YHAU - BACSU - GREMLIN Contacts

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YHAU - K(+)/H(+) antiporter YhaU

UniProt:	O07536	Sequences: MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHAPKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILINFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMFEDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIRSNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFFGAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGLTIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVFKWKPEVQPAKKQG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	405 (369)
Sequences:	15216 (10397)
Seq/√Len:	541.3

ECOLI - KEFB NHAP2 YBAL KEFC YJCE
BACSU - YHAU NHAK YJBQ
HALSA - Q9HNK1
SULSO - Q97UN8 Q97Z08 Q980D8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
188_L	192_I	3.586	1.00
209_P	213_K	3.524	1.00
106_L	310_G	3.508	1.00
201_F	205_R	3.492	1.00
316_M	326_H	3.465	1.00
205_R	209_P	3.445	1.00
193_A	196_Y	3.295	1.00
304_V	369_I	3.147	1.00
117_S	120_E	3.107	1.00
334_L	377_V	3.099	1.00
189_S	192_I	3.022	1.00
193_A	197_M	2.835	1.00
108_L	125_A	2.805	1.00
209_P	212_N	2.802	1.00
325_S	328_A	2.666	1.00
380_E	384_I	2.569	1.00
379_K	383_R	2.457	1.00
234_I	252_L	2.346	1.00
184_G	188_L	2.316	1.00
110_Y	306_L	2.300	1.00
86_I	89_G	2.284	1.00
108_L	118_F	2.180	1.00
301_L	305_I	2.167	1.00
203_A	234_I	2.127	1.00
300_A	365_L	2.106	1.00
191_L	195_G	2.054	1.00
109_L	118_F	2.039	1.00
18_A	22_A	2.031	1.00
343_S	363_A	2.023	1.00
109_L	112_F	2.018	1.00
297_V	301_L	1.885	1.00
320_R	329_S	1.865	1.00
109_L	113_I	1.860	1.00
59_E	62_E	1.850	1.00
105_S	109_L	1.843	1.00
183_V	186_A	1.819	1.00
316_M	333_G	1.819	1.00
92_I	156_G	1.815	1.00
81_S	84_K	1.784	1.00
192_I	196_Y	1.783	1.00
123_I	350_G	1.780	1.00
298_W	302_G	1.780	1.00
200_F	204_A	1.779	1.00
303_A	366_Y	1.772	1.00
319_G	329_S	1.760	1.00
202_I	205_R	1.755	1.00
39_L	44_A	1.740	1.00
187_L	191_L	1.731	1.00
351_I	360_K	1.726	1.00
196_Y	243_V	1.724	1.00
74_F	231_L	1.687	1.00
235_A	245_E	1.678	1.00
111_G	121_V	1.670	1.00
185_S	188_L	1.658	1.00
108_L	122_L	1.647	1.00
230_A	252_L	1.639	1.00
119_L	172_V	1.637	1.00
314_A	318_A	1.634	1.00
70_L	235_A	1.632	1.00
108_L	112_F	1.620	1.00
312_F	333_G	1.618	1.00
83_G	86_I	1.617	1.00
107_G	111_G	1.614	1.00
369_I	373_L	1.613	1.00
356_S	359_L	1.610	1.00
