PROJ - BACSU - GREMLIN Contacts

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PROJ - Glutamate 5-kinase 2

UniProt:	O07509	Sequences: MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDAGYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVASQILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVAGLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMRSKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFNSGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVNYSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	371 (361)
Sequences:	2585 (1564)
Seq/√Len:	82.3

ECOLI - PROB
BACSU - PROJ PROB

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
9_R	47_E	4.692	1.00
320_L	362_C	4.516	1.00
285_L	320_L	4.268	1.00
180_G	185_N	3.842	1.00
247_H	252_Q	3.749	1.00
56_V	147_L	3.736	1.00
287_D	323_S	3.627	1.00
346_K	354_L	3.518	1.00
12_V	38_V	3.433	1.00
80_S	102_S	3.328	1.00
16_S	57_A	3.327	1.00
283_M	318_V	3.163	1.00
340_L	361_V	3.162	1.00
124_M	136_I	3.096	1.00
290_S	322_D	3.090	1.00
202_E	225_K	3.034	1.00
322_D	326_T	2.989	1.00
49_I	163_I	2.970	1.00
327_E	330_L	2.959	1.00
305_V	361_V	2.846	1.00
282_E	309_K	2.764	1.00
176_G	190_K	2.752	1.00
319_R	327_E	2.721	1.00
284_I	307_K	2.721	1.00
193_R	259_E	2.712	1.00
179_D	189_K	2.681	1.00
42_K	131_G	2.634	1.00
346_K	350_T	2.608	1.00
18_S	239_A	2.577	1.00
282_E	321_M	2.530	1.00
341_Q	344_E	2.526	1.00
194_V	258_F	2.521	1.00
241_A	247_H	2.438	1.00
179_D	185_N	2.420	1.00
233_K	260_A	2.416	1.00
280_E	316_S	2.404	1.00
35_V	93_L	2.368	1.00
110_D	116_R	2.287	1.00
285_L	290_S	2.278	1.00
177_L	194_V	2.247	1.00
169_V	245_L	2.215	1.00
291_R	295_N	2.108	1.00
194_V	256_T	2.057	1.00
42_K	99_Y	2.049	1.00
71_K	74_E	2.020	1.00
175_D	238_Q	1.999	1.00
306_Q	323_S	1.979	1.00
290_S	328_I	1.915	1.00
120_V	162_L	1.909	1.00
180_G	187_E	1.865	1.00
285_L	293_I	1.864	1.00
284_I	309_K	1.853	1.00
233_K	257_Y	1.790	1.00
99_Y	133_I	1.769	1.00
284_I	323_S	1.765	1.00
14_I	50_L	1.747	1.00
74_E	126_V	1.724	1.00
334_N	366_F	1.720	1.00
228_M	234_G	1.693	1.00
282_E	319_R	1.693	1.00
180_G	188_A	1.691	1.00
38_V	48_V	1.681	1.00
195_S	259_E	1.661	1.00
39_V	99_Y	1.650	1.00
16_S	212_V	1.648	1.00
36_D	96_A	1.633	1.00
288_D	304_G	1.632	1.00
37_Q	243_D	1.628	1.00
10_V	46_Y	1.618	1.00
318_V	333_V	1.589	1.00
32_E	93_L	1.586	1.00
36_D	97_H	1.581	1.00
288_D	292_K	1.577	1.00
339_Q	357_Q	1.564	1.00
237_G	244_I	1.560	1.00
44_A	250_H	1.544	1.00
38_V	50_L	1.544	1.00
206_G	210_S	1.532	0.99
14_I	34_L	1.528	0.99
94_F	101_A	1.527	0.99
343_P	351_N	1.509	0.99
35_V	94_F	1.474	0.99
40_K	246_Y	1.434	0.99
156_A	168_L	1.424	0.99
88_E	92_K	1.419	0.99
31_L	89_A	1.411	0.99
11_V	165_A	1.373	0.99
182_P	188_A	1.370	0.99
317_V	332_I	1.370	0.99
