GREMLIN Database
YHED - Endospore coat-associated protein YheD
UniProt: O07545 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 453 (356)
Sequences: 729 (621)
Seq/√Len: 32.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
318_N324_T5.2661.00
87_G125_F5.0931.00
234_K298_G4.2971.00
397_D403_W3.4241.00
137_I154_L3.3831.00
115_H122_C3.3761.00
143_R148_E3.1191.00
321_G438_Y2.9691.00
212_F371_A2.8321.00
389_E411_P2.8171.00
317_K380_H2.7101.00
136_T151_I2.6451.00
139_G152_V2.5861.00
301_L395_G2.5831.00
197_W218_L2.5821.00
330_V354_V2.5781.00
396_I402_V2.4771.00
258_L280_F2.4360.99
138_E149_K2.4250.99
247_G293_F2.4220.99
236_Y298_G2.4150.99
314_H411_P2.3980.99
83_G442_K2.3800.99
302_I309_A2.3520.99
141_L152_V2.3480.99
333_S340_T2.2460.99
237_I293_F2.1900.99
413_R416_F2.1310.99
125_F137_I2.1260.99
327_A416_F2.0930.98
165_R168_E2.0510.98
388_G439_L2.0330.98
404_M407_A1.9720.98
341_H405_F1.9590.98
189_F388_G1.9460.97
123_F139_G1.9080.97
314_H331_K1.8970.97
125_F130_I1.8960.97
234_K250_Q1.8890.97
83_G121_Y1.8870.97
159_Y409_S1.8340.96
215_R231_A1.8300.96
395_G405_F1.8240.96
316_N432_S1.8190.96
120_G433_F1.8090.96
215_R297_Q1.8060.96
249_Y260_V1.8050.96
201_Q438_Y1.7990.96
314_H389_E1.7870.96
236_Y338_I1.7810.96
351_L365_I1.7790.96
85_L123_F1.7070.94
195_N241_N1.7050.94
160_D192_T1.6960.94
317_K323_W1.6840.94
88_I124_V1.6700.94
132_W179_R1.6590.94
160_D177_K1.6400.93
343_S412_G1.6290.93
251_L280_F1.6140.93
84_P120_G1.6130.93
319_R434_E1.5950.92
115_H120_G1.5880.92
280_F284_F1.5850.92
389_E410_R1.5710.91
232_Y295_I1.5670.91
351_L355_Y1.5660.91
200_H204_E1.5500.91
228_L235_V1.5470.91
87_G155_P1.5470.91
340_T407_A1.5460.91
189_F436_A1.5420.91
245_G310_D1.5360.91
147_W411_P1.5320.90
228_L295_I1.5170.90
111_L389_E1.5070.90
209_T375_A1.4980.89
165_R193_F1.4860.89
217_E224_L1.4820.89
201_Q307_K1.4780.89
215_R232_Y1.4680.88
87_G130_I1.4640.88
315_T376_S1.4640.88
315_T373_L1.4580.88
245_G408_N1.4580.88
147_W331_K1.4560.88
160_D410_R1.4420.87
83_G120_G1.4250.87
250_Q298_G1.4000.86
219_T225_I1.3880.85
102_K105_S1.3870.85
213_L436_A1.3860.85
328_I340_T1.3740.85
206_D378_V1.3710.85
387_I390_I1.3660.84
317_K395_G1.3650.84
329_A415_I1.3650.84
196_K393_D1.3610.84
300_D397_D1.3490.84
301_L346_G1.3450.84
339_T405_F1.3420.83
314_H428_T1.3390.83
326_T431_R1.3370.83
196_K406_E1.3260.83
239_P293_F1.3090.82
86_V120_G1.3080.82
217_E228_L1.3060.82
132_W154_L1.2980.81
193_F410_R1.2940.81
159_Y389_E1.2920.81
197_W216_S1.2790.80
339_T412_G1.2660.80
239_P247_G1.2510.79
389_E413_R1.2500.79
371_A404_M1.2480.79
343_S391_G1.2380.78
355_Y426_S1.2290.77
339_T343_S1.2110.76
297_Q403_W1.2100.76
238_K296_Q1.2090.76
242_G408_N1.2090.76
165_R410_R1.2080.76
371_A394_F1.1910.75
311_F330_V1.1830.75
209_T378_V1.1810.75
331_K413_R1.1790.74
392_F407_A1.1780.74
389_E403_W1.1730.74
216_S294_L1.1700.74
392_F404_M1.1630.73
162_L165_R1.1560.73
