GREMLIN Database
YHEC - Endospore coat-associated protein YheC
UniProt: O07544 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 363 (335)
Sequences: 897 (777)
Seq/√Len: 42.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
228_N234_N4.8561.00
308_A314_W3.9251.00
146_A208_Y3.8051.00
47_V66_I3.4201.00
227_K292_D3.3491.00
231_G348_Y2.9321.00
211_I306_C2.8331.00
49_A64_M2.7271.00
149_L203_Y2.7091.00
25_A32_F2.6721.00
109_W130_K2.6441.00
243_G250_A2.5661.00
124_Y283_I2.5621.00
46_R63_E2.5341.00
212_Q219_C2.4661.00
148_I208_Y2.4401.00
53_H60_N2.4331.00
300_E322_P2.4121.00
159_G203_Y2.4111.00
170_I191_F2.4041.00
240_V264_W2.3891.00
35_F47_V2.3261.00
48_K61_E2.2951.00
51_V64_M2.2021.00
315_I318_I2.1841.00
224_F322_P2.1791.00
101_I299_F2.1731.00
227_K233_W2.1531.00
224_F300_E2.0900.99
306_C316_L2.0760.99
146_A162_L2.0180.99
33_I64_M1.9970.99
35_F40_I1.9110.99
229_E344_K1.9110.99
157_G220_D1.8940.99
307_L313_I1.8530.98
127_E207_P1.8460.98
127_E144_E1.8170.98
30_I343_L1.8010.98
225_M288_P1.7590.98
121_I287_V1.7460.98
72_D104_G1.7410.98
109_W128_T1.7320.98
132_S136_Q1.7260.98
324_R327_I1.7230.98
77_G105_L1.7190.98
71_Y300_E1.7100.97
239_A326_S1.7070.97
161_I172_A1.7050.97
226_E236_V1.6360.97
261_F277_L1.6350.97
300_E321_K1.6230.96
113_H348_Y1.6100.96
253_S302_G1.6050.96
157_G319_N1.5970.96
127_E143_K1.5840.96
251_N316_L1.5780.96
151_P203_Y1.5760.96
285_Q288_P1.5750.96
59_W322_P1.5710.96
118_H290_Y1.5470.95
253_S323_G1.5420.95
71_Y320_S1.5400.95
162_L208_Y1.5390.95
112_L116_Q1.5390.95
298_L301_L1.5370.95
226_E342_P1.5270.95
172_A185_F1.5150.95
25_A30_I1.4800.94
129_I140_F1.4600.94
106_P323_G1.4560.94
108_K317_D1.4490.93
237_G327_I1.4470.93
107_D153_F1.4450.93
33_I51_V1.4410.93
283_I305_I1.4290.93
140_F205_L1.4270.93
220_D241_R1.4250.93
131_V137_I1.4170.93
42_P66_I1.4120.92
74_C77_G1.4110.92
108_K319_N1.4100.92
108_K157_G1.4080.92
129_I136_Q1.4010.92
149_L205_L1.3990.92
283_I315_I1.3920.92
261_F265_F1.3860.92
33_I49_A1.3840.92
148_I248_L1.3790.92
42_P91_W1.3740.91
72_D101_I1.3610.91
59_W241_R1.3590.91
221_I240_V1.3400.90
225_M285_Q1.3360.90
306_C311_G1.3340.90
241_R322_P1.3310.90
251_N302_G1.3300.90
224_F241_R1.3240.90
108_K304_D1.3190.90
102_G299_F1.3160.90
102_G106_P1.3070.89
150_K157_G1.3020.89
105_L321_K1.3020.89
303_L318_I1.2950.89
21_L300_E1.2850.88
41_S46_R1.2800.88
305_I313_I1.2800.88
104_G320_S1.2690.88
308_A312_R1.2640.88
215_E315_I1.2510.87
300_E314_W1.2490.87
106_P299_F1.2450.87
102_G126_P1.2380.86
154_G319_N1.2280.86
166_G169_N1.2250.86
249_L323_G1.2250.86
224_F324_R1.2220.86
148_I162_L1.2020.85
323_G326_S1.2010.85
109_W204_L1.1940.84
255_G322_P1.1910.84
121_I290_Y1.1850.84
223_L320_S1.1800.84
