YHAO - BACSU - GREMLIN Contacts

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YHAO - Uncharacterized metallophosphoesterase YhaO

UniProt:	O07522	Sequences: MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHMIDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGGEWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDAPFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPGNTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVEDTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRLDDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIKEQAQIILKRQLKVLDT	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	408 (343)
Sequences:	3478 (2816)
Seq/√Len:	152.0

ECOLI - SBCD
BACSU - YHAO SBCD
HALSA - MRE11
SULSO - MRE11

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
57_L	166_M	5.475	1.00
51_E	246_E	4.699	1.00
232_G	247_F	3.947	1.00
48_A	56_I	3.692	1.00
47_A	233_Y	3.676	1.00
53_V	235_L	3.607	1.00
8_I	53_V	3.559	1.00
44_M	220_T	3.471	1.00
6_T	237_H	3.386	1.00
7_F	55_F	3.369	1.00
230_D	249_R	3.140	1.00
10_A	58_L	2.987	1.00
51_E	248_Q	2.891	1.00
47_A	248_Q	2.814	1.00
42_R	82_R	2.812	1.00
46_D	50_R	2.758	1.00
235_L	248_Q	2.648	1.00
47_A	51_E	2.619	1.00
91_Y	136_I	2.597	1.00
234_Y	245_Y	2.559	1.00
237_H	246_E	2.506	1.00
41_V	79_Q	2.498	1.00
135_S	161_P	2.486	1.00
76_L	80_F	2.476	1.00
51_E	235_L	2.381	1.00
336_D	342_A	2.369	1.00
11_A	217_P	2.307	1.00
59_A	166_M	2.291	1.00
215_I	234_Y	2.246	1.00
238_V	243_I	2.222	1.00
274_M	277_D	2.183	1.00
10_A	13_L	2.172	1.00
7_F	236_V	2.170	1.00
206_V	212_P	2.100	1.00
332_L	348_D	2.050	1.00
9_H	197_A	2.043	1.00
174_S	201_I	1.981	1.00
55_F	136_I	1.965	1.00
48_A	88_I	1.963	1.00
57_L	136_I	1.960	1.00
55_F	91_Y	1.902	1.00
49_V	86_C	1.893	1.00
228_T	257_K	1.843	1.00
40_S	220_T	1.814	1.00
6_T	51_E	1.803	1.00
62_L	92_V	1.780	1.00
165_G	193_M	1.767	1.00
89_S	114_H	1.736	1.00
42_R	79_Q	1.734	1.00
233_Y	250_A	1.731	1.00
234_Y	247_F	1.728	1.00
43_H	251_H	1.717	1.00
126_F	135_S	1.704	1.00
326_E	329_V	1.702	1.00
40_S	44_M	1.693	1.00
349_P	353_G	1.693	1.00
92_V	115_I	1.684	1.00
48_A	83_L	1.678	1.00
237_H	244_S	1.676	1.00
15_L	76_L	1.671	1.00
136_I	164_I	1.660	1.00
133_I	161_P	1.658	1.00
8_I	235_L	1.634	1.00
48_A	53_V	1.628	1.00
261_D	264_E	1.619	1.00
38_F	75_F	1.616	1.00
165_G	196_W	1.608	1.00
350_F	354_L	1.594	1.00
204_R	234_Y	1.588	1.00
128_K	133_I	1.571	1.00
281_K	285_K	1.540	1.00
193_M	196_W	1.535	1.00
185_H	189_V	1.534	1.00
42_R	46_D	1.530	1.00
135_S	163_H	1.529	1.00
46_D	82_R	1.528	1.00
8_I	48_A	1.515	1.00
46_D	49_V	1.498	1.00
137_Y	193_M	1.495	1.00
116_F	138_G	1.494	1.00
