GREMLIN Database
AZR - FMN-dependent NADPH-azoreductase
UniProt: O07529 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 174 (166)
Sequences: 6644 (4445)
Seq/√Len: 345.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
30_D60_R3.6031.00
4_L64_A3.1131.00
77_G117_N2.8631.00
78_M121_V2.8171.00
52_L56_E2.7221.00
103_A111_G2.6741.00
142_D146_A2.5511.00
59_Q63_K2.5121.00
2_N28_H2.5081.00
99_V127_A2.4401.00
26_L157_K2.3881.00
17_R21_S2.2591.00
122_M127_A2.2501.00
5_V20_A2.1601.00
83_K87_D2.0441.00
101_L115_L2.0381.00
100_A159_L2.0271.00
55_Q59_Q1.9681.00
57_L85_A1.9561.00
7_N17_R1.9461.00
117_N120_T1.9361.00
56_E60_R1.7951.00
77_G121_V1.7841.00
150_E154_E1.7771.00
153_K157_K1.7721.00
73_E113_N1.7691.00
17_R33_D1.7361.00
16_T104_V1.6751.00
3_M66_A1.5921.00
20_A70_L1.5891.00
2_N63_K1.5771.00
25_A146_A1.5681.00
95_K126_Y1.5601.00
21_S24_A1.5201.00
69_L99_V1.5091.00
66_A163_L1.4701.00
152_I155_S1.4441.00
7_N20_A1.4421.00
5_V24_A1.3781.00
61_V89_L1.3721.00
132_K162_E1.3571.00
74_Y80_G1.3551.00
2_N30_D1.3481.00
103_A115_L1.3401.00
69_L122_M1.3131.00
99_V122_M1.3021.00
53_K56_E1.3001.00
71_S103_A1.2991.00
130_I166_F1.2831.00
86_L125_V1.2771.00
76_S113_N1.2671.00
100_A163_L1.2661.00
59_Q62_T1.2521.00
41_V84_N1.2381.00
128_N166_F1.2341.00
67_I94_F1.2251.00
71_S118_M1.2221.00
57_L89_L1.2211.00
80_G87_D1.2191.00
23_I102_L1.2161.00
61_V67_I1.1941.00
23_I68_V1.1831.00
38_V53_K1.1671.00
78_M117_N1.1641.00
41_V81_A1.1641.00
52_L55_Q1.1611.00
150_E153_K1.1561.00
71_S114_A1.1281.00
13_H18_I1.1161.00
3_M27_Y1.0971.00
16_T70_L1.0961.00
24_A31_L1.0731.00
6_I69_L1.0701.00
134_L159_L1.0411.00
66_A167_A1.0411.00
26_L160_V1.0381.00
123_R129_V1.0361.00
30_D64_A1.0251.00
58_K89_L1.0181.00
4_L32_I1.0141.00
105_A135_V1.0121.00
54_V88_F1.0091.00
69_L82_L1.0031.00
61_V85_A1.0021.00
26_L153_K1.0001.00
154_E157_K1.0001.00
7_N16_T0.9991.00
109_K112_I0.9921.00
154_E158_E0.9921.00
157_K161_E0.9911.00
142_D148_V0.9891.00
140_H149_A0.9861.00
22_Y25_A0.9861.00
80_G83_K0.9841.00
41_V80_G0.9781.00
23_I156_I0.9731.00
130_I163_L0.9631.00
56_E59_Q0.9611.00
27_Y164_S0.9481.00
136_L152_I0.9431.00
39_L85_A0.9181.00
19_A104_V0.9151.00
159_L163_L0.8981.00
151_N154_E0.8961.00
78_M83_K0.8901.00
68_V100_A0.8901.00
163_L167_A0.8881.00
101_L122_M0.8811.00
76_S124_G0.8781.00
83_K121_V0.8761.00
161_E165_M0.8631.00
69_L86_L0.8591.00
119_R123_R0.8591.00
71_S79_S0.8501.00
5_V29_T0.8481.00
151_N155_S0.8471.00
58_K93_Q0.8411.00
4_L60_R0.8411.00
96_Y128_N0.8351.00
126_Y162_E0.8291.00
15_R139_V0.8271.00
92_E95_K0.8251.00
60_R63_K0.8221.00
67_I97_K0.8211.00
158_E162_E0.8211.00
116_N120_T0.8201.00
62_T93_Q0.8171.00
115_L133_Q0.8151.00
51_L88_F0.8131.00
122_M129_V0.8051.00
5_V70_L0.8021.00
43_N46_A0.8021.00