38_V	133_I	1.355	0.99
104_I	141_T	1.349	0.99
171_L	237_G	1.341	0.99
84_G	87_M	1.336	0.99
313_K	336_S	1.333	0.99
32_E	96_A	1.328	0.99
94_F	133_I	1.319	0.98
287_D	324_K	1.312	0.98
114_E	118_N	1.312	0.98
68_R	75_K	1.303	0.98
7_M	46_Y	1.303	0.98
154_T	222_D	1.300	0.98
288_D	301_Y	1.290	0.98
178_Y	182_P	1.279	0.98
339_Q	342_E	1.279	0.98
12_V	245_L	1.271	0.98
290_S	294_T	1.257	0.98
289_C	300_L	1.248	0.98
202_E	221_L	1.231	0.98
50_L	90_Y	1.227	0.98
191_I	204_C	1.227	0.98
154_T	226_I	1.221	0.97
168_L	234_G	1.204	0.97
286_S	304_G	1.197	0.97
287_D	290_S	1.192	0.97
237_G	248_A	1.190	0.97
26_I	58_A	1.190	0.97
160_A	232_I	1.181	0.97
243_D	247_H	1.177	0.97
93_L	96_A	1.172	0.97
350_T	353_A	1.171	0.97
337_S	341_Q	1.159	0.97
289_C	304_G	1.157	0.96
123_T	127_L	1.142	0.96
284_I	321_M	1.133	0.96
126_V	129_E	1.132	0.96
227_V	234_G	1.130	0.96
32_E	36_D	1.129	0.96
302_L	351_N	1.117	0.96
235_F	248_A	1.115	0.96
311_K	337_S	1.112	0.96
301_Y	304_G	1.101	0.95
63_L	78_S	1.101	0.95
25_E	61_R	1.091	0.95
33_A	36_D	1.088	0.95
308_I	340_L	1.077	0.95
40_K	43_D	1.071	0.95
60_Y	69_P	1.069	0.95
28_I	92_K	1.067	0.94
321_M	327_E	1.065	0.94
345_K	348_E	1.062	0.94
307_K	344_E	1.059	0.94
289_C	292_K	1.055	0.94
42_K	133_I	1.053	0.94
109_S	113_D	1.050	0.94
191_I	194_V	1.042	0.94
7_M	167_M	1.041	0.94
62_K	91_S	1.038	0.94
297_Q	364_V	1.038	0.94
114_E	272_W	1.038	0.94
177_L	191_I	1.033	0.93
34_L	90_Y	1.027	0.93
109_S	116_R	1.026	0.93
331_G	362_C	1.026	0.93
299_S	363_H	1.018	0.93
288_D	299_S	1.015	0.93
302_L	345_K	1.013	0.93
17_S	213_G	1.010	0.93
247_H	254_E	1.008	0.93
287_D	291_R	1.007	0.93
104_I	124_M	1.006	0.93
246_Y	250_H	1.006	0.93
222_D	226_I	1.004	0.92
19_L	26_I	0.998	0.92
329_G	367_S	0.993	0.92
279_P	319_R	0.990	0.92
175_D	241_A	0.989	0.92
75_K	214_T	0.989	0.92
37_Q	244_I	0.982	0.92
206_G	209_G	0.976	0.91
175_D	178_Y	0.973	0.91
238_Q	241_A	0.972	0.91
16_S	25_E	0.970	0.91
8_K	46_Y	0.965	0.91
14_I	19_L	0.963	0.91
181_N	206_G	0.962	0.91
123_T	141_T	0.959	0.91
63_L	81_I	0.950	0.90
169_V	248_A	0.947	0.90
320_L	329_G	0.945	0.90
286_S	301_Y	0.944	0.90
20_T	27_S	0.942	0.90
176_G	236_L	0.937	0.90
144_V	148_K	0.937	0.90
299_S	304_G	0.934	0.89
42_K	48_V	0.933	0.89
16_S	156_A	0.930	0.89
243_D	246_Y	0.926	0.89
174_I	178_Y	0.925	0.89
308_I	312_F	0.923	0.89
167_M	233_K	0.920	0.89
14_I	38_V	0.918	0.89
20_T	58_A	0.917	0.89
302_L	348_E	0.913	0.88
78_S	81_I	0.908	0.88
76_Q	119_N	0.906	0.88
106_I	120_V	0.904	0.88
154_T	219_S	0.904	0.88
40_K	44_A	0.902	0.88
89_A	93_L	0.900	0.88
305_V	340_L	0.899	0.88
60_Y	78_S	0.896	0.87
336_S	339_Q	0.893	0.87
17_S	173_D	0.886	0.87
50_L	133_I	0.886	0.87
12_V	171_L	0.885	0.87
190_K	254_E	0.874	0.86
363_H	367_S	0.874	0.86
128_L	134_P	0.872	0.86
