GREMLIN Database
YHAU - K(+)/H(+) antiporter YhaU
UniProt: O07536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 405 (369)
Sequences: 15216 (10397)
Seq/√Len: 541.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
188_L192_I3.5861.00
209_P213_K3.5241.00
106_L310_G3.5081.00
201_F205_R3.4921.00
316_M326_H3.4651.00
205_R209_P3.4451.00
193_A196_Y3.2951.00
304_V369_I3.1471.00
117_S120_E3.1071.00
334_L377_V3.0991.00
189_S192_I3.0221.00
193_A197_M2.8351.00
108_L125_A2.8051.00
209_P212_N2.8021.00
325_S328_A2.6661.00
380_E384_I2.5691.00
379_K383_R2.4571.00
234_I252_L2.3461.00
184_G188_L2.3161.00
110_Y306_L2.3001.00
86_I89_G2.2841.00
108_L118_F2.1801.00
301_L305_I2.1671.00
203_A234_I2.1271.00
300_A365_L2.1061.00
191_L195_G2.0541.00
109_L118_F2.0391.00
18_A22_A2.0311.00
343_S363_A2.0231.00
109_L112_F2.0181.00
297_V301_L1.8851.00
320_R329_S1.8651.00
109_L113_I1.8601.00
59_E62_E1.8501.00
105_S109_L1.8431.00
183_V186_A1.8191.00
316_M333_G1.8191.00
92_I156_G1.8151.00
81_S84_K1.7841.00
192_I196_Y1.7831.00
123_I350_G1.7801.00
298_W302_G1.7801.00
200_F204_A1.7791.00
303_A366_Y1.7721.00
319_G329_S1.7601.00
202_I205_R1.7551.00
39_L44_A1.7401.00
187_L191_L1.7311.00
351_I360_K1.7261.00
196_Y243_V1.7241.00
74_F231_L1.6871.00
235_A245_E1.6781.00
111_G121_V1.6701.00
185_S188_L1.6581.00
108_L122_L1.6471.00
230_A252_L1.6391.00
119_L172_V1.6371.00
314_A318_A1.6341.00
70_L235_A1.6321.00
108_L112_F1.6201.00
312_F333_G1.6181.00
83_G86_I1.6171.00
107_G111_G1.6141.00
369_I373_L1.6131.00
356_S359_L1.6101.00
18_A36_L1.5981.00
317_V321_R1.5881.00
22_A32_F1.5751.00
150_E332_I1.5691.00
182_S185_S1.5691.00
289_D292_S1.5521.00
35_V39_L1.5401.00
106_L109_L1.5181.00
166_A346_V1.5111.00
320_R326_H1.4991.00
154_I335_T1.4991.00
238_S248_G1.4991.00
62_E66_R1.4981.00
306_L310_G1.4811.00
39_L42_P1.4421.00
203_A207_L1.4371.00
376_L380_E1.4261.00
97_T101_L1.4261.00
380_E383_R1.4251.00
148_N151_T1.4231.00
233_F237_F1.4211.00
194_F198_L1.4151.00
213_K216_D1.4021.00
206_K209_P1.4001.00
204_A208_P1.3851.00
60_I63_F1.3831.00
14_L36_L1.3771.00
347_A363_A1.3741.00
94_V322_A1.3731.00
188_L191_L1.3691.00
207_L230_A1.3631.00
316_M330_S1.3621.00
316_M320_R1.3591.00
89_G93_A1.3541.00
154_I332_I1.3501.00
130_I165_L1.3441.00
351_I357_A1.3261.00
105_S108_L1.3101.00
104_F129_T1.3091.00
11_A282_F1.2991.00
316_M329_S1.2991.00
150_E328_A1.2961.00
325_S329_S1.2961.00
91_S153_L1.2891.00
183_V187_L1.2871.00
41_G44_A1.2741.00
310_G314_A1.2701.00
195_G198_L1.2691.00
83_G87_K1.2501.00
20_V24_K1.2461.00
127_V347_A1.2321.00
331_N382_K1.2311.00
150_E331_N1.2301.00
307_T339_R1.2261.00
149_P328_A1.2211.00
298_W301_L1.2191.00
307_T366_Y1.2141.00
118_F122_L1.2131.00
110_Y113_I1.2111.00
128_I366_Y1.2111.00
97_T100_I1.2071.00
9_G229_A1.2051.00
121_V125_A1.2021.00
111_G124_L1.1991.00
101_L105_S1.1941.00
140_L151_T1.1901.00
363_A367_V1.1861.00
11_A15_V1.1781.00
74_F253_G1.1761.00
348_N352_A1.1721.00
88_S91_S1.1721.00
