7121.00
83_M87_L0.7111.00
76_D132_K0.7101.00
154_T177_T0.6991.00
12_V184_T0.6991.00
150_I199_G0.6931.00
161_A165_Y0.6921.00
148_W199_G0.6921.00
21_A28_I0.6891.00
28_I32_I0.6861.00
183_D186_D0.6821.00
20_A192_L0.6811.00
113_P118_F0.6751.00
6_L71_L0.6681.00
87_L140_M0.6681.00
30_A46_T0.6661.00
156_L179_I0.6651.00
137_V141_L0.6651.00
155_Y176_G0.6581.00
105_G131_A0.6571.00
109_S127_Q0.6541.00
141_L150_I0.6541.00
57_V85_H0.6501.00
114_G122_E0.6461.00
15_A185_A0.6401.00
66_I96_K0.6381.00
53_R57_V0.6341.00
134_H138_Y0.6321.00
26_F66_I0.6301.00
153_P156_L0.6261.00
69_S98_L0.6231.00
106_I138_Y0.6231.00
99_I191_E0.6171.00
61_M90_M0.6161.00
161_A164_V0.6081.00
166_R172_L0.6061.00
168_E172_L0.5981.00
36_H39_L0.5901.00
163_G166_R0.5891.00
82_A85_H0.5861.00
99_I192_L0.5861.00
14_Q18_T0.5861.00
106_I152_C0.5841.00
37_A40_P0.5821.00
132_K135_A0.5791.00
16_F189_Y0.5791.00
149_T195_G0.5791.00
99_I188_L0.5771.00
61_M86_I0.5761.00
167_T172_L0.5761.00
24_E190_R0.5751.00
76_D133_E0.5741.00
4_A60_I0.5731.00
15_A160_T0.5691.00
126_K131_A0.5691.00
133_E137_V0.5671.00
38_D41_L0.5671.00
103_T106_I0.5631.00
106_I124_K0.5601.00
27_D43_K0.5561.00
18_T182_G0.5521.00
50_N53_R0.5511.00
15_A159_G0.5511.00
80_S84_A0.5461.00
117_R120_T0.5451.00
17_L44_D0.5421.00
47_V56_D0.5421.00
5_L20_A0.5391.00
9_S34_S0.5391.00
124_K139_E0.5391.00
126_K135_A0.5361.00
88_S140_M0.5351.00
34_S38_D0.5351.00
17_L21_A0.5331.00
20_A26_F0.5321.00
117_R122_E0.5311.00
49_G60_I0.5301.00
4_A67_V0.5241.00
130_A133_E0.5231.00
80_S140_M0.5201.00
49_G53_R0.5191.00
155_Y178_S0.5191.00
113_P122_E0.5191.00
93_Q96_K0.5181.00
66_I99_I0.5171.00
129_R133_E0.5141.00
11_R15_A0.5121.00
109_S113_P0.5111.00
157_P178_S0.5111.00
195_G199_G0.5101.00
162_T166_R0.5091.00
106_I135_A0.5091.00
67_V95_I0.5061.00
33_R52_R0.5031.00
57_V61_M0.5001.00
72_G79_L0.5001.00
32_I36_H0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x4gA 2 0.9612 100 0.219 Contact Map
2pzmA 2 0.9757 100 0.224 Contact Map
1sb8A 2 0.9806 100 0.228 Contact Map
3m2pA 2 0.9466 100 0.23 Contact Map
2yy7A 2 0.9854 100 0.232 Contact Map
3rufA 2 0.9806 100 0.233 Contact Map
4pvcA 2 0.9951 100 0.24 Contact Map
3slgA 4 0.9757 100 0.242 Contact Map
1rkxA 3 0.9854 100 0.242 Contact Map
1i24A 4 0.9757 100 0.245 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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