GREMLIN Database
KHTT - K(+)/H(+) antiporter subunit KhtT
UniProt: O07535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 165 (153)
Sequences: 2316 (1831)
Seq/√Len: 148.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
120_I135_S4.9001.00
122_K141_D4.6591.00
93_V137_I4.0301.00
21_S24_K3.6361.00
31_D39_R2.7891.00
7_D12_G2.5211.00
104_L117_V2.2821.00
59_A62_I2.2471.00
102_R106_E2.2331.00
105_G134_D2.2151.00
103_T106_E2.1891.00
108_D111_Q2.1611.00
99_S107_L2.1141.00
17_I30_H2.1061.00
17_I37_I2.0521.00
103_T136_I2.0501.00
30_H33_G1.9881.00
63_A67_G1.9791.00
20_R26_T1.8861.00
100_I139_E1.8591.00
59_A63_A1.8381.00
67_G70_V1.8071.00
95_K139_E1.7861.00
122_K138_E1.7621.00
148_E151_H1.7511.00
113_Y151_H1.7241.00
90_W144_V1.6161.00
9_P14_K1.6131.00
22_H25_M1.6111.00
122_K135_S1.5571.00
114_D151_H1.5231.00
62_I67_G1.5211.00
10_G13_K1.5051.00
28_I31_D1.4841.00
31_D34_R1.4791.00
59_A65_I1.4741.00
109_V155_L1.4691.00
34_R37_I1.4541.00
137_I143_L1.4351.00
51_N54_L1.4341.00
69_M73_P1.4091.00
118_I146_S1.3891.00
20_R24_K1.3771.00
61_Q65_I1.3661.00
101_G138_E1.3631.00
120_I141_D1.3411.00
66_L73_P1.3041.00
110_R116_T1.2961.00
63_A66_L1.2871.00
30_H34_R1.2661.00
72_K75_A1.2471.00
65_I73_P1.2451.00
93_V100_I1.2071.00
145_L155_L1.1971.00
101_G139_E1.1871.00
119_A144_V1.1831.00
73_P76_L1.1731.00
31_D57_S1.1561.00
38_Y41_N1.1521.00
130_N133_A1.1451.00
117_V145_L1.1340.99
11_I17_I1.1260.99
88_I146_S1.1160.99
104_L131_P1.1130.99
108_D112_N1.1100.99
42_D47_E1.0830.99
39_R43_R1.0770.99
48_L52_I1.0580.99
68_G72_K1.0560.99
138_E141_D1.0290.99
48_L55_D1.0140.99
61_Q67_G1.0130.99
96_G100_I1.0090.99
51_N55_D1.0000.99
21_S27_I0.9910.99
116_T133_A0.9900.99
109_V115_V0.9880.99
35_R41_N0.9810.99
62_I66_L0.9760.98
52_I56_D0.9680.98
62_I69_M0.9640.98
69_M72_K0.9500.98
109_V117_V0.9480.98
21_S25_M0.9470.98
41_N45_P0.9400.98
68_G71_Y0.9380.98
52_I55_D0.9220.98
51_N57_S0.9150.98
20_R23_E0.9110.98
65_I69_M0.9040.97
119_A128_L0.9020.97
28_I32_D0.8980.97
103_T107_L0.8770.97
109_V113_Y0.8650.97
39_R42_D0.8630.97
105_G132_G0.8520.96
153_K156_I0.8390.96
79_I88_I0.8340.96
66_L70_V0.8250.96
51_N56_D0.8230.96
110_R113_Y0.8210.96
9_P30_H0.8180.95
78_S81_M0.8160.95
91_F145_L0.8150.95
29_I37_I0.8100.95
61_Q68_G0.8080.95
67_G73_P0.8050.95
84_S87_I0.8030.95
70_V73_P0.8010.95
40_F43_R0.8000.95
122_K128_L0.8000.95
6_N9_P0.7930.95
62_I73_P0.7930.95
52_I58_E0.7830.94
62_I65_I0.7790.94
45_P54_L0.7790.94
87_I149_R0.7770.94
20_R25_M0.7750.94
39_R56_D0.7640.93
35_R40_F0.7630.93
62_I115_V0.7620.93
27_I62_I0.7610.93
