GREMLIN Database
YHAH - Uncharacterized membrane protein YhaH
UniProt: O07516 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 118 (111)
Sequences: 176 (142)
Seq/√Len: 13.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_A33_L4.8591.00
61_Q65_A2.9630.97
19_G92_K2.7930.95
99_Q105_I2.3050.88
98_L101_E2.2570.87
5_R79_E2.1930.85
32_Q88_Q2.1120.83
21_A25_T2.0930.82
95_Q113_E2.0550.81
28_S36_K2.0440.81
95_Q112_L2.0400.80
65_A76_V1.9970.79
26_A37_M1.9940.79
91_I94_H1.8000.71
34_R47_T1.7450.69
16_I29_S1.7180.67
26_A110_R1.7040.67
65_A106_E1.6200.63
90_E99_Q1.6110.62
5_R51_L1.5980.62
30_G34_R1.5750.60
22_V69_S1.5740.60
50_R54_D1.5330.58
55_G76_V1.5170.58
95_Q105_I1.4460.54
18_G90_E1.4150.52
48_I52_K1.4140.52
9_T66_A1.4110.52
27_P32_Q1.3980.51
4_G7_L1.3940.51
105_I113_E1.3590.49
83_S95_Q1.3200.47
105_I112_L1.3150.47
37_M44_F1.2860.45
84_I104_D1.2850.45
18_G22_V1.2820.45
12_F80_L1.2680.44
45_E81_Q1.2680.44
58_L75_D1.2020.41
42_D54_D1.1930.40
22_V48_I1.1830.40
69_S108_K1.1460.38
84_I89_E1.1420.38
34_R113_E1.1410.38
22_V94_H1.1300.37
47_T51_L1.1240.37
7_L28_S1.1070.36
101_E109_I1.0770.35
99_Q107_E1.0700.34
56_L67_K1.0650.34
32_Q87_W1.0570.34
25_T38_K1.0480.33
52_K59_K1.0240.32
106_E110_R1.0230.32
62_L95_Q1.0130.32
18_G104_D1.0120.32
80_L100_K1.0100.31
68_E79_E1.0000.31
58_L66_A0.9880.30
4_G61_Q0.9820.30
17_I21_A0.9790.30
19_G41_Y0.9780.30
8_L81_Q0.9650.29
7_L74_K0.9650.29
57_A99_Q0.9530.29
34_R37_M0.9490.29
69_S74_K0.9440.29
11_L20_A0.9430.28
28_S41_Y0.9400.28
18_G92_K0.9260.28
50_R62_L0.9250.28
5_R43_S0.9240.28
55_G61_Q0.9230.28
13_V37_M0.8890.26
7_L78_G0.8760.26
11_L74_K0.8710.25
81_Q84_I0.8700.25
58_L69_S0.8660.25
34_R95_Q0.8620.25
87_W103_A0.8620.25
83_S87_W0.8580.25
42_D49_K0.8560.25
7_L69_S0.8550.25
22_V87_W0.8520.25
19_G90_E0.8480.25
64_K114_K0.8380.24
65_A70_T0.8250.24
73_I86_K0.8190.23
22_V91_I0.8170.23
66_A105_I0.8030.23
38_K51_L0.7940.22
15_G24_L0.7910.22
61_Q98_L0.7910.22
17_I31_K0.7840.22
25_T80_L0.7740.22
66_A81_Q0.7690.22
19_G104_D0.7630.21
31_K74_K0.7570.21
24_L42_D0.7540.21
36_K62_L0.7420.21
7_L87_W0.7340.20
77_G82_T0.7330.20
37_M63_I0.7050.19
10_G14_G0.7040.19
59_K62_L0.7000.19
47_T84_I0.6980.19
24_L106_E0.6970.19
31_K88_Q0.6950.19
38_K110_R0.6910.19
54_D65_A0.6850.19
9_T56_L0.6800.19
79_E102_I0.6730.18
65_A88_Q0.6690.18
70_T106_E0.6660.18
106_E113_E0.6630.18
109_I113_E0.6610.18
66_A90_E0.6570.18
28_S32_Q0.6550.18
18_G88_Q0.6470.17
10_G30_G0.6460.17
21_A33_L0.6460.17
11_L46_E0.6420.17
49_K73_I0.6350.17
21_A68_E0.6300.17
56_L82_T0.6280.17
66_A70_T0.6170.17
22_V33_L0.6080.16
14_G30_G0.6050.16
45_E78_G0.6040.16
105_I108_K0.5910.16
28_S102_I0.5860.16
15_G79_E0.5810.16
96_Q114_K0.5640.15
25_T104_D0.5640.15
18_G65_A0.5620.15
76_V98_L0.5620.15
50_R111_Q0.5620.15
54_D77_G0.5610.15
83_S101_E0.5600.15
24_L79_E0.5570.15
51_L75_D0.5530.15
94_H102_I0.5520.15
83_S108_K0.5490.15
9_T54_D0.5480.15
68_E89_E0.5460.15
35_E79_E0.5380.14
103_A108_K0.5340.14
66_A83_S0.5330.14
11_L97_D0.5330.14
15_G34_R0.5330.14
85_K114_K0.5310.14
34_R40_N0.5290.14
55_G62_L0.5240.14
83_S90_E0.5220.14
60_D96_Q0.5210.14
7_L54_D0.5200.14
17_I42_D0.5190.14
98_L105_I0.5180.14
12_F105_I0.5160.14
8_L105_I0.5160.14
58_L101_E0.5150.14
90_E104_D0.5150.14
32_Q48_I0.5080.14
35_E80_L0.5050.14
16_I111_Q0.5050.14
26_A64_K0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q4gX 1 0 94.9 0.831 Contact Map
4cgkA 3 0.5508 93.1 0.844 Contact Map
4aurA 1 0.8644 82.3 0.872 Contact Map
3qprA 8 0.0085 78.4 0.877 Contact Map
3s84A 2 0.8814 75.3 0.88 Contact Map
4rsiB 1 0.9068 70.5 0.884 Contact Map
3ghgB 3 0.8983 68.4 0.886 Contact Map
2nrjA 1 0.8814 60.3 0.892 Contact Map
3r2pA 2 0.7542 57.2 0.894 Contact Map
1i5pA 1 0.9153 56.5 0.894 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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