299_F349_L1.1710.83
326_S330_V1.1700.83
162_L173_T1.1670.83
29_G255_G1.1670.83
252_L258_A1.1630.83
304_D319_N1.1620.83
221_I261_F1.1600.83
157_G317_D1.1570.82
185_F194_W1.1540.82
108_K150_K1.1510.82
238_K250_A1.1440.82
41_S44_T1.1320.81
147_C232_E1.1260.81
121_I283_I1.1240.81
52_Y59_W1.1200.80
72_D321_K1.1180.80
141_L147_C1.1120.80
108_K206_Q1.1070.79
239_A323_G1.1070.79
150_K206_Q1.1060.79
140_F147_C1.1020.79
146_A164_K1.1010.79
72_D105_L1.1000.79
112_L125_I1.0850.78
145_K165_L1.0840.78
120_V286_S1.0780.78
150_K319_N1.0770.78
150_K220_D1.0760.77
302_G323_G1.0740.77
157_G251_N1.0650.77
51_V62_T1.0620.77
233_W288_P1.0620.77
157_G255_G1.0610.76
302_G306_C1.0570.76
114_D295_Y1.0550.76
207_P314_W1.0520.76
34_R249_L1.0480.76
338_L342_P1.0460.75
187_N190_S1.0450.75
302_G319_N1.0430.75
275_V312_R1.0430.75
347_Q351_S1.0430.75
151_P233_W1.0380.75
157_G206_Q1.0350.75
136_Q139_S1.0320.74
206_Q220_D1.0290.74
300_E320_S1.0290.74
306_C323_G1.0270.74
28_F344_K1.0240.74
239_A251_N1.0240.74
45_L66_I1.0220.74
58_T167_K1.0210.74
128_T296_G1.0140.73
250_A318_I1.0040.72
224_F316_L1.0010.72
72_D323_G0.9990.72
150_K317_D0.9960.72
72_D252_L0.9880.71
108_K222_R0.9880.71
220_D256_S0.9870.71
239_A324_R0.9830.71
165_L170_I0.9760.70
249_L254_G0.9740.70
125_I346_C0.9730.70
249_L316_L0.9730.70
73_R321_K0.9690.70
48_K190_S0.9620.69
324_R338_L0.9590.69
151_P159_G0.9590.69
224_F338_L0.9580.69
108_K302_G0.9570.69
59_W314_W0.9570.69
157_G302_G0.9560.69
259_L264_W0.9450.68
300_E324_R0.9440.68
237_G323_G0.9440.68
36_T39_D0.9430.68
62_T70_I0.9360.67
236_V341_C0.9330.67
220_D255_G0.9320.67
331_S334_Q0.9310.67
249_L256_S0.9290.66
240_V261_F0.9250.66
241_R332_P0.9210.66
14_E237_G0.9200.66
224_F321_K0.9200.66
35_F70_I0.9180.65
227_K314_W0.9100.65
287_V303_L0.9070.65
107_D152_A0.9060.64
255_G319_N0.9060.64
126_P207_P0.9020.64
69_Y91_W0.9010.64
296_G300_E0.8970.64
128_T206_Q0.8960.64
187_N210_N0.8950.63
101_I346_C0.8900.63
105_L320_S0.8900.63
154_G284_T0.8880.63
320_S323_G0.8870.63
101_I151_P0.8830.62
73_R300_E0.8760.62
222_R304_D0.8730.62
107_D298_L0.8720.61
265_F284_T0.8710.61
18_S22_A0.8710.61
93_K103_R0.8710.61
191_F195_C0.8700.61
224_F239_A0.8700.61
97_K141_L0.8690.61
241_R324_R0.8670.61
251_N325_K0.8660.61
105_L323_G0.8650.61
17_Y111_V0.8630.61
255_G321_K0.8600.60
342_P346_C0.8570.60
272_Q275_V0.8570.60
219_C240_V0.8520.60
20_E335_K0.8480.59
210_N309_K0.8440.59
90_E94_K0.8430.59
235_T285_Q0.8420.59
223_L347_Q0.8410.59
94_K117_Q0.8370.58
102_G208_Y0.8350.58
262_D277_L0.8280.57
163_L170_I0.8270.57
249_L253_S0.8210.57
255_G302_G0.8140.56
71_Y322_P0.8120.56
268_I276_L0.8110.56
75_F251_N0.8080.56
18_S34_R0.8060.55
124_Y312_R0.8050.55
163_L308_A0.8050.55