15_V19_S1.1711.00
104_F126_G1.1691.00
125_A129_T1.1681.00
296_A300_A1.1681.00
9_G13_V1.1661.00
344_I367_V1.1661.00
300_A304_V1.1651.00
112_F121_V1.1611.00
13_V229_A1.1591.00
185_S189_S1.1571.00
201_F255_V1.1541.00
190_I194_F1.1381.00
37_G41_G1.1281.00
20_V23_N1.1261.00
131_S136_V1.1201.00
308_I337_V1.1151.00
117_S121_V1.1151.00
112_F118_F1.1141.00
335_T378_T1.1081.00
326_H330_S1.1061.00
192_I195_G1.1051.00
116_F121_V1.1041.00
143_L379_K1.1011.00
84_K87_K1.0991.00
294_G297_V1.0981.00
234_I248_G1.0961.00
159_M250_L1.0951.00
296_A299_L1.0921.00
191_L194_F1.0911.00
153_L324_L1.0871.00
239_E245_E1.0781.00
313_I317_V1.0731.00
305_I309_L1.0651.00
17_I20_V1.0631.00
84_K152_E1.0601.00
89_G92_I1.0511.00
19_S22_A1.0501.00
138_K142_D1.0471.00
349_L353_G1.0471.00
238_S243_V1.0421.00
103_N107_G1.0421.00
75_Y79_E1.0421.00
237_F240_T1.0381.00
111_G116_F1.0381.00
88_S92_I1.0381.00
173_S353_G1.0371.00
362_F366_Y1.0331.00
127_V363_A1.0321.00
268_L272_F1.0311.00
94_V321_R1.0291.00
9_G236_G1.0251.00
299_L362_F1.0171.00
236_G240_T1.0101.00
308_I312_F1.0081.00
119_L176_I1.0061.00
140_L154_I1.0061.00
22_A25_I1.0051.00
99_Y103_N1.0021.00
324_L328_A0.9981.00
330_S333_G0.9971.00
205_R208_P0.9971.00
100_I164_F0.9891.00
320_R323_G0.9861.00
124_L128_I0.9841.00
98_I101_L0.9821.00
61_I283_S0.9821.00
303_A362_F0.9811.00
122_L172_V0.9811.00
111_G303_A0.9811.00
291_F295_E0.9781.00
207_L211_L0.9691.00
334_L381_S0.9631.00
223_F261_H0.9621.00
199_L243_V0.9591.00
16_A19_S0.9541.00
94_V98_I0.9531.00
124_L363_A0.9501.00
357_A361_P0.9471.00
16_A229_A0.9461.00
381_S384_I0.9451.00
98_I318_A0.9421.00
184_G187_L0.9411.00
264_R267_H0.9351.00
338_S374_G0.9311.00
339_R343_S0.9301.00
6_F9_G0.9301.00
317_V320_R0.9271.00
90_K94_V0.9261.00
249_A253_G0.9251.00
349_L352_A0.9201.00
43_H290_P0.9201.00
186_A189_S0.9151.00
116_F124_L0.9131.00
172_V176_I0.9121.00
299_L302_G0.9111.00
104_F168_Y0.9091.00
221_E225_I0.9061.00
110_Y302_G0.9021.00
107_G128_I0.9021.00
315_G332_I0.9011.00
312_F330_S0.8991.00
116_F120_E0.8971.00
130_I343_S0.8971.00
229_A233_F0.8941.00
82_V86_I0.8931.00
14_L40_V0.8921.00
19_S29_I0.8921.00
327_K331_N0.8911.00
57_S60_I0.8891.00
297_V300_A0.8881.00
14_L18_A0.8881.00
9_G233_F0.8881.00
73_L246_A0.8841.00
140_L146_T0.8831.00
227_I265_I0.8831.00
104_F108_L0.8781.00
9_G16_A0.8771.00
182_S187_L0.8761.00
182_S186_A0.8741.00
90_K93_A0.8711.00
123_I176_I0.8691.00
15_V22_A0.8681.00
106_L110_Y0.8681.00
78_L256_F0.8681.00
309_L313_I0.8671.00
43_H289_D0.8661.00
131_S158_I0.8651.00
208_P212_N0.8601.00
190_I193_A0.8591.00
319_G324_L0.8571.00
102_I314_A0.8561.00
185_S192_I0.8551.00
284_F364_A0.8511.00
136_V335_T0.8491.00
118_F121_V0.8461.00
102_I105_S0.8451.00
300_A362_F0.8451.00
299_L303_A0.8441.00
97_T164_F0.8431.00
200_F203_A0.8431.00
81_S258_E0.8391.00
77_G254_L0.8381.00
208_P255_V0.8381.00
99_Y311_N0.8361.00
324_L329_S0.8351.00
192_I197_M0.8341.00
15_V282_F0.8331.00
126_G346_V0.8321.00