18_A	36_L	1.598	1.00
317_V	321_R	1.588	1.00
22_A	32_F	1.575	1.00
150_E	332_I	1.569	1.00
182_S	185_S	1.569	1.00
289_D	292_S	1.552	1.00
35_V	39_L	1.540	1.00
106_L	109_L	1.518	1.00
166_A	346_V	1.511	1.00
320_R	326_H	1.499	1.00
154_I	335_T	1.499	1.00
238_S	248_G	1.499	1.00
62_E	66_R	1.498	1.00
306_L	310_G	1.481	1.00
39_L	42_P	1.442	1.00
203_A	207_L	1.437	1.00
376_L	380_E	1.426	1.00
97_T	101_L	1.426	1.00
380_E	383_R	1.425	1.00
148_N	151_T	1.423	1.00
233_F	237_F	1.421	1.00
194_F	198_L	1.415	1.00
213_K	216_D	1.402	1.00
206_K	209_P	1.400	1.00
204_A	208_P	1.385	1.00
60_I	63_F	1.383	1.00
14_L	36_L	1.377	1.00
347_A	363_A	1.374	1.00
94_V	322_A	1.373	1.00
188_L	191_L	1.369	1.00
207_L	230_A	1.363	1.00
316_M	330_S	1.362	1.00
316_M	320_R	1.359	1.00
89_G	93_A	1.354	1.00
154_I	332_I	1.350	1.00
130_I	165_L	1.344	1.00
351_I	357_A	1.326	1.00
105_S	108_L	1.310	1.00
104_F	129_T	1.309	1.00
11_A	282_F	1.299	1.00
316_M	329_S	1.299	1.00
150_E	328_A	1.296	1.00
325_S	329_S	1.296	1.00
91_S	153_L	1.289	1.00
183_V	187_L	1.287	1.00
41_G	44_A	1.274	1.00
310_G	314_A	1.270	1.00
195_G	198_L	1.269	1.00
83_G	87_K	1.250	1.00
20_V	24_K	1.246	1.00
127_V	347_A	1.232	1.00
331_N	382_K	1.231	1.00
150_E	331_N	1.230	1.00
307_T	339_R	1.226	1.00
149_P	328_A	1.221	1.00
298_W	301_L	1.219	1.00
307_T	366_Y	1.214	1.00
118_F	122_L	1.213	1.00
110_Y	113_I	1.211	1.00
128_I	366_Y	1.211	1.00
97_T	100_I	1.207	1.00
9_G	229_A	1.205	1.00
121_V	125_A	1.202	1.00
111_G	124_L	1.199	1.00
101_L	105_S	1.194	1.00
140_L	151_T	1.190	1.00
363_A	367_V	1.186	1.00
11_A	15_V	1.178	1.00
74_F	253_G	1.176	1.00
348_N	352_A	1.172	1.00
88_S	91_S	1.172	1.00
15_V	19_S	1.171	1.00
104_F	126_G	1.169	1.00
125_A	129_T	1.168	1.00
296_A	300_A	1.168	1.00
9_G	13_V	1.166	1.00
344_I	367_V	1.166	1.00
300_A	304_V	1.165	1.00
112_F	121_V	1.161	1.00
13_V	229_A	1.159	1.00
185_S	189_S	1.157	1.00
201_F	255_V	1.154	1.00
190_I	194_F	1.138	1.00
37_G	41_G	1.128	1.00
20_V	23_N	1.126	1.00
131_S	136_V	1.120	1.00
308_I	337_V	1.115	1.00
117_S	121_V	1.115	1.00
112_F	118_F	1.114	1.00
335_T	378_T	1.108	1.00
326_H	330_S	1.106	1.00
192_I	195_G	1.105	1.00
116_F	121_V	1.104	1.00
143_L	379_K	1.101	1.00
84_K	87_K	1.099	1.00
294_G	297_V	1.098	1.00
234_I	248_G	1.096	1.00
159_M	250_L	1.095	1.00
296_A	299_L	1.092	1.00
191_L	194_F	1.091	1.00
153_L	324_L	1.087	1.00
239_E	245_E	1.078	1.00
313_I	317_V	1.073	1.00
