GREMLIN Database
YHAX - Stress response protein YhaX
UniProt: O07539 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 288 (257)
Sequences: 10897 (9020)
Seq/√Len: 562.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_R265_Y4.1281.00
17_S259_D3.5351.00
220_A234_A3.1671.00
257_S260_E2.9811.00
231_I237_G2.9151.00
4_Q217_D2.7801.00
22_H261_Q2.7591.00
24_A261_Q2.6361.00
208_A218_V2.5681.00
245_P249_R2.4801.00
16_R20_K2.4711.00
24_A268_K2.4531.00
8_L39_V2.4121.00
43_T50_A2.4101.00
232_E250_K2.3221.00
205_A233_L2.1971.00
215_M233_L2.0381.00
199_S229_P2.0241.00
23_Q27_D1.9661.00
31_Y34_K1.9541.00
228_L247_I1.8711.00
228_L250_K1.8351.00
239_A251_A1.8301.00
80_F206_L1.8301.00
225_Y246_E1.8271.00
31_Y268_K1.8181.00
245_P248_K1.8051.00
225_Y244_V1.7931.00
256_R260_E1.7851.00
26_K56_S1.7771.00
5_L40_T1.7691.00
237_G252_D1.7671.00
3_K219_V1.7631.00
29_I39_V1.7621.00
73_E77_A1.7361.00
32_V37_I1.7331.00
7_A204_L1.7271.00
85_S88_H1.7121.00
214_S217_D1.7011.00
205_A209_S1.6991.00
31_Y35_K1.6571.00
236_L252_D1.6421.00
206_L209_S1.6251.00
253_W270_Y1.6131.00
247_I250_K1.6031.00
206_L210_E1.6021.00
238_V266_M1.5911.00
22_H25_T1.5681.00
204_L230_M1.5621.00
10_I15_L1.5521.00
202_A205_A1.5491.00
236_L253_W1.5371.00
201_E233_L1.5171.00
82_K206_L1.5101.00
8_L221_I1.5061.00
38_Y211_L1.4961.00
91_N180_A1.4711.00
97_E114_N1.4701.00
3_K37_I1.4701.00
27_D31_Y1.4581.00
221_I263_V1.4501.00
88_H180_A1.4261.00
220_A230_M1.4211.00
25_T261_Q1.4161.00
24_A265_Y1.3881.00
239_A243_A1.3781.00
3_K236_L1.3751.00
171_T175_T1.3731.00
216_D235_G1.3581.00
26_K30_E1.3561.00
253_W266_M1.3401.00
96_L160_V1.3401.00
143_S146_D1.3381.00
28_A264_A1.3351.00
3_K217_D1.3311.00
221_I266_M1.3241.00
33_K60_D1.3101.00
7_A42_V1.2851.00
231_I247_I1.2761.00
88_H91_N1.2711.00
241_G257_S1.2701.00
215_M218_V1.2671.00
86_D90_F1.2651.00
99_Y173_T1.2511.00
208_A215_M1.2421.00
246_E249_R1.2351.00
228_L232_E1.2301.00
30_E34_K1.2251.00
182_D229_P1.2211.00
253_W269_E1.2141.00
166_I169_D1.2091.00
263_V267_M1.2051.00
82_K195_P1.1881.00
6_L267_M1.1881.00
28_A268_K1.1861.00
78_P81_E1.1821.00
88_H181_V1.1821.00
95_V99_Y1.1791.00
16_R259_D1.1771.00
168_H172_E1.1731.00
248_K254_V1.1721.00
182_D197_G1.1691.00
5_L213_L1.1681.00
70_Y78_P1.1671.00
219_V270_Y1.1631.00
218_V234_A1.1531.00
266_M270_Y1.1471.00
5_L208_A1.1421.00
24_A28_A1.1401.00
40_T207_V1.1341.00
6_L32_V1.1251.00
10_I53_I1.1131.00
220_A231_I1.1111.00
168_H185_R1.1051.00
255_T266_M1.1021.00
64_I203_G1.1001.00
157_V192_N1.0881.00
242_N258_N1.0861.00
238_V255_T1.0821.00
255_T262_G1.0811.00
215_M235_G1.0741.00
7_A218_V1.0701.00
71_I206_L1.0691.00
195_P198_V1.0671.00
6_L37_I1.0651.00
240_M262_G1.0601.00
234_A237_G1.0581.00
23_Q26_K1.0521.00
17_S258_N1.0461.00
62_K211_L1.0391.00
