GREMLIN Database
YHAR - Putative enoyl-CoA hydratase/isomerase YhaR
UniProt: O07533 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (245)
Sequences: 30203 (20001)
Seq/√Len: 1277.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_V164_K3.2211.00
123_K181_A3.1371.00
178_G187_G3.0561.00
121_A176_L2.9641.00
99_A116_A2.8341.00
187_G190_P2.7621.00
14_E189_R2.6721.00
42_A94_K2.4941.00
39_E89_N2.4691.00
23_H56_K2.3201.00
163_K194_T2.3121.00
5_Q18_N2.2501.00
169_E172_D2.2161.00
217_E220_K2.1911.00
166_S169_E2.1631.00
8_C13_A2.1541.00
157_K163_K2.1251.00
124_N182_G2.1031.00
14_E52_R2.0861.00
154_K173_M2.0551.00
159_I206_T2.0431.00
8_C44_S2.0301.00
100_A188_A2.0101.00
133_G198_S1.9971.00
123_K168_S1.9531.00
6_Y13_A1.9331.00
35_K89_N1.9331.00
11_A47_L1.9211.00
16_I54_S1.8911.00
106_A128_A1.8761.00
18_N54_S1.8631.00
29_Q33_E1.8581.00
240_E249_R1.8451.00
243_R247_E1.8351.00
23_H57_G1.8331.00
120_L180_F1.8141.00
16_I52_R1.7971.00
156_K211_Q1.7731.00
13_A41_A1.7531.00
157_K177_D1.7361.00
189_R193_E1.6981.00
49_V93_M1.6801.00
117_D207_K1.6781.00
169_E173_M1.6541.00
40_M44_S1.6521.00
13_A46_A1.6361.00
152_E156_K1.6301.00
123_K182_G1.6091.00
32_S82_T1.5651.00
120_L191_I1.5641.00
168_S172_D1.5521.00
121_A127_L1.5331.00
180_F187_G1.5291.00
157_K178_G1.5211.00
41_A49_V1.5201.00
184_P187_G1.5031.00
42_A89_N1.4991.00
119_V153_A1.4741.00
113_A119_V1.4621.00
15_I37_A1.4541.00
122_E182_G1.4431.00
9_N189_R1.4291.00
101_I113_A1.4291.00
119_V149_R1.4281.00
156_K160_W1.4121.00
88_L219_K1.4111.00
156_K210_F1.4091.00
88_L92_Q1.4091.00
6_Y41_A1.4021.00
102_H124_N1.3881.00
171_A179_T1.3791.00
48_I192_I1.3721.00
10_G193_E1.3721.00
102_H122_E1.3721.00
5_Q54_S1.3641.00
205_E231_R1.3551.00
185_A188_A1.3481.00
154_K157_K1.3391.00
35_K39_E1.3391.00
110_L129_M1.3371.00
101_I105_A1.3291.00
91_Y145_L1.3281.00
38_V93_M1.3231.00
9_N193_E1.3231.00
90_L97_T1.3171.00
52_R102_H1.3111.00
9_N14_E1.3071.00
158_L165_L1.3031.00
56_K102_H1.2991.00
163_K169_E1.2611.00
28_E66_M1.2551.00
128_A164_K1.2431.00
72_D75_Q1.2411.00
27_N30_M1.2271.00
104_A126_V1.2231.00
35_K85_A1.2161.00
42_A93_M1.2101.00
57_G104_A1.2061.00
153_A177_D1.2041.00
208_G212_S1.1971.00
17_L30_M1.1851.00
154_K169_E1.1841.00
33_E37_A1.1751.00
238_H242_I1.1691.00
216_E220_K1.1591.00
132_I162_G1.1571.00
19_R22_A1.1521.00
198_S203_M1.1451.00
8_C45_E1.1221.00
212_S224_L1.1211.00
7_A16_I1.1161.00
22_A65_R1.1001.00
165_L173_M1.0971.00
122_E185_A1.0871.00
167_A179_T1.0861.00
28_E32_S1.0781.00
8_C40_M1.0781.00
201_L237_D1.0781.00
92_Q219_K1.0771.00
17_L59_S1.0751.00
151_G154_K1.0631.00
59_S109_G1.0581.00
33_E36_E1.0491.00
5_Q16_I1.0441.00