305_I	309_L	1.065	1.00
17_I	20_V	1.063	1.00
84_K	152_E	1.060	1.00
89_G	92_I	1.051	1.00
19_S	22_A	1.050	1.00
138_K	142_D	1.047	1.00
349_L	353_G	1.047	1.00
238_S	243_V	1.042	1.00
103_N	107_G	1.042	1.00
75_Y	79_E	1.042	1.00
237_F	240_T	1.038	1.00
111_G	116_F	1.038	1.00
88_S	92_I	1.038	1.00
173_S	353_G	1.037	1.00
362_F	366_Y	1.033	1.00
127_V	363_A	1.032	1.00
268_L	272_F	1.031	1.00
94_V	321_R	1.029	1.00
9_G	236_G	1.025	1.00
299_L	362_F	1.017	1.00
236_G	240_T	1.010	1.00
308_I	312_F	1.008	1.00
119_L	176_I	1.006	1.00
140_L	154_I	1.006	1.00
22_A	25_I	1.005	1.00
99_Y	103_N	1.002	1.00
324_L	328_A	0.998	1.00
330_S	333_G	0.997	1.00
205_R	208_P	0.997	1.00
100_I	164_F	0.989	1.00
320_R	323_G	0.986	1.00
124_L	128_I	0.984	1.00
98_I	101_L	0.982	1.00
61_I	283_S	0.982	1.00
303_A	362_F	0.981	1.00
122_L	172_V	0.981	1.00
111_G	303_A	0.981	1.00
291_F	295_E	0.978	1.00
207_L	211_L	0.969	1.00
334_L	381_S	0.963	1.00
223_F	261_H	0.962	1.00
199_L	243_V	0.959	1.00
16_A	19_S	0.954	1.00
94_V	98_I	0.953	1.00
124_L	363_A	0.950	1.00
357_A	361_P	0.947	1.00
16_A	229_A	0.946	1.00
381_S	384_I	0.945	1.00
98_I	318_A	0.942	1.00
184_G	187_L	0.941	1.00
264_R	267_H	0.935	1.00
338_S	374_G	0.931	1.00
339_R	343_S	0.930	1.00
6_F	9_G	0.930	1.00
317_V	320_R	0.927	1.00
90_K	94_V	0.926	1.00
249_A	253_G	0.925	1.00
349_L	352_A	0.920	1.00
43_H	290_P	0.920	1.00
186_A	189_S	0.915	1.00
116_F	124_L	0.913	1.00
172_V	176_I	0.912	1.00
299_L	302_G	0.911	1.00
104_F	168_Y	0.909	1.00
221_E	225_I	0.906	1.00
110_Y	302_G	0.902	1.00
107_G	128_I	0.902	1.00
315_G	332_I	0.901	1.00
312_F	330_S	0.899	1.00
116_F	120_E	0.897	1.00
130_I	343_S	0.897	1.00
229_A	233_F	0.894	1.00
82_V	86_I	0.893	1.00
14_L	40_V	0.892	1.00
19_S	29_I	0.892	1.00
327_K	331_N	0.891	1.00
57_S	60_I	0.889	1.00
297_V	300_A	0.888	1.00
14_L	18_A	0.888	1.00
9_G	233_F	0.888	1.00
73_L	246_A	0.884	1.00
140_L	146_T	0.883	1.00
227_I	265_I	0.883	1.00
104_F	108_L	0.878	1.00
9_G	16_A	0.877	1.00
182_S	187_L	0.876	1.00
182_S	186_A	0.874	1.00
90_K	93_A	0.871	1.00
123_I	176_I	0.869	1.00
15_V	22_A	0.868	1.00
106_L	110_Y	0.868	1.00
78_L	256_F	0.868	1.00
309_L	313_I	0.867	1.00
43_H	289_D	0.866	1.00
131_S	158_I	0.865	1.00
208_P	212_N	0.860	1.00
190_I	193_A	0.859	1.00
319_G	324_L	0.857	1.00
102_I	314_A	0.856	1.00
185_S	192_I	0.855	1.00
284_F	364_A	0.851	1.00
136_V	335_T	0.849	1.00
