YHEB - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

YHEB - UPF0754 membrane protein YheB

UniProt:	O07543	Sequences: MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVPFTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLSEVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEEKIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVLPELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFSTAPFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQFPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	377 (350)
Sequences:	1291 (959)
Seq/√Len:	51.3

ECOLI - YJIN
BACSU - YHEB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
53_R	56_E	6.374	1.00
47_P	51_P	4.701	1.00
15_A	364_G	3.795	1.00
11_I	364_G	3.592	1.00
85_K	308_L	3.432	1.00
228_E	231_N	3.273	1.00
348_S	352_F	3.143	1.00
337_V	341_E	3.094	1.00
6_T	371_A	2.850	1.00
59_K	333_D	2.734	1.00
7_F	375_I	2.696	1.00
83_A	308_L	2.457	1.00
80_V	312_S	2.439	1.00
329_K	333_D	2.434	1.00
351_E	358_L	2.364	1.00
34_K	39_F	2.339	1.00
13_I	45_F	2.322	1.00
58_A	332_V	2.322	1.00
326_E	330_E	2.287	1.00
351_E	356_T	2.266	1.00
146_L	149_L	2.215	1.00
57_L	66_V	2.190	1.00
199_M	211_S	2.149	1.00
199_M	204_V	2.149	1.00
148_E	152_I	2.139	1.00
214_A	218_L	2.105	1.00
66_V	325_E	2.094	1.00
22_N	28_M	2.081	1.00
21_T	28_M	2.008	1.00
40_G	44_P	2.005	1.00
239_K	242_W	1.951	0.99
336_P	339_R	1.935	0.99
199_M	207_F	1.915	0.99
7_F	371_A	1.914	0.99
45_F	354_M	1.884	0.99
174_V	178_E	1.866	0.99
11_I	368_A	1.856	0.99
19_A	360_G	1.821	0.99
22_N	356_T	1.808	0.99
207_F	211_S	1.789	0.99
69_L	335_F	1.788	0.99
83_A	86_T	1.788	0.99
207_F	210_N	1.788	0.99
61_M	332_V	1.772	0.99
21_T	356_T	1.765	0.99
20_V	366_I	1.763	0.99
13_I	69_L	1.758	0.99
145_S	158_L	1.726	0.99
31_R	51_P	1.709	0.99
168_Y	172_R	1.700	0.99
199_M	206_L	1.695	0.99
14_G	19_A	1.694	0.99
199_M	203_M	1.694	0.99
23_H	356_T	1.688	0.99
22_N	358_L	1.685	0.98
214_A	225_L	1.667	0.98
23_H	28_M	1.661	0.98
161_K	164_M	1.661	0.98
21_T	358_L	1.607	0.98
50_I	150_V	1.598	0.98
11_I	15_A	1.598	0.98
342_E	346_S	1.572	0.98
7_F	372_L	1.568	0.98
198_G	202_S	1.568	0.98
24_L	28_M	1.566	0.98
104_V	285_G	1.521	0.97
21_T	24_L	1.515	0.97
59_K	329_K	1.512	0.97
272_Q	277_A	1.502	0.97
226_R	230_T	1.500	0.97
359_G	363_G	1.486	0.97
37_Y	40_G	1.477	0.97
54_R	332_V	1.475	0.96
200_L	207_F	1.466	0.96
68_H	343_M	1.450	0.96
44_P	47_P	1.430	0.96
78_R	81_S	1.411	0.95
157_K	161_K	1.398	0.95
269_R	272_Q	1.387	0.95
189_M	193_F	1.380	0.95
288_T	291_Y	1.380	0.95
14_G	24_L	1.374	0.95
28_M	356_T	1.367	0.95
236_D	243_G	1.363	0.95
13_I	17_I	1.342	0.94
62_G	331_Q	1.338	0.94
