GREMLIN Database
YHCY - Sensor histidine kinase YhcY
UniProt: O07527 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 379 (332)
Sequences: 48169 (42303)
Seq/√Len: 2321.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
354_W366_S3.5991.00
205_A224_I3.4721.00
320_I364_K3.4381.00
321_D325_G3.1281.00
343_K347_E2.9821.00
358_A361_T2.9681.00
299_A322_H2.9111.00
316_E368_R2.7931.00
314_H368_R2.7881.00
307_S318_D2.7761.00
327_R330_A2.7511.00
316_E366_S2.7461.00
318_D366_S2.6861.00
318_D364_K2.6841.00
209_K225_Q2.6621.00
267_I303_T2.6391.00
279_E349_A2.6091.00
269_T307_S2.4941.00
342_M353_F2.4751.00
209_K222_D2.4331.00
355_I365_L2.4031.00
309_T316_E2.3801.00
305_Y320_I2.3671.00
202_S228_S2.3641.00
287_V346_A2.2791.00
267_I305_Y2.2701.00
269_T305_Y2.2141.00
45_G140_A2.1891.00
307_S320_I2.1791.00
309_T318_D2.1721.00
303_T322_H2.1291.00
356_E364_K2.0991.00
326_F330_A2.0841.00
356_E366_S2.0831.00
202_S229_Q1.9951.00
346_A351_A1.9571.00
299_A304_A1.9391.00
352_K368_R1.9381.00
253_E285_W1.9351.00
173_Y176_K1.9261.00
310_A371_L1.9161.00
246_G249_K1.9031.00
357_S363_T1.8931.00
346_A367_I1.8631.00
62_A65_P1.8621.00
265_K303_T1.8551.00
302_D322_H1.8341.00
287_V342_M1.8221.00
40_T58_L1.8121.00
357_S361_T1.7721.00
46_W66_P1.7711.00
204_T220_M1.7501.00
206_K225_Q1.7311.00
48_F137_N1.7151.00
280_Q283_M1.7111.00
311_S316_E1.6971.00
347_E352_K1.6831.00
209_K218_Q1.6771.00
248_E308_L1.6671.00
51_E55_S1.6501.00
317_L367_I1.6451.00
201_V228_S1.6421.00
33_L37_L1.6291.00
354_W368_R1.6291.00
232_L236_K1.6231.00
287_V345_R1.6101.00
181_M185_R1.5751.00
169_R173_Y1.5521.00
208_A221_I1.5511.00
173_Y177_N1.5471.00
345_R349_A1.5431.00
279_E284_L1.5421.00
183_R187_A1.5351.00
111_H115_T1.5251.00
299_A302_D1.5211.00
225_Q229_Q1.4901.00
258_Y289_Q1.4741.00
61_D65_P1.4361.00
128_D131_R1.4361.00
288_V317_L1.4221.00
127_E132_R1.4221.00
168_M171_S1.4071.00
204_T223_F1.4021.00
69_S112_C1.3951.00
43_Q47_I1.3921.00
205_A225_Q1.3901.00
270_Q308_L1.3861.00
327_R359_L1.3801.00
180_L183_R1.3751.00
48_F56_Y1.3671.00
211_L217_L1.3641.00
200_S227_L1.3541.00
172_E176_K1.3441.00
212_T217_L1.3441.00
287_V367_I1.3341.00
293_N297_K1.3341.00
208_A217_L1.3291.00
171_S175_Q1.3271.00
146_F150_E1.3261.00
46_W139_A1.3231.00
275_V310_A1.3211.00
121_H139_A1.2931.00
201_V224_I1.2861.00
64_L71_K1.2761.00
205_A228_S1.2621.00
32_V35_E1.2501.00
326_F363_T1.2461.00
324_A332_A1.2321.00
283_M286_R1.2241.00
315_A371_L1.2241.00
41_N61_D1.2221.00
180_L184_N1.2201.00
120_H140_A1.1891.00
59_A63_Y1.1861.00
283_M348_K1.1841.00
248_E252_A1.1831.00
30_D34_K1.1781.00
63_Y67_A1.1761.00
222_D226_N1.1711.00
48_F63_Y1.1701.00
175_Q178_A1.1631.00
