GREMLIN Database
YHEB - UPF0754 membrane protein YheB
UniProt: O07543 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (350)
Sequences: 1291 (959)
Seq/√Len: 51.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_R56_E6.3741.00
47_P51_P4.7011.00
15_A364_G3.7951.00
11_I364_G3.5921.00
85_K308_L3.4321.00
228_E231_N3.2731.00
348_S352_F3.1431.00
337_V341_E3.0941.00
6_T371_A2.8501.00
59_K333_D2.7341.00
7_F375_I2.6961.00
83_A308_L2.4571.00
80_V312_S2.4391.00
329_K333_D2.4341.00
351_E358_L2.3641.00
34_K39_F2.3391.00
13_I45_F2.3221.00
58_A332_V2.3221.00
326_E330_E2.2871.00
351_E356_T2.2661.00
146_L149_L2.2151.00
57_L66_V2.1901.00
199_M211_S2.1491.00
199_M204_V2.1491.00
148_E152_I2.1391.00
214_A218_L2.1051.00
66_V325_E2.0941.00
22_N28_M2.0811.00
21_T28_M2.0081.00
40_G44_P2.0051.00
239_K242_W1.9510.99
336_P339_R1.9350.99
199_M207_F1.9150.99
7_F371_A1.9140.99
45_F354_M1.8840.99
174_V178_E1.8660.99
11_I368_A1.8560.99
19_A360_G1.8210.99
22_N356_T1.8080.99
207_F211_S1.7890.99
69_L335_F1.7880.99
83_A86_T1.7880.99
207_F210_N1.7880.99
61_M332_V1.7720.99
21_T356_T1.7650.99
20_V366_I1.7630.99
13_I69_L1.7580.99
145_S158_L1.7260.99
31_R51_P1.7090.99
168_Y172_R1.7000.99
199_M206_L1.6950.99
14_G19_A1.6940.99
199_M203_M1.6940.99
23_H356_T1.6880.99
22_N358_L1.6850.98
214_A225_L1.6670.98
23_H28_M1.6610.98
161_K164_M1.6610.98
21_T358_L1.6070.98
50_I150_V1.5980.98
11_I15_A1.5980.98
342_E346_S1.5720.98
7_F372_L1.5680.98
198_G202_S1.5680.98
24_L28_M1.5660.98
104_V285_G1.5210.97
21_T24_L1.5150.97
59_K329_K1.5120.97
272_Q277_A1.5020.97
226_R230_T1.5000.97
359_G363_G1.4860.97
37_Y40_G1.4770.97
54_R332_V1.4750.96
200_L207_F1.4660.96
68_H343_M1.4500.96
44_P47_P1.4300.96
78_R81_S1.4110.95
157_K161_K1.3980.95
269_R272_Q1.3870.95
189_M193_F1.3800.95
288_T291_Y1.3800.95
14_G24_L1.3740.95
28_M356_T1.3670.95
236_D243_G1.3630.95
13_I17_I1.3420.94
62_G331_Q1.3380.94
28_M39_F1.3330.94
345_L353_K1.3330.94
34_K37_Y1.3300.94
231_N242_W1.3270.94
201_G207_F1.3190.93
358_L370_Q1.3160.93
360_G371_A1.3080.93
220_E223_K1.3040.93
345_L356_T1.2920.93
18_G30_F1.2890.93
64_M335_F1.2870.93
363_G367_G1.2860.93
28_M358_L1.2640.92
298_Q305_D1.2630.92
204_V209_G1.2540.92
198_G201_G1.2490.91
266_L282_N1.2490.91
183_K187_G1.2460.91
348_S356_T1.2420.91
205_Q208_L1.2410.91
22_N26_I1.2410.91
38_L44_P1.2290.91
354_M357_Y1.2250.91
18_G25_A1.2230.91
260_K263_I1.2170.90
214_A224_F1.2090.90
145_S297_Q1.2080.90
58_A62_G1.2000.90
88_A318_V1.1870.89
335_F354_M1.1800.89
359_G367_G1.1770.89
166_S217_V1.1700.89
252_E369_I1.1700.89
37_Y44_P1.1680.88
7_F368_A1.1650.88
22_N45_F1.1640.88
199_M205_Q1.1640.88
370_Q373_F1.1530.88
188_N192_D1.1500.88
12_V69_L1.1490.88
49_L340_L1.1460.87
74_G78_R1.1420.87
10_M13_I1.1400.87