28_M	39_F	1.333	0.94
345_L	353_K	1.333	0.94
34_K	37_Y	1.330	0.94
231_N	242_W	1.327	0.94
201_G	207_F	1.319	0.93
358_L	370_Q	1.316	0.93
360_G	371_A	1.308	0.93
220_E	223_K	1.304	0.93
345_L	356_T	1.292	0.93
18_G	30_F	1.289	0.93
64_M	335_F	1.287	0.93
363_G	367_G	1.286	0.93
28_M	358_L	1.264	0.92
298_Q	305_D	1.263	0.92
204_V	209_G	1.254	0.92
198_G	201_G	1.249	0.91
266_L	282_N	1.249	0.91
183_K	187_G	1.246	0.91
348_S	356_T	1.242	0.91
205_Q	208_L	1.241	0.91
22_N	26_I	1.241	0.91
38_L	44_P	1.229	0.91
354_M	357_Y	1.225	0.91
18_G	25_A	1.223	0.91
260_K	263_I	1.217	0.90
214_A	224_F	1.209	0.90
145_S	297_Q	1.208	0.90
58_A	62_G	1.200	0.90
88_A	318_V	1.187	0.89
335_F	354_M	1.180	0.89
359_G	367_G	1.177	0.89
166_S	217_V	1.170	0.89
252_E	369_I	1.170	0.89
37_Y	44_P	1.168	0.88
7_F	368_A	1.165	0.88
22_N	45_F	1.164	0.88
199_M	205_Q	1.164	0.88
370_Q	373_F	1.153	0.88
188_N	192_D	1.150	0.88
12_V	69_L	1.149	0.88
49_L	340_L	1.146	0.87
74_G	78_R	1.142	0.87
10_M	13_I	1.140	0.87
94_Q	97_Q	1.139	0.87
186_L	194_L	1.138	0.87
17_I	354_M	1.137	0.87
89_L	292_E	1.135	0.87
34_K	40_G	1.128	0.87
49_L	295_L	1.125	0.87
22_N	370_Q	1.124	0.86
306_K	310_G	1.122	0.86
17_I	24_L	1.121	0.86
345_L	352_F	1.119	0.86
301_P	305_D	1.117	0.86
21_T	26_I	1.116	0.86
240_N	243_G	1.113	0.86
366_I	370_Q	1.101	0.85
150_V	307_L	1.090	0.85
35_A	47_P	1.088	0.85
21_T	27_Q	1.077	0.84
21_T	45_F	1.075	0.84
240_N	244_K	1.075	0.84
132_D	260_K	1.074	0.84
62_G	71_T	1.073	0.84
28_M	47_P	1.067	0.83
19_A	123_D	1.064	0.83
93_E	293_S	1.063	0.83
50_I	57_L	1.059	0.83
23_H	345_L	1.059	0.83
67_N	319_L	1.059	0.83
28_M	370_Q	1.058	0.83
293_S	297_Q	1.056	0.83
134_L	137_L	1.056	0.83
203_M	206_L	1.053	0.83
355_I	363_G	1.049	0.82
34_K	38_L	1.047	0.82
266_L	297_Q	1.046	0.82
63_L	79_L	1.046	0.82
13_I	21_T	1.043	0.82
316_E	344_V	1.043	0.82
145_S	148_E	1.043	0.82
72_P	320_K	1.042	0.82
11_I	371_A	1.040	0.82
49_L	52_R	1.038	0.82
28_M	45_F	1.037	0.82
208_L	211_S	1.035	0.82
224_F	348_S	1.034	0.81
54_R	335_F	1.034	0.81
45_F	82_D	1.026	0.81
45_F	349_K	1.025	0.81
345_L	349_K	1.022	0.81
53_R	57_L	1.020	0.81
21_T	370_Q	1.018	0.80
13_I	22_N	1.016	0.80
356_T	362_L	1.014	0.80
146_L	151_P	1.010	0.80
22_N	40_G	1.009	0.80
22_N	351_E	1.002	0.79
200_L	204_V	1.002	0.79
22_N	27_Q	1.001	0.79
14_G	21_T	0.999	0.79
44_P	68_H	0.998	0.79
202_S	206_L	0.996	0.79
217_V	221_L	0.995	0.79
252_E	313_S	0.991	0.79
13_I	28_M	0.990	0.79
64_M	328_V	0.987	0.78
28_M	40_G	0.986	0.78
353_K	356_T	0.985	0.78
104_V	108_E	0.983	0.78
13_I	24_L	0.979	0.78
119_E	338_E	0.978	0.78
61_M	64_M	0.974	0.77
22_N	47_P	0.969	0.77
91_V	311_I	0.968	0.77
47_P	69_L	0.967	0.77