111_H117_G1.1621.00
26_K30_D1.1611.00
36_L40_T1.1601.00
202_S225_Q1.1511.00
200_S204_T1.1391.00
357_S360_G1.1361.00
346_A353_F1.1341.00
37_L41_N1.1301.00
233_A282_H1.1251.00
171_S174_Q1.1241.00
249_K253_E1.1201.00
252_A268_F1.1101.00
250_G254_A1.0971.00
170_L174_Q1.0931.00
246_G276_L1.0881.00
142_G146_F1.0841.00
218_Q222_D1.0791.00
314_H352_K1.0721.00
194_V231_A1.0711.00
223_F227_L1.0641.00
145_M148_E1.0521.00
214_D217_L1.0491.00
253_E281_E1.0451.00
70_R73_K1.0451.00
125_P132_R1.0421.00
295_C304_A1.0391.00
264_L268_F1.0271.00
288_V292_L1.0261.00
172_E175_Q1.0201.00
219_Q223_F1.0181.00
248_E270_Q1.0171.00
202_S232_L1.0141.00
110_L116_E1.0131.00
311_S368_R1.0051.00
60_A63_Y0.9991.00
286_R345_R0.9971.00
193_S197_M0.9961.00
85_T89_N0.9951.00
326_F355_I0.9941.00
281_E285_W0.9931.00
205_A209_K0.9861.00
31_E35_E0.9841.00
219_Q222_D0.9841.00
185_R189_E0.9811.00
143_K146_F0.9801.00
193_S290_E0.9791.00
61_D64_L0.9791.00
178_A181_M0.9741.00
258_Y292_L0.9721.00
30_D33_L0.9711.00
313_C371_L0.9711.00
203_L207_A0.9681.00
195_N232_L0.9641.00
305_Y322_H0.9611.00
285_W289_Q0.9591.00
50_I56_Y0.9571.00
190_L238_L0.9561.00
51_E57_T0.9531.00
49_L134_G0.9511.00
69_S73_K0.9491.00
227_L230_D0.9481.00
205_A221_I0.9481.00
291_A342_M0.9451.00
49_L58_L0.9451.00
34_K38_S0.9361.00
59_A64_L0.9331.00
321_D362_G0.9331.00
290_E342_M0.9321.00
120_H144_T0.9301.00
278_D372_K0.9301.00
311_S314_H0.9291.00
292_L304_A0.9281.00
344_E347_E0.9271.00
271_K308_L0.9251.00
254_A285_W0.9221.00
271_K309_T0.9221.00
64_L70_R0.9191.00
179_L183_R0.9181.00
346_A369_L0.9141.00
59_A74_V0.9131.00
213_K217_L0.9111.00
170_L176_K0.9091.00
257_S289_Q0.9091.00
283_M345_R0.9051.00
255_I258_Y0.9041.00
255_I268_F0.9021.00
259_G296_K0.9011.00
291_A365_L0.8951.00
195_N236_K0.8921.00
233_A237_A0.8901.00
169_R172_E0.8881.00
254_A258_Y0.8871.00
316_E354_W0.8851.00
170_L173_Y0.8841.00
215_E218_Q0.8821.00
56_Y60_A0.8781.00
271_K274_P0.8761.00
264_L296_K0.8711.00
119_T122_A0.8701.00
178_A182_E0.8681.00
27_A31_E0.8661.00
169_R176_K0.8651.00
252_A256_K0.8651.00
254_A257_S0.8631.00
351_A369_L0.8571.00
97_N100_N0.8491.00
29_L32_V0.8491.00
250_G253_E0.8421.00
193_S286_R0.8381.00
192_D290_E0.8361.00
147_D150_E0.8351.00
257_S285_W0.8341.00
109_N117_G0.8261.00
298_H332_A0.8181.00
202_S206_K0.8151.00
123_T135_L0.8151.00
241_Q340_K0.8131.00
239_I243_R0.8111.00
288_V319_I0.8061.00
50_I123_T0.8061.00
251_L308_L0.8041.00
193_S234_E0.8021.00
73_K112_C0.7971.00
49_L57_T0.7941.00
86_K90_G0.7911.00
204_T224_I0.7891.00
237_A283_M0.7891.00
224_I228_S0.7881.00
58_L71_K0.7881.00
61_D71_K0.7841.00
55_S78_E0.7841.00
174_Q177_N0.7821.00
277_T280_Q0.7811.00
328_Y358_A0.7801.00
