GREMLIN Database
YHAZ - Uncharacterized protein YhaZ
UniProt: O07541 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 357 (352)
Sequences: 496 (393)
Seq/√Len: 21.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_V195_N4.7131.00
107_E140_H4.7121.00
138_S179_K4.6371.00
119_V130_M4.1751.00
149_A176_I3.6271.00
292_F333_H3.3651.00
328_L333_H3.3071.00
292_F323_Q3.3021.00
208_R240_A3.2591.00
143_E185_S3.1081.00
274_F342_V3.0560.99
261_P272_F3.0220.99
291_D341_S2.8820.99
65_Y102_S2.8720.99
35_T60_T2.8710.99
327_D333_H2.6830.99
99_W103_I2.6160.98
144_H187_Y2.6050.98
153_S195_N2.5420.98
65_Y69_L2.5390.98
182_Q221_T2.4880.98
212_D239_Q2.4610.97
162_S167_K2.4570.97
214_W225_I2.4400.97
341_S348_V2.3840.97
156_R202_T2.3680.97
50_M114_T2.3400.97
210_V214_W2.3360.96
54_T89_D2.3180.96
186_L189_R2.2650.96
289_A343_I2.1950.95
5_K45_T2.1640.95
288_Y323_Q2.1570.94
186_L223_W2.1420.94
137_W148_L2.1120.94
4_L46_L2.0910.93
293_V299_R2.0730.93
264_I270_L2.0650.93
99_W129_K2.0560.93
215_Y225_I2.0180.92
181_M214_W1.9960.92
257_L342_V1.9950.92
182_Q218_H1.9900.92
221_T224_I1.9790.91
186_L190_K1.9390.91
58_Y90_Y1.9210.90
107_E145_V1.9030.90
111_Q142_N1.8840.89
274_F319_Y1.8810.89
107_E133_Q1.8780.89
286_I344_I1.8780.89
130_M133_Q1.8720.89
287_E305_K1.8700.89
229_Y240_A1.8630.89
99_W126_D1.8200.87
69_L102_S1.8140.87
276_I286_I1.8050.87
123_L163_I1.8010.87
124_L164_P1.7990.87
126_D129_K1.7960.87
69_L105_A1.7830.86
163_I203_H1.7540.85
153_S173_V1.7460.85
211_A225_I1.7410.85
132_A242_A1.7340.85
64_Q67_E1.6810.83
16_L86_L1.6630.82
106_L115_S1.6490.82
190_K224_I1.6400.81
31_R60_T1.6370.81
295_A332_K1.6180.80
16_L79_F1.5920.79
333_H356_V1.5690.78
62_P71_I1.5550.78
131_I153_S1.5510.77
291_D301_Q1.5450.77
123_L131_I1.5410.77
163_I166_L1.5130.76
138_S149_A1.5110.75
124_L329_T1.4900.74
47_K92_E1.4820.74
216_G222_D1.4810.74
337_I353_D1.4690.73
40_D52_R1.4630.73
139_E179_K1.4080.70
200_S329_T1.4060.70
233_L244_F1.3970.69
200_S264_I1.3870.69
118_A185_S1.3750.68
231_T235_K1.3630.67
66_V98_H1.3610.67
160_G246_Y1.3610.67
163_I172_P1.3560.67
65_Y105_A1.3390.66
229_Y244_F1.3370.66
269_S322_I1.3350.66
102_S122_F1.3340.66
205_H237_D1.3170.65
266_I324_S1.3110.64
68_A90_Y1.2970.63
44_L52_R1.2910.63
214_W229_Y1.2910.63
96_L125_L1.2820.63
17_I70_T1.2670.62
323_Q333_H1.2620.61
97_A125_L1.2540.61
178_E213_Q1.2540.61
166_L175_P1.2420.60
114_T127_Q1.2400.60
142_N187_Y1.2390.60
48_E75_T1.2360.60
123_L329_T1.2360.60
190_K227_H1.2290.59
344_I349_K1.2250.59
234_K303_V1.2220.59
8_Y50_M1.1890.57
178_E181_M1.1820.56
45_T48_E1.1810.56
96_L300_H1.1780.56
76_A112_Y1.1690.55
127_Q166_L1.1630.55
181_M210_V1.1540.54
166_L195_N1.1510.54
20_V57_L1.1460.54
51_R93_Q1.1390.53
169_D172_P1.1370.53
27_F32_F1.1340.53
65_Y90_Y1.1300.53
50_M54_T1.1260.52
87_F114_T1.1240.52
