GREMLIN Database
YHAJ - Uncharacterized membrane protein YhaJ
UniProt: O07518 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (169)
Sequences: 119 (97)
Seq/√Len: 7.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_H161_Q2.9170.84
18_I151_I2.7600.80
149_K152_K2.5970.76
108_F144_F2.4060.70
21_T144_F2.3980.69
4_W168_I2.2660.65
108_F140_C2.2620.64
74_I77_K2.2200.63
55_G139_Y2.1830.62
66_K104_L2.1030.59
136_H140_C2.0610.57
27_I71_L1.9570.53
5_K8_N1.9240.52
63_F161_Q1.9150.51
112_T135_I1.8580.49
57_L121_A1.8570.49
68_I77_K1.8510.49
158_F166_L1.8490.49
69_H160_D1.8170.47
101_L147_A1.8000.47
29_V135_I1.7280.44
127_H141_L1.6910.42
59_V110_L1.6780.42
62_L108_F1.6750.42
87_L125_H1.6730.42
108_F114_V1.6570.41
64_V142_P1.6450.41
1_M154_P1.6430.41
30_F34_F1.6410.40
113_P117_Y1.6270.40
9_L136_H1.6200.40
136_H139_Y1.6000.39
16_V135_I1.5960.39
4_W72_P1.5860.38
68_I117_Y1.5790.38
86_I134_G1.5740.38
34_F119_A1.5690.38
79_K159_I1.5140.36
100_M150_L1.4920.35
55_G59_V1.4670.34
63_F160_D1.4640.34
56_G110_L1.4580.34
59_V116_F1.4150.32
100_M132_I1.3980.32
39_L151_I1.3880.31
51_V54_F1.3860.31
33_T36_A1.3860.31
34_F139_Y1.3810.31
74_I97_K1.3750.31
104_L132_I1.3720.31
77_K97_K1.3670.31
58_L121_A1.3590.30
29_V137_A1.3510.30
3_C17_R1.3180.29
101_L131_M1.3150.29
50_Y96_P1.2990.28
16_V159_I1.2890.28
154_P168_I1.2850.28
112_T137_A1.2730.28
30_F125_H1.2600.27
72_P154_P1.2380.26
2_N136_H1.2360.26
62_L133_S1.2100.26
10_M61_I1.2080.26
12_D153_A1.2040.25
8_N135_I1.1810.25
139_Y157_A1.1770.25
68_I103_S1.1400.24
63_F127_H1.1340.23
23_V134_G1.1320.23
34_F151_I1.1200.23
31_I167_D1.1050.23
70_V104_L1.1020.22
38_E155_K1.0990.22
34_F37_F1.0960.22
54_F59_V1.0940.22
73_I147_A1.0850.22
20_L135_I1.0840.22
141_L155_K1.0730.22
64_V170_V1.0660.21
62_L100_M1.0540.21
95_I119_A1.0540.21
67_V150_L1.0480.21
58_L157_A1.0470.21
48_D140_C1.0390.21
9_L31_I1.0380.21
58_L164_D1.0240.20
62_L161_Q1.0190.20
46_L131_M1.0170.20
97_K169_L1.0110.20
25_F120_L1.0040.20
54_F64_V0.9940.20
31_I164_D0.9920.20
116_F121_A0.9890.20
37_F126_A0.9880.19
97_K128_Y0.9880.19
26_M77_K0.9820.19
75_C99_T0.9820.19
74_I145_L0.9800.19
28_L111_I0.9730.19
89_M104_L0.9670.19
52_S105_V0.9650.19
109_L120_L0.9600.19
128_Y159_I0.9370.18
77_K126_A0.9360.18
65_H107_P0.9350.18
154_P157_A0.9350.18
140_C163_A0.9340.18
57_L101_L0.9310.18
29_V61_I0.9280.18
34_F125_H0.9220.18
102_I105_V0.9200.18
49_E159_I0.9200.18
25_F75_C0.9120.18
38_E54_F0.9110.18
49_E109_L0.9110.18
15_A109_L0.9080.18
77_K153_A0.9050.18
123_P127_H0.9050.18
115_L136_H0.8970.17
97_K161_Q0.8940.17
62_L114_V0.8920.17
1_M11_K0.8810.17
11_K46_L0.8780.17
58_L109_L0.8750.17
61_I68_I0.8740.17
79_K87_L0.8710.17
28_L159_I0.8700.17
26_M138_G0.8660.17
60_V71_L0.8630.17
51_V146_L0.8560.16
23_V53_L0.8520.16
77_K102_I0.8480.16
2_N31_I0.8450.16