79_G82_Y0.7771.00
29_L33_L0.7771.00
196_Q203_L0.7741.00
204_T227_L0.7721.00
25_I28_T0.7701.00
240_W283_M0.7691.00
60_A66_P0.7681.00
95_A98_I0.7671.00
118_I145_M0.7661.00
64_L74_V0.7661.00
342_M346_A0.7641.00
223_F226_N0.7611.00
85_T88_N0.7601.00
196_Q200_S0.7601.00
200_S203_L0.7581.00
36_L39_L0.7571.00
250_G255_I0.7531.00
300_G324_A0.7511.00
199_F202_S0.7511.00
200_S223_F0.7471.00
191_H197_M0.7451.00
292_L306_V0.7451.00
294_N338_G0.7441.00
291_A367_I0.7441.00
226_N253_E0.7431.00
82_Y87_F0.7411.00
247_L317_L0.7401.00
123_T137_N0.7391.00
265_K268_F0.7381.00
195_N239_I0.7371.00
321_D363_T0.7361.00
79_G84_L0.7351.00
120_H123_T0.7351.00
35_E39_L0.7341.00
254_A289_Q0.7331.00
88_N91_G0.7321.00
287_V349_A0.7301.00
193_S196_Q0.7301.00
32_V36_L0.7221.00
86_K91_G0.7221.00
284_L349_A0.7221.00
149_E152_H0.7171.00
283_M349_A0.7161.00
208_A220_M0.7161.00
80_E84_L0.7161.00
303_T320_I0.7161.00
222_D225_Q0.7141.00
192_D196_Q0.7131.00
271_K275_V0.7131.00
67_A109_N0.7121.00
251_L288_V0.7111.00
177_N181_M0.7091.00
148_E152_H0.7071.00
87_F90_G0.7071.00
291_A353_F0.7071.00
27_A30_D0.7061.00
113_F117_G0.7011.00
325_G363_T0.7011.00
264_L299_A0.6981.00
28_T32_V0.6981.00
35_E38_S0.6941.00
259_G264_L0.6931.00
35_E49_L0.6921.00
128_D133_F0.6911.00
182_E185_R0.6911.00
207_A211_L0.6911.00
71_K75_L0.6901.00
33_L36_L0.6901.00
255_I266_I0.6851.00
91_G95_A0.6851.00
236_K240_W0.6851.00
46_W63_Y0.6831.00
216_N220_M0.6831.00
355_I363_T0.6821.00
87_F91_G0.6801.00
101_C104_I0.6771.00
232_L235_M0.6771.00
326_F365_L0.6761.00
211_L220_M0.6741.00
25_I29_L0.6721.00
81_C84_L0.6691.00
250_G258_Y0.6681.00
186_L190_L0.6681.00
228_S232_L0.6671.00
230_D285_W0.6661.00
249_K281_E0.6661.00
208_A224_I0.6661.00
324_A363_T0.6651.00
259_G262_I0.6641.00
247_L315_A0.6581.00
273_C310_A0.6581.00
252_A270_Q0.6571.00
45_G138_V0.6571.00
206_K209_K0.6571.00
96_A100_N0.6551.00
252_A255_I0.6551.00
198_L235_M0.6541.00
102_K105_E0.6531.00
251_L306_V0.6521.00
209_K221_I0.6521.00
82_Y86_K0.6511.00
38_S42_L0.6491.00
217_L220_M0.6481.00
262_I296_K0.6471.00
298_H324_A0.6461.00
250_G257_S0.6431.00
308_L317_L0.6371.00
50_I54_G0.6341.00
297_K332_A0.6341.00
206_K210_T0.6331.00
240_W243_R0.6321.00
211_L214_D0.6301.00
147_D151_L0.6301.00
274_P308_L0.6291.00
250_G279_E0.6281.00
28_T31_E0.6241.00
82_Y85_T0.6221.00
344_E348_K0.6211.00
207_A220_M0.6191.00
111_H114_D0.6191.00
84_L88_N0.6181.00
58_L61_D0.6171.00
44_S139_A0.6171.00
201_V205_A0.6151.00
199_F203_L0.6141.00
326_F357_S0.6141.00
51_E54_G0.6111.00
295_C319_I0.6101.00
112_C117_G0.6081.00
69_S74_V0.6061.00
43_Q46_W0.6061.00
59_A67_A0.6051.00
337_L341_G0.6051.00
253_E257_S0.6041.00
