GREMLIN Database
PROJ - Glutamate 5-kinase 2
UniProt: O07509 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 371 (361)
Sequences: 2585 (1564)
Seq/√Len: 82.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_R47_E4.6921.00
320_L362_C4.5161.00
285_L320_L4.2681.00
180_G185_N3.8421.00
247_H252_Q3.7491.00
56_V147_L3.7361.00
287_D323_S3.6271.00
346_K354_L3.5181.00
12_V38_V3.4331.00
80_S102_S3.3281.00
16_S57_A3.3271.00
283_M318_V3.1631.00
340_L361_V3.1621.00
124_M136_I3.0961.00
290_S322_D3.0901.00
202_E225_K3.0341.00
322_D326_T2.9891.00
49_I163_I2.9701.00
327_E330_L2.9591.00
305_V361_V2.8461.00
282_E309_K2.7641.00
176_G190_K2.7521.00
319_R327_E2.7211.00
284_I307_K2.7211.00
193_R259_E2.7121.00
179_D189_K2.6811.00
42_K131_G2.6341.00
346_K350_T2.6081.00
18_S239_A2.5771.00
282_E321_M2.5301.00
341_Q344_E2.5261.00
194_V258_F2.5211.00
241_A247_H2.4381.00
179_D185_N2.4201.00
233_K260_A2.4161.00
280_E316_S2.4041.00
35_V93_L2.3681.00
110_D116_R2.2871.00
285_L290_S2.2781.00
177_L194_V2.2471.00
169_V245_L2.2151.00
291_R295_N2.1081.00
194_V256_T2.0571.00
42_K99_Y2.0491.00
71_K74_E2.0201.00
175_D238_Q1.9991.00
306_Q323_S1.9791.00
290_S328_I1.9151.00
120_V162_L1.9091.00
180_G187_E1.8651.00
285_L293_I1.8641.00
284_I309_K1.8531.00
233_K257_Y1.7901.00
99_Y133_I1.7691.00
284_I323_S1.7651.00
14_I50_L1.7471.00
74_E126_V1.7241.00
334_N366_F1.7201.00
228_M234_G1.6931.00
282_E319_R1.6931.00
180_G188_A1.6911.00
38_V48_V1.6811.00
195_S259_E1.6611.00
39_V99_Y1.6501.00
16_S212_V1.6481.00
36_D96_A1.6331.00
288_D304_G1.6321.00
37_Q243_D1.6281.00
10_V46_Y1.6181.00
318_V333_V1.5891.00
32_E93_L1.5861.00
36_D97_H1.5811.00
288_D292_K1.5771.00
339_Q357_Q1.5641.00
237_G244_I1.5601.00
44_A250_H1.5441.00
38_V50_L1.5441.00
206_G210_S1.5320.99
14_I34_L1.5280.99
94_F101_A1.5270.99
343_P351_N1.5090.99
35_V94_F1.4740.99
40_K246_Y1.4340.99
156_A168_L1.4240.99
88_E92_K1.4190.99
31_L89_A1.4110.99
11_V165_A1.3730.99
182_P188_A1.3700.99
317_V332_I1.3700.99
38_V133_I1.3550.99
104_I141_T1.3490.99
171_L237_G1.3410.99
84_G87_M1.3360.99
313_K336_S1.3330.99
32_E96_A1.3280.99
94_F133_I1.3190.98
287_D324_K1.3120.98
114_E118_N1.3120.98
68_R75_K1.3030.98
7_M46_Y1.3030.98
154_T222_D1.3000.98
288_D301_Y1.2900.98
178_Y182_P1.2790.98
339_Q342_E1.2790.98
12_V245_L1.2710.98
290_S294_T1.2570.98
289_C300_L1.2480.98
202_E221_L1.2310.98
50_L90_Y1.2270.98
191_I204_C1.2270.98
154_T226_I1.2210.97
168_L234_G1.2040.97
286_S304_G1.1970.97
287_D290_S1.1920.97
237_G248_A1.1900.97
26_I58_A1.1900.97
160_A232_I1.1810.97
243_D247_H1.1770.97
93_L96_A1.1720.97
350_T353_A1.1710.97
337_S341_Q1.1590.97
289_C304_G1.1570.96
123_T127_L1.1420.96
284_I321_M1.1330.96
126_V129_E1.1320.96
227_V234_G1.1300.96
32_E36_D1.1290.96
302_L351_N1.1170.96
235_F248_A1.1150.96
311_K337_S1.1120.96
301_Y304_G1.1010.95
63_L78_S1.1010.95
25_E61_R1.0910.95
33_A36_D1.0880.95