29_K33_L1.1230.52
328_L356_V1.1120.52
169_D203_H1.1040.51
172_P195_N1.1040.51
13_I53_V1.1040.51
12_L16_L1.1000.51
172_P199_I1.0850.50
50_M85_I1.0810.50
233_L287_E1.0730.49
209_K239_Q1.0690.49
72_L109_F1.0660.49
103_I130_M1.0630.48
172_P203_H1.0580.48
337_I355_Q1.0520.48
115_S227_H1.0320.46
28_N31_R1.0320.46
289_A301_Q1.0300.46
31_R35_T1.0280.46
50_M86_L1.0130.45
20_V71_I1.0060.45
339_T353_D1.0000.44
104_K133_Q0.9940.44
14_S233_L0.9920.44
134_L153_S0.9900.43
47_K160_G0.9890.43
106_L109_F0.9830.43
304_F331_R0.9830.43
35_T59_E0.9830.43
271_E322_I0.9820.43
99_W160_G0.9800.43
268_E313_K0.9740.42
107_E162_S0.9730.42
89_D118_A0.9700.42
57_L61_L0.9650.42
18_H29_K0.9630.42
344_I347_E0.9610.42
340_L354_F0.9600.42
236_G303_V0.9580.41
82_L114_T0.9580.41
112_Y233_L0.9550.41
74_D128_E0.9550.41
176_I308_E0.9490.41
232_L237_D0.9430.40
200_S276_I0.9410.40
51_R89_D0.9370.40
133_Q136_A0.9350.40
316_T344_I0.9350.40
163_I202_T0.9300.40
141_K176_I0.9290.40
16_L20_V0.9270.39
13_I41_W0.9260.39
73_R101_E0.9190.39
67_E209_K0.9180.39
61_L68_A0.9170.39
211_A214_W0.9150.39
266_I327_D0.9090.38
87_F113_S0.9060.38
16_L46_L0.9030.38
341_S351_S0.9020.38
162_S287_E0.9010.38
305_K354_F0.8980.38
190_K223_W0.8950.37
160_G164_P0.8950.37
81_G106_L0.8930.37
56_S60_T0.8930.37
55_V94_Y0.8900.37
8_Y12_L0.8880.37
41_W285_R0.8830.37
52_R160_G0.8830.37
233_L272_F0.8830.37
17_I32_F0.8820.37
8_Y41_W0.8820.37
226_K308_E0.8810.37
108_S111_Q0.8800.37
312_R315_E0.8800.37
167_K306_I0.8750.36
185_S190_K0.8720.36
294_K300_H0.8670.36
205_H318_S0.8660.36
233_L308_E0.8660.36
211_A229_Y0.8660.36
160_G278_S0.8650.36
261_P270_L0.8630.35
100_E129_K0.8580.35
131_I264_I0.8580.35
36_L40_D0.8520.35
166_L202_T0.8510.35
36_L56_S0.8500.35
119_V134_L0.8490.35
237_D305_K0.8490.35
301_Q348_V0.8460.34
274_F306_I0.8450.34
69_L101_E0.8440.34
47_K89_D0.8430.34
208_R237_D0.8400.34
233_L285_R0.8340.34
106_L149_A0.8340.34
184_E220_H0.8290.33
112_Y343_I0.8260.33
34_D212_D0.8260.33
311_I315_E0.8250.33
305_K308_E0.8230.33
271_E320_T0.8230.33
185_S189_R0.8190.33
292_F327_D0.8180.33
95_G102_S0.8160.33
232_L235_K0.8150.33
215_Y243_L0.8140.33
281_D312_R0.8140.33
130_M140_H0.8130.32
109_F115_S0.8110.32
103_I133_Q0.8110.32
41_W287_E0.8080.32
130_M134_L0.8060.32
86_L109_F0.8030.32
205_H248_N0.8020.32
163_I167_K0.7970.32
224_I228_A0.7960.32
58_Y94_Y0.7960.32
208_R239_Q0.7930.31
208_R243_L0.7920.31
16_L75_T0.7920.31
166_L172_P0.7900.31
246_Y308_E0.7900.31
287_E308_E0.7890.31
231_T343_I0.7880.31
23_S71_I0.7830.31
225_I244_F0.7820.31
84_G87_F0.7810.31
30_N67_E0.7790.31
141_K253_Q0.7790.31
175_P179_K0.7750.30
176_I190_K0.7720.30
155_P199_I0.7700.30
200_S243_L0.7660.30
327_D332_K0.7660.30
143_E187_Y0.7660.30
125_L332_K0.7660.30
131_I195_N0.7640.30
113_S285_R0.7640.30
52_R225_I0.7620.30
