YHAZ - BACSU - GREMLIN Contacts

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YHAZ - Uncharacterized protein YhaZ

UniProt:	O07541	Sequences: MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPELTLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEESIKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWGKSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTHPHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYIHSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHYKGIHTLSVIINGEVKDSLDFQVC	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	357 (352)
Sequences:	496 (393)
Seq/√Len:	21.0

BACSU - YHAZ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
173_V	195_N	4.713	1.00
107_E	140_H	4.712	1.00
138_S	179_K	4.637	1.00
119_V	130_M	4.175	1.00
149_A	176_I	3.627	1.00
292_F	333_H	3.365	1.00
328_L	333_H	3.307	1.00
292_F	323_Q	3.302	1.00
208_R	240_A	3.259	1.00
143_E	185_S	3.108	1.00
274_F	342_V	3.056	0.99
261_P	272_F	3.022	0.99
291_D	341_S	2.882	0.99
65_Y	102_S	2.872	0.99
35_T	60_T	2.871	0.99
327_D	333_H	2.683	0.99
99_W	103_I	2.616	0.98
144_H	187_Y	2.605	0.98
153_S	195_N	2.542	0.98
65_Y	69_L	2.539	0.98
182_Q	221_T	2.488	0.98
212_D	239_Q	2.461	0.97
162_S	167_K	2.457	0.97
214_W	225_I	2.440	0.97
341_S	348_V	2.384	0.97
156_R	202_T	2.368	0.97
50_M	114_T	2.340	0.97
210_V	214_W	2.336	0.96
54_T	89_D	2.318	0.96
186_L	189_R	2.265	0.96
289_A	343_I	2.195	0.95
5_K	45_T	2.164	0.95
288_Y	323_Q	2.157	0.94
186_L	223_W	2.142	0.94
137_W	148_L	2.112	0.94
4_L	46_L	2.091	0.93
293_V	299_R	2.073	0.93
264_I	270_L	2.065	0.93
99_W	129_K	2.056	0.93
215_Y	225_I	2.018	0.92
181_M	214_W	1.996	0.92
257_L	342_V	1.995	0.92
182_Q	218_H	1.990	0.92
221_T	224_I	1.979	0.91
186_L	190_K	1.939	0.91
58_Y	90_Y	1.921	0.90
107_E	145_V	1.903	0.90
111_Q	142_N	1.884	0.89
274_F	319_Y	1.881	0.89
107_E	133_Q	1.878	0.89
286_I	344_I	1.878	0.89
130_M	133_Q	1.872	0.89
287_E	305_K	1.870	0.89
229_Y	240_A	1.863	0.89
99_W	126_D	1.820	0.87
69_L	102_S	1.814	0.87
276_I	286_I	1.805	0.87
123_L	163_I	1.801	0.87
124_L	164_P	1.799	0.87
126_D	129_K	1.796	0.87
69_L	105_A	1.783	0.86
163_I	203_H	1.754	0.85
153_S	173_V	1.746	0.85
211_A	225_I	1.741	0.85
132_A	242_A	1.734	0.85
64_Q	67_E	1.681	0.83
16_L	86_L	1.663	0.82
106_L	115_S	1.649	0.82
190_K	224_I	1.640	0.81
31_R	60_T	1.637	0.81
295_A	332_K	1.618	0.80
16_L	79_F	1.592	0.79
333_H	356_V	1.569	0.78
62_P	71_I	1.555	0.78
131_I	153_S	1.551	0.77
291_D	301_Q	1.545	0.77
123_L	131_I	1.541	0.77
163_I	166_L	1.513	0.76
138_S	149_A	1.511	0.75
124_L	329_T	1.490	0.74
47_K	92_E	1.482	0.74
216_G	222_D	1.481	0.74
337_I	353_D	1.469	0.73
40_D	52_R	1.463	0.73
139_E	179_K	1.408	0.70
