GREMLIN Database
YHAO - Uncharacterized metallophosphoesterase YhaO
UniProt: O07522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 408 (343)
Sequences: 3478 (2816)
Seq/√Len: 152.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_L166_M5.4751.00
51_E246_E4.6991.00
232_G247_F3.9471.00
48_A56_I3.6921.00
47_A233_Y3.6761.00
53_V235_L3.6071.00
8_I53_V3.5591.00
44_M220_T3.4711.00
6_T237_H3.3861.00
7_F55_F3.3691.00
230_D249_R3.1401.00
10_A58_L2.9871.00
51_E248_Q2.8911.00
47_A248_Q2.8141.00
42_R82_R2.8121.00
46_D50_R2.7581.00
235_L248_Q2.6481.00
47_A51_E2.6191.00
91_Y136_I2.5971.00
234_Y245_Y2.5591.00
237_H246_E2.5061.00
41_V79_Q2.4981.00
135_S161_P2.4861.00
76_L80_F2.4761.00
51_E235_L2.3811.00
336_D342_A2.3691.00
11_A217_P2.3071.00
59_A166_M2.2911.00
215_I234_Y2.2461.00
238_V243_I2.2221.00
274_M277_D2.1831.00
10_A13_L2.1721.00
7_F236_V2.1701.00
206_V212_P2.1001.00
332_L348_D2.0501.00
9_H197_A2.0431.00
174_S201_I1.9811.00
55_F136_I1.9651.00
48_A88_I1.9631.00
57_L136_I1.9601.00
55_F91_Y1.9021.00
49_V86_C1.8931.00
228_T257_K1.8431.00
40_S220_T1.8141.00
6_T51_E1.8031.00
62_L92_V1.7801.00
165_G193_M1.7671.00
89_S114_H1.7361.00
42_R79_Q1.7341.00
233_Y250_A1.7311.00
234_Y247_F1.7281.00
43_H251_H1.7171.00
126_F135_S1.7041.00
326_E329_V1.7021.00
40_S44_M1.6931.00
349_P353_G1.6931.00
92_V115_I1.6841.00
48_A83_L1.6781.00
237_H244_S1.6761.00
15_L76_L1.6711.00
136_I164_I1.6601.00
133_I161_P1.6581.00
8_I235_L1.6341.00
48_A53_V1.6281.00
261_D264_E1.6191.00
38_F75_F1.6161.00
165_G196_W1.6081.00
350_F354_L1.5941.00
204_R234_Y1.5881.00
128_K133_I1.5711.00
281_K285_K1.5401.00
193_M196_W1.5351.00
185_H189_V1.5341.00
42_R46_D1.5301.00
135_S163_H1.5291.00
46_D82_R1.5281.00
8_I48_A1.5151.00
46_D49_V1.4981.00
137_Y193_M1.4951.00
116_F138_G1.4941.00
33_I36_S1.4921.00
93_I166_M1.4901.00
91_Y138_G1.4841.00
236_V245_Y1.4661.00
352_G356_E1.4281.00
8_I233_Y1.4201.00
17_S223_R1.4151.00
19_F33_I1.3901.00
49_V82_R1.3791.00
9_H195_Y1.3751.00
278_T281_K1.3641.00
132_R162_F1.3571.00
274_M278_T1.3241.00
10_A44_M1.3181.00
134_A164_I1.3171.00
37_T223_R1.3161.00
23_S34_K1.3061.00
137_Y163_H1.2901.00
11_A59_A1.2881.00
277_D281_K1.2661.00
58_L90_V1.2641.00
185_H214_V1.2621.00
356_E359_D1.2571.00
162_F238_V1.2521.00
267_N270_A1.2501.00
171_L207_L1.2481.00
13_L62_L1.2461.00
236_V243_I1.2341.00
129_E132_R1.2321.00
75_F79_Q1.2301.00
76_L92_V1.2291.00
196_W214_V1.2271.00
94_F117_S1.2201.00
77_K106_P1.2111.00
129_E162_F1.2091.00
271_L275_V1.2061.00
138_G166_M1.2051.00
13_L58_L1.2021.00
341_E344_L1.1991.00
61_D97_H1.1951.00
38_F42_R1.1941.00
204_R232_G1.1931.00
62_L76_L1.1921.00
275_V283_R1.1771.00
8_I47_A1.1751.00
120_V123_E1.1631.00
225_I255_W1.1591.00
219_N223_R1.1551.00