22_N	37_Y	0.965	0.77
353_K	358_L	0.962	0.77
14_G	22_N	0.961	0.76
21_T	351_E	0.959	0.76
264_F	268_R	0.959	0.76
28_M	351_E	0.955	0.76
237_L	242_W	0.949	0.76
45_F	69_L	0.947	0.75
7_F	11_I	0.946	0.75
93_E	296_T	0.946	0.75
24_L	45_F	0.945	0.75
23_H	352_F	0.943	0.75
203_M	211_S	0.936	0.75
22_N	345_L	0.936	0.75
345_L	358_L	0.934	0.74
21_T	40_G	0.932	0.74
27_Q	36_Y	0.932	0.74
10_M	14_G	0.930	0.74
343_M	347_I	0.926	0.74
332_V	347_I	0.924	0.74
62_G	329_K	0.922	0.73
23_H	27_Q	0.921	0.73
28_M	362_L	0.921	0.73
228_E	242_W	0.918	0.73
83_A	304_L	0.918	0.73
21_T	47_P	0.917	0.73
21_T	37_Y	0.909	0.72
162_I	218_L	0.899	0.71
10_M	19_A	0.899	0.71
202_S	207_F	0.898	0.71
27_Q	37_Y	0.898	0.71
37_Y	45_F	0.897	0.71
65_V	339_R	0.896	0.71
64_M	360_G	0.891	0.71
39_F	47_P	0.889	0.71
14_G	351_E	0.887	0.70
45_F	356_T	0.884	0.70
25_A	30_F	0.883	0.70
350_K	354_M	0.881	0.70
22_N	39_F	0.881	0.70
12_V	35_A	0.880	0.70
242_W	246_R	0.875	0.69
282_N	285_G	0.872	0.69
22_N	341_E	0.872	0.69
45_F	358_L	0.872	0.69
309_E	313_S	0.870	0.69
207_F	284_I	0.869	0.69
45_F	351_E	0.865	0.69
149_L	153_E	0.865	0.69
10_M	354_M	0.857	0.68
333_D	348_S	0.855	0.68
8_I	12_V	0.853	0.67
79_L	115_M	0.853	0.67
7_F	366_I	0.852	0.67
10_M	45_F	0.851	0.67
19_A	22_N	0.842	0.66
26_I	356_T	0.840	0.66
9_F	15_A	0.838	0.66
355_I	359_G	0.838	0.66
28_M	341_E	0.835	0.66
193_F	197_R	0.832	0.66
319_L	331_Q	0.831	0.65
144_Q	235_S	0.831	0.65
21_T	345_L	0.825	0.65
39_F	45_F	0.825	0.65
289_V	292_E	0.825	0.65
62_G	347_I	0.824	0.65
17_I	45_F	0.823	0.65
286_T	289_V	0.818	0.64
138_F	262_L	0.818	0.64
24_L	61_M	0.816	0.64
343_M	360_G	0.815	0.64
69_L	343_M	0.813	0.64
12_V	341_E	0.805	0.63
75_I	333_D	0.803	0.63
193_F	220_E	0.801	0.63
64_M	343_M	0.800	0.62
37_Y	47_P	0.798	0.62
252_E	255_E	0.798	0.62
21_T	341_E	0.797	0.62
23_H	348_S	0.783	0.61
22_N	85_K	0.783	0.61
24_L	349_K	0.783	0.61
15_A	106_V	0.781	0.61
54_R	64_M	0.779	0.60
24_L	356_T	0.777	0.60
23_H	351_E	0.776	0.60
198_G	207_F	0.776	0.60
192_D	298_Q	0.771	0.60
21_T	39_F	0.769	0.59
57_L	335_F	0.767	0.59
177_F	180_D	0.767	0.59
340_L	344_V	0.765	0.59
146_L	270_V	0.764	0.59
190_I	364_G	0.763	0.59
165_I	264_F	0.763	0.59
364_G	371_A	0.757	0.58
355_I	367_G	0.756	0.58
15_A	38_L	0.755	0.58
200_L	250_F	0.754	0.58
24_L	358_L	0.754	0.58
172_R	175_R	0.752	0.58
215_D	219_P	0.751	0.58
249_T	252_E	0.750	0.57
332_V	340_L	0.747	0.57
75_I	365_I	0.747	0.57
35_A	39_F	0.746	0.57
22_N	82_D	0.745	0.57
54_R	337_V	0.742	0.57
357_Y	362_L	0.741	0.57
27_Q	357_Y	0.740	0.56
8_I	284_I	0.740	0.56
23_H	358_L	0.739	0.56
51_P	338_E	0.738	0.56
199_M	208_L	0.737	0.56
351_E	370_Q	0.730	0.55