118_F	121_V	0.846	1.00
102_I	105_S	0.845	1.00
300_A	362_F	0.845	1.00
299_L	303_A	0.844	1.00
97_T	164_F	0.843	1.00
200_F	203_A	0.843	1.00
81_S	258_E	0.839	1.00
77_G	254_L	0.838	1.00
208_P	255_V	0.838	1.00
99_Y	311_N	0.836	1.00
324_L	329_S	0.835	1.00
192_I	197_M	0.834	1.00
15_V	282_F	0.833	1.00
126_G	346_V	0.832	1.00
358_T	362_F	0.830	1.00
10_T	14_L	0.829	1.00
327_K	330_S	0.826	1.00
126_G	168_Y	0.825	1.00
220_N	264_R	0.818	1.00
304_V	308_I	0.812	1.00
301_L	304_V	0.809	1.00
292_S	361_P	0.808	1.00
91_S	94_V	0.804	1.00
15_V	18_A	0.804	1.00
187_L	190_I	0.802	1.00
367_V	371_A	0.801	1.00
102_I	106_L	0.800	1.00
339_R	367_V	0.799	1.00
181_T	185_S	0.799	1.00
304_V	370_L	0.796	1.00
264_R	268_L	0.794	1.00
38_M	41_G	0.791	1.00
133_S	158_I	0.790	1.00
70_L	245_E	0.790	1.00
189_S	193_A	0.790	1.00
194_F	197_M	0.788	1.00
38_M	44_A	0.786	1.00
199_L	204_A	0.786	1.00
312_F	316_M	0.786	1.00
296_A	358_T	0.786	1.00
12_L	15_V	0.786	1.00
131_S	161_E	0.785	1.00
318_A	322_A	0.782	1.00
288_I	364_A	0.779	1.00
93_A	97_T	0.777	1.00
95_G	315_G	0.776	1.00
33_L	278_A	0.776	1.00
331_N	378_T	0.772	1.00
190_I	197_M	0.771	1.00
198_L	201_F	0.770	1.00
132_S	161_E	0.768	1.00
23_N	26_K	0.762	1.00
208_P	211_L	0.761	1.00
202_I	206_K	0.757	1.00
71_F	276_F	0.756	1.00
307_T	311_N	0.754	1.00
40_V	286_L	0.754	1.00
371_A	374_G	0.752	1.00
128_I	307_T	0.752	1.00
132_S	135_I	0.752	1.00
32_F	36_L	0.752	1.00
19_S	32_F	0.751	1.00
106_L	314_A	0.747	1.00
227_I	231_L	0.746	1.00
292_S	295_E	0.743	1.00
225_I	274_D	0.740	1.00
228_F	231_L	0.739	1.00
307_T	370_L	0.739	1.00
120_E	356_S	0.736	1.00
236_G	239_E	0.733	1.00
227_I	256_F	0.731	1.00
231_L	235_A	0.728	1.00
319_G	332_I	0.726	1.00
331_N	335_T	0.724	1.00
173_S	177_L	0.724	1.00
233_F	236_G	0.720	1.00
361_P	364_A	0.720	1.00
91_S	324_L	0.718	1.00
280_F	345_I	0.718	1.00
7_E	10_T	0.718	1.00
329_S	333_G	0.713	1.00
108_L	111_G	0.712	1.00
347_A	360_K	0.711	1.00
309_L	312_F	0.709	1.00
34_I	368_L	0.706	1.00
21_I	24_K	0.706	1.00
358_T	361_P	0.705	1.00
347_A	359_L	0.705	1.00
199_L	238_S	0.705	1.00
266_E	270_V	0.695	1.00
235_A	249_A	0.694	1.00
227_I	230_A	0.693	1.00
224_I	268_L	0.691	1.00
223_F	227_I	0.689	1.00
330_S	381_S	0.689	1.00
377_V	380_E	0.686	1.00
243_V	248_G	0.685	1.00
156_G	159_M	0.684	1.00
323_G	329_S	0.684	1.00
273_R	277_G	0.684	1.00
38_M	290_P	0.682	1.00
372_I	376_L	0.680	1.00
