YHEG - BACSU - GREMLIN Contacts

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YHEG - Uncharacterized protein YheG

UniProt:	O07548	Sequences: MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKDRTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIGTAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGTATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	206 (189)
Sequences:	52717 (35059)
Seq/√Len:	2550.2

ECOLI - GALE RMLB1 GM4D YBJS YFCH RMLB2 RMLD HLDD YEEZ FCL QOR2 YRAR YBJT ARNA
BACSU - YHEG YWNB YHFK GALE YTCB RMLB YFNG YFHF YTBQ SPSK YESF EPSC
HALSA - Q9HSV1 Q9HML4 Q9HSE7 Q9HSU9 Q9HR86 Q9HRD1 Q9HSQ3 Q9HNV3 Q9HS50 Q9HPF1
SULSO - Q97VN5 Q7LXE8 Q97UM3 Q980W1 Q97XG1 Q97XJ9 Q7LXG5 Q7LX44

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
8_A	30_A	2.964	1.00
19_Q	186_D	2.404	1.00
77_D	81_T	2.386	1.00
66_I	192_L	2.337	1.00
19_Q	189_Y	2.311	1.00
101_I	188_L	2.265	1.00
31_L	49_G	2.204	1.00
58_K	92_E	2.131	1.00
153_P	188_L	2.088	1.00
97_R	147_D	2.046	1.00
49_G	56_D	1.956	1.00
29_F	45_R	1.954	1.00
68_I	192_L	1.929	1.00
29_F	47_V	1.912	1.00
141_L	148_W	1.890	1.00
29_F	64_A	1.886	1.00
151_I	191_E	1.882	1.00
84_A	140_M	1.879	1.00
69_S	100_T	1.829	1.00
53_R	56_D	1.799	1.00
119_E	122_E	1.796	1.00
58_K	89_V	1.770	1.00
135_A	139_E	1.739	1.00
186_D	190_R	1.716	1.00
83_M	137_V	1.709	1.00
19_Q	24_E	1.667	1.00
4_A	64_A	1.657	1.00
16_F	70_C	1.654	1.00
189_Y	193_V	1.649	1.00
6_L	69_S	1.645	1.00
54_L	88_S	1.602	1.00
16_F	185_A	1.600	1.00
81_T	84_A	1.599	1.00
5_L	17_L	1.588	1.00
190_R	194_T	1.556	1.00
70_C	101_I	1.543	1.00
84_A	88_S	1.524	1.00
24_E	189_Y	1.521	1.00
16_F	68_I	1.513	1.00
58_K	93_Q	1.490	1.00
54_L	58_K	1.483	1.00
102_G	106_I	1.469	1.00
76_D	136_K	1.466	1.00
19_Q	185_A	1.449	1.00
12_V	156_L	1.443	1.00
3_I	26_F	1.425	1.00
56_D	59_K	1.418	1.00
54_L	85_H	1.416	1.00
97_R	149_T	1.413	1.00
91_E	144_S	1.400	1.00
52_R	77_D	1.389	1.00
67_V	90_M	1.350	1.00
124_K	135_A	1.348	1.00
8_A	17_L	1.347	1.00
24_E	193_V	1.346	1.00
153_P	184_T	1.327	1.00
27_D	45_R	1.316	1.00
17_L	30_A	1.312	1.00
51_A	82_A	1.311	1.00
65_E	96_K	1.306	1.00
19_Q	22_A	1.304	1.00
101_I	153_P	1.300	1.00
62_E	93_Q	1.294	1.00
4_A	31_L	1.279	1.00
100_T	137_V	1.278	1.00
132_K	136_K	1.275	1.00
179_I	184_T	1.267	1.00
26_F	193_V	1.262	1.00
118_F	122_E	1.247	1.00
139_E	142_K	1.242	1.00
34_S	46_T	1.241	1.00
30_A	44_D	1.234	1.00
142_K	150_I	1.220	1.00
130_A	134_H	1.217	1.00
15_A	182_G	1.213	1.00
68_I	188_L	1.207	1.00
100_T	150_I	1.194	1.00
6_L	86_I	1.193	1.00
19_Q	182_G	1.187	1.00