38_F78_K1.1551.00
80_F90_V1.1501.00
40_S250_A1.1451.00
45_I83_L1.1441.00
136_I166_M1.1391.00
331_P334_L1.1371.00
215_I245_Y1.1331.00
45_I79_Q1.1241.00
288_P291_V1.1150.99
44_M233_Y1.1110.99
17_S64_D1.1090.99
351_F355_F1.1060.99
7_F57_L1.0880.99
35_E39_A1.0840.99
204_R247_F1.0760.99
353_G356_E1.0700.99
290_C300_P1.0690.99
107_I111_E1.0610.99
259_A294_V1.0570.99
69_S72_A1.0500.99
292_R297_G1.0470.99
34_K71_K1.0460.99
315_L318_L1.0350.99
275_V279_F1.0320.99
139_F167_L1.0280.99
55_F164_I1.0230.99
39_A42_R1.0180.99
55_F134_A1.0140.99
327_R330_W1.0120.99
239_T242_D1.0110.99
153_R156_R1.0110.99
40_S221_Q1.0110.99
274_M279_F1.0040.99
334_L338_T1.0030.99
164_I236_V1.0020.99
275_V281_K1.0010.99
104_W108_E0.9980.99
36_S221_Q0.9970.99
43_H46_D0.9790.99
84_R112_N0.9770.99
126_F133_I0.9730.99
221_Q253_V0.9720.99
318_L322_E0.9680.99
63_F73_Q0.9450.98
321_Q324_E0.9440.98
61_D96_N0.9430.98
59_A93_I0.9370.98
43_H250_A0.9360.98
286_G289_V0.9360.98
328_F352_G0.9290.98
56_I90_V0.9270.98
57_L236_V0.9270.98
6_T235_L0.9270.98
149_N187_D0.9240.98
281_K284_K0.9220.98
311_L315_L0.9190.98
274_M281_K0.9160.98
322_E325_E0.9150.98
262_V266_K0.9140.98
61_D202_H0.9100.98
348_D352_G0.9080.98
235_L246_E0.9050.98
44_M53_V0.8960.98
64_D223_R0.8950.98
290_C294_V0.8950.98
315_L319_Q0.8910.97
36_S253_V0.8890.97
354_L358_I0.8860.97
350_F353_G0.8860.97
49_V85_E0.8850.97
50_R248_Q0.8840.97
49_V88_I0.8830.97
97_H168_H0.8820.97
56_I88_I0.8800.97
298_T301_E0.8710.97
233_Y248_Q0.8660.97
5_L237_H0.8650.97
57_L164_I0.8640.97
164_I238_V0.8600.97
82_R86_C0.8600.97
257_K294_V0.8530.97
213_A243_I0.8510.97
9_H198_L0.8510.97
219_N231_K0.8490.97
256_E273_Q0.8460.97
277_D280_S0.8410.96
47_A50_R0.8360.96
38_F82_R0.8360.96
15_L38_F0.8330.96
278_T283_R0.8330.96
124_K135_S0.8320.96
134_A238_V0.8310.96
14_H202_H0.8300.96
222_A252_D0.8260.96
260_V264_E0.8260.96
168_H200_H0.8260.96
15_L69_S0.8240.96
347_L351_F0.8240.96
289_V305_E0.8220.96
311_L314_F0.8200.96
325_E333_R0.8170.96
195_Y215_I0.8170.96
351_F358_I0.8170.96
64_D231_K0.8140.96
79_Q83_L0.8130.96
54_D237_H0.8080.95
41_V45_I0.8080.95
34_K75_F0.8050.95
37_T63_F0.8030.95
294_V297_G0.8020.95
316_E320_E0.8010.95
69_S73_Q0.7990.95
155_R158_T0.7980.95
343_N346_N0.7970.95
70_L73_Q0.7960.95
91_Y116_F0.7860.95
11_A62_L0.7860.95
129_E133_I0.7860.95
80_F112_N0.7840.95
39_A253_V0.7780.94
5_L238_V0.7780.94
292_R299_A0.7760.94
163_H194_D0.7760.94
48_A55_F0.7750.94
59_A217_P0.7690.94
347_L354_L0.7680.94
206_V215_I0.7680.94
345_T348_D0.7670.94
271_L274_M0.7660.94
94_F100_L0.7620.94
349_P352_G0.7610.94
97_H202_H0.7560.94
300_P303_L0.7510.93
333_R337_E0.7510.93
204_R215_I0.7460.93
318_L323_A0.7450.93
262_V295_L0.7440.93
309_G315_L0.7440.93