60_Y	68_R	0.870	0.86
102_S	127_L	0.867	0.86
10_V	41_L	0.865	0.86
180_G	186_P	0.865	0.86
31_L	35_V	0.864	0.85
286_S	289_C	0.855	0.85
277_S	317_V	0.850	0.85
172_S	258_F	0.847	0.84
197_I	201_I	0.846	0.84
334_N	360_F	0.845	0.84
335_Y	343_P	0.843	0.84
318_V	362_C	0.834	0.83
18_S	30_K	0.832	0.83
319_R	330_L	0.832	0.83
343_P	355_I	0.832	0.83
17_S	214_T	0.827	0.83
248_A	251_E	0.827	0.83
124_M	128_L	0.823	0.83
97_H	101_A	0.822	0.83
173_D	182_P	0.821	0.82
190_K	253_A	0.819	0.82
58_A	85_L	0.819	0.82
174_I	183_R	0.816	0.82
279_P	330_L	0.811	0.82
70_E	135_I	0.810	0.82
27_S	240_D	0.808	0.81
10_V	249_V	0.807	0.81
362_C	367_S	0.806	0.81
285_L	328_I	0.804	0.81
56_V	75_K	0.796	0.80
183_R	209_G	0.792	0.80
228_M	258_F	0.791	0.80
71_K	126_V	0.788	0.80
283_M	344_E	0.788	0.80
35_V	39_V	0.787	0.80
181_N	188_A	0.786	0.80
235_F	257_Y	0.783	0.79
41_L	46_Y	0.782	0.79
74_E	130_R	0.780	0.79
91_S	101_A	0.775	0.79
167_M	257_Y	0.772	0.78
39_V	97_H	0.768	0.78
234_G	258_F	0.768	0.78
65_F	78_S	0.764	0.78
43_D	99_Y	0.763	0.78
286_S	299_S	0.763	0.78
80_S	141_T	0.762	0.77
20_T	57_A	0.762	0.77
121_R	125_N	0.760	0.77
205_A	208_T	0.756	0.77
290_S	323_S	0.753	0.77
47_E	129_E	0.751	0.76
185_N	189_K	0.750	0.76
333_V	336_S	0.749	0.76
149_F	219_S	0.747	0.76
311_K	341_Q	0.747	0.76
236_L	258_F	0.746	0.76
208_T	213_G	0.745	0.76
31_L	93_L	0.744	0.76
218_R	222_D	0.737	0.75
120_V	159_V	0.736	0.75
237_G	241_A	0.735	0.75
360_F	363_H	0.735	0.75
77_A	127_L	0.734	0.75
73_P	122_N	0.732	0.75
332_I	356_D	0.730	0.74
60_Y	75_K	0.729	0.74
27_S	30_K	0.729	0.74
243_D	250_H	0.728	0.74
9_R	125_N	0.727	0.74
160_A	168_L	0.723	0.74
47_E	131_G	0.721	0.73
109_S	115_Y	0.717	0.73
245_L	248_A	0.717	0.73
289_C	299_S	0.716	0.73
222_D	225_K	0.716	0.73
56_V	72_L	0.714	0.73
201_I	204_C	0.714	0.73
344_E	348_E	0.712	0.73
348_E	351_N	0.711	0.72
192_Q	253_A	0.710	0.72
351_N	357_Q	0.709	0.72
84_G	274_A	0.708	0.72
21_S	27_S	0.706	0.72
259_E	316_S	0.706	0.72
282_E	318_V	0.705	0.72
161_G	271_Q	0.705	0.72
219_S	234_G	0.704	0.72
200_D	203_A	0.704	0.72
161_G	230_S	0.699	0.71
49_I	136_I	0.697	0.71
172_S	234_G	0.694	0.71
27_S	58_A	0.692	0.70
251_E	255_G	0.691	0.70
8_K	166_D	0.691	0.70
57_A	212_V	0.691	0.70
20_T	26_I	0.691	0.70
269_K	332_I	0.689	0.70
287_D	322_D	0.687	0.70
338_V	341_Q	0.687	0.70
161_G	232_I	0.687	0.70
334_N	358_E	0.687	0.70
293_I	319_R	0.685	0.70
45_G	98_G	0.684	0.70
221_L	258_F	0.683	0.69
342_E	354_L	0.683	0.69
111_F	120_V	0.683	0.69
65_F	69_P	0.683	0.69
119_N	144_V	0.681	0.69
283_M	320_L	0.681	0.69
194_V	201_I	0.680	0.69
189_K	250_H	0.679	0.69
307_K	341_Q	0.678	0.69
106_I	159_V	0.677	0.69
121_R	164_D	0.677	0.69
145_N	148_K	0.674	0.68
19_L	172_S	0.673	0.68
279_P	327_E	0.672	0.68
30_K	172_S	0.672	0.68
