GREMLIN Database
YHAP - Uncharacterized protein YhaP
UniProt: O07523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 419 (355)
Sequences: 9633 (8092)
Seq/√Len: 429.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_A101_L5.3021.00
92_V104_M4.7591.00
289_F358_M4.1551.00
88_S91_E3.8511.00
110_D114_T3.7851.00
95_Q101_L3.5991.00
8_L240_L3.2151.00
7_M233_A3.1301.00
9_S13_K3.0881.00
94_K98_D3.0871.00
115_I120_K3.0021.00
89_E93_T2.8761.00
8_L236_L2.7521.00
96_V104_M2.6281.00
341_A345_T2.5701.00
4_F8_L2.5631.00
226_P229_Q2.5271.00
55_A86_K2.4251.00
95_Q100_S2.4231.00
247_A287_V2.3161.00
93_T97_K2.3121.00
86_K95_Q2.2671.00
373_A377_G2.2321.00
58_D61_N2.2001.00
107_I111_E2.1371.00
251_G255_L2.1361.00
59_E106_I2.1351.00
136_A140_T2.1101.00
11_T234_K2.0951.00
56_V68_S2.0551.00
132_T136_A2.0391.00
377_G381_L2.0341.00
293_G355_P2.0071.00
290_F355_P2.0071.00
60_T112_K1.9581.00
91_E95_Q1.9381.00
303_F389_I1.9041.00
296_L383_I1.9011.00
58_D64_Y1.8771.00
51_K81_D1.8671.00
59_E89_E1.8411.00
53_K81_D1.8261.00
295_F383_I1.8041.00
381_L385_I1.7701.00
89_E106_I1.7601.00
87_Q91_E1.7591.00
53_K83_K1.7521.00
292_L380_L1.7501.00
115_I122_L1.7441.00
347_T353_F1.7341.00
4_F236_L1.7171.00
12_Y244_T1.7061.00
357_I375_G1.6981.00
285_Y362_V1.6891.00
368_P371_Q1.6251.00
120_K123_T1.6181.00
246_L290_F1.5971.00
336_L347_T1.5961.00
13_K17_M1.5771.00
239_G295_F1.5751.00
324_L329_F1.5731.00
299_T383_I1.5661.00
57_V92_V1.5601.00
5_W9_S1.5331.00
361_R367_I1.5261.00
348_S354_T1.4791.00
212_E234_K1.4761.00
120_K124_I1.4651.00
101_L104_M1.4571.00
115_I121_A1.4501.00
289_F376_I1.4491.00
94_K97_K1.4391.00
210_A213_K1.4381.00
141_K144_V1.4261.00
185_G188_Y1.4201.00
239_G291_L1.4171.00
55_A95_Q1.4131.00
341_A344_I1.4131.00
292_L383_I1.4091.00
132_T140_T1.4081.00
284_I288_I1.4041.00
289_F362_V1.3881.00
118_T121_A1.3861.00
348_S353_F1.3861.00
228_I391_A1.3821.00
336_L339_P1.3681.00
184_V187_V1.3671.00
108_K111_E1.3671.00
242_G294_Y1.3661.00
13_K16_I1.3651.00
110_D113_G1.3591.00
141_K145_G1.3401.00
300_L321_M1.3361.00
325_V329_F1.3331.00
378_I382_T1.3261.00
59_E109_R1.3191.00
130_Y133_L1.3171.00
192_F195_Y1.3061.00
243_I291_L1.2931.00
69_K72_K1.2891.00
212_E217_V1.2821.00
90_D93_T1.2821.00
374_V378_I1.2761.00
129_T132_T1.2701.00
187_V191_L1.2671.00
144_V147_A1.2631.00
292_L376_I1.2611.00
344_I348_S1.2601.00
91_E94_K1.2591.00
4_F229_Q1.2571.00
310_R313_D1.2541.00
296_L386_L1.2541.00
196_F200_M1.2441.00
63_L112_K1.2311.00
130_Y134_Q1.2261.00
306_S393_I1.2161.00
185_G189_I1.2151.00
392_R396_G1.2141.00
303_F390_G1.2121.00
4_F232_F1.2111.00
388_V392_R1.2091.00
353_F357_I1.2001.00
121_A124_I1.1961.00
133_L136_A1.1941.00
131_Q134_Q1.1931.00
8_L237_G1.1931.00
282_T285_Y1.1931.00
201_Y204_M1.1911.00
139_Q143_A1.1851.00
361_R365_L1.1851.00
301_A305_G1.1791.00
70_Q73_A1.1771.00