119_G345_G1.1550.73
242_G342_L1.1490.73
239_P323_W1.1440.72
147_W403_W1.1340.72
208_R374_T1.1330.71
352_A365_I1.1320.71
333_S354_V1.1310.71
245_G345_G1.1290.71
345_G391_G1.1250.71
345_G411_P1.1250.71
413_R428_T1.1200.71
200_H213_L1.1140.70
209_T371_A1.1130.70
397_D401_K1.1130.70
196_K408_N1.1060.70
274_Y283_E1.1020.69
245_G296_Q1.1010.69
331_K421_L1.0910.69
194_F388_G1.0870.68
305_Q404_M1.0860.68
329_A412_G1.0820.68
150_K158_V1.0780.68
329_A341_H1.0650.67
190_N388_G1.0600.66
266_A364_V1.0570.66
83_G441_E1.0530.66
310_D345_G1.0530.66
395_G400_G1.0480.65
237_I295_I1.0480.65
386_F435_Y1.0430.65
160_D344_N1.0390.65
314_H413_R1.0340.64
245_G406_E1.0270.64
196_K296_Q1.0220.63
89_F127_A1.0190.63
389_E409_S1.0190.63
218_L374_T1.0160.63
391_G395_G1.0120.63
339_T344_N1.0040.62
251_L258_L0.9990.62
191_K340_T0.9920.61
137_I185_Q0.9870.61
341_H391_G0.9860.61
395_G412_G0.9850.60
238_K406_E0.9820.60
160_D189_F0.9800.60
194_F407_A0.9780.60
238_K245_G0.9730.60
131_N136_T0.9720.59
196_K238_K0.9660.59
107_F199_V0.9630.59
373_L376_S0.9620.59
235_V295_I0.9620.59
188_W333_S0.9530.58
317_K403_W0.9510.58
298_G333_S0.9510.58
142_Y147_W0.9500.58
234_K297_Q0.9500.58
316_N326_T0.9470.57
249_Y284_F0.9450.57
160_D412_G0.9370.57
159_Y411_P0.9360.57
163_P193_F0.9340.56
428_T432_S0.9340.56
311_F351_L0.9250.56
412_G415_I0.9230.55
311_F368_L0.9230.55
323_W376_S0.9180.55
196_K245_G0.9170.55
194_F412_G0.9150.55
237_I396_I0.9140.55
197_W294_L0.9130.55
393_D406_E0.9130.55
375_A392_F0.9110.54
348_V413_R0.9090.54
301_L400_G0.9070.54
209_T295_I0.9060.54
255_D362_V0.9020.54
201_Q204_E0.9020.54
239_P411_P0.9010.54
118_A434_E0.8990.53
158_V213_L0.8980.53
193_F411_P0.8970.53
296_Q310_D0.8950.53
250_Q261_K0.8930.53
198_N306_G0.8930.53
143_R146_G0.8910.53
323_W341_H0.8900.53
314_H405_F0.8880.53
123_F152_V0.8880.53
185_Q229_C0.8800.52
394_F402_V0.8790.52
327_A412_G0.8760.52
83_G440_S0.8750.51
234_K252_T0.8720.51
131_N273_D0.8710.51
316_N431_R0.8660.51
228_L297_Q0.8660.51
318_N325_V0.8620.50
85_L120_G0.8610.50
111_L267_K0.8590.50
432_S436_A0.8570.50
360_E363_E0.8560.50
110_K425_D0.8550.50
372_A376_S0.8530.50
366_K381_D0.8510.49
144_E282_A0.8500.49
297_Q337_S0.8480.49
331_K411_P0.8450.49
131_N134_E0.8440.49
144_E204_E0.8440.49
314_H410_R0.8400.49
325_V373_L0.8400.49
363_E369_S0.8390.48
278_A373_L0.8370.48
391_G408_N0.8370.48
281_L338_I0.8370.48
260_V274_Y0.8350.48
372_A375_A0.8350.48
339_T427_L0.8350.48
168_E410_R0.8340.48
160_D411_P0.8320.48
108_F340_T0.8280.48
216_S296_Q0.8280.48
314_H345_G0.8220.47
200_H334_G0.8220.47
144_E255_D0.8220.47
224_L227_E0.8200.47
345_G410_R0.8170.47
135_G152_V0.8130.46
407_A416_F0.8120.46
296_Q408_N0.8110.46
146_G223_E0.8100.46
349_K354_V0.8080.46
84_P441_E0.8060.46
276_D300_D0.8050.46
177_K188_W0.8050.46
86_V440_S0.8040.46
256_G285_Q0.8020.45
327_A427_L0.8010.45
87_G137_I0.8000.45
89_F160_D0.7980.45
341_H421_L0.7980.45