33_I	36_S	1.492	1.00
93_I	166_M	1.490	1.00
91_Y	138_G	1.484	1.00
236_V	245_Y	1.466	1.00
352_G	356_E	1.428	1.00
8_I	233_Y	1.420	1.00
17_S	223_R	1.415	1.00
19_F	33_I	1.390	1.00
49_V	82_R	1.379	1.00
9_H	195_Y	1.375	1.00
278_T	281_K	1.364	1.00
132_R	162_F	1.357	1.00
274_M	278_T	1.324	1.00
10_A	44_M	1.318	1.00
134_A	164_I	1.317	1.00
37_T	223_R	1.316	1.00
23_S	34_K	1.306	1.00
137_Y	163_H	1.290	1.00
11_A	59_A	1.288	1.00
277_D	281_K	1.266	1.00
58_L	90_V	1.264	1.00
185_H	214_V	1.262	1.00
356_E	359_D	1.257	1.00
162_F	238_V	1.252	1.00
267_N	270_A	1.250	1.00
171_L	207_L	1.248	1.00
13_L	62_L	1.246	1.00
236_V	243_I	1.234	1.00
129_E	132_R	1.232	1.00
75_F	79_Q	1.230	1.00
76_L	92_V	1.229	1.00
196_W	214_V	1.227	1.00
94_F	117_S	1.220	1.00
77_K	106_P	1.211	1.00
129_E	162_F	1.209	1.00
271_L	275_V	1.206	1.00
138_G	166_M	1.205	1.00
13_L	58_L	1.202	1.00
341_E	344_L	1.199	1.00
61_D	97_H	1.195	1.00
38_F	42_R	1.194	1.00
204_R	232_G	1.193	1.00
62_L	76_L	1.192	1.00
275_V	283_R	1.177	1.00
8_I	47_A	1.175	1.00
120_V	123_E	1.163	1.00
225_I	255_W	1.159	1.00
219_N	223_R	1.155	1.00
38_F	78_K	1.155	1.00
80_F	90_V	1.150	1.00
40_S	250_A	1.145	1.00
45_I	83_L	1.144	1.00
136_I	166_M	1.139	1.00
331_P	334_L	1.137	1.00
215_I	245_Y	1.133	1.00
45_I	79_Q	1.124	1.00
288_P	291_V	1.115	0.99
44_M	233_Y	1.111	0.99
17_S	64_D	1.109	0.99
351_F	355_F	1.106	0.99
7_F	57_L	1.088	0.99
35_E	39_A	1.084	0.99
204_R	247_F	1.076	0.99
353_G	356_E	1.070	0.99
290_C	300_P	1.069	0.99
107_I	111_E	1.061	0.99
259_A	294_V	1.057	0.99
69_S	72_A	1.050	0.99
292_R	297_G	1.047	0.99
34_K	71_K	1.046	0.99
315_L	318_L	1.035	0.99
275_V	279_F	1.032	0.99
139_F	167_L	1.028	0.99
55_F	164_I	1.023	0.99
39_A	42_R	1.018	0.99
55_F	134_A	1.014	0.99
327_R	330_W	1.012	0.99
239_T	242_D	1.011	0.99
153_R	156_R	1.011	0.99
40_S	221_Q	1.011	0.99
274_M	279_F	1.004	0.99
334_L	338_T	1.003	0.99
164_I	236_V	1.002	0.99
275_V	281_K	1.001	0.99
104_W	108_E	0.998	0.99
36_S	221_Q	0.997	0.99
43_H	46_D	0.979	0.99
84_R	112_N	0.977	0.99
126_F	133_I	0.973	0.99
221_Q	253_V	0.972	0.99
318_L	322_E	0.968	0.99
63_F	73_Q	0.945	0.98
321_Q	324_E	0.944	0.98
61_D	96_N	0.943	0.98
59_A	93_I	0.937	0.98
43_H	250_A	0.936	0.98
286_G	289_V	0.936	0.98
328_F	352_G	0.929	0.98
56_I	90_V	0.927	0.98
57_L	236_V	0.927	0.98
6_T	235_L	0.927	0.98
149_N	187_D	0.924	0.98
281_K	284_K	0.922	0.98
311_L	315_L	0.919	0.98
274_M	281_K	0.916	0.98
322_E	325_E	0.915	0.98
262_V	266_K	0.914	0.98
61_D	202_H	0.910	0.98
348_D	352_G	0.908	0.98
235_L	246_E	0.905	0.98
44_M	53_V	0.896	0.98
64_D	223_R	0.895	0.98
290_C	294_V	0.895	0.98
315_L	319_Q	0.891	0.97
36_S	253_V	0.889	0.97