203_K229_G0.7440.93
275_V284_K0.7430.93
299_A305_E0.7410.93
55_F236_V0.7390.93
94_F140_S0.7350.93
168_H202_H0.7350.93
208_S213_A0.7320.92
36_S39_A0.7310.92
97_H200_H0.7300.92
7_F238_V0.7290.92
117_S122_E0.7250.92
172_S190_K0.7240.92
219_N224_H0.7240.92
346_N349_P0.7230.92
276_E280_S0.7230.92
45_I86_C0.7230.92
280_S283_R0.7230.92
356_E360_R0.7230.92
54_D89_S0.7210.92
273_Q277_D0.7200.92
225_I292_R0.7160.92
317_A320_E0.7160.92
34_K37_T0.7160.92
302_W305_E0.7150.92
315_L321_Q0.7120.91
15_L41_V0.7070.91
275_V278_T0.7060.91
292_R305_E0.7060.91
119_A122_E0.7030.91
347_L350_F0.7020.91
342_A345_T0.7020.91
197_A215_I0.7010.91
44_M48_A0.7010.91
45_I48_A0.6990.91
155_R193_M0.6970.91
344_L347_L0.6960.90
11_A196_W0.6930.90
163_H169_G0.6920.90
16_D72_A0.6910.90
272_F275_V0.6900.90
181_C201_I0.6870.90
96_N168_H0.6860.90
45_I82_R0.6850.90
92_V113_V0.6840.90
14_H61_D0.6820.90
7_F134_A0.6820.90
16_D68_R0.6810.90
137_Y165_G0.6810.90
291_V297_G0.6800.89
325_E329_V0.6780.89
56_I79_Q0.6780.89
134_A162_F0.6770.89
174_S208_S0.6760.89
8_I56_I0.6750.89
331_P351_F0.6730.89
340_N343_N0.6730.89
162_F194_D0.6710.89
96_N200_H0.6700.89
79_Q82_R0.6690.89
206_V234_Y0.6690.89
240_N243_I0.6670.89
143_A146_L0.6660.88
259_A306_A0.6650.88
220_T233_Y0.6630.88
312_D315_L0.6620.88
271_L285_K0.6620.88
12_D16_D0.6610.88
354_L357_D0.6570.88
17_S33_I0.6560.88
42_R75_F0.6560.88
291_V295_L0.6560.88
345_T349_P0.6560.88
288_P292_R0.6550.88
309_G312_D0.6540.88
286_G292_R0.6530.88
14_H200_H0.6520.87
346_N350_F0.6520.87
329_V335_D0.6520.87
327_R331_P0.6490.87
81_E84_R0.6480.87
259_A296_Q0.6460.87
275_V285_K0.6460.87
353_G360_R0.6440.87
99_H140_S0.6440.87
220_T250_A0.6430.87
238_V242_D0.6380.86
37_T219_N0.6340.86
319_Q322_E0.6330.86
341_E346_N0.6320.86
294_V298_T0.6320.86
81_E85_E0.6320.86
260_V265_A0.6320.86
326_E334_L0.6320.86
54_D128_K0.6310.86
36_S254_L0.6270.85
16_D223_R0.6250.85
318_L321_Q0.6230.85
262_V286_G0.6230.85
292_R295_L0.6230.85
47_A235_L0.6220.85
191_S211_H0.6210.85
48_A89_S0.6200.85
317_A321_Q0.6200.85
128_K134_A0.6200.85
208_S212_P0.6180.84
297_G305_E0.6170.84
174_S205_Q0.6160.84
329_V332_L0.6130.84
217_P220_T0.6110.84
290_C303_L0.6070.83
93_I231_K0.6060.83
37_T221_Q0.6040.83
57_L197_A0.6030.83
351_F354_L0.6020.83
33_I221_Q0.6010.83
340_N345_T0.6010.83
83_L90_V0.6000.83
263_T267_N0.5990.83
36_S274_M0.5980.83
212_P215_I0.5980.83
16_D34_K0.5960.82
33_I253_V0.5950.82
331_P343_N0.5940.82
349_P357_D0.5920.82
273_Q276_E0.5920.82
7_F136_I0.5910.82
19_F225_I0.5900.82
215_I247_F0.5890.82
140_S216_Y0.5870.81
94_F115_I0.5850.81
289_V301_E0.5840.81
332_L342_A0.5830.81
341_E358_I0.5820.81
320_E323_A0.5800.81
130_G133_I0.5800.81
76_L115_I0.5800.81
170_T188_L0.5790.80