111_S142_G1.0381.00
7_A14_E1.0341.00
186_E190_P1.0251.00
83_I140_G1.0181.00
49_V95_K1.0171.00
118_I191_I1.0161.00
36_E40_M1.0141.00
216_E224_L1.0141.00
97_T116_A1.0091.00
52_R100_A0.9911.00
37_A40_M0.9801.00
46_A95_K0.9761.00
150_I154_K0.9691.00
94_K204_I0.9601.00
149_R153_A0.9591.00
192_I196_L0.9541.00
181_A184_P0.9451.00
168_S171_A0.9391.00
49_V97_T0.9351.00
14_E50_L0.9351.00
19_R63_D0.9321.00
110_L127_L0.9211.00
239_Q243_R0.9181.00
122_E183_D0.9181.00
171_A176_L0.9161.00
50_L188_A0.9151.00
208_G228_A0.9151.00
200_L204_I0.9141.00
55_G102_H0.9091.00
143_H225_E0.9041.00
126_V166_S0.8991.00
220_K223_S0.8921.00
12_V48_I0.8911.00
189_R192_I0.8771.00
132_I206_T0.8741.00
100_A185_A0.8741.00
77_K81_D0.8731.00
123_K179_T0.8701.00
205_E228_A0.8651.00
152_E214_Q0.8561.00
224_L227_S0.8531.00
205_E208_G0.8521.00
102_H185_A0.8441.00
31_L86_V0.8421.00
101_I127_L0.8391.00
137_V232_M0.8381.00
205_E232_M0.8331.00
171_A178_G0.8311.00
35_K82_T0.8301.00
15_I49_V0.8211.00
8_C46_A0.8191.00
158_L173_M0.8181.00
101_I119_V0.8171.00
106_A164_K0.8161.00
146_L150_I0.8161.00
38_V90_L0.8141.00
188_A192_I0.8121.00
186_E189_R0.8111.00
42_A95_K0.8081.00
159_I210_F0.8081.00
23_H60_A0.8081.00
118_I177_D0.8031.00
144_Y221_V0.8031.00
39_E43_A0.8031.00
28_E82_T0.7991.00
74_D78_R0.7971.00
224_L228_A0.7961.00
187_G191_I0.7931.00
150_I158_L0.7921.00
111_S131_F0.7891.00
39_E85_A0.7811.00
190_P194_T0.7811.00
178_G191_I0.7741.00
65_R246_L0.7661.00
133_G164_K0.7641.00
157_K161_S0.7591.00
51_L116_A0.7581.00
209_I228_A0.7571.00
32_S36_E0.7561.00
26_L30_M0.7511.00
35_K86_V0.7491.00
41_A46_A0.7471.00
228_A231_R0.7461.00
194_T198_S0.7431.00
93_M97_T0.7391.00
44_S95_K0.7381.00
81_D85_A0.7381.00
94_K208_G0.7351.00
167_A176_L0.7341.00
87_T115_C0.7341.00
57_G102_H0.7321.00
236_K239_Q0.7321.00
27_N66_M0.7301.00
114_L175_L0.7291.00
6_Y37_A0.7271.00
199_P237_D0.7231.00
47_L200_L0.7221.00
19_R27_N0.7171.00
190_P193_E0.7161.00
242_I246_L0.7121.00
50_L100_A0.7111.00
195_L203_M0.7111.00
131_F139_D0.7091.00
170_A175_L0.7091.00
223_S227_S0.7071.00
107_G130_N0.7051.00
151_G155_A0.7041.00
144_Y147_K0.7031.00
218_L222_L0.6991.00
81_D226_R0.6991.00
6_Y40_M0.6951.00
120_L178_G0.6871.00
12_V50_L0.6801.00
201_L235_T0.6781.00
127_L176_L0.6701.00
152_E211_Q0.6701.00
226_R230_E0.6701.00
30_M33_E0.6701.00
124_N167_A0.6691.00
37_A41_A0.6681.00
161_S191_I0.6671.00
51_L97_T0.6641.00
11_A45_E0.6641.00
101_I125_A0.6631.00
176_L179_T0.6581.00
23_H104_A0.6571.00
209_I224_L0.6561.00
19_R25_A0.6561.00
29_Q32_S0.6561.00
77_K227_S0.6531.00
68_T243_R0.6481.00
154_K171_A0.6471.00
50_L189_R0.6441.00
227_S231_R0.6391.00
138_P206_T0.6371.00