354_L	358_I	0.886	0.97
350_F	353_G	0.886	0.97
49_V	85_E	0.885	0.97
50_R	248_Q	0.884	0.97
49_V	88_I	0.883	0.97
97_H	168_H	0.882	0.97
56_I	88_I	0.880	0.97
298_T	301_E	0.871	0.97
233_Y	248_Q	0.866	0.97
5_L	237_H	0.865	0.97
57_L	164_I	0.864	0.97
164_I	238_V	0.860	0.97
82_R	86_C	0.860	0.97
257_K	294_V	0.853	0.97
213_A	243_I	0.851	0.97
9_H	198_L	0.851	0.97
219_N	231_K	0.849	0.97
256_E	273_Q	0.846	0.97
277_D	280_S	0.841	0.96
47_A	50_R	0.836	0.96
38_F	82_R	0.836	0.96
15_L	38_F	0.833	0.96
278_T	283_R	0.833	0.96
124_K	135_S	0.832	0.96
134_A	238_V	0.831	0.96
14_H	202_H	0.830	0.96
222_A	252_D	0.826	0.96
260_V	264_E	0.826	0.96
168_H	200_H	0.826	0.96
15_L	69_S	0.824	0.96
347_L	351_F	0.824	0.96
289_V	305_E	0.822	0.96
311_L	314_F	0.820	0.96
325_E	333_R	0.817	0.96
195_Y	215_I	0.817	0.96
351_F	358_I	0.817	0.96
64_D	231_K	0.814	0.96
79_Q	83_L	0.813	0.96
54_D	237_H	0.808	0.95
41_V	45_I	0.808	0.95
34_K	75_F	0.805	0.95
37_T	63_F	0.803	0.95
294_V	297_G	0.802	0.95
316_E	320_E	0.801	0.95
69_S	73_Q	0.799	0.95
155_R	158_T	0.798	0.95
343_N	346_N	0.797	0.95
70_L	73_Q	0.796	0.95
91_Y	116_F	0.786	0.95
11_A	62_L	0.786	0.95
129_E	133_I	0.786	0.95
80_F	112_N	0.784	0.95
39_A	253_V	0.778	0.94
5_L	238_V	0.778	0.94
292_R	299_A	0.776	0.94
163_H	194_D	0.776	0.94
48_A	55_F	0.775	0.94
59_A	217_P	0.769	0.94
347_L	354_L	0.768	0.94
206_V	215_I	0.768	0.94
345_T	348_D	0.767	0.94
271_L	274_M	0.766	0.94
94_F	100_L	0.762	0.94
349_P	352_G	0.761	0.94
97_H	202_H	0.756	0.94
300_P	303_L	0.751	0.93
333_R	337_E	0.751	0.93
204_R	215_I	0.746	0.93
318_L	323_A	0.745	0.93
262_V	295_L	0.744	0.93
309_G	315_L	0.744	0.93
203_K	229_G	0.744	0.93
275_V	284_K	0.743	0.93
299_A	305_E	0.741	0.93
55_F	236_V	0.739	0.93
94_F	140_S	0.735	0.93
168_H	202_H	0.735	0.93
208_S	213_A	0.732	0.92
36_S	39_A	0.731	0.92
97_H	200_H	0.730	0.92
7_F	238_V	0.729	0.92
117_S	122_E	0.725	0.92
172_S	190_K	0.724	0.92
219_N	224_H	0.724	0.92
346_N	349_P	0.723	0.92
276_E	280_S	0.723	0.92
45_I	86_C	0.723	0.92
280_S	283_R	0.723	0.92
356_E	360_R	0.723	0.92
54_D	89_S	0.721	0.92
273_Q	277_D	0.720	0.92
225_I	292_R	0.716	0.92
317_A	320_E	0.716	0.92
34_K	37_T	0.716	0.92
302_W	305_E	0.715	0.92
315_L	321_Q	0.712	0.91
15_L	41_V	0.707	0.91
275_V	278_T	0.706	0.91
292_R	305_E	0.706	0.91
119_A	122_E	0.703	0.91
347_L	350_F	0.702	0.91
342_A	345_T	0.702	0.91
197_A	215_I	0.701	0.91
44_M	48_A	0.701	0.91
45_I	48_A	0.699	0.91
155_R	193_M	0.697	0.91
344_L	347_L	0.696	0.90
11_A	196_W	0.693	0.90
163_H	169_G	0.692	0.90
16_D	72_A	0.691	0.90
272_F	275_V	0.690	0.90
181_C	201_I	0.687	0.90
96_N	168_H	0.686	0.90
45_I	82_R	0.685	0.90