19_A136_L0.8001.00
18_I21_S0.7971.00
10_P81_A0.7921.00
128_N131_P0.7881.00
28_H33_D0.7781.00
21_S25_A0.7771.00
77_G83_K0.7771.00
32_I36_E0.7701.00
60_R64_A0.7621.00
75_H91_S0.7611.00
70_L102_L0.7581.00
117_N121_V0.7551.00
86_L121_V0.7501.00
40_P53_K0.7431.00
124_G131_P0.7421.00
160_V164_S0.7421.00
14_G17_R0.7411.00
86_L122_M0.7350.99
32_I60_R0.7280.99
15_R18_I0.7280.99
77_G87_D0.7250.99
161_E164_S0.7220.99
86_L118_M0.7170.99
23_I160_V0.7140.99
42_F46_A0.7140.99
22_Y153_K0.7130.99
89_L94_F0.7090.99
5_V31_L0.7060.99
23_I70_L0.7020.99
66_A98_P0.6960.99
94_F127_A0.6950.99
140_H152_I0.6910.99
99_V129_V0.6880.99
3_M167_A0.6860.99
112_I116_N0.6840.99
67_I99_V0.6800.99
108_G138_P0.6740.99
6_I57_L0.6720.99
149_A152_I0.6700.99
10_P80_G0.6650.99
72_P79_S0.6630.99
130_I162_E0.6630.99
14_G33_D0.6610.99
85_A89_L0.6580.99
8_G71_S0.6510.99
96_Y126_Y0.6460.99
11_R44_G0.6420.99
113_N116_N0.6410.99
69_L118_M0.6390.99
141_I147_T0.6380.99
113_N120_T0.6370.99
44_G48_Q0.6370.99
40_P54_V0.6360.99
67_I127_A0.6320.98
119_R133_Q0.6280.98
58_K62_T0.6270.98
30_D63_K0.6260.98
61_V93_Q0.6250.98
21_S31_L0.6240.98
115_L135_V0.6190.98
148_V151_N0.6140.98
52_L59_Q0.6140.98
126_Y132_K0.6130.98
75_H90_S0.6100.98
78_M118_M0.6080.98
158_E161_E0.6080.98
39_L43_N0.6040.98
5_V68_V0.6010.98
46_A50_E0.6010.98
68_V102_L0.6010.98
123_R131_P0.5990.98
50_E54_V0.5960.98
37_F41_V0.5950.98
19_A102_L0.5920.98
4_L67_I0.5850.97
47_E91_S0.5790.97
37_F43_N0.5770.97
157_K160_V0.5730.97
96_Y165_M0.5730.97
8_G82_L0.5730.97
100_A130_I0.5690.97
42_F47_E0.5690.97
51_L54_V0.5660.97
3_M29_T0.5600.97
45_E84_N0.5590.97
109_K113_N0.5590.97
16_T20_A0.5580.97
84_N88_F0.5530.96
143_V148_V0.5510.96
4_L61_V0.5500.96
100_A134_L0.5420.96
81_A85_A0.5350.96
96_Y162_E0.5350.96
21_S33_D0.5340.96
22_Y26_L0.5340.96
2_N65_D0.5340.96
90_S93_Q0.5310.96
76_S120_T0.5270.95
162_E165_M0.5240.95
24_A29_T0.5220.95
73_E76_S0.5220.95
12_K35_S0.5210.95
111_G115_L0.5210.95
98_P167_A0.5170.95
71_S82_L0.5170.95
46_A49_S0.5170.95
34_L85_A0.5160.95
155_S158_E0.5130.95
55_Q58_K0.5120.95
42_F84_N0.5100.94
163_L166_F0.5100.94
33_D36_E0.5090.94
136_L140_H0.5070.94
18_I141_I0.5060.94
35_S38_V0.5010.94
40_P43_N0.5010.94
33_D38_V0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fzvA 5 0.977 100 0.374 Contact Map
3gfsA 5 0.9713 100 0.382 Contact Map
3u7rA 4 0.977 100 0.399 Contact Map
2q62A 4 0.9713 100 0.4 Contact Map
3svlA 4 0.9598 100 0.41 Contact Map
4hs4A 6 0.9713 100 0.427 Contact Map
3k1yA 4 0.9598 100 0.429 Contact Map
1rttA 1 0.9368 100 0.431 Contact Map
3fvwA 1 0.9483 100 0.438 Contact Map
4ptzC 4 0.954 100 0.457 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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