293_V334_Y0.7610.30
111_Q140_H0.7590.29
156_R276_I0.7510.29
21_R42_P0.7500.29
79_F85_I0.7470.29
172_P202_T0.7460.29
185_S221_T0.7460.29
136_A169_D0.7450.29
50_M121_P0.7450.29
103_I324_S0.7430.29
224_I257_L0.7420.28
113_S142_N0.7420.28
75_T87_F0.7400.28
211_A228_A0.7360.28
73_R108_S0.7350.28
113_S134_L0.7350.28
227_H305_K0.7340.28
186_L224_I0.7320.28
62_P68_A0.7320.28
18_H59_E0.7310.28
94_Y102_S0.7310.28
39_E290_I0.7310.28
17_I268_E0.7300.28
200_S207_L0.7300.28
208_R212_D0.7290.28
111_Q270_L0.7290.28
266_I292_F0.7270.28
272_F340_L0.7260.28
305_K311_I0.7230.27
252_I273_S0.7230.27
69_L184_E0.7230.27
278_S282_Q0.7220.27
8_Y86_L0.7210.27
109_F153_S0.7190.27
72_L89_D0.7170.27
40_D284_V0.7160.27
249_A347_E0.7150.27
12_L160_G0.7140.27
119_V211_A0.7140.27
84_G167_K0.7110.27
52_R329_T0.7110.27
50_M84_G0.7100.27
6_E52_R0.7100.27
205_H340_L0.7030.26
238_K347_E0.7030.26
225_I311_I0.7010.26
264_I272_F0.6990.26
25_P241_L0.6980.26
24_Y71_I0.6920.26
23_S280_R0.6870.26
27_F95_G0.6860.26
108_S289_A0.6840.25
290_I323_Q0.6830.25
87_F140_H0.6800.25
8_Y130_M0.6790.25
134_L162_S0.6790.25
266_I328_L0.6770.25
212_D347_E0.6750.25
231_T288_Y0.6750.25
88_P221_T0.6750.25
82_L86_L0.6740.25
176_I226_K0.6730.25
130_M162_S0.6700.25
11_E36_L0.6690.25
127_Q165_A0.6670.25
215_Y224_I0.6670.25
189_R331_R0.6640.24
64_Q237_D0.6630.24
279_D314_N0.6600.24
228_A335_K0.6600.24
294_K329_T0.6600.24
226_K348_V0.6600.24
140_H145_V0.6580.24
21_R26_D0.6560.24
88_P109_F0.6550.24
96_L121_P0.6550.24
85_I163_I0.6550.24
84_G114_T0.6540.24
173_V176_I0.6530.24
210_V229_Y0.6520.24
109_F113_S0.6480.24
199_I235_K0.6480.24
340_L352_L0.6470.24
213_Q306_I0.6460.24
210_V213_Q0.6460.24
160_G326_K0.6440.23
121_P202_T0.6430.23
89_D140_H0.6420.23
226_K352_L0.6410.23
91_V109_F0.6410.23
313_K318_S0.6400.23
259_C262_K0.6390.23
219_P298_Q0.6380.23
61_L71_I0.6370.23
219_P314_N0.6360.23
113_S287_E0.6340.23
131_I166_L0.6320.23
47_K50_M0.6320.23
294_K333_H0.6320.23
119_V133_Q0.6300.23
332_K341_S0.6300.23
17_I71_I0.6290.23
199_I202_T0.6290.23
45_T126_D0.6280.23
31_R59_E0.6280.23
254_L257_L0.6280.23
115_S331_R0.6270.23
138_S319_Y0.6260.23
156_R199_I0.6220.22
5_K201_K0.6210.22
240_A306_I0.6200.22
56_S81_G0.6190.22
69_L94_Y0.6180.22
65_Y91_V0.6180.22
143_E190_K0.6170.22
134_L149_A0.6150.22
303_V341_S0.6150.22
283_K315_E0.6150.22
128_E315_E0.6140.22
51_R117_F0.6100.22
47_K85_I0.6080.22
175_P245_G0.6050.22
9_N12_L0.6040.22
82_L307_T0.6040.22
296_R334_Y0.6040.22
216_G244_F0.6040.22
181_M225_I0.6020.22
41_W52_R0.6020.22
248_N340_L0.6000.21
115_S322_I0.6000.21
309_T315_E0.6000.21
27_F178_E0.6000.21
95_G134_L0.5990.21
113_S211_A0.5990.21
207_L264_I0.5980.21
13_I36_L0.5980.21
72_L281_D0.5960.21
53_V90_Y0.5940.21
133_Q137_W0.5920.21
16_L229_Y0.5900.21
59_E271_E0.5900.21