94_Q97_Q1.1390.87
186_L194_L1.1380.87
17_I354_M1.1370.87
89_L292_E1.1350.87
34_K40_G1.1280.87
49_L295_L1.1250.87
22_N370_Q1.1240.86
306_K310_G1.1220.86
17_I24_L1.1210.86
345_L352_F1.1190.86
301_P305_D1.1170.86
21_T26_I1.1160.86
240_N243_G1.1130.86
366_I370_Q1.1010.85
150_V307_L1.0900.85
35_A47_P1.0880.85
21_T27_Q1.0770.84
21_T45_F1.0750.84
240_N244_K1.0750.84
132_D260_K1.0740.84
62_G71_T1.0730.84
28_M47_P1.0670.83
19_A123_D1.0640.83
93_E293_S1.0630.83
50_I57_L1.0590.83
23_H345_L1.0590.83
67_N319_L1.0590.83
28_M370_Q1.0580.83
293_S297_Q1.0560.83
134_L137_L1.0560.83
203_M206_L1.0530.83
355_I363_G1.0490.82
34_K38_L1.0470.82
266_L297_Q1.0460.82
63_L79_L1.0460.82
13_I21_T1.0430.82
316_E344_V1.0430.82
145_S148_E1.0430.82
72_P320_K1.0420.82
11_I371_A1.0400.82
49_L52_R1.0380.82
28_M45_F1.0370.82
208_L211_S1.0350.82
224_F348_S1.0340.81
54_R335_F1.0340.81
45_F82_D1.0260.81
45_F349_K1.0250.81
345_L349_K1.0220.81
53_R57_L1.0200.81
21_T370_Q1.0180.80
13_I22_N1.0160.80
356_T362_L1.0140.80
146_L151_P1.0100.80
22_N40_G1.0090.80
22_N351_E1.0020.79
200_L204_V1.0020.79
22_N27_Q1.0010.79
14_G21_T0.9990.79
44_P68_H0.9980.79
202_S206_L0.9960.79
217_V221_L0.9950.79
252_E313_S0.9910.79
13_I28_M0.9900.79
64_M328_V0.9870.78
28_M40_G0.9860.78
353_K356_T0.9850.78
104_V108_E0.9830.78
13_I24_L0.9790.78
119_E338_E0.9780.78
61_M64_M0.9740.77
22_N47_P0.9690.77
91_V311_I0.9680.77
47_P69_L0.9670.77
22_N37_Y0.9650.77
353_K358_L0.9620.77
14_G22_N0.9610.76
21_T351_E0.9590.76
264_F268_R0.9590.76
28_M351_E0.9550.76
237_L242_W0.9490.76
45_F69_L0.9470.75
7_F11_I0.9460.75
93_E296_T0.9460.75
24_L45_F0.9450.75
23_H352_F0.9430.75
203_M211_S0.9360.75
22_N345_L0.9360.75
345_L358_L0.9340.74
21_T40_G0.9320.74
27_Q36_Y0.9320.74
10_M14_G0.9300.74
343_M347_I0.9260.74
332_V347_I0.9240.74
62_G329_K0.9220.73
23_H27_Q0.9210.73
28_M362_L0.9210.73
228_E242_W0.9180.73
83_A304_L0.9180.73
21_T47_P0.9170.73
21_T37_Y0.9090.72
162_I218_L0.8990.71
10_M19_A0.8990.71
202_S207_F0.8980.71
27_Q37_Y0.8980.71
37_Y45_F0.8970.71
65_V339_R0.8960.71
64_M360_G0.8910.71
39_F47_P0.8890.71
14_G351_E0.8870.70
45_F356_T0.8840.70
25_A30_F0.8830.70
350_K354_M0.8810.70
22_N39_F0.8810.70
12_V35_A0.8800.70
242_W246_R0.8750.69
282_N285_G0.8720.69
22_N341_E0.8720.69
45_F358_L0.8720.69
309_E313_S0.8700.69
207_F284_I0.8690.69
45_F351_E0.8650.69
149_L153_E0.8650.69
10_M354_M0.8570.68
333_D348_S0.8550.68
8_I12_V0.8530.67
79_L115_M0.8530.67
7_F366_I0.8520.67
10_M45_F0.8510.67
19_A22_N0.8420.66
26_I356_T0.8400.66
9_F15_A0.8380.66
355_I359_G0.8380.66
28_M341_E0.8350.66
193_F197_R0.8320.66
319_L331_Q0.8310.65
144_Q235_S0.8310.65
21_T345_L0.8250.65
39_F45_F0.8250.65
289_V292_E0.8250.65
62_G347_I0.8240.65
17_I45_F0.8230.65
286_T289_V0.8180.64