51_A	71_L	1.185	1.00
140_M	143_E	1.171	1.00
115_K	119_E	1.170	1.00
18_T	160_T	1.169	1.00
90_M	98_L	1.169	1.00
157_P	180_S	1.167	1.00
99_I	151_I	1.153	1.00
100_T	141_L	1.149	1.00
3_I	66_I	1.141	1.00
9_S	32_I	1.134	1.00
73_T	78_T	1.131	1.00
89_V	92_E	1.130	1.00
88_S	91_E	1.127	1.00
21_A	44_D	1.121	1.00
69_S	83_M	1.112	1.00
57_V	89_V	1.111	1.00
20_A	189_Y	1.109	1.00
156_L	184_T	1.103	1.00
80_S	136_K	1.101	1.00
85_H	88_S	1.085	1.00
81_T	85_H	1.080	1.00
115_K	122_E	1.073	1.00
67_V	86_I	1.072	1.00
21_A	43_K	1.071	1.00
88_S	92_E	1.056	1.00
79_L	133_E	1.050	1.00
151_I	188_L	1.044	1.00
87_L	98_L	1.025	1.00
86_I	98_L	1.025	1.00
78_T	82_A	1.022	1.00
15_A	181_V	1.018	1.00
3_I	20_A	1.015	1.00
90_M	95_I	1.009	1.00
31_L	56_D	1.006	1.00
34_S	37_A	1.005	1.00
149_T	191_E	1.003	1.00
70_C	188_L	1.002	1.00
18_T	22_A	0.995	1.00
87_L	141_L	0.993	1.00
76_D	80_S	0.989	1.00
138_Y	152_C	0.987	1.00
181_V	185_A	0.987	1.00
98_L	141_L	0.983	1.00
35_Q	48_M	0.970	1.00
104_A	154_T	0.969	1.00
61_M	64_A	0.967	1.00
91_E	146_L	0.963	1.00
186_D	189_Y	0.960	1.00
76_D	81_T	0.959	1.00
89_V	93_Q	0.958	1.00
11_R	158_D	0.951	1.00
11_R	181_V	0.951	1.00
61_M	67_V	0.944	1.00
59_K	62_E	0.939	1.00
180_S	183_D	0.935	1.00
15_A	18_T	0.932	1.00
142_K	148_W	0.927	1.00
54_L	92_E	0.922	1.00
32_I	46_T	0.919	1.00
58_K	62_E	0.917	1.00
61_M	89_V	0.912	1.00
3_I	68_I	0.909	1.00
190_R	193_V	0.900	1.00
15_A	19_Q	0.893	1.00
17_L	28_I	0.889	1.00
61_M	93_Q	0.888	1.00
132_K	143_E	0.884	1.00
34_S	48_M	0.882	1.00
56_D	60_I	0.878	1.00
16_F	20_A	0.875	1.00
116_Y	122_E	0.870	1.00
29_F	63_N	0.866	1.00
66_I	97_R	0.855	1.00
14_Q	160_T	0.842	1.00
31_L	60_I	0.840	1.00
83_M	141_L	0.836	1.00
91_E	145_S	0.835	1.00
165_Y	168_E	0.825	1.00
47_V	60_I	0.822	1.00
55_E	58_K	0.816	1.00
31_L	57_V	0.816	1.00
33_R	50_N	0.811	1.00
136_K	139_E	0.807	1.00
128_T	131_A	0.804	1.00
185_A	189_Y	0.799	1.00
16_F	188_L	0.797	1.00
52_R	78_T	0.797	1.00
85_H	89_V	0.791	1.00
113_P	116_Y	0.790	1.00
55_E	59_K	0.789	1.00
96_K	147_D	0.785	1.00
139_E	143_E	0.778	1.00
102_G	138_Y	0.776	1.00
3_I	192_L	0.776	1.00
136_K	140_M	0.772	1.00
69_S	86_I	0.768	1.00
115_K	118_F	0.739	1.00
132_K	139_E	0.730	1.00
161_A	166_R	0.729	1.00
54_L	89_V	0.726	1.00
67_V	98_L	0.725	1.00
164_V	167_T	0.724	1.00
4_A	61_M	0.724	1.00
129_R	132_K	0.723	1.00
34_S	39_L	0.723	1.00
159_G	180_S	0.722	1.00
97_R	195_G	0.716	1.00
26_F	65_E	0.712	1.00
151_I	187_F	0.712	1.00
83_M	87_L	0.711	1.00
76_D	132_K	0.710	1.00
154_T	177_T	0.699	1.00
12_V	184_T	0.699	1.00
150_I	199_G	0.693	1.00
161_A	165_Y	0.692	1.00