17_R78_R0.8390.16
71_L149_K0.8250.16
95_I144_F0.8210.16
37_F136_H0.8190.16
24_C27_I0.8100.15
111_I132_I0.8100.15
100_M104_L0.8070.15
144_F157_A0.7920.15
101_L159_I0.7900.15
55_G76_K0.7860.15
5_K13_Y0.7780.15
33_T137_A0.7780.15
23_V145_L0.7660.15
36_A114_V0.7660.15
84_F166_L0.7650.15
129_F147_A0.7610.14
28_L37_F0.7580.14
146_L159_I0.7570.14
116_F164_D0.7360.14
24_C140_C0.7340.14
128_Y146_L0.7340.14
91_T133_S0.7330.14
104_L133_S0.7310.14
38_E110_L0.7250.14
112_T150_L0.7240.14
138_G142_P0.7230.14
4_W30_F0.7220.14
71_L118_A0.7210.14
4_W13_Y0.7170.14
4_W154_P0.7150.14
6_T154_P0.7110.14
7_I31_I0.7070.13
11_K72_P0.7060.13
63_F91_T0.7020.13
4_W8_N0.6960.13
66_K91_T0.6960.13
68_I109_L0.6960.13
69_H143_D0.6900.13
87_L113_P0.6890.13
31_I44_T0.6890.13
53_L120_L0.6820.13
135_I167_D0.6790.13
108_F136_H0.6780.13
81_E119_A0.6780.13
70_V112_T0.6730.13
59_V64_V0.6710.13
14_G128_Y0.6680.13
4_W153_A0.6670.13
63_F134_G0.6660.13
105_V117_Y0.6650.13
55_G158_F0.6640.13
79_K89_M0.6590.13
127_H135_I0.6580.13
57_L73_I0.6540.12
18_I90_R0.6530.12
56_G122_F0.6500.12
46_L61_I0.6500.12
6_T170_V0.6480.12
122_F145_L0.6470.12
13_Y32_S0.6450.12
18_I85_Y0.6440.12
94_R165_G0.6430.12
63_F148_L0.6420.12
72_P122_F0.6410.12
11_K154_P0.6400.12
150_L166_L0.6390.12
27_I96_P0.6350.12
54_F81_E0.6300.12
23_V88_R0.6280.12
9_L159_I0.6280.12
63_F133_S0.6270.12
48_D127_H0.6260.12
1_M4_W0.6250.12
20_L147_A0.6200.12
22_A94_R0.6190.12
25_F112_T0.6190.12
53_L150_L0.6180.12
73_I115_L0.6160.12
97_K143_D0.6150.12
40_L82_K0.6150.12
95_I104_L0.6120.12
145_L169_L0.6100.12
55_G146_L0.6090.12
30_F168_I0.6040.12
112_T162_E0.6040.12
59_V78_R0.6010.12
78_R119_A0.5990.12
80_I86_I0.5930.11
29_V170_V0.5930.11
100_M140_C0.5920.11
30_F112_T0.5830.11
28_L103_S0.5820.11
135_I162_E0.5740.11
59_V141_L0.5720.11
13_Y77_K0.5700.11
4_W157_A0.5700.11
34_F153_A0.5610.11
8_N150_L0.5560.11
91_T115_L0.5550.11
9_L86_I0.5540.11
45_S80_I0.5500.11
96_P154_P0.5470.11
136_H170_V0.5460.11
29_V112_T0.5430.11
14_G34_F0.5420.11
153_A168_I0.5400.11
140_C170_V0.5340.11
2_N29_V0.5200.10
41_R109_L0.5190.10
97_K145_L0.5190.10
17_R169_L0.5170.10
131_M147_A0.5150.10
16_V20_L0.5150.10
40_L122_F0.5110.10
28_L101_L0.5100.10
66_K90_R0.5090.10
23_V141_L0.5080.10
55_G86_I0.5040.10
80_I166_L0.5020.10
24_C40_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ar4A 1 0.4535 4.7 0.965 Contact Map
1qp6A 2 0.1977 4.5 0.965 Contact Map
4ldeA 1 0.5 4.2 0.966 Contact Map
2lxwA 1 0.1221 3.8 0.966 Contact Map
4ev6A 3 0.4302 3.6 0.967 Contact Map
4yayA 1 0.4535 3.5 0.967 Contact Map
3ixzA 1 0.5 3.2 0.968 Contact Map
4n6hA 1 0.5407 3.1 0.968 Contact Map
4i0uA 4 0.4186 3 0.968 Contact Map
3tkkA 2 0.3372 2.7 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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