229_Q233_A0.6031.00
269_T309_T0.6011.00
194_V197_M0.6011.00
220_M224_I0.6001.00
146_F149_E0.5981.00
291_A319_I0.5981.00
290_E293_N0.5981.00
297_K331_H0.5971.00
56_Y59_A0.5971.00
77_C81_C0.5971.00
282_H285_W0.5961.00
49_L136_L0.5961.00
204_T207_A0.5921.00
80_E83_C0.5921.00
142_G145_M0.5911.00
249_K252_A0.5901.00
286_R289_Q0.5901.00
275_V371_L0.5881.00
84_L87_F0.5841.00
240_W244_P0.5831.00
306_V319_I0.5821.00
191_H290_E0.5821.00
39_L43_Q0.5791.00
48_F121_H0.5791.00
117_G122_A0.5781.00
81_C85_T0.5761.00
145_M149_E0.5751.00
177_N180_L0.5751.00
50_I135_L0.5751.00
143_K147_D0.5741.00
209_K212_T0.5721.00
79_G83_C0.5711.00
52_E132_R0.5711.00
202_S205_A0.5711.00
181_M184_N0.5711.00
314_H370_P0.5691.00
297_K333_G0.5681.00
320_I358_A0.5671.00
195_N231_A0.5651.00
46_W62_A0.5651.00
74_V77_C0.5641.00
213_K218_Q0.5641.00
254_A292_L0.5631.00
109_N112_C0.5631.00
306_V317_L0.5621.00
26_K29_L0.5611.00
118_I121_H0.5611.00
93_R97_N0.5611.00
270_Q274_P0.5581.00
176_K179_L0.5571.00
204_T208_A0.5561.00
246_G250_G0.5551.00
197_M231_A0.5521.00
248_E272_G0.5521.00
85_T90_G0.5521.00
258_Y293_N0.5501.00
250_G285_W0.5501.00
187_A190_L0.5481.00
193_S341_G0.5461.00
318_D356_E0.5461.00
183_R191_H0.5461.00
179_L182_E0.5431.00
86_K89_N0.5421.00
126_L134_G0.5411.00
184_N189_E0.5401.00
144_T148_E0.5391.00
354_W367_I0.5381.00
90_G93_R0.5381.00
340_K344_E0.5361.00
91_G98_I0.5361.00
46_W60_A0.5321.00
304_A319_I0.5321.00
214_D218_Q0.5301.00
351_A370_P0.5301.00
46_W49_L0.5291.00
243_R335_P0.5281.00
121_H124_V0.5281.00
191_H196_Q0.5281.00
240_W286_R0.5261.00
351_A367_I0.5261.00
35_E58_L0.5251.00
184_N245_G0.5251.00
191_H195_N0.5241.00
45_G62_A0.5231.00
284_L288_V0.5231.00
82_Y98_I0.5221.00
258_Y296_K0.5211.00
220_M223_F0.5211.00
48_F139_A0.5201.00
168_M172_E0.5191.00
63_Y66_P0.5171.00
289_Q293_N0.5171.00
109_N114_D0.5161.00
114_D117_G0.5151.00
113_F116_E0.5131.00
353_F365_L0.5131.00
263_G301_T0.5121.00
49_L59_A0.5111.00
39_L42_L0.5111.00
124_V136_L0.5091.00
174_Q178_A0.5081.00
328_Y357_S0.5081.00
189_E196_Q0.5051.00
227_L231_A0.5031.00
52_E131_R0.5031.00
232_L238_L0.5011.00
179_L184_N0.5011.00
261_L264_L0.5001.00
109_N119_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.8681 100 0.362 Contact Map
3a0rA 2 0.8127 100 0.367 Contact Map
4gczA 2 0.8997 100 0.368 Contact Map
4r3aA 1 0.7995 100 0.422 Contact Map
4bixA 2 0.5435 100 0.469 Contact Map
4q20A 2 0.5409 100 0.47 Contact Map
4r39A 1 0.5251 100 0.474 Contact Map
4ctiA 2 0.5831 100 0.479 Contact Map
3d36A 2 0.5198 100 0.484 Contact Map
3jz3A 2 0.3852 100 0.484 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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