138_F262_L0.8180.64
24_L61_M0.8160.64
343_M360_G0.8150.64
69_L343_M0.8130.64
12_V341_E0.8050.63
75_I333_D0.8030.63
193_F220_E0.8010.63
64_M343_M0.8000.62
37_Y47_P0.7980.62
252_E255_E0.7980.62
21_T341_E0.7970.62
23_H348_S0.7830.61
22_N85_K0.7830.61
24_L349_K0.7830.61
15_A106_V0.7810.61
54_R64_M0.7790.60
24_L356_T0.7770.60
23_H351_E0.7760.60
198_G207_F0.7760.60
192_D298_Q0.7710.60
21_T39_F0.7690.59
57_L335_F0.7670.59
177_F180_D0.7670.59
340_L344_V0.7650.59
146_L270_V0.7640.59
190_I364_G0.7630.59
165_I264_F0.7630.59
364_G371_A0.7570.58
355_I367_G0.7560.58
15_A38_L0.7550.58
200_L250_F0.7540.58
24_L358_L0.7540.58
172_R175_R0.7520.58
215_D219_P0.7510.58
249_T252_E0.7500.57
332_V340_L0.7470.57
75_I365_I0.7470.57
35_A39_F0.7460.57
22_N82_D0.7450.57
54_R337_V0.7420.57
357_Y362_L0.7410.57
27_Q357_Y0.7400.56
8_I284_I0.7400.56
23_H358_L0.7390.56
51_P338_E0.7380.56
199_M208_L0.7370.56
351_E370_Q0.7300.55
307_L311_I0.7270.55
54_R58_A0.7270.55
337_V345_L0.7210.55
68_H227_N0.7200.54
351_E354_M0.7200.54
335_F360_G0.7160.54
28_M36_Y0.7150.54
10_M371_A0.7150.54
21_T85_K0.7140.54
6_T365_I0.7140.54
118_P213_L0.7120.54
358_L362_L0.7100.53
13_I345_L0.7090.53
143_D158_L0.7090.53
330_E333_D0.7060.53
94_Q132_D0.7050.53
146_L223_K0.7030.53
66_V319_L0.7010.52
135_H186_L0.7010.52
316_E333_D0.6980.52
14_G47_P0.6980.52
340_L347_I0.6960.52
63_L67_N0.6920.52
54_R328_V0.6900.51
21_T36_Y0.6880.51
204_V207_F0.6880.51
52_R77_K0.6850.51
22_N36_Y0.6830.51
23_H349_K0.6800.50
21_T347_I0.6800.50
283_T286_T0.6790.50
317_S369_I0.6790.50
341_E347_I0.6780.50
71_T347_I0.6780.50
79_L276_T0.6770.50
152_I156_E0.6760.50
11_I19_A0.6760.50
364_G369_I0.6720.49
345_L351_E0.6720.49
62_G332_V0.6710.49
146_L153_E0.6700.49
223_K226_R0.6700.49
19_A356_T0.6690.49
332_V335_F0.6680.49
118_P266_L0.6660.49
22_N347_I0.6630.48
34_K52_R0.6610.48
183_K338_E0.6600.48
71_T341_E0.6600.48
126_I137_L0.6590.48
40_G45_F0.6560.48
365_I369_I0.6560.48
114_G188_N0.6540.48
356_T370_Q0.6540.48
201_G205_Q0.6540.48
54_R346_S0.6540.48
198_G204_V0.6510.47
201_G206_L0.6510.47
315_L340_L0.6500.47
245_L250_F0.6500.47
177_F221_L0.6470.47
245_L267_K0.6470.47
189_M252_E0.6450.47
362_L366_I0.6430.46
191_D197_R0.6430.46
326_E329_K0.6420.46
205_Q210_N0.6370.46
40_G47_P0.6360.46
34_K44_P0.6360.46
179_S221_L0.6350.46
165_I170_L0.6350.46
21_T82_D0.6340.45
72_P76_K0.6320.45
132_D136_E0.6320.45
21_T362_L0.6290.45
153_E156_E0.6280.45
294_E298_Q0.6280.45
126_I279_F0.6280.45
7_F35_A0.6270.45
345_L360_G0.6260.45
14_G356_T0.6260.45
160_E163_P0.6260.45
353_K360_G0.6240.44
233_L237_L0.6240.44
167_G170_L0.6230.44
164_M167_G0.6230.44
183_K193_F0.6220.44
144_Q150_V0.6220.44
51_P314_N0.6210.44
180_D196_E0.6190.44
78_R350_K0.6190.44
202_S212_S0.6160.44