221_I280_V0.8050.55
297_P345_R0.8000.55
36_T88_I0.7980.55
211_I316_L0.7970.55
101_I105_L0.7920.54
94_K168_K0.7860.54
237_G337_Q0.7850.53
135_E184_T0.7850.53
235_T238_K0.7800.53
58_T202_Q0.7790.53
304_D317_D0.7770.53
156_G325_K0.7760.53
227_K306_C0.7740.52
206_Q317_D0.7710.52
241_R253_S0.7700.52
45_L64_M0.7670.52
73_R237_G0.7670.52
106_P318_I0.7640.51
224_F302_G0.7640.51
266_E307_L0.7540.50
226_E316_L0.7530.50
53_H58_T0.7530.50
275_V281_F0.7520.50
303_L315_I0.7520.50
131_V205_L0.7470.50
175_H254_G0.7460.50
163_L172_A0.7460.50
142_S271_K0.7440.50
116_Q163_L0.7440.50
89_V209_L0.7420.49
70_I301_L0.7400.49
146_A207_P0.7400.49
287_V291_L0.7390.49
71_Y321_K0.7360.49
226_E300_E0.7330.49
206_Q319_N0.7330.49
53_H268_I0.7320.48
220_D319_N0.7320.48
221_I315_I0.7310.48
102_G288_P0.7290.48
284_T288_P0.7290.48
251_N323_G0.7280.48
115_L290_Y0.7270.48
164_K171_T0.7240.48
261_F280_V0.7190.47
197_K260_T0.7190.47
226_E341_C0.7180.47
105_L322_P0.7170.47
72_D254_G0.7130.47
18_S148_I0.7130.47
233_W314_W0.7060.46
169_N281_F0.7050.46
251_N255_G0.7010.45
39_D49_A0.7000.45
139_S279_D0.6970.45
72_D89_V0.6960.45
151_P322_P0.6940.45
56_S168_K0.6930.45
12_Q15_A0.6920.45
165_L182_T0.6910.45
207_P323_G0.6910.45
239_A253_S0.6900.44
75_F105_L0.6850.44
249_L327_I0.6840.44
224_F255_G0.6810.44
258_A331_S0.6800.44
206_Q241_R0.6780.43
106_P298_L0.6780.43
140_F207_P0.6780.43
224_F323_G0.6770.43
256_S322_P0.6760.43
270_K346_C0.6750.43
144_E205_L0.6750.43
301_L323_G0.6730.43
20_E59_W0.6730.43
199_L204_L0.6730.43
249_L318_I0.6710.43
222_R319_N0.6700.43
184_T189_T0.6690.43
77_G321_K0.6690.43
43_D51_V0.6660.42
160_V203_Y0.6660.42
31_R205_L0.6650.42
16_D50_S0.6630.42
101_I297_P0.6630.42
237_G258_A0.6610.42
241_R303_L0.6610.42
109_W296_G0.6610.42
37_P298_L0.6600.42
101_I106_P0.6580.42
162_L316_L0.6580.42
223_L238_K0.6580.42
60_N112_L0.6560.41
301_L318_I0.6540.41
243_G264_W0.6530.41
102_G105_L0.6520.41
74_C105_L0.6500.41
210_N308_A0.6500.41
233_W308_A0.6490.41
157_G241_R0.6480.41
21_L346_C0.6480.41
113_H116_Q0.6460.40
60_N193_T0.6430.40
108_K220_D0.6430.40
14_E18_S0.6420.40
153_F248_L0.6410.40
44_T275_V0.6410.40
157_G304_D0.6390.40
130_K286_S0.6350.39
150_K304_D0.6350.39
211_I256_S0.6340.39
72_D100_F0.6320.39
97_K232_E0.6320.39
226_E339_Y0.6290.39
89_V100_F0.6290.39
224_F249_L0.6290.39
20_E239_A0.6280.39
226_E251_N0.6280.39
75_F316_L0.6270.39
287_V318_I0.6270.39
47_V97_K0.6260.39
233_W251_N0.6250.39
139_S190_S0.6180.38
116_Q307_L0.6170.38
111_V348_Y0.6160.38
14_E250_A0.6150.38
75_F323_G0.6140.38
24_R343_L0.6110.37
163_L257_D0.6110.37
161_I203_Y0.6110.37
237_G253_S0.6100.37
298_L303_L0.6090.37
148_I239_A0.6080.37
255_G306_C0.6070.37
70_I100_F0.6030.37