228_L251_L0.7930.45
313_V409_S0.7930.45
272_I375_A0.7920.45
195_N387_I0.7820.44
302_I311_F0.7820.44
233_K253_R0.7790.44
405_F432_S0.7730.43
156_N440_S0.7690.43
222_V278_A0.7690.43
341_H407_A0.7670.43
363_E401_K0.7650.42
231_A294_L0.7610.42
304_F309_A0.7590.42
125_F158_V0.7560.42
364_V396_I0.7540.41
190_N298_G0.7540.41
263_T339_T0.7520.41
111_L342_L0.7520.41
356_D396_I0.7510.41
251_L347_T0.7510.41
142_Y257_G0.7510.41
300_D398_Q0.7500.41
296_Q406_E0.7490.41
314_H412_G0.7490.41
168_E193_F0.7490.41
316_N429_K0.7490.41
104_R413_R0.7490.41
123_F141_L0.7480.41
85_L90_T0.7440.41
88_I112_V0.7410.40
341_H412_G0.7390.40
393_D408_N0.7380.40
391_G412_G0.7370.40
107_F244_L0.7370.40
309_A330_V0.7370.40
86_V122_C0.7370.40
238_K310_D0.7370.40
314_H341_H0.7350.40
110_K329_A0.7350.40
329_A413_R0.7320.40
342_L348_V0.7320.40
316_N321_G0.7320.40
87_G151_I0.7310.40
233_K254_T0.7290.39
270_T289_N0.7270.39
301_L391_G0.7270.39
194_F409_S0.7240.39
235_V322_K0.7240.39
125_F317_K0.7210.39
193_F239_P0.7200.39
338_I403_W0.7190.39
90_T343_S0.7170.39
214_P297_Q0.7160.38
235_V371_A0.7150.38
311_F404_M0.7150.38
190_N194_F0.7120.38
232_Y297_Q0.7120.38
345_G395_G0.7120.38
307_K347_T0.7110.38
108_F124_V0.7080.38
104_R314_H0.7060.38
229_C235_V0.7050.38
222_V276_D0.7050.38
259_T271_S0.7030.37
248_I267_K0.7020.37
236_Y248_I0.7000.37
411_P414_S0.7000.37
312_R393_D0.7000.37
104_R108_F0.6990.37
296_Q331_K0.6980.37
207_P227_E0.6940.37
90_T124_V0.6940.37
331_K392_F0.6930.37
329_A343_S0.6930.37
193_F409_S0.6920.37
176_T180_L0.6870.36
114_L130_I0.6840.36
143_R401_K0.6820.36
84_P121_Y0.6810.36
135_G184_Y0.6800.36
89_F158_V0.6790.36
310_D346_G0.6790.36
87_G123_F0.6780.36
415_I419_P0.6760.35
316_N331_K0.6760.35
326_T342_L0.6760.35
102_K404_M0.6730.35
234_K300_D0.6720.35
324_T427_L0.6710.35
124_V339_T0.6660.35
263_T344_N0.6660.35
175_H381_D0.6650.35
227_E279_S0.6630.34
320_K324_T0.6600.34
90_T108_F0.6590.34
204_E290_P0.6570.34
89_F293_F0.6570.34
125_F318_N0.6560.34
111_L411_P0.6560.34
242_G298_G0.6540.34
345_G408_N0.6530.34
211_P361_R0.6530.34
351_L368_L0.6520.34
178_K257_G0.6510.33
286_K350_T0.6490.33
339_T389_E0.6450.33
148_E382_H0.6440.33
126_G129_Q0.6430.33
341_H345_G0.6430.33
148_E200_H0.6430.33
116_E255_D0.6430.33
110_K147_W0.6420.33
316_N327_A0.6410.33
160_D193_F0.6400.33
294_L325_V0.6390.33
351_L369_S0.6380.33
292_D306_G0.6370.32
391_G429_K0.6360.32
107_F329_A0.6360.32
331_K407_A0.6350.32
190_N214_P0.6350.32
199_V390_I0.6340.32
252_T366_K0.6330.32
353_E356_D0.6320.32
185_Q322_K0.6310.32
228_L294_L0.6310.32
357_D381_D0.6310.32
399_N423_H0.6270.32
129_Q139_G0.6270.32
249_Y321_G0.6250.32
206_D427_L0.6240.32
222_V352_A0.6230.31
220_P224_L0.6230.31
104_R412_G0.6220.31
437_S441_E0.6220.31
208_R366_K0.6200.31
244_L429_K0.6190.31
210_A254_T0.6190.31
245_G391_G0.6190.31
390_I407_A0.6180.31
145_N374_T0.6170.31
329_A416_F0.6170.31
331_K425_D0.6140.31