221_L230_Q1.1751.00
140_T144_V1.1711.00
293_G297_Y1.1651.00
66_V69_K1.1631.00
345_T348_S1.1611.00
354_T378_I1.1591.00
345_T349_F1.1571.00
376_I380_L1.1511.00
60_T110_D1.1511.00
326_V329_F1.1461.00
105_L117_G1.1451.00
54_I105_L1.1411.00
303_F386_L1.1351.00
296_L382_T1.1341.00
12_Y240_L1.1341.00
8_L233_A1.1281.00
5_W8_L1.1271.00
324_L328_G1.1211.00
96_V101_L1.1211.00
354_T375_G1.1191.00
250_I290_F1.1111.00
342_G345_T1.1081.00
53_K102_D1.1041.00
106_I120_K1.1041.00
378_I381_L1.1021.00
115_I119_Y1.0961.00
382_T386_L1.0941.00
115_I123_T1.0891.00
251_G254_S1.0881.00
138_T142_T1.0861.00
303_F393_I1.0841.00
140_T143_A1.0831.00
122_L125_S1.0821.00
58_D68_S1.0711.00
34_V252_A1.0701.00
54_I103_G1.0671.00
139_Q142_T1.0671.00
191_L195_Y1.0621.00
186_L190_M1.0611.00
64_Y112_K1.0601.00
57_V86_K1.0591.00
134_Q138_T1.0571.00
350_I353_F1.0561.00
131_Q135_Q1.0531.00
89_E104_M1.0521.00
228_I232_F1.0501.00
182_Q186_L1.0441.00
299_T386_L1.0421.00
210_A214_S1.0401.00
367_I371_Q1.0351.00
339_P344_I1.0311.00
252_A256_S1.0221.00
184_V192_F1.0211.00
370_W374_V1.0211.00
233_A237_G1.0201.00
118_T124_I1.0191.00
240_L244_T1.0121.00
7_M225_M1.0061.00
231_M391_A1.0061.00
131_Q136_A1.0051.00
189_I192_F1.0021.00
286_A359_F0.9931.00
137_L141_K0.9871.00
336_L344_I0.9811.00
126_D132_T0.9801.00
183_T191_L0.9781.00
284_I287_V0.9711.00
57_V104_M0.9701.00
184_V188_Y0.9611.00
55_A104_M0.9611.00
340_D344_I0.9601.00
342_G346_V0.9591.00
61_N109_R0.9551.00
322_T326_V0.9551.00
188_Y192_F0.9511.00
136_A141_K0.9421.00
116_S119_Y0.9381.00
235_L299_T0.9371.00
86_K101_L0.9371.00
18_A21_F0.9371.00
285_Y288_I0.9361.00
87_Q95_Q0.9241.00
118_T122_L0.9221.00
229_Q233_A0.9131.00
130_Y136_A0.9131.00
192_F197_S0.9121.00
385_I389_I0.9121.00
12_Y237_G0.9081.00
316_Q319_T0.9041.00
93_T120_K0.9021.00
60_T107_I0.8971.00
90_D94_K0.8961.00
70_Q143_A0.8901.00
294_Y298_A0.8901.00
187_V190_M0.8901.00
320_P324_L0.8881.00
296_L379_T0.8861.00
190_M194_I0.8841.00
121_A125_S0.8841.00
200_M203_S0.8811.00
194_I202_A0.8781.00
299_T387_A0.8751.00
185_G192_F0.8751.00
375_G379_T0.8721.00
115_I118_T0.8681.00
183_T186_L0.8671.00
143_A147_A0.8621.00
16_I19_K0.8611.00
303_F307_V0.8591.00
66_V70_Q0.8531.00
187_V192_F0.8521.00
10_H212_E0.8491.00
68_S72_K0.8491.00
118_T123_T0.8491.00
129_T134_Q0.8421.00
383_I387_A0.8391.00
145_G150_G0.8361.00
146_T149_L0.8261.00
374_V377_G0.8261.00
198_V201_Y0.8221.00
191_L194_I0.8221.00
42_I45_F0.8181.00
188_Y191_L0.8171.00
58_D107_I0.8171.00
33_L253_G0.8161.00
136_A139_Q0.8161.00
106_I118_T0.8121.00
126_D130_Y0.8091.00
183_T192_F0.8001.00
33_L37_N0.8001.00
195_Y355_P0.7991.00
185_G191_L0.7981.00
217_V220_I0.7981.00
65_P69_K0.7911.00
283_V287_V0.7901.00
195_Y201_Y0.7881.00
56_V82_V0.7871.00
72_K82_V0.7831.00
239_G298_A0.7831.00
128_S132_T0.7781.00
196_F199_I0.7751.00
58_D65_P0.7731.00