148_W	199_G	0.692	1.00
21_A	28_I	0.689	1.00
28_I	32_I	0.686	1.00
183_D	186_D	0.682	1.00
20_A	192_L	0.681	1.00
113_P	118_F	0.675	1.00
6_L	71_L	0.668	1.00
87_L	140_M	0.668	1.00
30_A	46_T	0.666	1.00
156_L	179_I	0.665	1.00
137_V	141_L	0.665	1.00
155_Y	176_G	0.658	1.00
105_G	131_A	0.657	1.00
109_S	127_Q	0.654	1.00
141_L	150_I	0.654	1.00
57_V	85_H	0.650	1.00
114_G	122_E	0.646	1.00
15_A	185_A	0.640	1.00
66_I	96_K	0.638	1.00
53_R	57_V	0.634	1.00
134_H	138_Y	0.632	1.00
26_F	66_I	0.630	1.00
153_P	156_L	0.626	1.00
69_S	98_L	0.623	1.00
106_I	138_Y	0.623	1.00
99_I	191_E	0.617	1.00
61_M	90_M	0.616	1.00
161_A	164_V	0.608	1.00
166_R	172_L	0.606	1.00
168_E	172_L	0.598	1.00
36_H	39_L	0.590	1.00
163_G	166_R	0.589	1.00
82_A	85_H	0.586	1.00
99_I	192_L	0.586	1.00
14_Q	18_T	0.586	1.00
106_I	152_C	0.584	1.00
37_A	40_P	0.582	1.00
132_K	135_A	0.579	1.00
16_F	189_Y	0.579	1.00
149_T	195_G	0.579	1.00
99_I	188_L	0.577	1.00
61_M	86_I	0.576	1.00
167_T	172_L	0.576	1.00
24_E	190_R	0.575	1.00
76_D	133_E	0.574	1.00
4_A	60_I	0.573	1.00
15_A	160_T	0.569	1.00
126_K	131_A	0.569	1.00
133_E	137_V	0.567	1.00
38_D	41_L	0.567	1.00
103_T	106_I	0.563	1.00
106_I	124_K	0.560	1.00
27_D	43_K	0.556	1.00
18_T	182_G	0.552	1.00
50_N	53_R	0.551	1.00
15_A	159_G	0.551	1.00
80_S	84_A	0.546	1.00
117_R	120_T	0.545	1.00
17_L	44_D	0.542	1.00
47_V	56_D	0.542	1.00
5_L	20_A	0.539	1.00
9_S	34_S	0.539	1.00
124_K	139_E	0.539	1.00
126_K	135_A	0.536	1.00
88_S	140_M	0.535	1.00
34_S	38_D	0.535	1.00
17_L	21_A	0.533	1.00
20_A	26_F	0.532	1.00
117_R	122_E	0.531	1.00
49_G	60_I	0.530	1.00
4_A	67_V	0.524	1.00
130_A	133_E	0.523	1.00
80_S	140_M	0.520	1.00
49_G	53_R	0.519	1.00
155_Y	178_S	0.519	1.00
113_P	122_E	0.519	1.00
93_Q	96_K	0.518	1.00
66_I	99_I	0.517	1.00
129_R	133_E	0.514	1.00
11_R	15_A	0.512	1.00
109_S	113_P	0.511	1.00
157_P	178_S	0.511	1.00
195_G	199_G	0.510	1.00
162_T	166_R	0.509	1.00
106_I	135_A	0.509	1.00
67_V	95_I	0.506	1.00
33_R	52_R	0.503	1.00
57_V	61_M	0.500	1.00
72_G	79_L	0.500	1.00
32_I	36_H	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2x4gA	2	0.9612	100	0.219	Contact Map
2pzmA	2	0.9757	100	0.224	Contact Map
1sb8A	2	0.9806	100	0.228	Contact Map
3m2pA	2	0.9466	100	0.23	Contact Map
2yy7A	2	0.9854	100	0.232	Contact Map
3rufA	2	0.9806	100	0.233	Contact Map
4pvcA	2	0.9951	100	0.24	Contact Map
3slgA	4	0.9757	100	0.242	Contact Map
1rkxA	3	0.9854	100	0.242	Contact Map
1i24A	4	0.9757	100	0.245	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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