GREMLIN Database
TRPP - Probable tryptophan transport protein
UniProt: O07515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 172 (165)
Sequences: 181 (155)
Seq/√Len: 12.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
64_A73_Q7.0691.00
86_L113_L3.8340.99
56_G84_A3.1370.97
30_M139_V2.8020.94
53_L56_G2.5570.90
78_I121_S2.3260.85
44_L155_Y2.2950.84
49_V85_F2.1880.81
82_V101_G2.1790.81
126_V129_P2.1110.79
42_G55_I2.1030.78
20_H66_T2.1000.78
18_A143_A1.9810.74
2_K5_E1.9760.74
79_D121_S1.8780.70
129_P135_L1.8670.69
75_P121_S1.8630.69
69_F122_A1.8330.68
107_T151_M1.8300.68
43_I91_F1.8210.67
31_K68_A1.7960.66
69_F135_L1.7800.66
35_M39_M1.7580.65
25_P29_G1.6930.61
67_T73_Q1.6450.59
59_T65_L1.6070.57
122_A135_L1.5920.57
4_K138_A1.5520.55
35_M62_I1.5140.53
141_L145_V1.5050.52
25_P68_A1.5010.52
25_P64_A1.4870.51
14_A153_I1.4790.51
65_L113_L1.4750.51
2_K101_G1.4680.50
109_I152_I1.4360.49
75_P122_A1.4120.48
134_A138_A1.4090.47
132_F136_F1.4090.47
3_T7_V1.4050.47
9_M151_M1.4030.47
85_F117_V1.3980.47
91_F130_G1.3890.46
69_F129_P1.3800.46
64_A123_L1.3620.45
117_V127_G1.3530.45
9_M42_G1.3510.44
31_K107_T1.3460.44
116_I136_F1.2990.42
12_F102_A1.2950.42
9_M51_N1.2870.41
88_F145_V1.2650.40
32_P143_A1.2510.40
2_K9_M1.2480.39
43_I87_F1.2360.39
48_R153_I1.2340.39
82_V117_V1.1970.37
13_A59_T1.1940.37
139_V143_A1.1900.37
30_M68_A1.1850.36
11_L76_N1.1840.36
81_P88_F1.1770.36
131_G137_A1.1680.36
40_F143_A1.1680.36
67_T81_P1.1630.35
105_V149_I1.1570.35
46_F156_P1.1560.35
20_H67_T1.1400.34
112_I144_A1.1320.34
3_T6_L1.1190.33
71_A127_G1.1160.33
65_L124_L1.1070.33
108_V148_T1.0870.32
122_A143_A1.0850.32
64_A67_T1.0830.32
101_G112_I1.0810.32
56_G75_P1.0770.32
81_P159_Q1.0580.31
43_I74_I1.0510.30
45_L164_R1.0350.30
65_L105_V1.0160.29
13_A55_I1.0160.29
25_P148_T1.0090.29
25_P73_Q1.0090.29
111_T147_N1.0080.29
59_T164_R1.0060.29
154_I165_S0.9950.28
2_K17_A0.9920.28
15_I153_I0.9870.28
109_I146_L0.9760.27
29_G63_S0.9720.27
18_A63_S0.9660.27
100_T156_P0.9570.27
5_E9_M0.9420.26
82_V86_L0.9420.26
59_T103_A0.9410.26
17_A62_I0.9280.25
103_A117_V0.9250.25
96_K136_F0.9150.25
75_P112_I0.9120.25
9_M14_A0.9090.25
30_M135_L0.9060.25
98_R105_V0.8960.24
42_G51_N0.8950.24
32_P139_V0.8950.24
45_L131_G0.8920.24
9_M46_F0.8890.24
28_G112_I0.8890.24
42_G46_F0.8820.24
25_P75_P0.8810.24
11_L151_M0.8810.24
109_I134_A0.8760.24
109_I113_L0.8750.24
44_L124_L0.8700.23
10_A153_I0.8690.23
47_P84_A0.8630.23
21_S49_V0.8620.23
69_F126_V0.8580.23
48_R51_N0.8560.23
6_L59_T0.8520.23
56_G100_T0.8460.22
12_F125_I0.8410.22
63_S108_V0.8400.22
18_A153_I0.8330.22
6_L45_L0.8300.22
73_Q123_L0.8270.22
105_V141_L0.8260.22
75_P125_I0.8200.22
74_I120_S0.8190.22
107_T148_T0.8190.22