307_L	311_I	0.727	0.55
54_R	58_A	0.727	0.55
337_V	345_L	0.721	0.55
68_H	227_N	0.720	0.54
351_E	354_M	0.720	0.54
335_F	360_G	0.716	0.54
28_M	36_Y	0.715	0.54
10_M	371_A	0.715	0.54
21_T	85_K	0.714	0.54
6_T	365_I	0.714	0.54
118_P	213_L	0.712	0.54
358_L	362_L	0.710	0.53
13_I	345_L	0.709	0.53
143_D	158_L	0.709	0.53
330_E	333_D	0.706	0.53
94_Q	132_D	0.705	0.53
146_L	223_K	0.703	0.53
66_V	319_L	0.701	0.52
135_H	186_L	0.701	0.52
316_E	333_D	0.698	0.52
14_G	47_P	0.698	0.52
340_L	347_I	0.696	0.52
63_L	67_N	0.692	0.52
54_R	328_V	0.690	0.51
21_T	36_Y	0.688	0.51
204_V	207_F	0.688	0.51
52_R	77_K	0.685	0.51
22_N	36_Y	0.683	0.51
23_H	349_K	0.680	0.50
21_T	347_I	0.680	0.50
283_T	286_T	0.679	0.50
317_S	369_I	0.679	0.50
341_E	347_I	0.678	0.50
71_T	347_I	0.678	0.50
79_L	276_T	0.677	0.50
152_I	156_E	0.676	0.50
11_I	19_A	0.676	0.50
364_G	369_I	0.672	0.49
345_L	351_E	0.672	0.49
62_G	332_V	0.671	0.49
146_L	153_E	0.670	0.49
223_K	226_R	0.670	0.49
19_A	356_T	0.669	0.49
332_V	335_F	0.668	0.49
118_P	266_L	0.666	0.49
22_N	347_I	0.663	0.48
34_K	52_R	0.661	0.48
183_K	338_E	0.660	0.48
71_T	341_E	0.660	0.48
126_I	137_L	0.659	0.48
40_G	45_F	0.656	0.48
365_I	369_I	0.656	0.48
114_G	188_N	0.654	0.48
356_T	370_Q	0.654	0.48
201_G	205_Q	0.654	0.48
54_R	346_S	0.654	0.48
198_G	204_V	0.651	0.47
201_G	206_L	0.651	0.47
315_L	340_L	0.650	0.47
245_L	250_F	0.650	0.47
177_F	221_L	0.647	0.47
245_L	267_K	0.647	0.47
189_M	252_E	0.645	0.47
362_L	366_I	0.643	0.46
191_D	197_R	0.643	0.46
326_E	329_K	0.642	0.46
205_Q	210_N	0.637	0.46
40_G	47_P	0.636	0.46
34_K	44_P	0.636	0.46
179_S	221_L	0.635	0.46
165_I	170_L	0.635	0.46
21_T	82_D	0.634	0.45
72_P	76_K	0.632	0.45
132_D	136_E	0.632	0.45
21_T	362_L	0.629	0.45
153_E	156_E	0.628	0.45
294_E	298_Q	0.628	0.45
126_I	279_F	0.628	0.45
7_F	35_A	0.627	0.45
345_L	360_G	0.626	0.45
14_G	356_T	0.626	0.45
160_E	163_P	0.626	0.45
353_K	360_G	0.624	0.44
233_L	237_L	0.624	0.44
167_G	170_L	0.623	0.44
164_M	167_G	0.623	0.44
183_K	193_F	0.622	0.44
144_Q	150_V	0.622	0.44
51_P	314_N	0.621	0.44
180_D	196_E	0.619	0.44
78_R	350_K	0.619	0.44
202_S	212_S	0.616	0.44
53_R	340_L	0.615	0.44
371_A	374_V	0.614	0.43
13_I	353_K	0.614	0.43
27_Q	47_P	0.614	0.43
335_F	351_E	0.613	0.43
345_L	357_Y	0.612	0.43
354_M	358_L	0.611	0.43
57_L	347_I	0.608	0.43
217_V	332_V	0.604	0.42
8_I	67_N	0.604	0.42
233_L	243_G	0.603	0.42
145_S	157_K	0.602	0.42
69_L	360_G	0.602	0.42
57_L	60_Q	0.601	0.42
149_L	152_I	0.600	0.42
177_F	192_D	0.600	0.42
335_F	356_T	0.598	0.42
22_N	362_L	0.598	0.42
198_G	206_L	0.597	0.42
19_A	27_Q	0.597	0.42
24_L	337_V	0.594	0.41
366_I	371_A	0.594	0.41