68_G	280_F	0.680	1.00
38_M	43_H	0.680	1.00
75_Y	273_R	0.680	1.00
231_L	234_I	0.679	1.00
73_L	130_I	0.679	1.00
234_I	238_S	0.679	1.00
259_T	262_S	0.675	1.00
101_L	104_F	0.675	1.00
302_G	305_I	0.675	1.00
366_Y	370_L	0.674	1.00
96_G	99_Y	0.673	1.00
261_H	264_R	0.673	1.00
373_L	377_V	0.669	1.00
158_I	161_E	0.667	1.00
190_I	196_Y	0.665	1.00
40_V	43_H	0.665	1.00
181_T	184_G	0.665	1.00
71_F	228_F	0.665	1.00
126_G	130_I	0.664	1.00
143_L	382_K	0.663	1.00
94_V	318_A	0.662	1.00
93_A	96_G	0.662	1.00
203_A	206_K	0.661	1.00
18_A	32_F	0.660	1.00
96_G	157_I	0.658	1.00
165_L	346_V	0.658	1.00
280_F	341_E	0.658	1.00
166_A	244_A	0.657	1.00
260_E	263_D	0.656	1.00
19_S	23_N	0.656	1.00
148_N	152_E	0.656	1.00
17_I	21_I	0.656	1.00
74_F	227_I	0.656	1.00
92_I	157_I	0.655	1.00
119_L	175_L	0.655	1.00
41_G	286_L	0.653	1.00
170_S	174_G	0.652	1.00
237_F	241_I	0.650	1.00
380_E	385_Y	0.646	1.00
80_F	250_L	0.645	1.00
263_D	267_H	0.642	1.00
18_A	21_I	0.641	1.00
327_K	385_Y	0.641	1.00
73_L	250_L	0.640	1.00
82_V	85_L	0.640	1.00
178_G	181_T	0.639	1.00
132_S	343_S	0.638	1.00
219_S	223_F	0.637	1.00
29_I	33_L	0.634	1.00
15_V	278_A	0.634	1.00
354_G	357_A	0.633	1.00
304_V	373_L	0.633	1.00
161_E	337_V	0.631	1.00
168_Y	172_V	0.631	1.00
169_L	349_L	0.630	1.00
71_F	231_L	0.629	1.00
360_K	363_A	0.628	1.00
214_L	223_F	0.626	1.00
91_S	95_G	0.626	1.00
192_I	243_V	0.625	1.00
62_E	287_S	0.623	1.00
351_I	356_S	0.620	1.00
254_L	257_S	0.618	1.00
16_A	22_A	0.616	1.00
206_K	210_L	0.616	1.00
22_A	26_K	0.615	1.00
70_L	231_L	0.615	1.00
212_N	216_D	0.614	1.00
88_S	149_P	0.613	1.00
108_L	121_V	0.611	1.00
348_N	360_K	0.610	1.00
284_F	341_E	0.609	1.00
312_F	315_G	0.609	1.00
79_E	266_E	0.608	1.00
328_A	331_N	0.607	1.00
199_L	202_I	0.607	1.00
196_Y	200_F	0.603	1.00
167_V	170_S	0.602	1.00
312_F	334_L	0.598	1.00
308_I	373_L	0.596	1.00
262_S	266_E	0.596	1.00
103_N	314_A	0.594	1.00
61_I	65_G	0.592	1.00
181_T	186_A	0.590	1.00
205_R	212_N	0.588	1.00
74_F	252_L	0.587	1.00
95_G	332_I	0.587	1.00
134_A	162_D	0.586	0.99
196_Y	241_I	0.582	0.99
123_I	127_V	0.582	0.99
251_L	255_V	0.581	0.99
75_Y	269_V	0.581	0.99
382_K	386_R	0.579	0.99
56_Q	59_E	0.579	0.99
95_G	153_L	0.578	0.99
174_G	178_G	0.578	0.99
201_F	204_A	0.578	0.99
227_I	269_V	0.576	0.99
33_L	282_F	0.574	0.99
342_F	345_I	0.570	0.99
295_E	298_W	0.568	0.99
91_S	322_A	0.568	0.99
157_I	315_G	0.566	0.99