308_I340_L1.0770.95
40_K43_D1.0710.95
60_Y69_P1.0690.95
28_I92_K1.0670.94
321_M327_E1.0650.94
345_K348_E1.0620.94
307_K344_E1.0590.94
289_C292_K1.0550.94
42_K133_I1.0530.94
109_S113_D1.0500.94
191_I194_V1.0420.94
7_M167_M1.0410.94
62_K91_S1.0380.94
297_Q364_V1.0380.94
114_E272_W1.0380.94
177_L191_I1.0330.93
34_L90_Y1.0270.93
109_S116_R1.0260.93
331_G362_C1.0260.93
299_S363_H1.0180.93
288_D299_S1.0150.93
302_L345_K1.0130.93
17_S213_G1.0100.93
247_H254_E1.0080.93
287_D291_R1.0070.93
104_I124_M1.0060.93
246_Y250_H1.0060.93
222_D226_I1.0040.92
19_L26_I0.9980.92
329_G367_S0.9930.92
279_P319_R0.9900.92
175_D241_A0.9890.92
75_K214_T0.9890.92
37_Q244_I0.9820.92
206_G209_G0.9760.91
175_D178_Y0.9730.91
238_Q241_A0.9720.91
16_S25_E0.9700.91
8_K46_Y0.9650.91
14_I19_L0.9630.91
181_N206_G0.9620.91
123_T141_T0.9590.91
63_L81_I0.9500.90
169_V248_A0.9470.90
320_L329_G0.9450.90
286_S301_Y0.9440.90
20_T27_S0.9420.90
176_G236_L0.9370.90
144_V148_K0.9370.90
299_S304_G0.9340.89
42_K48_V0.9330.89
16_S156_A0.9300.89
243_D246_Y0.9260.89
174_I178_Y0.9250.89
308_I312_F0.9230.89
167_M233_K0.9200.89
14_I38_V0.9180.89
20_T58_A0.9170.89
302_L348_E0.9130.88
78_S81_I0.9080.88
76_Q119_N0.9060.88
106_I120_V0.9040.88
154_T219_S0.9040.88
40_K44_A0.9020.88
89_A93_L0.9000.88
305_V340_L0.8990.88
60_Y78_S0.8960.87
336_S339_Q0.8930.87
17_S173_D0.8860.87
50_L133_I0.8860.87
12_V171_L0.8850.87
190_K254_E0.8740.86
363_H367_S0.8740.86
128_L134_P0.8720.86
60_Y68_R0.8700.86
102_S127_L0.8670.86
10_V41_L0.8650.86
180_G186_P0.8650.86
31_L35_V0.8640.85
286_S289_C0.8550.85
277_S317_V0.8500.85
172_S258_F0.8470.84
197_I201_I0.8460.84
334_N360_F0.8450.84
335_Y343_P0.8430.84
318_V362_C0.8340.83
18_S30_K0.8320.83
319_R330_L0.8320.83
343_P355_I0.8320.83
17_S214_T0.8270.83
248_A251_E0.8270.83
124_M128_L0.8230.83
97_H101_A0.8220.83
173_D182_P0.8210.82
190_K253_A0.8190.82
58_A85_L0.8190.82
174_I183_R0.8160.82
279_P330_L0.8110.82
70_E135_I0.8100.82
27_S240_D0.8080.81
10_V249_V0.8070.81
362_C367_S0.8060.81
285_L328_I0.8040.81
56_V75_K0.7960.80
183_R209_G0.7920.80
228_M258_F0.7910.80
71_K126_V0.7880.80
283_M344_E0.7880.80
35_V39_V0.7870.80
181_N188_A0.7860.80
235_F257_Y0.7830.79
41_L46_Y0.7820.79
74_E130_R0.7800.79
91_S101_A0.7750.79
167_M257_Y0.7720.78
39_V97_H0.7680.78
234_G258_F0.7680.78
65_F78_S0.7640.78
43_D99_Y0.7630.78
286_S299_S0.7630.78
80_S141_T0.7620.77
20_T57_A0.7620.77
121_R125_N0.7600.77
205_A208_T0.7560.77
290_S323_S0.7530.77
47_E129_E0.7510.76
185_N189_K0.7500.76
333_V336_S0.7490.76
149_F219_S0.7470.76
311_K341_Q0.7470.76
236_L258_F0.7460.76
208_T213_G0.7450.76
31_L93_L0.7440.76
218_R222_D0.7370.75
120_V159_V0.7360.75
237_G241_A0.7350.75
360_F363_H0.7350.75
77_A127_L0.7340.75
73_P122_N0.7320.75
332_I356_D0.7300.74
60_Y75_K0.7290.74
27_S30_K0.7290.74
243_D250_H0.7280.74
9_R125_N0.7270.74
160_A168_L0.7230.74