200_S	329_T	1.406	0.70
233_L	244_F	1.397	0.69
200_S	264_I	1.387	0.69
118_A	185_S	1.375	0.68
231_T	235_K	1.363	0.67
66_V	98_H	1.361	0.67
160_G	246_Y	1.361	0.67
163_I	172_P	1.356	0.67
65_Y	105_A	1.339	0.66
229_Y	244_F	1.337	0.66
269_S	322_I	1.335	0.66
102_S	122_F	1.334	0.66
205_H	237_D	1.317	0.65
266_I	324_S	1.311	0.64
68_A	90_Y	1.297	0.63
44_L	52_R	1.291	0.63
214_W	229_Y	1.291	0.63
96_L	125_L	1.282	0.63
17_I	70_T	1.267	0.62
323_Q	333_H	1.262	0.61
97_A	125_L	1.254	0.61
178_E	213_Q	1.254	0.61
166_L	175_P	1.242	0.60
114_T	127_Q	1.240	0.60
142_N	187_Y	1.239	0.60
48_E	75_T	1.236	0.60
123_L	329_T	1.236	0.60
190_K	227_H	1.229	0.59
344_I	349_K	1.225	0.59
234_K	303_V	1.222	0.59
8_Y	50_M	1.189	0.57
178_E	181_M	1.182	0.56
45_T	48_E	1.181	0.56
96_L	300_H	1.178	0.56
76_A	112_Y	1.169	0.55
127_Q	166_L	1.163	0.55
181_M	210_V	1.154	0.54
166_L	195_N	1.151	0.54
20_V	57_L	1.146	0.54
51_R	93_Q	1.139	0.53
169_D	172_P	1.137	0.53
27_F	32_F	1.134	0.53
65_Y	90_Y	1.130	0.53
50_M	54_T	1.126	0.52
87_F	114_T	1.124	0.52
29_K	33_L	1.123	0.52
328_L	356_V	1.112	0.52
169_D	203_H	1.104	0.51
172_P	195_N	1.104	0.51
13_I	53_V	1.104	0.51
12_L	16_L	1.100	0.51
172_P	199_I	1.085	0.50
50_M	85_I	1.081	0.50
233_L	287_E	1.073	0.49
209_K	239_Q	1.069	0.49
72_L	109_F	1.066	0.49
103_I	130_M	1.063	0.48
172_P	203_H	1.058	0.48
337_I	355_Q	1.052	0.48
115_S	227_H	1.032	0.46
28_N	31_R	1.032	0.46
289_A	301_Q	1.030	0.46
31_R	35_T	1.028	0.46
50_M	86_L	1.013	0.45
20_V	71_I	1.006	0.45
339_T	353_D	1.000	0.44
104_K	133_Q	0.994	0.44
14_S	233_L	0.992	0.44
134_L	153_S	0.990	0.43
47_K	160_G	0.989	0.43
106_L	109_F	0.983	0.43
304_F	331_R	0.983	0.43
35_T	59_E	0.983	0.43
271_E	322_I	0.982	0.43
99_W	160_G	0.980	0.43
268_E	313_K	0.974	0.42
107_E	162_S	0.973	0.42
89_D	118_A	0.970	0.42
57_L	61_L	0.965	0.42
18_H	29_K	0.963	0.42
344_I	347_E	0.961	0.42
340_L	354_F	0.960	0.42
236_G	303_V	0.958	0.41
82_L	114_T	0.958	0.41
112_Y	233_L	0.955	0.41
74_D	128_E	0.955	0.41
176_I	308_E	0.949	0.41
232_L	237_D	0.943	0.40
200_S	276_I	0.941	0.40
51_R	89_D	0.937	0.40
133_Q	136_A	0.935	0.40
316_T	344_I	0.935	0.40
163_I	202_T	0.930	0.40
141_K	176_I	0.929	0.40
16_L	20_V	0.927	0.39
13_I	41_W	0.926	0.39
73_R	101_E	0.919	0.39
67_E	209_K	0.918	0.39
61_L	68_A	0.917	0.39
211_A	214_W	0.915	0.39
266_I	327_D	0.909	0.38
87_F	113_S	0.906	0.38
16_L	46_L	0.903	0.38
341_S	351_S	0.902	0.38
162_S	287_E	0.901	0.38
305_K	354_F	0.898	0.38
190_K	223_W	0.895	0.37
160_G	164_P	0.895	0.37
81_G	106_L	0.893	0.37
56_S	60_T	0.893	0.37
55_V	94_Y	0.890	0.37
8_Y	12_L	0.888	0.37
41_W	285_R	0.883	0.37
52_R	160_G	0.883	0.37
233_L	272_F	0.883	0.37
17_I	32_F	0.882	0.37
8_Y	41_W	0.882	0.37