135_I	371_A	0.565	0.99
6_F	10_T	0.564	0.99
291_F	294_G	0.564	0.99
64_F	334_L	0.563	0.99
130_I	133_S	0.563	0.99
198_L	247_I	0.563	0.99
332_I	335_T	0.562	0.99
351_I	354_G	0.562	0.99
100_I	104_F	0.562	0.99
193_A	242_H	0.562	0.99
197_M	200_F	0.560	0.99
36_L	282_F	0.560	0.99
124_L	362_F	0.559	0.99
191_L	198_L	0.559	0.99
318_A	321_R	0.556	0.99
239_E	242_H	0.556	0.99
288_I	361_P	0.555	0.99
79_E	141_V	0.555	0.99
19_S	33_L	0.555	0.99
244_A	247_I	0.554	0.99
221_E	274_D	0.551	0.99
134_A	342_F	0.550	0.99
327_K	384_I	0.550	0.99
5_V	70_L	0.550	0.99
343_S	346_V	0.549	0.99
96_G	164_F	0.549	0.99
326_H	329_S	0.548	0.99
257_S	262_S	0.547	0.99
136_V	139_V	0.546	0.99
189_S	196_Y	0.546	0.99
149_P	324_L	0.546	0.99
371_A	375_P	0.544	0.99
71_F	75_Y	0.544	0.99
169_L	346_V	0.536	0.99
76_L	137_A	0.535	0.99
130_I	161_E	0.534	0.99
165_L	169_L	0.534	0.99
82_V	254_L	0.531	0.99
96_G	378_T	0.531	0.99
331_N	381_S	0.531	0.99
141_V	270_V	0.530	0.99
38_M	288_I	0.530	0.99
278_A	282_F	0.530	0.99
132_S	341_E	0.530	0.99
100_I	161_E	0.529	0.99
302_G	306_L	0.527	0.99
111_G	125_A	0.527	0.99
128_I	339_R	0.527	0.99
39_L	43_H	0.525	0.99
165_L	342_F	0.524	0.99
183_V	188_L	0.523	0.99
99_Y	161_E	0.523	0.99
157_I	340_G	0.523	0.99
108_L	172_V	0.522	0.99
212_N	260_E	0.521	0.99
334_L	374_G	0.521	0.99
166_A	342_F	0.520	0.99
99_Y	315_G	0.519	0.99
112_F	117_S	0.518	0.99
224_I	228_F	0.517	0.99
235_A	239_E	0.516	0.99
99_Y	157_I	0.515	0.99
176_I	355_L	0.513	0.99
157_I	161_E	0.513	0.99
12_L	275_F	0.511	0.99
378_T	381_S	0.511	0.99
140_L	335_T	0.511	0.99
138_K	141_V	0.509	0.99
173_S	176_I	0.509	0.99
62_E	283_S	0.507	0.99
169_L	173_S	0.506	0.99
377_V	381_S	0.506	0.99
228_F	232_F	0.506	0.99
107_G	125_A	0.504	0.98
296_A	362_F	0.504	0.98
92_I	111_G	0.503	0.98
77_G	250_L	0.502	0.98
19_S	278_A	0.502	0.98
100_I	165_L	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4bwzA	2	0.9333	100	0.248	Contact Map
4czbA	2	0.9407	100	0.262	Contact Map
4cz8A	2	0.9333	100	0.287	Contact Map
1zcdA	1	0.8173	99.9	0.644	Contact Map
3zuxA	1	0.7457	98.7	0.836	Contact Map
4n7wA	2	0.7432	98.3	0.856	Contact Map
2mdfA	1	0.1407	98.3	0.857	Contact Map
2l0eA	1	0.0765	91.8	0.92	Contact Map
2k3cA	1	0.0765	88.6	0.925	Contact Map
2m7xA	1	0.0741	70.1	0.938	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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