47_E131_G0.7210.73
109_S115_Y0.7170.73
245_L248_A0.7170.73
289_C299_S0.7160.73
222_D225_K0.7160.73
56_V72_L0.7140.73
201_I204_C0.7140.73
344_E348_E0.7120.73
348_E351_N0.7110.72
192_Q253_A0.7100.72
351_N357_Q0.7090.72
84_G274_A0.7080.72
21_S27_S0.7060.72
259_E316_S0.7060.72
282_E318_V0.7050.72
161_G271_Q0.7050.72
219_S234_G0.7040.72
200_D203_A0.7040.72
161_G230_S0.6990.71
49_I136_I0.6970.71
172_S234_G0.6940.71
27_S58_A0.6920.70
251_E255_G0.6910.70
8_K166_D0.6910.70
57_A212_V0.6910.70
20_T26_I0.6910.70
269_K332_I0.6890.70
287_D322_D0.6870.70
338_V341_Q0.6870.70
161_G232_I0.6870.70
334_N358_E0.6870.70
293_I319_R0.6850.70
45_G98_G0.6840.70
221_L258_F0.6830.69
342_E354_L0.6830.69
111_F120_V0.6830.69
65_F69_P0.6830.69
119_N144_V0.6810.69
283_M320_L0.6810.69
194_V201_I0.6800.69
189_K250_H0.6790.69
307_K341_Q0.6780.69
106_I159_V0.6770.69
121_R164_D0.6770.69
145_N148_K0.6740.68
19_L172_S0.6730.68
279_P327_E0.6720.68
30_K172_S0.6720.68
244_I247_H0.6700.68
302_L335_Y0.6700.68
270_E299_S0.6680.68
28_I32_E0.6670.68
111_F158_K0.6660.67
352_R357_Q0.6650.67
167_M235_F0.6640.67
288_D303_D0.6610.67
284_I287_D0.6610.67
49_I278_G0.6600.67
90_Y210_S0.6580.67
173_D178_Y0.6570.66
148_K154_T0.6570.66
56_V67_Q0.6560.66
148_K214_T0.6560.66
308_I341_Q0.6560.66
284_I306_Q0.6550.66
144_V227_V0.6540.66
306_Q321_M0.6510.66
269_K366_F0.6500.66
313_K316_S0.6490.65
118_N121_R0.6480.65
76_Q146_R0.6470.65
29_R32_E0.6470.65
293_I300_L0.6400.64
350_T354_L0.6400.64
294_T326_T0.6400.64
292_K304_G0.6390.64
347_K350_T0.6380.64
111_F149_F0.6380.64
343_P348_E0.6360.64
281_G312_F0.6340.64
120_V181_N0.6340.64
271_Q276_N0.6340.64
272_W312_F0.6320.63
135_I336_S0.6310.63
177_L236_L0.6290.63
335_Y357_Q0.6290.63
88_E91_S0.6280.63
18_S277_S0.6280.63
26_I89_A0.6280.63
221_L236_L0.6260.63
284_I308_I0.6250.63
84_G91_S0.6250.63
108_R276_N0.6230.62
173_D188_A0.6230.62
235_F254_E0.6210.62
293_I369_P0.6210.62
227_V232_I0.6210.62
288_D348_E0.6190.62
50_L273_I0.6190.62
193_R257_Y0.6190.62
197_I221_L0.6160.61
33_A243_D0.6160.61
35_V90_Y0.6160.61
65_F81_I0.6150.61
358_E366_F0.6150.61
29_R36_D0.6130.61
102_S161_G0.6130.61
55_A78_S0.6110.61
108_R154_T0.6110.61
331_G363_H0.6090.61
209_G214_T0.6080.60
289_C301_Y0.6080.60
24_G210_S0.6070.60
200_D205_A0.6030.60
113_D116_R0.6030.60
298_S303_D0.6030.60
308_I337_S0.6030.60
67_Q70_E0.6010.60
207_D218_R0.5990.59
287_D353_A0.5990.59
270_E331_G0.5960.59
150_G214_T0.5960.59
191_I208_T0.5950.59
181_N185_N0.5930.59
283_M333_V0.5920.58
176_G315_G0.5920.58
112_S158_K0.5890.58
47_E128_L0.5870.58
206_G221_L0.5850.58
303_D345_K0.5850.58
173_D209_G0.5840.57
364_V367_S0.5810.57
146_R301_Y0.5810.57
48_V133_I0.5810.57
149_F158_K0.5800.57
284_I318_V0.5800.57
25_E142_V0.5800.57
171_L244_I0.5800.57
286_S292_K0.5800.57
197_I202_E0.5790.57
305_V352_R0.5790.57
73_P115_Y0.5790.57
36_D204_C0.5780.57
354_L357_Q0.5780.57