238_K408_N0.6140.31
87_G436_A0.6140.31
380_H402_V0.6130.31
251_L325_V0.6120.31
337_S344_N0.6100.31
165_R189_F0.6100.31
114_L433_F0.6080.30
130_I148_E0.6080.30
317_K407_A0.6060.30
133_E141_L0.6060.30
145_N322_K0.6050.30
84_P442_K0.6020.30
130_I337_S0.6020.30
107_F111_L0.6010.30
101_F429_K0.6010.30
314_H339_T0.5990.30
380_H396_I0.5970.30
134_E363_E0.5960.30
254_T295_I0.5940.29
310_D408_N0.5920.29
92_G158_V0.5910.29
276_D279_S0.5910.29
88_I122_C0.5900.29
231_A251_L0.5890.29
145_N178_K0.5870.29
262_H396_I0.5860.29
216_S350_T0.5860.29
244_L309_A0.5850.29
106_L140_L0.5820.29
355_Y428_T0.5790.28
308_P328_I0.5780.28
116_E141_L0.5760.28
158_V188_W0.5740.28
108_F112_V0.5730.28
109_S442_K0.5720.28
145_N306_G0.5710.28
289_N295_I0.5700.28
227_E443_A0.5680.28
165_R248_I0.5670.28
112_V402_V0.5650.27
315_T325_V0.5600.27
124_V428_T0.5600.27
293_F396_I0.5580.27
346_G395_G0.5570.27
124_V304_F0.5560.27
345_G413_R0.5560.27
252_T303_E0.5550.27
140_L372_A0.5520.27
327_A413_R0.5510.27
321_G333_S0.5500.26
323_W411_P0.5500.26
199_V438_Y0.5490.26
160_D342_L0.5490.26
158_V185_Q0.5470.26
356_D399_N0.5470.26
162_L193_F0.5460.26
190_N236_Y0.5460.26
341_H414_S0.5460.26
199_V203_L0.5450.26
316_N380_H0.5450.26
139_G288_H0.5440.26
97_L324_T0.5430.26
263_T380_H0.5420.26
330_V351_L0.5400.26
137_I401_K0.5390.26
98_E101_F0.5390.26
331_K343_S0.5380.26
311_F328_I0.5380.26
159_Y410_R0.5370.26
346_G411_P0.5350.26
100_P105_S0.5340.25
183_E290_P0.5340.25
135_G359_A0.5330.25
227_E367_K0.5300.25
395_G409_S0.5300.25
230_G437_S0.5290.25
226_D277_A0.5280.25
115_H329_A0.5280.25
305_Q342_L0.5270.25
200_H350_T0.5270.25
151_I255_D0.5260.25
352_A356_D0.5260.25
392_F424_V0.5260.25
219_T295_I0.5240.25
108_F236_Y0.5230.25
348_V419_P0.5220.25
128_H175_H0.5200.25
185_Q252_T0.5200.25
141_L150_K0.5200.25
280_F396_I0.5200.25
301_L310_D0.5190.25
324_T431_R0.5180.24
325_V328_I0.5170.24
391_G413_R0.5170.24
108_F160_D0.5160.24
204_E251_L0.5150.24
161_R416_F0.5140.24
114_L237_I0.5140.24
209_T213_L0.5140.24
325_V376_S0.5130.24
118_A299_V0.5120.24
215_R235_V0.5100.24
328_I351_L0.5080.24
327_A418_H0.5080.24
366_K399_N0.5070.24
261_K338_I0.5060.24
299_V367_K0.5060.24
88_I116_E0.5060.24
200_H300_D0.5050.24
193_F412_G0.5050.24
294_L394_F0.5040.24
389_E432_S0.5030.24
142_Y174_Q0.5020.23
213_L376_S0.5020.23
172_L270_T0.5010.23
194_F341_H0.5000.23
223_E279_S0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ylrA 1 0.5629 100 0.771 Contact Map
4i4tF 1 0.638 100 0.775 Contact Map
1gsaA 3 0.649 100 0.776 Contact Map
3vpbA 3 0.6049 99.9 0.787 Contact Map
4iwxA 3 0.6313 99.9 0.803 Contact Map
3vpdA 3 0.6026 99.9 0.809 Contact Map
2p0aA 3 0.6291 99.9 0.829 Contact Map
3n6xA 2 0.6556 99.8 0.834 Contact Map
4c5cA 2 0.6247 99.8 0.837 Contact Map
3k3pA 2 0.6313 99.8 0.837 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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