28_M	353_K	0.592	0.41
253_A	327_I	0.591	0.41
98_K	107_K	0.590	0.41
244_K	249_T	0.590	0.41
201_G	208_L	0.589	0.41
79_L	256_K	0.589	0.41
354_M	371_A	0.587	0.41
113_A	175_R	0.586	0.41
252_E	261_A	0.583	0.40
19_A	371_A	0.583	0.40
44_P	332_V	0.580	0.40
73_E	89_L	0.580	0.40
138_F	208_L	0.578	0.40
196_E	204_V	0.576	0.40
234_L	243_G	0.575	0.40
166_S	186_L	0.575	0.40
28_M	37_Y	0.575	0.40
233_L	369_I	0.574	0.39
361_L	366_I	0.573	0.39
19_A	46_T	0.572	0.39
64_M	69_L	0.571	0.39
19_A	364_G	0.571	0.39
78_R	320_K	0.569	0.39
157_K	190_I	0.569	0.39
112_K	287_L	0.564	0.38
62_G	172_R	0.563	0.38
75_I	84_A	0.562	0.38
165_I	173_S	0.562	0.38
201_G	210_N	0.562	0.38
23_H	26_I	0.561	0.38
190_I	197_R	0.560	0.38
139_R	143_D	0.558	0.38
118_P	365_I	0.557	0.38
28_M	347_I	0.557	0.38
39_F	44_P	0.557	0.38
170_L	173_S	0.557	0.38
150_V	156_E	0.556	0.38
144_Q	148_E	0.556	0.38
15_A	46_T	0.555	0.38
68_H	332_V	0.555	0.38
67_N	198_G	0.554	0.37
190_I	193_F	0.553	0.37
191_D	196_E	0.550	0.37
366_I	369_I	0.550	0.37
161_K	177_F	0.548	0.37
35_A	44_P	0.546	0.37
293_S	296_T	0.542	0.36
13_I	26_I	0.538	0.36
130_T	247_E	0.538	0.36
14_G	367_G	0.537	0.36
94_Q	217_V	0.536	0.36
86_T	304_L	0.536	0.36
14_G	28_M	0.535	0.36
187_G	191_D	0.535	0.36
28_M	82_D	0.534	0.36
197_R	340_L	0.532	0.35
132_D	255_E	0.531	0.35
160_E	293_S	0.531	0.35
191_D	194_L	0.531	0.35
167_G	231_N	0.531	0.35
11_I	361_L	0.529	0.35
60_Q	347_I	0.528	0.35
28_M	345_L	0.526	0.35
218_L	246_R	0.525	0.35
47_P	308_L	0.523	0.34
26_I	358_L	0.523	0.34
203_M	207_F	0.522	0.34
248_Y	252_E	0.520	0.34
45_F	370_Q	0.520	0.34
37_Y	356_T	0.520	0.34
62_G	66_V	0.520	0.34
184_I	252_E	0.520	0.34
332_V	341_E	0.519	0.34
47_P	351_E	0.519	0.34
36_Y	47_P	0.518	0.34
213_L	216_R	0.518	0.34
89_L	93_E	0.517	0.34
252_E	256_K	0.516	0.34
178_E	268_R	0.513	0.34
145_S	235_S	0.513	0.34
36_Y	356_T	0.513	0.34
150_V	318_V	0.511	0.33
270_V	286_T	0.509	0.33
194_L	197_R	0.509	0.33
57_L	345_L	0.507	0.33
215_D	218_L	0.504	0.33
221_L	261_A	0.504	0.33
59_K	365_I	0.503	0.33
22_N	322_L	0.503	0.33
133_K	136_E	0.502	0.33
323_R	326_E	0.502	0.33
267_K	271_L	0.501	0.32
151_P	160_E	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2kluA	1	0.0769	55.3	0.957	Contact Map
4im7A	1	0.6048	30.7	0.963	Contact Map
2ks1B	1	0.0875	29.8	0.963	Contact Map
2gj4A	2	0.3501	25.6	0.964	Contact Map
2m20A	2	0.0663	23.7	0.965	Contact Map
1lj8A	1	0.5676	23	0.965	Contact Map
2l2tA	2	0.0849	20.6	0.966	Contact Map
2nnwA	2	0.2095	20.4	0.966	Contact Map
3mhsB	1	0.2361	18.6	0.966	Contact Map
2kncB	1	0.0875	16.3	0.967	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0105 seconds.