226_K	308_E	0.881	0.37
108_S	111_Q	0.880	0.37
312_R	315_E	0.880	0.37
167_K	306_I	0.875	0.36
185_S	190_K	0.872	0.36
294_K	300_H	0.867	0.36
205_H	318_S	0.866	0.36
233_L	308_E	0.866	0.36
211_A	229_Y	0.866	0.36
160_G	278_S	0.865	0.36
261_P	270_L	0.863	0.35
100_E	129_K	0.858	0.35
131_I	264_I	0.858	0.35
36_L	40_D	0.852	0.35
166_L	202_T	0.851	0.35
36_L	56_S	0.850	0.35
119_V	134_L	0.849	0.35
237_D	305_K	0.849	0.35
301_Q	348_V	0.846	0.34
274_F	306_I	0.845	0.34
69_L	101_E	0.844	0.34
47_K	89_D	0.843	0.34
208_R	237_D	0.840	0.34
233_L	285_R	0.834	0.34
106_L	149_A	0.834	0.34
184_E	220_H	0.829	0.33
112_Y	343_I	0.826	0.33
34_D	212_D	0.826	0.33
311_I	315_E	0.825	0.33
305_K	308_E	0.823	0.33
271_E	320_T	0.823	0.33
185_S	189_R	0.819	0.33
292_F	327_D	0.818	0.33
95_G	102_S	0.816	0.33
232_L	235_K	0.815	0.33
215_Y	243_L	0.814	0.33
281_D	312_R	0.814	0.33
130_M	140_H	0.813	0.32
109_F	115_S	0.811	0.32
103_I	133_Q	0.811	0.32
41_W	287_E	0.808	0.32
130_M	134_L	0.806	0.32
86_L	109_F	0.803	0.32
205_H	248_N	0.802	0.32
163_I	167_K	0.797	0.32
224_I	228_A	0.796	0.32
58_Y	94_Y	0.796	0.32
208_R	239_Q	0.793	0.31
208_R	243_L	0.792	0.31
16_L	75_T	0.792	0.31
166_L	172_P	0.790	0.31
246_Y	308_E	0.790	0.31
287_E	308_E	0.789	0.31
231_T	343_I	0.788	0.31
23_S	71_I	0.783	0.31
225_I	244_F	0.782	0.31
84_G	87_F	0.781	0.31
30_N	67_E	0.779	0.31
141_K	253_Q	0.779	0.31
175_P	179_K	0.775	0.30
176_I	190_K	0.772	0.30
155_P	199_I	0.770	0.30
200_S	243_L	0.766	0.30
327_D	332_K	0.766	0.30
143_E	187_Y	0.766	0.30
125_L	332_K	0.766	0.30
131_I	195_N	0.764	0.30
113_S	285_R	0.764	0.30
52_R	225_I	0.762	0.30
293_V	334_Y	0.761	0.30
111_Q	140_H	0.759	0.29
156_R	276_I	0.751	0.29
21_R	42_P	0.750	0.29
79_F	85_I	0.747	0.29
172_P	202_T	0.746	0.29
185_S	221_T	0.746	0.29
136_A	169_D	0.745	0.29
50_M	121_P	0.745	0.29
103_I	324_S	0.743	0.29
224_I	257_L	0.742	0.28
113_S	142_N	0.742	0.28
75_T	87_F	0.740	0.28
211_A	228_A	0.736	0.28
73_R	108_S	0.735	0.28
113_S	134_L	0.735	0.28
227_H	305_K	0.734	0.28
186_L	224_I	0.732	0.28
62_P	68_A	0.732	0.28
18_H	59_E	0.731	0.28
94_Y	102_S	0.731	0.28
39_E	290_I	0.731	0.28
17_I	268_E	0.730	0.28
200_S	207_L	0.730	0.28
208_R	212_D	0.729	0.28
111_Q	270_L	0.729	0.28
266_I	292_F	0.727	0.28
272_F	340_L	0.726	0.28
305_K	311_I	0.723	0.27
252_I	273_S	0.723	0.27
69_L	184_E	0.723	0.27
278_S	282_Q	0.722	0.27
8_Y	86_L	0.721	0.27
109_F	153_S	0.719	0.27
72_L	89_D	0.717	0.27
40_D	284_V	0.716	0.27
249_A	347_E	0.715	0.27
12_L	160_G	0.714	0.27
119_V	211_A	0.714	0.27
84_G	167_K	0.711	0.27
52_R	329_T	0.711	0.27
50_M	84_G	0.710	0.27
6_E	52_R	0.710	0.27
205_H	340_L	0.703	0.26
238_K	347_E	0.703	0.26
225_I	311_I	0.701	0.26
264_I	272_F	0.699	0.26