43_D92_K0.5750.56
270_E363_H0.5740.56
149_F214_T0.5730.56
93_L101_A0.5730.56
60_Y212_V0.5730.56
340_L344_E0.5720.56
39_V42_K0.5710.56
290_S320_L0.5710.56
183_R188_A0.5710.56
295_N298_S0.5710.56
125_N129_E0.5700.56
232_I340_L0.5700.56
258_F276_N0.5690.55
345_K350_T0.5690.55
309_K367_S0.5680.55
178_Y190_K0.5680.55
65_F68_R0.5680.55
16_S213_G0.5670.55
37_Q41_L0.5670.55
309_K321_M0.5660.55
291_R296_G0.5650.55
7_M10_V0.5640.55
146_R288_D0.5630.55
351_N356_D0.5620.55
178_Y188_A0.5620.55
16_S172_S0.5610.54
31_L259_E0.5580.54
281_G318_V0.5580.54
80_S100_V0.5570.54
198_T205_A0.5570.54
108_R158_K0.5560.54
146_R286_S0.5550.54
85_L91_S0.5540.54
337_S349_L0.5530.53
56_V87_M0.5530.53
50_L101_A0.5520.53
292_K299_S0.5510.53
285_L300_L0.5510.53
344_E354_L0.5500.53
331_G367_S0.5500.53
12_V50_L0.5500.53
190_K193_R0.5490.53
60_Y65_F0.5490.53
19_L61_R0.5470.53
239_A277_S0.5460.52
117_Y161_G0.5450.52
77_A123_T0.5450.52
44_A291_R0.5440.52
39_V43_D0.5440.52
55_A135_I0.5440.52
271_Q275_F0.5420.52
351_N354_L0.5410.52
31_L90_Y0.5410.52
147_L237_G0.5410.52
12_V291_R0.5410.52
343_P356_D0.5400.52
362_C369_P0.5400.52
342_E355_I0.5400.52
10_V169_V0.5390.52
65_F74_E0.5380.51
37_Q246_Y0.5370.51
46_Y172_S0.5350.51
48_V189_K0.5350.51
114_E269_K0.5340.51
150_G223_A0.5340.51
30_K33_A0.5340.51
226_I234_G0.5330.51
197_I205_A0.5320.51
112_S117_Y0.5290.50
351_N355_I0.5290.50
36_D40_K0.5290.50
26_I133_I0.5290.50
304_G345_K0.5280.50
348_E359_A0.5270.50
69_P75_K0.5270.50
322_D325_G0.5260.50
87_M156_A0.5250.50
247_H251_E0.5240.50
26_I50_L0.5230.49
18_S173_D0.5220.49
170_I173_D0.5220.49
344_E369_P0.5190.49
316_S340_L0.5190.49
43_D189_K0.5190.49
34_L221_L0.5190.49
11_V51_V0.5190.49
182_P186_P0.5180.49
177_L221_L0.5180.49
201_I205_A0.5170.49
300_L312_F0.5170.49
198_T203_A0.5160.49
31_L358_E0.5150.48
26_I61_R0.5150.48
156_A161_G0.5150.48
156_A273_I0.5150.48
60_Y70_E0.5140.48
201_I213_G0.5140.48
157_A223_A0.5130.48
62_K85_L0.5120.48
52_S228_M0.5110.48
17_S209_G0.5110.48
299_S331_G0.5100.48
211_I221_L0.5100.48
294_T369_P0.5100.48
157_A173_D0.5090.48
18_S248_A0.5080.47
175_D190_K0.5080.47
133_I296_G0.5070.47
181_N197_I0.5060.47
270_E297_Q0.5060.47
69_P330_L0.5050.47
18_S37_Q0.5030.47
229_A266_L0.5020.47
310_G318_V0.5020.47
163_I227_V0.5020.47
28_I89_A0.5010.47
19_L31_L0.5000.46
311_K338_V0.5000.46
120_V227_V0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j5vA 2 0.8706 100 0.257 Contact Map
4q1tA 4 0.9461 100 0.268 Contact Map
2akoA 2 0.6469 100 0.599 Contact Map
3ll9A 2 0.6199 100 0.654 Contact Map
3d40A 2 0.6415 100 0.659 Contact Map
1z9dA 5 0.6253 100 0.662 Contact Map
2e9yA 2 0.6577 100 0.668 Contact Map
1e19A 2 0.655 100 0.668 Contact Map
3ll5A 2 0.6092 100 0.672 Contact Map
3nwyA 5 0.6253 100 0.676 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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