244_I	247_H	0.670	0.68
302_L	335_Y	0.670	0.68
270_E	299_S	0.668	0.68
28_I	32_E	0.667	0.68
111_F	158_K	0.666	0.67
352_R	357_Q	0.665	0.67
167_M	235_F	0.664	0.67
288_D	303_D	0.661	0.67
284_I	287_D	0.661	0.67
49_I	278_G	0.660	0.67
90_Y	210_S	0.658	0.67
173_D	178_Y	0.657	0.66
148_K	154_T	0.657	0.66
56_V	67_Q	0.656	0.66
148_K	214_T	0.656	0.66
308_I	341_Q	0.656	0.66
284_I	306_Q	0.655	0.66
144_V	227_V	0.654	0.66
306_Q	321_M	0.651	0.66
269_K	366_F	0.650	0.66
313_K	316_S	0.649	0.65
118_N	121_R	0.648	0.65
76_Q	146_R	0.647	0.65
29_R	32_E	0.647	0.65
293_I	300_L	0.640	0.64
350_T	354_L	0.640	0.64
294_T	326_T	0.640	0.64
292_K	304_G	0.639	0.64
347_K	350_T	0.638	0.64
111_F	149_F	0.638	0.64
343_P	348_E	0.636	0.64
281_G	312_F	0.634	0.64
120_V	181_N	0.634	0.64
271_Q	276_N	0.634	0.64
272_W	312_F	0.632	0.63
135_I	336_S	0.631	0.63
177_L	236_L	0.629	0.63
335_Y	357_Q	0.629	0.63
88_E	91_S	0.628	0.63
18_S	277_S	0.628	0.63
26_I	89_A	0.628	0.63
221_L	236_L	0.626	0.63
284_I	308_I	0.625	0.63
84_G	91_S	0.625	0.63
108_R	276_N	0.623	0.62
173_D	188_A	0.623	0.62
235_F	254_E	0.621	0.62
293_I	369_P	0.621	0.62
227_V	232_I	0.621	0.62
288_D	348_E	0.619	0.62
50_L	273_I	0.619	0.62
193_R	257_Y	0.619	0.62
197_I	221_L	0.616	0.61
33_A	243_D	0.616	0.61
35_V	90_Y	0.616	0.61
65_F	81_I	0.615	0.61
358_E	366_F	0.615	0.61
29_R	36_D	0.613	0.61
102_S	161_G	0.613	0.61
55_A	78_S	0.611	0.61
108_R	154_T	0.611	0.61
331_G	363_H	0.609	0.61
209_G	214_T	0.608	0.60
289_C	301_Y	0.608	0.60
24_G	210_S	0.607	0.60
200_D	205_A	0.603	0.60
113_D	116_R	0.603	0.60
298_S	303_D	0.603	0.60
308_I	337_S	0.603	0.60
67_Q	70_E	0.601	0.60
207_D	218_R	0.599	0.59
287_D	353_A	0.599	0.59
270_E	331_G	0.596	0.59
150_G	214_T	0.596	0.59
191_I	208_T	0.595	0.59
181_N	185_N	0.593	0.59
283_M	333_V	0.592	0.58
176_G	315_G	0.592	0.58
112_S	158_K	0.589	0.58
47_E	128_L	0.587	0.58
206_G	221_L	0.585	0.58
303_D	345_K	0.585	0.58
173_D	209_G	0.584	0.57
364_V	367_S	0.581	0.57
146_R	301_Y	0.581	0.57
48_V	133_I	0.581	0.57
149_F	158_K	0.580	0.57
284_I	318_V	0.580	0.57
25_E	142_V	0.580	0.57
171_L	244_I	0.580	0.57
286_S	292_K	0.580	0.57
197_I	202_E	0.579	0.57
305_V	352_R	0.579	0.57
73_P	115_Y	0.579	0.57
36_D	204_C	0.578	0.57
354_L	357_Q	0.578	0.57
43_D	92_K	0.575	0.56
270_E	363_H	0.574	0.56
149_F	214_T	0.573	0.56
93_L	101_A	0.573	0.56
60_Y	212_V	0.573	0.56
340_L	344_E	0.572	0.56
39_V	42_K	0.571	0.56
290_S	320_L	0.571	0.56
183_R	188_A	0.571	0.56
295_N	298_S	0.571	0.56
125_N	129_E	0.570	0.56
232_I	340_L	0.570	0.56
258_F	276_N	0.569	0.55
345_K	350_T	0.569	0.55
309_K	367_S	0.568	0.55
178_Y	190_K	0.568	0.55
65_F	68_R	0.568	0.55
16_S	213_G	0.567	0.55
37_Q	41_L	0.567	0.55
309_K	321_M	0.566	0.55
291_R	296_G	0.565	0.55
7_M	10_V	0.564	0.55
146_R	288_D	0.563	0.55