93_T104_M0.7721.00
361_R371_Q0.7721.00
300_L386_L0.7711.00
185_G190_M0.7691.00
67_F107_I0.7671.00
54_I82_V0.7631.00
37_N257_L0.7611.00
308_V313_D0.7611.00
235_L295_F0.7601.00
137_L140_T0.7601.00
132_T135_Q0.7591.00
61_N64_Y0.7561.00
235_L298_A0.7561.00
186_L191_L0.7521.00
32_V36_T0.7511.00
116_S124_I0.7511.00
12_Y16_I0.7491.00
10_H14_N0.7491.00
130_Y141_K0.7491.00
369_F372_A0.7481.00
182_Q190_M0.7481.00
328_G331_I0.7481.00
354_T357_I0.7471.00
6_I9_S0.7461.00
340_D343_F0.7441.00
132_T137_L0.7411.00
134_Q145_G0.7401.00
153_Q159_L0.7401.00
183_T190_M0.7391.00
38_L256_S0.7351.00
37_N40_S0.7341.00
371_Q374_V0.7291.00
116_S123_T0.7291.00
289_F372_A0.7271.00
308_V317_T0.7261.00
377_G380_L0.7251.00
304_L308_V0.7241.00
35_V38_L0.7241.00
146_T151_V0.7211.00
321_M325_V0.7191.00
191_L203_S0.7181.00
133_L137_L0.7141.00
71_L133_L0.7141.00
88_S92_V0.7141.00
64_Y107_I0.7131.00
243_I247_A0.7111.00
334_F338_A0.7091.00
7_M230_Q0.7081.00
290_F359_F0.7081.00
58_D112_K0.7071.00
67_F111_E0.7051.00
183_T188_Y0.7051.00
218_M230_Q0.7051.00
389_I392_R0.7031.00
144_V148_E0.7031.00
372_A376_I0.7031.00
132_T141_K0.7021.00
357_I361_R0.7021.00
116_S120_K0.6981.00
362_V372_A0.6981.00
89_E92_V0.6961.00
195_Y202_A0.6951.00
186_L192_F0.6931.00
285_Y376_I0.6911.00
190_M193_V0.6911.00
339_P342_G0.6901.00
186_L189_I0.6901.00
135_Q138_T0.6891.00
386_L390_G0.6891.00
119_Y124_I0.6881.00
202_A301_A0.6881.00
236_L240_L0.6861.00
25_T28_T0.6821.00
182_Q191_L0.6811.00
380_L384_V0.6801.00
346_V350_I0.6801.00
8_L12_Y0.6771.00
323_L326_V0.6761.00
92_V95_Q0.6731.00
130_Y138_T0.6731.00
142_T145_G0.6721.00
261_Q286_A0.6701.00
11_T237_G0.6691.00
24_S28_T0.6691.00
188_Y195_Y0.6691.00
126_D133_L0.6641.00
212_E216_R0.6641.00
331_I335_G0.6611.00
116_S122_L0.6611.00
358_M375_G0.6590.99
123_T126_D0.6550.99
191_L197_S0.6530.99
261_Q283_V0.6520.99
358_M361_R0.6500.99
245_Q249_I0.6490.99
193_V196_F0.6480.99
129_T137_L0.6460.99
23_I27_I0.6450.99
86_K89_E0.6450.99
87_Q101_L0.6440.99
116_S121_A0.6440.99
118_T125_S0.6410.99
292_L379_T0.6390.99
358_M372_A0.6380.99
4_F233_A0.6380.99
32_V40_S0.6340.99
285_Y372_A0.6340.99
147_A150_G0.6330.99
87_Q92_V0.6330.99
250_I286_A0.6300.99
186_L193_V0.6290.99
71_L105_L0.6290.99
383_I386_L0.6260.99
188_Y196_F0.6250.99
347_T350_I0.6240.99
33_L36_T0.6240.99
361_R375_G0.6220.99
188_Y199_I0.6200.99
130_Y140_T0.6200.99
385_I388_V0.6190.99
145_G148_E0.6190.99
369_F373_A0.6170.99
336_L353_F0.6160.99
372_A375_G0.6160.99
355_P358_M0.6140.99
80_L103_G0.6130.99
67_F71_L0.6130.99
6_I10_H0.6120.99
39_E42_I0.6110.99
186_L201_Y0.6100.99
211_T214_S0.6080.99
206_A314_V0.6050.99
358_M362_V0.6030.99
148_E151_V0.6000.99
297_Y301_A0.6000.99
210_A216_R0.5980.99
184_V195_Y0.5980.99
133_L140_T0.5970.99
62_E65_P0.5970.99
370_W373_A0.5970.99
27_I31_L0.5970.99
92_V103_G0.5970.99
