GREMLIN Database
YHEA - UPF0342 protein YheA
UniProt: O07542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 117 (111)
Sequences: 481 (355)
Seq/√Len: 33.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_K30_D3.5271.00
8_V11_D3.2471.00
64_Q68_T3.2351.00
68_T72_K3.2331.00
13_E17_R3.2021.00
38_A80_H3.0601.00
33_N39_K2.8161.00
39_K43_E2.5271.00
35_D82_K2.4821.00
8_V15_A2.4511.00
44_N76_L2.1680.99
47_D51_R2.1150.99
4_N10_Y2.0570.98
31_E85_Q1.9010.97
36_E40_R1.8350.97
4_N7_D1.7910.96
55_K66_E1.7850.96
7_D10_Y1.7670.96
46_R90_E1.6820.94
35_D80_H1.6650.94
6_Y10_Y1.6620.94
23_T26_K1.6400.94
20_E24_R1.6370.93
71_Q75_A1.6270.93
86_L112_Y1.6120.93
24_R27_N1.5080.90
51_R69_Q1.4910.90
84_S88_E1.4790.89
78_Q84_S1.4640.89
75_A79_Q1.4050.87
31_E34_A1.4020.87
90_E112_Y1.3120.83
44_N81_E1.3070.83
6_Y99_E1.2850.81
13_E106_K1.2460.79
29_Y86_L1.2280.78
6_Y103_I1.2080.77
32_V39_K1.2060.77
31_E82_K1.1650.75
10_Y14_N1.1500.74
19_S96_L1.1500.74
11_D15_A1.1390.73
68_T71_Q1.0750.68
48_V73_T1.0630.67
99_E102_K1.0500.67
24_R89_A1.0430.66
89_A92_R1.0400.66
45_F70_A0.9980.63
21_E96_L0.9950.62
5_F15_A0.9830.61
48_V70_A0.9800.61
97_I108_L0.9800.61
24_R28_L0.9750.61
8_V42_F0.9680.60
84_S104_I0.9600.59
55_K60_E0.9580.59
24_R85_Q0.9520.59
42_F74_V0.9510.59
3_V21_E0.9160.56
101_N105_M0.9060.55
21_E92_R0.8890.54
53_Q101_N0.8860.53
83_I90_E0.8750.52
14_N18_G0.8680.52
53_Q94_S0.8670.52
23_T27_N0.8640.52
77_V98_G0.8630.51
45_F101_N0.8540.51
29_Y112_Y0.8350.49
52_L71_Q0.8340.49
11_D14_N0.8320.49
20_E89_A0.8270.48
55_K70_A0.8240.48
52_L66_E0.8200.48
41_M44_N0.8110.47
62_I70_A0.8090.47
81_E85_Q0.8060.47
43_E46_R0.7920.45
5_F93_M0.7900.45
60_E110_E0.7850.45
27_N31_E0.7830.45
30_D34_A0.7810.45
80_H87_M0.7710.44
14_N92_R0.7700.44
22_F79_Q0.7660.43
40_R44_N0.7640.43
57_M96_L0.7620.43
103_I108_L0.7480.42
77_V105_M0.7460.42
18_G23_T0.7450.42
53_Q57_M0.7350.41
11_D24_R0.7260.40
87_M91_Q0.6990.38
9_A91_Q0.6910.37
45_F83_I0.6910.37
55_K63_T0.6860.37
82_K85_Q0.6840.37
42_F112_Y0.6830.37
101_N112_Y0.6810.36
99_E103_I0.6750.36
93_M100_L0.6690.36
42_F107_P0.6630.35
97_I111_L0.6600.35
86_L90_E0.6560.35
20_E23_T0.6540.34
42_F91_Q0.6440.34
85_Q97_I0.6390.33
37_S64_Q0.6380.33
82_K89_A0.6360.33
5_F28_L0.6300.33
74_V109_E0.6270.32
9_A12_L0.6260.32
56_Q62_I0.6250.32
99_E106_K0.6220.32
42_F83_I0.6220.32
93_M107_P0.6220.32
29_Y105_M0.6160.32
25_L71_Q0.6150.31
46_R70_A0.6100.31
28_L82_K0.6080.31
69_Q84_S0.6050.31
85_Q88_E0.6020.31
28_L73_T0.6020.31
34_A43_E0.5970.30
16_L34_A0.5950.30
37_S95_M0.5940.30
23_T103_I0.5920.30
3_V18_G0.5920.30
65_E95_M0.5900.30
92_R98_G0.5860.29
28_L33_N0.5760.29
75_A88_E0.5750.29
72_K75_A0.5740.29
16_L27_N0.5720.28
95_M103_I0.5710.28
90_E101_N0.5710.28
37_S40_R0.5680.28
43_E68_T0.5670.28
46_R101_N0.5670.28
17_R38_A0.5660.28
5_F8_V0.5650.28
62_I93_M0.5630.28
56_Q104_I0.5520.27
3_V19_S0.5470.27
55_K107_P0.5430.26
93_M108_L0.5400.26
25_L29_Y0.5390.26
39_K80_H0.5380.26
43_E47_D0.5380.26
46_R87_M0.5330.26
26_K51_R0.5300.26
9_A21_E0.5280.26
22_F53_Q0.5220.25
71_Q94_S0.5210.25
59_G66_E0.5210.25
9_A19_S0.5200.25
23_T73_T0.5180.25
29_Y42_F0.5160.25
43_E60_E0.5160.25
9_A108_L0.5110.24
56_Q87_M0.5080.24
13_E42_F0.5070.24
38_A82_K0.5020.24
25_L38_A0.5010.24
10_Y84_S0.5000.24
27_N30_D0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oeqA 4 1 100 0.313 Contact Map
2oeeA 2 0.7949 100 0.319 Contact Map
2iazA 4 0.9573 100 0.338 Contact Map
2pihA 2 0.9915 99.9 0.366 Contact Map
2kfdA 1 0.359 42.8 0.913 Contact Map
3ghgA 2 0.9829 12.2 0.933 Contact Map
1t10A 2 0.8291 11.5 0.934 Contact Map
4kqtA 1 0.9145 10.3 0.935 Contact Map
1vq8N 1 0.2906 8.1 0.938 Contact Map
4em6D 2 0.8632 8 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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