72_D253_S0.6030.37
17_Y239_A0.6030.37
70_I97_K0.6020.36
209_L316_L0.6020.36
223_L280_V0.6010.36
163_L191_F0.6000.36
105_L151_P0.6000.36
277_L281_F0.5990.36
316_L342_P0.5990.36
302_G322_P0.5950.36
77_G101_I0.5940.36
228_N232_E0.5940.36
251_N256_S0.5940.36
49_A225_M0.5920.36
146_A210_N0.5920.36
128_T220_D0.5920.36
74_C342_P0.5920.36
44_T123_P0.5900.35
323_G327_I0.5890.35
186_S190_S0.5890.35
70_I190_S0.5870.35
151_P160_V0.5850.35
197_K282_S0.5820.35
70_I151_P0.5810.35
133_R179_D0.5810.35
208_Y243_G0.5760.34
278_D293_E0.5730.34
160_V250_A0.5730.34
134_Y262_D0.5720.34
345_R349_L0.5720.34
239_A320_S0.5690.34
288_P301_L0.5670.33
183_K287_V0.5670.33
216_Q243_G0.5670.33
225_M235_T0.5620.33
233_W265_F0.5610.33
148_I299_F0.5600.33
144_E184_T0.5560.33
117_Q294_R0.5560.33
32_F226_E0.5560.33
40_I295_Y0.5560.33
77_G160_V0.5560.33
102_G207_P0.5550.32
98_T204_L0.5550.32
233_W284_T0.5530.32
204_L271_K0.5530.32
202_Q303_L0.5530.32
29_G256_S0.5530.32
16_D70_I0.5520.32
160_V251_N0.5520.32
175_H346_C0.5510.32
135_E232_E0.5510.32
259_L263_S0.5500.32
237_G324_R0.5500.32
258_A324_R0.5490.32
216_Q255_G0.5470.32
198_V202_Q0.5470.32
147_C278_D0.5440.32
241_R330_V0.5430.31
164_K210_N0.5420.31
171_T182_T0.5400.31
117_Q125_I0.5400.31
88_I92_L0.5400.31
147_C205_L0.5390.31
128_T204_L0.5380.31
184_T246_H0.5370.31
68_D350_F0.5360.31
128_T224_F0.5360.31
72_D299_F0.5360.31
191_F307_L0.5340.31
117_Q167_K0.5340.31
319_N322_P0.5310.31
249_L337_Q0.5300.30
53_H120_V0.5300.30
25_A239_A0.5290.30
59_W300_E0.5260.30
18_S111_V0.5250.30
17_Y323_G0.5250.30
36_T302_G0.5240.30
292_D307_L0.5220.30
179_D193_T0.5220.30
126_P211_I0.5220.30
73_R126_P0.5200.30
34_R252_L0.5200.30
103_R250_A0.5200.30
241_R335_K0.5190.30
35_F227_K0.5190.30
150_K302_G0.5160.29
202_Q216_Q0.5140.29
235_T288_P0.5140.29
169_N232_E0.5140.29
86_K262_D0.5130.29
92_L238_K0.5130.29
263_S266_E0.5120.29
49_A192_K0.5100.29
21_L111_V0.5070.29
168_K293_E0.5070.29
102_G148_I0.5070.29
142_S347_Q0.5060.29
106_P320_S0.5060.29
276_L307_L0.5050.28
317_D327_I0.5050.28
221_I238_K0.5040.28
138_H163_L0.5010.28
242_R259_L0.5010.28
113_H143_K0.5010.28
78_K257_D0.5010.28
156_G241_R0.5000.28
225_M303_L0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1gsaA 3 0.8072 100 0.713 Contact Map
4ylrA 1 0.7052 100 0.73 Contact Map
4i4tF 1 0.7824 100 0.731 Contact Map
3vpbA 3 0.7521 99.9 0.737 Contact Map
4iwxA 3 0.7824 99.9 0.742 Contact Map
3vpdA 3 0.741 99.9 0.761 Contact Map
3k3pA 2 0.7741 99.9 0.783 Contact Map
3n6xA 2 0.6171 99.9 0.783 Contact Map
4c5cA 2 0.7603 99.9 0.784 Contact Map
2p0aA 3 0.7658 99.9 0.785 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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