358_T362_F0.8301.00
10_T14_L0.8291.00
327_K330_S0.8261.00
126_G168_Y0.8251.00
220_N264_R0.8181.00
304_V308_I0.8121.00
301_L304_V0.8091.00
292_S361_P0.8081.00
91_S94_V0.8041.00
15_V18_A0.8041.00
187_L190_I0.8021.00
367_V371_A0.8011.00
102_I106_L0.8001.00
339_R367_V0.7991.00
181_T185_S0.7991.00
304_V370_L0.7961.00
264_R268_L0.7941.00
38_M41_G0.7911.00
133_S158_I0.7901.00
70_L245_E0.7901.00
189_S193_A0.7901.00
194_F197_M0.7881.00
38_M44_A0.7861.00
199_L204_A0.7861.00
312_F316_M0.7861.00
296_A358_T0.7861.00
12_L15_V0.7861.00
131_S161_E0.7851.00
318_A322_A0.7821.00
288_I364_A0.7791.00
93_A97_T0.7771.00
95_G315_G0.7761.00
33_L278_A0.7761.00
331_N378_T0.7721.00
190_I197_M0.7711.00
198_L201_F0.7701.00
132_S161_E0.7681.00
23_N26_K0.7621.00
208_P211_L0.7611.00
202_I206_K0.7571.00
71_F276_F0.7561.00
307_T311_N0.7541.00
40_V286_L0.7541.00
371_A374_G0.7521.00
128_I307_T0.7521.00
132_S135_I0.7521.00
32_F36_L0.7521.00
19_S32_F0.7511.00
106_L314_A0.7471.00
227_I231_L0.7461.00
292_S295_E0.7431.00
225_I274_D0.7401.00
228_F231_L0.7391.00
307_T370_L0.7391.00
120_E356_S0.7361.00
236_G239_E0.7331.00
227_I256_F0.7311.00
231_L235_A0.7281.00
319_G332_I0.7261.00
331_N335_T0.7241.00
173_S177_L0.7241.00
233_F236_G0.7201.00
361_P364_A0.7201.00
91_S324_L0.7181.00
280_F345_I0.7181.00
7_E10_T0.7181.00
329_S333_G0.7131.00
108_L111_G0.7121.00
347_A360_K0.7111.00
309_L312_F0.7091.00
34_I368_L0.7061.00
21_I24_K0.7061.00
358_T361_P0.7051.00
347_A359_L0.7051.00
199_L238_S0.7051.00
266_E270_V0.6951.00
235_A249_A0.6941.00
227_I230_A0.6931.00
224_I268_L0.6911.00
223_F227_I0.6891.00
330_S381_S0.6891.00
377_V380_E0.6861.00
243_V248_G0.6851.00
156_G159_M0.6841.00
323_G329_S0.6841.00
273_R277_G0.6841.00
38_M290_P0.6821.00
372_I376_L0.6801.00
68_G280_F0.6801.00
38_M43_H0.6801.00
75_Y273_R0.6801.00
231_L234_I0.6791.00
73_L130_I0.6791.00
234_I238_S0.6791.00
259_T262_S0.6751.00
101_L104_F0.6751.00
302_G305_I0.6751.00
366_Y370_L0.6741.00
96_G99_Y0.6731.00
261_H264_R0.6731.00
373_L377_V0.6691.00
158_I161_E0.6671.00
190_I196_Y0.6651.00
40_V43_H0.6651.00
181_T184_G0.6651.00
71_F228_F0.6651.00
126_G130_I0.6641.00
143_L382_K0.6631.00
94_V318_A0.6621.00
93_A96_G0.6621.00
203_A206_K0.6611.00
18_A32_F0.6601.00
96_G157_I0.6581.00
165_L346_V0.6581.00
280_F341_E0.6581.00
166_A244_A0.6571.00
260_E263_D0.6561.00
19_S23_N0.6561.00
148_N152_E0.6561.00
17_I21_I0.6561.00
74_F227_I0.6561.00
92_I157_I0.6551.00
119_L175_L0.6551.00
41_G286_L0.6531.00
170_S174_G0.6521.00
237_F241_I0.6501.00
380_E385_Y0.6461.00
80_F250_L0.6451.00
263_D267_H0.6421.00
18_A21_I0.6411.00
327_K385_Y0.6411.00
73_L250_L0.6401.00
82_V85_L0.6401.00
178_G181_T0.6391.00
132_S343_S0.6381.00
219_S223_F0.6371.00
29_I33_L0.6341.00
15_V278_A0.6341.00
354_G357_A0.6331.00
304_V373_L0.6331.00
161_E337_V0.6311.00
168_Y172_V0.6311.00
169_L349_L0.6301.00
71_F231_L0.6291.00
360_K363_A0.6281.00
214_L223_F0.6261.00
91_S95_G0.6261.00
192_I243_V0.6251.00