351_N	356_D	0.562	0.55
178_Y	188_A	0.562	0.55
16_S	172_S	0.561	0.54
31_L	259_E	0.558	0.54
281_G	318_V	0.558	0.54
80_S	100_V	0.557	0.54
198_T	205_A	0.557	0.54
108_R	158_K	0.556	0.54
146_R	286_S	0.555	0.54
85_L	91_S	0.554	0.54
337_S	349_L	0.553	0.53
56_V	87_M	0.553	0.53
50_L	101_A	0.552	0.53
292_K	299_S	0.551	0.53
285_L	300_L	0.551	0.53
344_E	354_L	0.550	0.53
331_G	367_S	0.550	0.53
12_V	50_L	0.550	0.53
190_K	193_R	0.549	0.53
60_Y	65_F	0.549	0.53
19_L	61_R	0.547	0.53
239_A	277_S	0.546	0.52
117_Y	161_G	0.545	0.52
77_A	123_T	0.545	0.52
44_A	291_R	0.544	0.52
39_V	43_D	0.544	0.52
55_A	135_I	0.544	0.52
271_Q	275_F	0.542	0.52
351_N	354_L	0.541	0.52
31_L	90_Y	0.541	0.52
147_L	237_G	0.541	0.52
12_V	291_R	0.541	0.52
343_P	356_D	0.540	0.52
362_C	369_P	0.540	0.52
342_E	355_I	0.540	0.52
10_V	169_V	0.539	0.52
65_F	74_E	0.538	0.51
37_Q	246_Y	0.537	0.51
46_Y	172_S	0.535	0.51
48_V	189_K	0.535	0.51
114_E	269_K	0.534	0.51
150_G	223_A	0.534	0.51
30_K	33_A	0.534	0.51
226_I	234_G	0.533	0.51
197_I	205_A	0.532	0.51
112_S	117_Y	0.529	0.50
351_N	355_I	0.529	0.50
36_D	40_K	0.529	0.50
26_I	133_I	0.529	0.50
304_G	345_K	0.528	0.50
348_E	359_A	0.527	0.50
69_P	75_K	0.527	0.50
322_D	325_G	0.526	0.50
87_M	156_A	0.525	0.50
247_H	251_E	0.524	0.50
26_I	50_L	0.523	0.49
18_S	173_D	0.522	0.49
170_I	173_D	0.522	0.49
344_E	369_P	0.519	0.49
316_S	340_L	0.519	0.49
43_D	189_K	0.519	0.49
34_L	221_L	0.519	0.49
11_V	51_V	0.519	0.49
182_P	186_P	0.518	0.49
177_L	221_L	0.518	0.49
201_I	205_A	0.517	0.49
300_L	312_F	0.517	0.49
198_T	203_A	0.516	0.49
31_L	358_E	0.515	0.48
26_I	61_R	0.515	0.48
156_A	161_G	0.515	0.48
156_A	273_I	0.515	0.48
60_Y	70_E	0.514	0.48
201_I	213_G	0.514	0.48
157_A	223_A	0.513	0.48
62_K	85_L	0.512	0.48
52_S	228_M	0.511	0.48
17_S	209_G	0.511	0.48
299_S	331_G	0.510	0.48
211_I	221_L	0.510	0.48
294_T	369_P	0.510	0.48
157_A	173_D	0.509	0.48
18_S	248_A	0.508	0.47
175_D	190_K	0.508	0.47
133_I	296_G	0.507	0.47
181_N	197_I	0.506	0.47
270_E	297_Q	0.506	0.47
69_P	330_L	0.505	0.47
18_S	37_Q	0.503	0.47
229_A	266_L	0.502	0.47
310_G	318_V	0.502	0.47
163_I	227_V	0.502	0.47
28_I	89_A	0.501	0.47
19_L	31_L	0.500	0.46
311_K	338_V	0.500	0.46
120_V	227_V	0.500	0.46

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2j5vA	2	0.8706	100	0.257	Contact Map
4q1tA	4	0.9461	100	0.268	Contact Map
2akoA	2	0.6469	100	0.599	Contact Map
3ll9A	2	0.6199	100	0.654	Contact Map
3d40A	2	0.6415	100	0.659	Contact Map
1z9dA	5	0.6253	100	0.662	Contact Map
2e9yA	2	0.6577	100	0.668	Contact Map
1e19A	2	0.655	100	0.668	Contact Map
3ll5A	2	0.6092	100	0.672	Contact Map
3nwyA	5	0.6253	100	0.676	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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