193_E197_A0.6371.00
191_I194_T0.6341.00
131_F138_P0.6311.00
39_E42_A0.6301.00
106_A130_N0.6291.00
128_A162_G0.6271.00
6_Y15_I0.6251.00
212_S216_E0.6221.00
93_M96_V0.6211.00
98_I192_I0.6201.00
48_I98_I0.6191.00
111_S139_D0.6181.00
240_E244_A0.6181.00
48_I196_L0.6151.00
137_V209_I0.6141.00
41_A95_K0.6131.00
85_A88_L0.6111.00
12_V189_R0.6111.00
152_E210_F0.6091.00
78_R82_T0.6091.00
36_E39_E0.6071.00
241_G244_A0.6061.00
8_C11_A0.6031.00
120_L187_G0.6031.00
22_A25_A0.6031.00
99_A119_V0.6031.00
120_L188_A0.6031.00
157_K169_E0.6011.00
129_M142_G0.5981.00
73_P231_R0.5971.00
143_H221_V0.5971.00
131_F229_Q0.5951.00
236_K240_E0.5951.00
180_F185_A0.5941.00
201_L232_M0.5931.00
165_L170_A0.5921.00
104_A164_K0.5921.00
62_G67_M0.5911.00
160_W203_M0.5871.00
168_S179_T0.5851.00
243_R246_L0.5831.00
240_E247_E0.5831.00
34_L86_V0.5821.00
22_A63_D0.5811.00
121_A125_A0.5801.00
219_K223_S0.5791.00
12_V192_I0.5771.00
237_D241_G0.5771.00
47_L196_L0.5751.00
113_A116_A0.5731.00
136_L238_H0.5721.00
15_I51_L0.5721.00
206_T209_I0.5691.00
102_H182_G0.5651.00
149_R177_D0.5641.00
240_E243_R0.5621.00
129_M159_I0.5611.00
77_K230_E0.5601.00
144_Y148_K0.5591.00
166_S172_D0.5591.00
132_I198_S0.5581.00
111_S129_M0.5581.00
111_S141_G0.5581.00
150_I155_A0.5561.00
156_K207_K0.5541.00
100_A192_I0.5531.00
129_M146_L0.5511.00
85_A89_N0.5491.00
120_L185_A0.5431.00
38_V89_N0.5431.00
163_K178_G0.5411.00
167_A171_A0.5381.00
64_I134_I0.5381.00
110_L175_L0.5361.00
38_V97_T0.5341.00
107_G129_M0.5341.00
238_H241_G0.5321.00
137_V206_T0.5321.00
110_L114_L0.5301.00
161_S195_L0.5291.00
154_K172_D0.5291.00
170_A176_L0.5261.00
161_S194_T0.5261.00
26_L108_L0.5261.00
150_I173_M0.5231.00
118_I195_L0.5181.00
15_I38_V0.5181.00
216_E221_V0.5171.00
194_T197_A0.5161.00
138_P159_I0.5141.00
62_G108_L0.5121.00
29_Q66_M0.5111.00
108_L140_G0.5111.00
91_Y218_L0.5111.00
27_N63_D0.5101.00
68_T246_L0.5101.00
122_E125_A0.5101.00
132_I203_M0.5081.00
31_L35_K0.5081.00
207_K211_Q0.5071.00
99_A113_A0.5071.00
15_I41_A0.5071.00
12_V196_L0.5061.00
208_G224_L0.5041.00
97_T117_D0.5041.00
184_P190_P0.5031.00
115_C145_L0.5031.00
46_A49_V0.5011.00
157_K191_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fbmA 3 0.9608 100 0.088 Contact Map
4jfcA 3 0.9922 100 0.092 Contact Map
3kqfA 3 0.9961 100 0.095 Contact Map
4og1A 3 0.949 100 0.097 Contact Map
4lk5A 3 0.9647 100 0.097 Contact Map
3bptA 1 0.9961 100 0.098 Contact Map
2gtrA 3 0.9922 100 0.098 Contact Map
3hinA 5 0.9843 100 0.1 Contact Map
3peaA 3 0.9961 100 0.1 Contact Map
3g64A 6 1 100 0.102 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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