75_P78_I0.8080.21
104_A152_I0.8060.21
48_R104_A0.8040.21
34_M41_M0.8030.21
39_M55_I0.7990.21
63_S161_I0.7950.21
133_A149_I0.7950.21
34_M151_M0.7940.21
88_F123_L0.7840.20
44_L105_V0.7770.20
148_T152_I0.7720.20
116_I134_A0.7690.20
2_K67_T0.7660.20
148_T159_Q0.7640.20
63_S156_P0.7630.20
23_I37_I0.7620.20
145_V165_S0.7590.20
121_S129_P0.7590.20
30_M69_F0.7510.19
12_F163_R0.7470.19
25_P57_I0.7440.19
10_A98_R0.7330.19
2_K133_A0.7280.19
6_L52_V0.7200.18
124_L144_A0.7140.18
5_E75_P0.7140.18
113_L121_S0.7140.18
81_P90_L0.7130.18
9_M18_A0.7110.18
91_F148_T0.7040.18
22_I43_I0.6880.17
18_A28_G0.6800.17
17_A46_F0.6800.17
15_I123_L0.6750.17
161_I165_S0.6750.17
2_K50_Q0.6670.17
43_I55_I0.6640.17
7_V11_L0.6600.17
61_I149_I0.6570.17
56_G99_K0.6510.16
105_V153_I0.6490.16
5_E8_I0.6470.16
43_I109_I0.6430.16
16_G20_H0.6410.16
66_T151_M0.6330.16
86_L93_L0.6320.16
34_M130_G0.6230.16
90_L109_I0.6190.16
96_K150_S0.6190.16
9_M55_I0.6180.15
71_A74_I0.6170.15
58_V67_T0.6140.15
14_A160_T0.6110.15
151_M156_P0.6110.15
145_V161_I0.6090.15
18_A22_I0.6060.15
41_M151_M0.6040.15
10_A61_I0.6030.15
6_L32_P0.6030.15
13_A18_A0.6020.15
4_K10_A0.6000.15
27_L31_K0.5980.15
17_A95_R0.5970.15
87_F95_R0.5970.15
25_P38_M0.5950.15
45_L59_T0.5950.15
27_L34_M0.5920.15
160_T163_R0.5920.15
34_M81_P0.5910.15
75_P116_I0.5880.15
76_N83_S0.5850.15
6_L164_R0.5830.15
112_I153_I0.5820.15
153_I156_P0.5780.14
143_A162_L0.5760.14
31_K66_T0.5750.14
86_L138_A0.5730.14
32_P38_M0.5710.14
49_V156_P0.5710.14
83_S147_N0.5660.14
84_A87_F0.5660.14
12_F155_Y0.5660.14
22_I153_I0.5630.14
77_I99_K0.5610.14
57_I82_V0.5610.14
91_F98_R0.5600.14
27_L44_L0.5590.14
117_V124_L0.5540.14
126_V143_A0.5510.14
14_A42_G0.5480.14
25_P31_K0.5470.14
82_V92_L0.5440.14
71_A144_A0.5440.14
37_I134_A0.5430.14
126_V135_L0.5390.14
130_G138_A0.5360.13
18_A161_I0.5350.13
128_L132_F0.5340.13
53_L57_I0.5320.13
113_L144_A0.5310.13
8_I91_F0.5300.13
82_V120_S0.5280.13
38_M59_T0.5280.13
87_F113_L0.5250.13
46_F55_I0.5230.13
136_F149_I0.5180.13
1_M119_L0.5170.13
93_L124_L0.5160.13
125_I158_V0.5140.13
23_I75_P0.5140.13
106_L161_I0.5120.13
35_M124_L0.5100.13
30_M138_A0.5080.13
20_H33_D0.5060.13
5_E157_I0.5030.13
43_I52_V0.5030.13
109_I137_A0.5010.13
77_I121_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rfsS 1 0.9244 98.9 0.823 Contact Map
3p5nA 2 0.8953 98.7 0.836 Contact Map
3rlbA 1 0.9419 98.6 0.841 Contact Map
4hzuS 1 0.9128 98.2 0.86 Contact Map
4tkrA 2 0.9244 97.8 0.872 Contact Map
4huqS 1 0.9012 97.7 0.876 Contact Map
4z7fA 2 0.9186 97.6 0.877 Contact Map
4dveA 3 0.9477 94.1 0.912 Contact Map
4czbA 2 0.8488 4.1 0.967 Contact Map
3hzqA 3 0.4419 3.7 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0072 seconds.