181_M218_H0.5890.21
86_L113_S0.5890.21
16_L19_H0.5880.21
8_Y164_P0.5870.21
91_V267_G0.5860.21
259_C264_I0.5840.21
54_T121_P0.5830.21
52_R56_S0.5830.21
4_L82_L0.5830.21
339_T351_S0.5810.21
26_D205_H0.5800.21
288_Y356_V0.5800.21
135_L138_S0.5800.21
106_L118_A0.5780.20
95_G201_K0.5760.20
107_E272_F0.5760.20
86_L287_E0.5760.20
209_K335_K0.5760.20
90_Y102_S0.5750.20
313_K350_D0.5750.20
168_S286_I0.5740.20
67_E253_Q0.5730.20
32_F53_V0.5720.20
122_F130_M0.5720.20
179_K195_N0.5710.20
128_E296_R0.5710.20
233_L261_P0.5670.20
228_A237_D0.5640.20
10_E14_S0.5640.20
197_N331_R0.5640.20
28_N257_L0.5630.20
85_I113_S0.5590.20
301_Q308_E0.5580.20
266_I325_F0.5570.20
168_S259_C0.5570.20
32_F72_L0.5570.20
54_T88_P0.5570.20
69_L109_F0.5550.20
41_W92_E0.5550.20
134_L140_H0.5540.19
88_P118_A0.5540.19
209_K213_Q0.5540.19
32_F201_K0.5510.19
4_L328_L0.5490.19
278_S354_F0.5490.19
41_W244_F0.5480.19
60_T257_L0.5460.19
233_L310_N0.5440.19
36_L226_K0.5430.19
32_F90_Y0.5420.19
82_L223_W0.5410.19
14_S276_I0.5410.19
264_I325_F0.5410.19
283_K333_H0.5400.19
320_T353_D0.5400.19
22_S252_I0.5390.19
41_W113_S0.5380.19
175_P340_L0.5370.19
200_S238_K0.5370.19
53_V290_I0.5370.19
88_P115_S0.5350.19
43_E63_K0.5340.19
175_P356_V0.5330.19
326_K354_F0.5320.19
123_L127_Q0.5320.19
92_E119_V0.5310.19
82_L328_L0.5300.18
233_L319_Y0.5300.18
98_H123_L0.5300.18
12_L202_T0.5300.18
86_L153_S0.5300.18
38_L131_I0.5290.18
152_G197_N0.5290.18
74_D254_L0.5290.18
121_P126_D0.5250.18
203_H277_H0.5250.18
121_P127_Q0.5250.18
75_T195_N0.5240.18
124_L161_K0.5240.18
118_A243_L0.5230.18
189_R220_H0.5230.18
77_P124_L0.5230.18
99_W130_M0.5230.18
251_S281_D0.5230.18
244_F287_E0.5210.18
283_K292_F0.5210.18
261_P299_R0.5200.18
134_L210_V0.5200.18
186_L220_H0.5200.18
213_Q314_N0.5170.18
292_F328_L0.5160.18
275_Y316_T0.5160.18
259_C352_L0.5160.18
92_E121_P0.5150.18
88_P113_S0.5140.18
143_E186_L0.5100.18
94_Y284_V0.5100.18
82_L323_Q0.5090.18
8_Y111_Q0.5080.18
84_G292_F0.5080.18
174_L285_R0.5080.18
273_S281_D0.5070.18
114_T348_V0.5060.18
265_V268_E0.5060.18
47_K118_A0.5060.18
201_K343_I0.5060.18
287_E301_Q0.5050.18
85_I166_L0.5050.18
23_S114_T0.5040.17
122_F156_R0.5040.17
59_E66_V0.5020.17
18_H21_R0.5020.17
208_R329_T0.5020.17
292_F338_H0.5020.17
276_I315_E0.5000.17
226_K354_F0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l9tA 1 0.5434 100 0.81 Contact Map
4x8qA 1 0.5574 100 0.813 Contact Map
3jxyA 1 0.5854 99.9 0.845 Contact Map
2b6cA 2 0.563 99.9 0.861 Contact Map
3zboA 1 0.5798 99.7 0.88 Contact Map
2db0A 1 0.6134 93 0.964 Contact Map
4jw2A 1 0.2045 88.2 0.968 Contact Map
1oyzA 1 0.7199 88.1 0.968 Contact Map
4lacA 1 0.5658 88 0.968 Contact Map
1te4A 1 0.3081 87.4 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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