62_E287_S0.6231.00
351_I356_S0.6201.00
254_L257_S0.6181.00
16_A22_A0.6161.00
206_K210_L0.6161.00
22_A26_K0.6151.00
70_L231_L0.6151.00
212_N216_D0.6141.00
88_S149_P0.6131.00
108_L121_V0.6111.00
348_N360_K0.6101.00
284_F341_E0.6091.00
312_F315_G0.6091.00
79_E266_E0.6081.00
328_A331_N0.6071.00
199_L202_I0.6071.00
196_Y200_F0.6031.00
167_V170_S0.6021.00
312_F334_L0.5981.00
308_I373_L0.5961.00
262_S266_E0.5961.00
103_N314_A0.5941.00
61_I65_G0.5921.00
181_T186_A0.5901.00
205_R212_N0.5881.00
74_F252_L0.5871.00
95_G332_I0.5871.00
134_A162_D0.5860.99
196_Y241_I0.5820.99
123_I127_V0.5820.99
251_L255_V0.5810.99
75_Y269_V0.5810.99
382_K386_R0.5790.99
56_Q59_E0.5790.99
95_G153_L0.5780.99
174_G178_G0.5780.99
201_F204_A0.5780.99
227_I269_V0.5760.99
33_L282_F0.5740.99
342_F345_I0.5700.99
295_E298_W0.5680.99
91_S322_A0.5680.99
157_I315_G0.5660.99
135_I371_A0.5650.99
6_F10_T0.5640.99
291_F294_G0.5640.99
64_F334_L0.5630.99
130_I133_S0.5630.99
198_L247_I0.5630.99
332_I335_T0.5620.99
351_I354_G0.5620.99
100_I104_F0.5620.99
193_A242_H0.5620.99
197_M200_F0.5600.99
36_L282_F0.5600.99
124_L362_F0.5590.99
191_L198_L0.5590.99
318_A321_R0.5560.99
239_E242_H0.5560.99
288_I361_P0.5550.99
79_E141_V0.5550.99
19_S33_L0.5550.99
244_A247_I0.5540.99
221_E274_D0.5510.99
134_A342_F0.5500.99
327_K384_I0.5500.99
5_V70_L0.5500.99
343_S346_V0.5490.99
96_G164_F0.5490.99
326_H329_S0.5480.99
257_S262_S0.5470.99
136_V139_V0.5460.99
189_S196_Y0.5460.99
149_P324_L0.5460.99
371_A375_P0.5440.99
71_F75_Y0.5440.99
169_L346_V0.5360.99
76_L137_A0.5350.99
130_I161_E0.5340.99
165_L169_L0.5340.99
82_V254_L0.5310.99
96_G378_T0.5310.99
331_N381_S0.5310.99
141_V270_V0.5300.99
38_M288_I0.5300.99
278_A282_F0.5300.99
132_S341_E0.5300.99
100_I161_E0.5290.99
302_G306_L0.5270.99
111_G125_A0.5270.99
128_I339_R0.5270.99
39_L43_H0.5250.99
165_L342_F0.5240.99
183_V188_L0.5230.99
99_Y161_E0.5230.99
157_I340_G0.5230.99
108_L172_V0.5220.99
212_N260_E0.5210.99
334_L374_G0.5210.99
166_A342_F0.5200.99
99_Y315_G0.5190.99
112_F117_S0.5180.99
224_I228_F0.5170.99
235_A239_E0.5160.99
99_Y157_I0.5150.99
176_I355_L0.5130.99
157_I161_E0.5130.99
12_L275_F0.5110.99
378_T381_S0.5110.99
140_L335_T0.5110.99
138_K141_V0.5090.99
173_S176_I0.5090.99
62_E283_S0.5070.99
169_L173_S0.5060.99
377_V381_S0.5060.99
228_F232_F0.5060.99
107_G125_A0.5040.98
296_A362_F0.5040.98
92_I111_G0.5030.98
77_G250_L0.5020.98
19_S278_A0.5020.98
100_I165_L0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.9333 100 0.248 Contact Map
4czbA 2 0.9407 100 0.262 Contact Map
4cz8A 2 0.9333 100 0.287 Contact Map
1zcdA 1 0.8173 99.9 0.644 Contact Map
3zuxA 1 0.7457 98.7 0.836 Contact Map
4n7wA 2 0.7432 98.3 0.856 Contact Map
2mdfA 1 0.1407 98.3 0.857 Contact Map
2l0eA 1 0.0765 91.8 0.92 Contact Map
2k3cA 1 0.0765 88.6 0.925 Contact Map
2m7xA 1 0.0741 70.1 0.938 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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