145_G149_L0.5970.99
303_F306_S0.5970.99
83_K101_L0.5960.99
319_T323_L0.5950.99
106_I116_S0.5940.99
379_T382_T0.5930.99
319_T322_T0.5920.99
133_L145_G0.5920.99
136_A142_T0.5920.99
192_F201_Y0.5920.99
380_L383_I0.5910.99
332_A356_M0.5900.99
115_I124_I0.5880.99
358_M376_I0.5870.99
138_T141_K0.5870.99
354_T382_T0.5860.99
239_G243_I0.5850.99
194_I201_Y0.5840.99
187_V194_I0.5820.99
19_K22_I0.5800.99
187_V200_M0.5800.99
191_L196_F0.5790.99
185_G200_M0.5780.99
104_M120_K0.5760.99
367_I372_A0.5760.99
349_F382_T0.5750.99
183_T189_I0.5690.99
260_N280_A0.5690.99
358_M379_T0.5680.99
86_K92_V0.5670.98
166_G169_A0.5670.98
207_M311_I0.5670.98
34_V38_L0.5660.98
15_K241_V0.5650.98
130_Y137_L0.5620.98
189_I193_V0.5610.98
136_A144_V0.5590.98
127_E140_T0.5590.98
65_P68_S0.5580.98
134_Q144_V0.5580.98
208_E211_T0.5570.98
188_Y360_L0.5560.98
95_Q98_D0.5560.98
92_V96_V0.5560.98
232_F236_L0.5550.98
182_Q185_G0.5550.98
183_T187_V0.5550.98
197_S200_M0.5530.98
325_V352_F0.5490.98
36_T39_E0.5480.98
146_T150_G0.5470.98
129_T133_L0.5470.98
29_V32_V0.5470.98
188_Y198_V0.5450.98
331_I347_T0.5430.98
225_M229_Q0.5400.98
183_T194_I0.5390.98
130_Y145_G0.5380.98
99_E122_L0.5380.98
60_T111_E0.5380.98
325_V328_G0.5370.98
29_V39_E0.5370.98
163_V167_Q0.5350.98
258_K261_Q0.5350.98
182_Q194_I0.5340.98
60_T108_K0.5340.98
119_Y125_S0.5330.98
10_H13_K0.5330.98
36_T40_S0.5330.98
187_V193_V0.5330.98
312_E315_Q0.5290.98
29_V314_V0.5290.98
188_Y201_Y0.5280.98
225_M230_Q0.5270.98
316_Q324_L0.5260.98
325_V350_I0.5250.98
368_P373_A0.5250.98
126_D144_V0.5250.98
185_G194_I0.5230.97
387_A391_A0.5220.97
67_F70_Q0.5220.97
128_S140_T0.5210.97
184_V191_L0.5210.97
129_T138_T0.5180.97
134_Q142_T0.5180.97
195_Y199_I0.5170.97
58_D110_D0.5160.97
127_E133_L0.5160.97
247_A283_V0.5150.97
189_I194_I0.5150.97
213_K216_R0.5150.97
117_G122_L0.5140.97
285_Y289_F0.5130.97
287_V290_F0.5110.97
188_Y202_A0.5100.97
61_N85_S0.5100.97
94_K100_S0.5100.97
254_S258_K0.5100.97
39_E45_F0.5090.97
206_A210_A0.5080.97
302_A390_G0.5070.97
57_V88_S0.5070.97
117_G123_T0.5070.97
324_L327_A0.5070.97
133_L141_K0.5070.97
61_N65_P0.5060.97
125_S128_S0.5060.97
291_L295_F0.5040.97
189_I195_Y0.5040.97
331_I334_F0.5030.97
102_D122_L0.5030.97
305_G314_V0.5010.97
135_Q139_Q0.5010.97
247_A250_I0.5010.97
222_I230_Q0.5010.97
86_K91_E0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cniA 2 0.3126 99.3 0.794 Contact Map
2p0sA 2 0.3007 99.1 0.81 Contact Map
1dz3A 2 0.2745 44.4 0.946 Contact Map
2plnA 2 0.2673 43.8 0.946 Contact Map
3hv2A 2 0.2888 39.9 0.948 Contact Map
4nicA 2 0.2745 39.3 0.948 Contact Map
4d6yA 2 0.2482 37 0.949 Contact Map
2zayA 1 0.253 36.1 0.949 Contact Map
3n53A 2 0.2434 35.9 0.949 Contact Map
3cg4A 1 0.2625 34.8 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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