92_V	113_V	0.684	0.90
14_H	61_D	0.682	0.90
7_F	134_A	0.682	0.90
16_D	68_R	0.681	0.90
137_Y	165_G	0.681	0.90
291_V	297_G	0.680	0.89
325_E	329_V	0.678	0.89
56_I	79_Q	0.678	0.89
134_A	162_F	0.677	0.89
174_S	208_S	0.676	0.89
8_I	56_I	0.675	0.89
331_P	351_F	0.673	0.89
340_N	343_N	0.673	0.89
162_F	194_D	0.671	0.89
96_N	200_H	0.670	0.89
79_Q	82_R	0.669	0.89
206_V	234_Y	0.669	0.89
240_N	243_I	0.667	0.89
143_A	146_L	0.666	0.88
259_A	306_A	0.665	0.88
220_T	233_Y	0.663	0.88
312_D	315_L	0.662	0.88
271_L	285_K	0.662	0.88
12_D	16_D	0.661	0.88
354_L	357_D	0.657	0.88
17_S	33_I	0.656	0.88
42_R	75_F	0.656	0.88
291_V	295_L	0.656	0.88
345_T	349_P	0.656	0.88
288_P	292_R	0.655	0.88
309_G	312_D	0.654	0.88
286_G	292_R	0.653	0.88
14_H	200_H	0.652	0.87
346_N	350_F	0.652	0.87
329_V	335_D	0.652	0.87
327_R	331_P	0.649	0.87
81_E	84_R	0.648	0.87
259_A	296_Q	0.646	0.87
275_V	285_K	0.646	0.87
353_G	360_R	0.644	0.87
99_H	140_S	0.644	0.87
220_T	250_A	0.643	0.87
238_V	242_D	0.638	0.86
37_T	219_N	0.634	0.86
319_Q	322_E	0.633	0.86
341_E	346_N	0.632	0.86
294_V	298_T	0.632	0.86
81_E	85_E	0.632	0.86
260_V	265_A	0.632	0.86
326_E	334_L	0.632	0.86
54_D	128_K	0.631	0.86
36_S	254_L	0.627	0.85
16_D	223_R	0.625	0.85
318_L	321_Q	0.623	0.85
262_V	286_G	0.623	0.85
292_R	295_L	0.623	0.85
47_A	235_L	0.622	0.85
191_S	211_H	0.621	0.85
48_A	89_S	0.620	0.85
317_A	321_Q	0.620	0.85
128_K	134_A	0.620	0.85
208_S	212_P	0.618	0.84
297_G	305_E	0.617	0.84
174_S	205_Q	0.616	0.84
329_V	332_L	0.613	0.84
217_P	220_T	0.611	0.84
290_C	303_L	0.607	0.83
93_I	231_K	0.606	0.83
37_T	221_Q	0.604	0.83
57_L	197_A	0.603	0.83
351_F	354_L	0.602	0.83
33_I	221_Q	0.601	0.83
340_N	345_T	0.601	0.83
83_L	90_V	0.600	0.83
263_T	267_N	0.599	0.83
36_S	274_M	0.598	0.83
212_P	215_I	0.598	0.83
16_D	34_K	0.596	0.82
33_I	253_V	0.595	0.82
331_P	343_N	0.594	0.82
349_P	357_D	0.592	0.82
273_Q	276_E	0.592	0.82
7_F	136_I	0.591	0.82
19_F	225_I	0.590	0.82
215_I	247_F	0.589	0.82
140_S	216_Y	0.587	0.81
94_F	115_I	0.585	0.81
289_V	301_E	0.584	0.81
332_L	342_A	0.583	0.81
341_E	358_I	0.582	0.81
320_E	323_A	0.580	0.81
130_G	133_I	0.580	0.81
76_L	115_I	0.580	0.81
170_T	188_L	0.579	0.80
183_F	225_I	0.579	0.80
331_P	335_D	0.579	0.80
258_A	293_L	0.577	0.80
326_E	336_D	0.576	0.80
349_P	359_D	0.576	0.80
17_S	170_T	0.576	0.80
61_D	168_H	0.576	0.80
264_E	270_A	0.574	0.80
327_R	335_D	0.573	0.80
162_F	243_I	0.573	0.80
310_T	318_L	0.570	0.79
13_L	44_M	0.568	0.79
167_L	198_L	0.568	0.79
142_Q	182_P	0.568	0.79
289_V	300_P	0.567	0.79
13_L	79_Q	0.567	0.79
310_T	313_E	0.567	0.79
56_I	83_L	0.566	0.79
58_L	76_L	0.564	0.79
84_R	113_V	0.564	0.79