25_P	241_L	0.698	0.26
24_Y	71_I	0.692	0.26
23_S	280_R	0.687	0.26
27_F	95_G	0.686	0.26
108_S	289_A	0.684	0.25
290_I	323_Q	0.683	0.25
87_F	140_H	0.680	0.25
8_Y	130_M	0.679	0.25
134_L	162_S	0.679	0.25
266_I	328_L	0.677	0.25
212_D	347_E	0.675	0.25
231_T	288_Y	0.675	0.25
88_P	221_T	0.675	0.25
82_L	86_L	0.674	0.25
176_I	226_K	0.673	0.25
130_M	162_S	0.670	0.25
11_E	36_L	0.669	0.25
127_Q	165_A	0.667	0.25
215_Y	224_I	0.667	0.25
189_R	331_R	0.664	0.24
64_Q	237_D	0.663	0.24
279_D	314_N	0.660	0.24
228_A	335_K	0.660	0.24
294_K	329_T	0.660	0.24
226_K	348_V	0.660	0.24
140_H	145_V	0.658	0.24
21_R	26_D	0.656	0.24
88_P	109_F	0.655	0.24
96_L	121_P	0.655	0.24
85_I	163_I	0.655	0.24
84_G	114_T	0.654	0.24
173_V	176_I	0.653	0.24
210_V	229_Y	0.652	0.24
109_F	113_S	0.648	0.24
199_I	235_K	0.648	0.24
340_L	352_L	0.647	0.24
213_Q	306_I	0.646	0.24
210_V	213_Q	0.646	0.24
160_G	326_K	0.644	0.23
121_P	202_T	0.643	0.23
89_D	140_H	0.642	0.23
226_K	352_L	0.641	0.23
91_V	109_F	0.641	0.23
313_K	318_S	0.640	0.23
259_C	262_K	0.639	0.23
219_P	298_Q	0.638	0.23
61_L	71_I	0.637	0.23
219_P	314_N	0.636	0.23
113_S	287_E	0.634	0.23
131_I	166_L	0.632	0.23
47_K	50_M	0.632	0.23
294_K	333_H	0.632	0.23
119_V	133_Q	0.630	0.23
332_K	341_S	0.630	0.23
17_I	71_I	0.629	0.23
199_I	202_T	0.629	0.23
45_T	126_D	0.628	0.23
31_R	59_E	0.628	0.23
254_L	257_L	0.628	0.23
115_S	331_R	0.627	0.23
138_S	319_Y	0.626	0.23
156_R	199_I	0.622	0.22
5_K	201_K	0.621	0.22
240_A	306_I	0.620	0.22
56_S	81_G	0.619	0.22
69_L	94_Y	0.618	0.22
65_Y	91_V	0.618	0.22
143_E	190_K	0.617	0.22
134_L	149_A	0.615	0.22
303_V	341_S	0.615	0.22
283_K	315_E	0.615	0.22
128_E	315_E	0.614	0.22
51_R	117_F	0.610	0.22
47_K	85_I	0.608	0.22
175_P	245_G	0.605	0.22
9_N	12_L	0.604	0.22
82_L	307_T	0.604	0.22
296_R	334_Y	0.604	0.22
216_G	244_F	0.604	0.22
181_M	225_I	0.602	0.22
41_W	52_R	0.602	0.22
248_N	340_L	0.600	0.21
115_S	322_I	0.600	0.21
309_T	315_E	0.600	0.21
27_F	178_E	0.600	0.21
95_G	134_L	0.599	0.21
113_S	211_A	0.599	0.21
207_L	264_I	0.598	0.21
13_I	36_L	0.598	0.21
72_L	281_D	0.596	0.21
53_V	90_Y	0.594	0.21
133_Q	137_W	0.592	0.21
16_L	229_Y	0.590	0.21
59_E	271_E	0.590	0.21
181_M	218_H	0.589	0.21
86_L	113_S	0.589	0.21
16_L	19_H	0.588	0.21
8_Y	164_P	0.587	0.21
91_V	267_G	0.586	0.21
259_C	264_I	0.584	0.21
54_T	121_P	0.583	0.21
52_R	56_S	0.583	0.21
4_L	82_L	0.583	0.21
339_T	351_S	0.581	0.21
26_D	205_H	0.580	0.21
288_Y	356_V	0.580	0.21
135_L	138_S	0.580	0.21
106_L	118_A	0.578	0.20
95_G	201_K	0.576	0.20
107_E	272_F	0.576	0.20
86_L	287_E	0.576	0.20
209_K	335_K	0.576	0.20
90_Y	102_S	0.575	0.20
313_K	350_D	0.575	0.20
168_S	286_I	0.574	0.20
67_E	253_Q	0.573	0.20