49_L56_D0.7610.93
110_R152_L0.7590.93
43_R46_D0.7540.93
43_R51_N0.7520.93
99_S155_L0.7490.93
147_G151_H0.7400.92
126_E154_K0.7350.92
128_L135_S0.7320.92
65_I71_Y0.7280.92
90_W142_T0.7240.92
55_D58_E0.7150.91
21_S26_T0.7090.91
115_V145_L0.7040.90
63_A73_P0.7000.90
95_K140_N0.7000.90
86_L146_S0.6980.90
123_H126_E0.6910.90
61_Q66_L0.6890.89
59_A69_M0.6870.89
38_Y44_D0.6870.89
135_S138_E0.6860.89
71_Y74_Q0.6860.89
41_N47_E0.6760.89
61_Q73_P0.6690.88
15_F18_E0.6610.87
110_R133_A0.6590.87
6_N14_K0.6560.87
50_S53_S0.6520.87
69_M75_A0.6510.87
42_D137_I0.6480.86
75_A155_L0.6470.86
19_T41_N0.6460.86
59_A66_L0.6460.86
33_G36_E0.6330.85
59_A67_G0.6230.84
50_S55_D0.6220.84
43_R47_E0.6170.84
60_R66_L0.6160.83
104_L108_D0.6150.83
59_A70_V0.6110.83
101_G136_I0.6070.83
89_E130_N0.6060.82
31_D35_R0.6050.82
86_L118_I0.6050.82
65_I68_G0.6020.82
23_E144_V0.5970.82
50_S54_L0.5970.82
29_I58_E0.5940.81
5_E9_P0.5930.81
14_K23_E0.5930.81
35_R42_D0.5920.81
16_E144_V0.5920.81
78_S82_A0.5910.81
23_E44_D0.5890.81
60_R69_M0.5870.80
29_I34_R0.5870.80
7_D33_G0.5850.80
29_I32_D0.5820.80
38_Y42_D0.5810.80
121_I142_T0.5750.79
37_I44_D0.5730.79
73_P78_S0.5720.79
54_L58_E0.5690.78
94_E139_E0.5630.78
36_E40_F0.5630.78
66_L74_Q0.5620.78
29_I41_N0.5610.77
66_L76_L0.5600.77
16_E24_K0.5570.77
37_I42_D0.5530.76
30_H35_R0.5500.76
59_A74_Q0.5490.76
22_H144_V0.5490.76
63_A69_M0.5470.76
33_G46_D0.5470.76
34_R38_Y0.5460.76
14_K41_N0.5450.75
153_K157_H0.5440.75
58_E104_L0.5440.75
115_V155_L0.5420.75
94_E112_N0.5410.75
60_R68_G0.5380.74
37_I40_F0.5370.74
30_H37_I0.5330.74
68_G73_P0.5320.74
105_G109_V0.5320.74
80_E87_I0.5280.73
40_F45_P0.5240.73
114_D143_L0.5220.72
39_R47_E0.5210.72
49_L52_I0.5200.72
50_S56_D0.5200.72
34_R39_R0.5200.72
87_I116_T0.5180.72
5_E35_R0.5180.72
102_R112_N0.5170.72
19_T27_I0.5140.71
54_L57_S0.5130.71
23_E26_T0.5130.71
154_K157_H0.5130.71
147_G155_L0.5080.70
107_L135_S0.5080.70
105_G133_A0.5060.70
60_R67_G0.5040.70
63_A70_V0.5030.69
115_V151_H0.5020.69
126_E150_K0.5020.69
17_I20_R0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aefA 2 0.9879 99.9 0.412 Contact Map
1lnqA 6 0.9697 99.9 0.42 Contact Map
4gx0A 3 0.9394 99.9 0.423 Contact Map
3mt5A 5 0.9333 99.8 0.441 Contact Map
3nafA 3 0.9515 99.8 0.449 Contact Map
4g65A 2 0.9636 99.8 0.461 Contact Map
4hpfA 3 0.9273 99.8 0.468 Contact Map
3l4bC 2 0.9394 99.8 0.484 Contact Map
4j91A 3 0.9394 99.6 0.547 Contact Map
1vctA 3 0.8848 99.6 0.554 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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