GREMLIN Database
HIT - Protein hit
UniProt: O07513 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 145 (132)
Sequences: 4283 (2854)
Seq/√Len: 248.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_C10_C3.3991.00
27_H63_Q3.0661.00
24_E47_K3.0401.00
48_T60_L2.9981.00
10_C49_H2.7251.00
28_V67_A2.7251.00
7_C49_H2.7041.00
58_D69_P2.6601.00
57_T60_L2.4181.00
25_D63_Q2.4021.00
68_V103_M2.3661.00
31_F45_I2.1061.00
56_F101_Y2.0021.00
28_V63_Q1.9951.00
11_K16_D1.9521.00
58_D66_H1.9061.00
20_A132_Q1.9051.00
15_G21_K1.8921.00
62_K66_H1.8881.00
19_S29_L1.7411.00
133_N137_S1.7071.00
48_T57_T1.6971.00
10_C14_A1.6891.00
64_Y103_M1.6771.00
21_K29_L1.6741.00
23_Y67_A1.6251.00
126_Y131_L1.5771.00
42_T71_I1.5681.00
22_V42_T1.4961.00
85_N108_R1.4781.00
50_I57_T1.4771.00
29_L47_K1.4251.00
39_K130_D1.4241.00
132_Q136_S1.4191.00
61_A65_F1.4111.00
82_I93_K1.3941.00
52_N55_E1.3901.00
135_S139_A1.3791.00
74_A78_E1.3581.00
69_P73_R1.3321.00
65_F103_M1.3091.00
76_R84_L1.2671.00
21_K24_E1.2411.00
44_V68_V1.2351.00
54_Y76_R1.2151.00
12_I19_S1.1911.00
88_N103_M1.1641.00
50_I56_F1.1601.00
61_A69_P1.1491.00
29_L45_I1.1261.00
38_T109_Y1.1121.00
50_I60_L1.1111.00
32_L42_T1.1091.00
44_V105_I1.0971.00
128_P132_Q1.0881.00
127_K130_D1.0851.00
126_Y134_I1.0841.00
64_Y101_Y1.0791.00
52_N76_R1.0651.00
93_K110_G1.0651.00
30_A42_T1.0481.00
51_E55_E1.0481.00
118_V121_T1.0321.00
75_I138_I1.0281.00
75_I105_I1.0271.00
20_A128_P1.0251.00
30_A71_I1.0241.00
20_A131_L1.0211.00
9_F98_V1.0181.00
51_E91_G1.0161.00
53_V65_F0.9931.00
20_A32_L0.9811.00
39_K137_S0.9711.00
131_L135_S0.9461.00
81_P109_Y0.9411.00
68_V86_T0.9261.00
85_N89_N0.9251.00
27_H60_L0.9231.00
133_N136_S0.9221.00
11_K17_I0.9211.00
129_E132_Q0.9121.00
65_F68_V0.9111.00
130_D133_N0.8881.00
63_Q67_A0.8811.00
79_F134_I0.8781.00
25_D70_K0.8560.99
42_T75_I0.8540.99
40_G107_P0.8490.99
25_D67_A0.8400.99
72_A84_L0.8380.99
51_E99_F0.8270.99
116_G119_W0.8250.99
56_F60_L0.8200.99
38_T106_I0.8130.99
8_I98_V0.8120.99
52_N91_G0.8030.99
6_N11_K0.8030.99
88_N101_Y0.7990.99
136_S139_A0.7970.99
58_D62_K0.7920.99
83_G93_K0.7910.99
72_A76_R0.7880.99
13_I45_I0.7780.99
56_F61_A0.7760.99
50_I55_E0.7740.99
86_T103_M0.7730.99
128_P131_L0.7720.99
30_A67_A0.7720.99
78_E137_S0.7680.99
82_I109_Y0.7600.99
82_I110_G0.7550.99
13_I29_L0.7480.98
50_I101_Y0.7460.98
66_H69_P0.7460.98
52_N99_F0.7410.98
39_K134_I0.7400.98
96_Q99_F0.7200.98
85_N94_A0.7150.98
8_I11_K0.7110.98
76_R91_G0.7080.98
84_L105_I0.6920.97
13_I47_K0.6910.97
126_Y130_D0.6880.97
129_E133_N0.6860.97
12_I34_I0.6820.97
74_A138_I0.6790.97
135_S138_I0.6690.97
75_I81_P0.6670.97
54_Y73_R0.6610.97
66_H70_K0.6590.97
60_L63_Q0.6580.97
91_G94_A0.6550.96
125_D128_P0.6510.96
20_A135_S0.6430.96
115_F118_V0.6340.96
15_G19_S0.6320.96
28_V64_Y0.6260.95
122_H125_D0.6240.95
54_Y84_L0.6220.95
126_Y129_E0.6220.95
92_E99_F0.6190.95
134_I137_S0.6170.95
76_R81_P0.6150.95
8_I17_I0.6120.95
53_V86_T0.6080.95
25_D28_V0.6080.95
116_G120_K0.6080.95
132_Q139_A0.6070.95
114_G117_A0.6060.95
22_V139_A0.6050.95
131_L134_I0.6030.94
118_V122_H0.6010.94
52_N90_N0.6010.94
108_R112_G0.5960.94
20_A34_I0.5950.94
130_D134_I0.5940.94
12_I31_F0.5940.94
81_P84_L0.5940.94
79_F109_Y0.5930.94
12_I45_I0.5920.94
37_V87_L0.5840.93
39_K133_N0.5680.92
9_F45_I0.5670.92
33_D106_I0.5620.92
78_E138_I0.5590.92
37_V97_S0.5580.92
83_G108_R0.5560.92
109_Y112_G0.5550.92
63_Q66_H0.5550.92
6_N14_A0.5530.91
54_Y72_A0.5430.91
78_E81_P0.5400.90
108_R111_K0.5340.90
72_A86_T0.5340.90
32_L131_L0.5330.90
44_V67_A0.5330.90
85_N106_I0.5320.90
12_I15_G0.5300.90
30_A44_V0.5290.90
68_V75_I0.5280.89
117_A121_T0.5250.89
23_Y30_A0.5240.89
127_K132_Q0.5220.89
83_G96_Q0.5170.89
41_H104_H0.5170.89
129_E137_S0.5140.88
117_A120_K0.5130.88
71_I74_A0.5130.88
53_V88_N0.5120.88
35_S125_D0.5100.88
119_W122_H0.5080.88
70_K74_A0.5070.88
96_Q108_R0.5030.87
56_F64_Y0.5020.87
61_A66_H0.5010.87
87_L106_I0.5000.87
62_K65_F0.5000.87
21_K47_K0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ksvA 2 0.9586 100 0.208 Contact Map
1y23A 2 0.9724 100 0.225 Contact Map
3l7xA 2 0.9586 100 0.232 Contact Map
3imiA 2 0.9793 100 0.233 Contact Map
3lb5A 2 0.9448 100 0.24 Contact Map
2eo4A 2 0.9448 100 0.259 Contact Map
3anoA 4 0.9862 100 0.261 Contact Map
3o0mA 2 0.9241 100 0.274 Contact Map
1emsA 3 0.8828 100 0.282 Contact Map
3r6fA 2 0.8966 100 0.295 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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