244_V247_I1.0391.00
184_I194_V1.0361.00
199_S202_A1.0331.00
264_A268_K1.0281.00
180_A196_K1.0251.00
33_K61_A1.0251.00
14_L25_T1.0221.00
208_A233_L1.0191.00
71_I80_F1.0111.00
256_R262_G1.0061.00
243_A248_K1.0041.00
30_E33_K1.0041.00
94_Q98_S0.9941.00
219_V236_L0.9931.00
5_L218_V0.9891.00
30_E58_K0.9871.00
224_Q244_V0.9771.00
14_L29_I0.9721.00
201_E229_P0.9701.00
238_V253_W0.9701.00
219_V238_V0.9691.00
90_F94_Q0.9541.00
266_M269_E0.9531.00
241_G248_K0.9521.00
208_A235_G0.9501.00
208_A213_L0.9491.00
207_V211_L0.9481.00
265_Y269_E0.9471.00
32_V39_V0.9391.00
204_L234_A0.9391.00
82_K197_G0.9371.00
219_V266_M0.9321.00
241_G260_E0.9211.00
172_E175_T0.9201.00
169_D172_E0.9191.00
8_L263_V0.9181.00
194_V199_S0.9151.00
47_F65_T0.9141.00
205_A215_M0.9141.00
69_A198_V0.9131.00
225_Y228_L0.9121.00
72_A78_P0.9101.00
121_N125_K0.9011.00
240_M255_T0.8981.00
91_N94_Q0.8971.00
265_Y268_K0.8911.00
51_Q76_D0.8911.00
241_G256_R0.8911.00
218_V235_G0.8881.00
27_D30_E0.8831.00
239_A247_I0.8781.00
95_V98_S0.8771.00
79_F210_E0.8721.00
71_I203_G0.8711.00
43_T65_T0.8661.00
169_D173_T0.8661.00
139_Q142_E0.8611.00
51_Q55_K0.8601.00
32_V271_F0.8551.00
84_I195_P0.8541.00
25_T264_A0.8541.00
65_T70_Y0.8531.00
7_A40_T0.8391.00
87_D91_N0.8351.00
231_I250_K0.8321.00
95_V178_F0.8291.00
42_V64_I0.8291.00
81_E108_E0.8271.00
72_A76_D0.8241.00
98_S173_T0.8151.00
218_V233_L0.8091.00
94_Q145_S0.8081.00
47_F72_A0.8061.00
168_H171_T0.8031.00
8_L14_L0.8031.00
81_E156_P0.8001.00
235_G252_D0.8001.00
110_Y139_Q0.8001.00
246_E250_K0.7971.00
46_H66_H0.7931.00
10_I41_L0.7921.00
256_R269_E0.7911.00
25_T28_A0.7891.00
37_I219_V0.7881.00
142_E145_S0.7831.00
240_M243_A0.7831.00
64_I207_V0.7801.00
162_T166_I0.7801.00
220_A237_G0.7781.00
6_L219_V0.7781.00
183_V193_I0.7761.00
16_R22_H0.7721.00
90_F149_M0.7701.00
28_A31_Y0.7691.00
243_A247_I0.7621.00
65_T72_A0.7601.00
179_P196_K0.7591.00
77_A210_E0.7591.00
14_L21_I0.7581.00
231_I251_A0.7551.00
171_T185_R0.7531.00
91_N178_F0.7531.00
32_V267_M0.7491.00
142_E146_D0.7471.00
121_N124_G0.7421.00
164_H168_H0.7421.00
37_I271_F0.7371.00
217_D235_G0.7331.00
182_D199_S0.7321.00
93_V97_E0.7301.00
237_G247_I0.7211.00
24_A264_A0.7211.00
118_V121_N0.7191.00
253_W265_Y0.7141.00
162_T167_Q0.7141.00
12_G240_M0.7121.00
95_V173_T0.7081.00
40_T62_K0.7061.00
173_T176_K0.7051.00
91_N95_V0.7051.00
41_L50_A0.7041.00
16_R258_N0.7041.00
163_E166_I0.7011.00
223_H243_A0.7001.00
18_N259_D0.6991.00
204_L220_A0.6991.00
198_V202_A0.6981.00
14_L258_N0.6971.00
87_D90_F0.6941.00
50_A65_T0.6931.00
202_A206_L0.6911.00
50_A63_L0.6891.00
122_L125_K0.6891.00
182_D196_K0.6881.00
69_A195_P0.6881.00
223_H240_M0.6801.00
67_S192_N0.6751.00
172_E176_K0.6751.00
42_V230_M0.6741.00
141_V144_L0.6731.00
5_L207_V0.6621.00