32_F	53_V	0.572	0.20
122_F	130_M	0.572	0.20
179_K	195_N	0.571	0.20
128_E	296_R	0.571	0.20
233_L	261_P	0.567	0.20
228_A	237_D	0.564	0.20
10_E	14_S	0.564	0.20
197_N	331_R	0.564	0.20
28_N	257_L	0.563	0.20
85_I	113_S	0.559	0.20
301_Q	308_E	0.558	0.20
266_I	325_F	0.557	0.20
168_S	259_C	0.557	0.20
32_F	72_L	0.557	0.20
54_T	88_P	0.557	0.20
69_L	109_F	0.555	0.20
41_W	92_E	0.555	0.20
134_L	140_H	0.554	0.19
88_P	118_A	0.554	0.19
209_K	213_Q	0.554	0.19
32_F	201_K	0.551	0.19
4_L	328_L	0.549	0.19
278_S	354_F	0.549	0.19
41_W	244_F	0.548	0.19
60_T	257_L	0.546	0.19
233_L	310_N	0.544	0.19
36_L	226_K	0.543	0.19
32_F	90_Y	0.542	0.19
82_L	223_W	0.541	0.19
14_S	276_I	0.541	0.19
264_I	325_F	0.541	0.19
283_K	333_H	0.540	0.19
320_T	353_D	0.540	0.19
22_S	252_I	0.539	0.19
41_W	113_S	0.538	0.19
175_P	340_L	0.537	0.19
200_S	238_K	0.537	0.19
53_V	290_I	0.537	0.19
88_P	115_S	0.535	0.19
43_E	63_K	0.534	0.19
175_P	356_V	0.533	0.19
326_K	354_F	0.532	0.19
123_L	127_Q	0.532	0.19
92_E	119_V	0.531	0.19
82_L	328_L	0.530	0.18
233_L	319_Y	0.530	0.18
98_H	123_L	0.530	0.18
12_L	202_T	0.530	0.18
86_L	153_S	0.530	0.18
38_L	131_I	0.529	0.18
152_G	197_N	0.529	0.18
74_D	254_L	0.529	0.18
121_P	126_D	0.525	0.18
203_H	277_H	0.525	0.18
121_P	127_Q	0.525	0.18
75_T	195_N	0.524	0.18
124_L	161_K	0.524	0.18
118_A	243_L	0.523	0.18
189_R	220_H	0.523	0.18
77_P	124_L	0.523	0.18
99_W	130_M	0.523	0.18
251_S	281_D	0.523	0.18
244_F	287_E	0.521	0.18
283_K	292_F	0.521	0.18
261_P	299_R	0.520	0.18
134_L	210_V	0.520	0.18
186_L	220_H	0.520	0.18
213_Q	314_N	0.517	0.18
292_F	328_L	0.516	0.18
275_Y	316_T	0.516	0.18
259_C	352_L	0.516	0.18
92_E	121_P	0.515	0.18
88_P	113_S	0.514	0.18
143_E	186_L	0.510	0.18
94_Y	284_V	0.510	0.18
82_L	323_Q	0.509	0.18
8_Y	111_Q	0.508	0.18
84_G	292_F	0.508	0.18
174_L	285_R	0.508	0.18
273_S	281_D	0.507	0.18
114_T	348_V	0.506	0.18
265_V	268_E	0.506	0.18
47_K	118_A	0.506	0.18
201_K	343_I	0.506	0.18
287_E	301_Q	0.505	0.18
85_I	166_L	0.505	0.18
23_S	114_T	0.504	0.17
122_F	156_R	0.504	0.17
59_E	66_V	0.502	0.17
18_H	21_R	0.502	0.17
208_R	329_T	0.502	0.17
292_F	338_H	0.502	0.17
276_I	315_E	0.500	0.17
226_K	354_F	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3l9tA	1	0.5434	100	0.81	Contact Map
4x8qA	1	0.5574	100	0.813	Contact Map
3jxyA	1	0.5854	99.9	0.845	Contact Map
2b6cA	2	0.563	99.9	0.861	Contact Map
3zboA	1	0.5798	99.7	0.88	Contact Map
2db0A	1	0.6134	93	0.964	Contact Map
4jw2A	1	0.2045	88.2	0.968	Contact Map
1oyzA	1	0.7199	88.1	0.968	Contact Map
4lacA	1	0.5658	88	0.968	Contact Map
1te4A	1	0.3081	87.4	0.968	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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