183_F225_I0.5790.80
331_P335_D0.5790.80
258_A293_L0.5770.80
326_E336_D0.5760.80
349_P359_D0.5760.80
17_S170_T0.5760.80
61_D168_H0.5760.80
264_E270_A0.5740.80
327_R335_D0.5730.80
162_F243_I0.5730.80
310_T318_L0.5700.79
13_L44_M0.5680.79
167_L198_L0.5680.79
142_Q182_P0.5680.79
289_V300_P0.5670.79
13_L79_Q0.5670.79
310_T313_E0.5670.79
56_I83_L0.5660.79
58_L76_L0.5640.79
84_R113_V0.5640.79
320_E324_E0.5640.79
319_Q324_E0.5640.79
109_W113_V0.5630.79
96_N202_H0.5630.79
63_F179_P0.5610.78
275_V280_S0.5590.78
342_A346_N0.5590.78
131_R162_F0.5580.78
311_L318_L0.5570.78
110_P113_V0.5560.78
290_C297_G0.5560.78
59_A80_F0.5550.78
221_Q255_W0.5550.78
259_A278_T0.5540.78
314_F320_E0.5540.78
47_A53_V0.5530.77
124_K127_F0.5530.77
128_K132_R0.5520.77
330_W334_L0.5510.77
265_A296_Q0.5500.77
315_L325_E0.5490.77
177_H180_Y0.5490.77
72_A140_S0.5480.77
357_D360_R0.5460.77
44_M79_Q0.5450.76
19_F255_W0.5440.76
75_F217_P0.5440.76
327_R343_N0.5420.76
271_L283_R0.5420.76
327_R334_L0.5410.76
222_A231_K0.5410.76
297_G301_E0.5400.76
346_N360_R0.5400.76
82_R85_E0.5400.76
300_P304_L0.5380.75
53_V56_I0.5380.75
257_K292_R0.5370.75
8_I44_M0.5350.75
349_P356_E0.5340.75
10_A220_T0.5340.75
326_E330_W0.5330.75
99_H103_E0.5320.75
122_E150_Q0.5320.75
167_L188_L0.5320.75
36_S219_N0.5320.75
195_Y236_V0.5310.75
64_D103_E0.5310.75
41_V75_F0.5310.75
41_V58_L0.5300.74
353_G357_D0.5300.74
100_L117_S0.5300.74
116_F166_M0.5290.74
316_E321_Q0.5290.74
300_P305_E0.5280.74
84_R111_E0.5270.74
313_E316_E0.5270.74
53_V88_I0.5260.74
319_Q323_A0.5250.74
335_D339_E0.5250.74
127_F131_R0.5240.74
159_D192_G0.5240.74
159_D316_E0.5240.74
164_I275_V0.5230.73
34_K72_A0.5220.73
12_D202_H0.5220.73
137_Y169_G0.5200.73
189_V208_S0.5200.73
83_L88_I0.5190.73
17_S219_N0.5150.72
45_I49_V0.5140.72
271_L279_F0.5140.72
33_I68_R0.5140.72
274_M280_S0.5130.72
8_I232_G0.5130.72
335_D347_L0.5120.72
153_R158_T0.5110.72
44_M56_I0.5100.72
13_L41_V0.5100.72
325_E328_F0.5100.72
144_R170_T0.5080.71
341_E357_D0.5070.71
9_H217_P0.5070.71
329_V334_L0.5070.71
207_L212_P0.5070.71
186_D189_V0.5050.71
301_E304_L0.5050.71
290_C295_L0.5050.71
18_P64_D0.5040.71
16_D69_S0.5040.71
180_Y201_I0.5010.70
113_V229_G0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ykeA 2 0.7843 100 0.422 Contact Map
4ltyC 1 0.7475 100 0.443 Contact Map
4fbwA 2 0.7623 100 0.474 Contact Map
3t1iA 2 0.7721 100 0.475 Contact Map
1ii7A 2 0.7304 100 0.479 Contact Map
4fbkA 2 0.7745 100 0.481 Contact Map
3thoB 2 0.7745 100 0.486 Contact Map
3av0A 1 0.8603 100 0.504 Contact Map
4nzvA 1 0.7181 100 0.506 Contact Map
2a22A 1 0.4706 99.9 0.716 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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