62_K73_E0.6611.00
229_P232_E0.6601.00
24_A27_D0.6561.00
99_Y169_D0.6551.00
205_A208_A0.6551.00
93_V105_L0.6501.00
164_H188_D0.6491.00
10_I50_A0.6481.00
40_T61_A0.6471.00
236_L266_M0.6411.00
237_G251_A0.6411.00
157_V186_V0.6371.00
37_I217_D0.6331.00
97_E103_I0.6331.00
221_I238_V0.6281.00
261_Q264_A0.6271.00
62_K207_V0.6241.00
83_R156_P0.6211.00
255_T265_Y0.6211.00
97_E145_S0.6211.00
242_N248_K0.6201.00
239_A250_K0.6191.00
47_F51_Q0.6171.00
90_F145_S0.6171.00
187_N224_Q0.6161.00
167_Q171_T0.6121.00
253_W256_R0.6081.00
134_I138_V0.6071.00
14_L41_L0.6031.00
78_P108_E0.6011.00
10_I14_L0.6001.00
182_D194_V0.5991.00
54_A63_L0.5951.00
201_E205_A0.5901.00
175_T183_V0.5891.00
70_Y108_E0.5881.00
25_T29_I0.5851.00
6_L221_I0.5841.00
256_R266_M0.5801.00
33_K58_K0.5791.00
146_D149_M0.5781.00
221_I255_T0.5781.00
94_Q97_E0.5771.00
41_L54_A0.5771.00
38_Y61_A0.5771.00
164_H185_R0.5750.99
183_V191_L0.5730.99
159_E192_N0.5720.99
73_E79_F0.5720.99
240_M258_N0.5710.99
225_Y247_I0.5710.99
8_L32_V0.5710.99
71_I210_E0.5700.99
21_I26_K0.5680.99
160_V193_I0.5670.99
228_L231_I0.5670.99
89_T93_V0.5650.99
242_N257_S0.5640.99
197_G202_A0.5630.99
42_V67_S0.5630.99
247_I251_A0.5610.99
15_L258_N0.5600.99
66_H190_K0.5580.99
60_D74_K0.5580.99
71_I207_V0.5560.99
3_K38_Y0.5550.99
213_L218_V0.5500.99
27_D268_K0.5490.99
29_I267_M0.5490.99
52_K55_K0.5490.99
73_E210_E0.5490.99
107_H112_I0.5480.99
17_S257_S0.5480.99
32_V264_A0.5460.99
22_H264_A0.5450.99
38_Y62_K0.5450.99
28_A32_V0.5440.99
21_I45_R0.5430.99
221_I267_M0.5420.99
66_H159_E0.5410.99
29_I33_K0.5410.99
104_R159_E0.5410.99
33_K39_V0.5410.99
264_A267_M0.5400.99
236_L270_Y0.5390.99
213_L235_G0.5390.99
66_H69_A0.5360.99
86_D152_P0.5330.99
261_Q265_Y0.5320.99
201_E218_V0.5290.99
215_M234_A0.5270.99
20_K56_S0.5260.99
16_R261_Q0.5250.99
115_K142_E0.5220.99
82_K198_V0.5210.99
238_V252_D0.5200.99
93_V103_I0.5190.99
267_M271_F0.5190.99
84_I181_V0.5170.99
54_A59_L0.5170.99
244_V248_K0.5170.99
38_Y213_L0.5160.99
96_L103_I0.5150.99
95_V174_I0.5150.99
66_H192_N0.5120.99
241_G254_V0.5110.99
107_H110_Y0.5100.99
14_L263_V0.5090.99
92_I181_V0.5080.99
250_K253_W0.5070.99
159_E190_K0.5070.99
46_H49_S0.5060.99
234_A252_D0.5060.99
44_N226_D0.5020.99
85_S180_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dnpA 2 0.9514 100 0.265 Contact Map
3pgvA 3 0.8889 100 0.277 Contact Map
2b30A 2 0.9201 100 0.283 Contact Map
1nrwA 1 0.9201 100 0.284 Contact Map
3l7yA 1 0.9062 100 0.289 Contact Map
1nf2A 4 0.9201 100 0.299 Contact Map
1rkqA 1 0.9167 100 0.302 Contact Map
4qjbA 1 0.9097 100 0.305 Contact Map
1rlmA 1 0.9236 100 0.309 Contact Map
3daoA 1 0.9062 100 0.313 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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