320_E	324_E	0.564	0.79
319_Q	324_E	0.564	0.79
109_W	113_V	0.563	0.79
96_N	202_H	0.563	0.79
63_F	179_P	0.561	0.78
275_V	280_S	0.559	0.78
342_A	346_N	0.559	0.78
131_R	162_F	0.558	0.78
311_L	318_L	0.557	0.78
110_P	113_V	0.556	0.78
290_C	297_G	0.556	0.78
59_A	80_F	0.555	0.78
221_Q	255_W	0.555	0.78
259_A	278_T	0.554	0.78
314_F	320_E	0.554	0.78
47_A	53_V	0.553	0.77
124_K	127_F	0.553	0.77
128_K	132_R	0.552	0.77
330_W	334_L	0.551	0.77
265_A	296_Q	0.550	0.77
315_L	325_E	0.549	0.77
177_H	180_Y	0.549	0.77
72_A	140_S	0.548	0.77
357_D	360_R	0.546	0.77
44_M	79_Q	0.545	0.76
19_F	255_W	0.544	0.76
75_F	217_P	0.544	0.76
327_R	343_N	0.542	0.76
271_L	283_R	0.542	0.76
327_R	334_L	0.541	0.76
222_A	231_K	0.541	0.76
297_G	301_E	0.540	0.76
346_N	360_R	0.540	0.76
82_R	85_E	0.540	0.76
300_P	304_L	0.538	0.75
53_V	56_I	0.538	0.75
257_K	292_R	0.537	0.75
8_I	44_M	0.535	0.75
349_P	356_E	0.534	0.75
10_A	220_T	0.534	0.75
326_E	330_W	0.533	0.75
99_H	103_E	0.532	0.75
122_E	150_Q	0.532	0.75
167_L	188_L	0.532	0.75
36_S	219_N	0.532	0.75
195_Y	236_V	0.531	0.75
64_D	103_E	0.531	0.75
41_V	75_F	0.531	0.75
41_V	58_L	0.530	0.74
353_G	357_D	0.530	0.74
100_L	117_S	0.530	0.74
116_F	166_M	0.529	0.74
316_E	321_Q	0.529	0.74
300_P	305_E	0.528	0.74
84_R	111_E	0.527	0.74
313_E	316_E	0.527	0.74
53_V	88_I	0.526	0.74
319_Q	323_A	0.525	0.74
335_D	339_E	0.525	0.74
127_F	131_R	0.524	0.74
159_D	192_G	0.524	0.74
159_D	316_E	0.524	0.74
164_I	275_V	0.523	0.73
34_K	72_A	0.522	0.73
12_D	202_H	0.522	0.73
137_Y	169_G	0.520	0.73
189_V	208_S	0.520	0.73
83_L	88_I	0.519	0.73
17_S	219_N	0.515	0.72
45_I	49_V	0.514	0.72
271_L	279_F	0.514	0.72
33_I	68_R	0.514	0.72
274_M	280_S	0.513	0.72
8_I	232_G	0.513	0.72
335_D	347_L	0.512	0.72
153_R	158_T	0.511	0.72
44_M	56_I	0.510	0.72
13_L	41_V	0.510	0.72
325_E	328_F	0.510	0.72
144_R	170_T	0.508	0.71
341_E	357_D	0.507	0.71
9_H	217_P	0.507	0.71
329_V	334_L	0.507	0.71
207_L	212_P	0.507	0.71
186_D	189_V	0.505	0.71
301_E	304_L	0.505	0.71
290_C	295_L	0.505	0.71
18_P	64_D	0.504	0.71
16_D	69_S	0.504	0.71
180_Y	201_I	0.501	0.70
113_V	229_G	0.500	0.70

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4ykeA	2	0.7843	100	0.422	Contact Map
4ltyC	1	0.7475	100	0.443	Contact Map
4fbwA	2	0.7623	100	0.474	Contact Map
3t1iA	2	0.7721	100	0.475	Contact Map
1ii7A	2	0.7304	100	0.479	Contact Map
4fbkA	2	0.7745	100	0.481	Contact Map
3thoB	2	0.7745	100	0.486	Contact Map
3av0A	1	0.8603	100	0.504	Contact Map
4nzvA	1	0.7181	100	0.506	Contact Map
2a22A	1	0.4706	99.9	0.716	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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