53_R340_L0.6150.44
371_A374_V0.6140.43
13_I353_K0.6140.43
27_Q47_P0.6140.43
335_F351_E0.6130.43
345_L357_Y0.6120.43
354_M358_L0.6110.43
57_L347_I0.6080.43
217_V332_V0.6040.42
8_I67_N0.6040.42
233_L243_G0.6030.42
145_S157_K0.6020.42
69_L360_G0.6020.42
57_L60_Q0.6010.42
149_L152_I0.6000.42
177_F192_D0.6000.42
335_F356_T0.5980.42
22_N362_L0.5980.42
198_G206_L0.5970.42
19_A27_Q0.5970.42
24_L337_V0.5940.41
366_I371_A0.5940.41
28_M353_K0.5920.41
253_A327_I0.5910.41
98_K107_K0.5900.41
244_K249_T0.5900.41
201_G208_L0.5890.41
79_L256_K0.5890.41
354_M371_A0.5870.41
113_A175_R0.5860.41
252_E261_A0.5830.40
19_A371_A0.5830.40
44_P332_V0.5800.40
73_E89_L0.5800.40
138_F208_L0.5780.40
196_E204_V0.5760.40
234_L243_G0.5750.40
166_S186_L0.5750.40
28_M37_Y0.5750.40
233_L369_I0.5740.39
361_L366_I0.5730.39
19_A46_T0.5720.39
64_M69_L0.5710.39
19_A364_G0.5710.39
78_R320_K0.5690.39
157_K190_I0.5690.39
112_K287_L0.5640.38
62_G172_R0.5630.38
75_I84_A0.5620.38
165_I173_S0.5620.38
201_G210_N0.5620.38
23_H26_I0.5610.38
190_I197_R0.5600.38
139_R143_D0.5580.38
118_P365_I0.5570.38
28_M347_I0.5570.38
39_F44_P0.5570.38
170_L173_S0.5570.38
150_V156_E0.5560.38
144_Q148_E0.5560.38
15_A46_T0.5550.38
68_H332_V0.5550.38
67_N198_G0.5540.37
190_I193_F0.5530.37
191_D196_E0.5500.37
366_I369_I0.5500.37
161_K177_F0.5480.37
35_A44_P0.5460.37
293_S296_T0.5420.36
13_I26_I0.5380.36
130_T247_E0.5380.36
14_G367_G0.5370.36
94_Q217_V0.5360.36
86_T304_L0.5360.36
14_G28_M0.5350.36
187_G191_D0.5350.36
28_M82_D0.5340.36
197_R340_L0.5320.35
132_D255_E0.5310.35
160_E293_S0.5310.35
191_D194_L0.5310.35
167_G231_N0.5310.35
11_I361_L0.5290.35
60_Q347_I0.5280.35
28_M345_L0.5260.35
218_L246_R0.5250.35
47_P308_L0.5230.34
26_I358_L0.5230.34
203_M207_F0.5220.34
248_Y252_E0.5200.34
45_F370_Q0.5200.34
37_Y356_T0.5200.34
62_G66_V0.5200.34
184_I252_E0.5200.34
332_V341_E0.5190.34
47_P351_E0.5190.34
36_Y47_P0.5180.34
213_L216_R0.5180.34
89_L93_E0.5170.34
252_E256_K0.5160.34
178_E268_R0.5130.34
145_S235_S0.5130.34
36_Y356_T0.5130.34
150_V318_V0.5110.33
270_V286_T0.5090.33
194_L197_R0.5090.33
57_L345_L0.5070.33
215_D218_L0.5040.33
221_L261_A0.5040.33
59_K365_I0.5030.33
22_N322_L0.5030.33
133_K136_E0.5020.33
323_R326_E0.5020.33
267_K271_L0.5010.32
151_P160_E0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.0769 55.3 0.957 Contact Map
4im7A 1 0.6048 30.7 0.963 Contact Map
2ks1B 1 0.0875 29.8 0.963 Contact Map
2gj4A 2 0.3501 25.6 0.964 Contact Map
2m20A 2 0.0663 23.7 0.965 Contact Map
1lj8A 1 0.5676 23 0.965 Contact Map
2l2tA 2 0.0849 20.6 0.966 Contact Map
2nnwA 2 0.2095 20.4 0.966 Contact Map
3mhsB 1 0.2361 18.6 0.966 Contact Map
2kncB 1 0.0875 16.3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0106 seconds.