GREMLIN Database
CZCO - Uncharacterized oxidoreductase CzcO
UniProt: O07085 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (286)
Sequences: 55020 (39570)
Seq/√Len: 2339.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_L272_V4.8851.00
162_N184_V3.6861.00
186_Y251_K3.5081.00
32_K96_E3.4271.00
3_D119_K3.1801.00
3_D26_K2.9601.00
184_V249_I2.8931.00
162_N273_N2.8101.00
16_I122_V2.6621.00
108_L115_E2.6491.00
4_T20_L2.6441.00
164_L188_A2.6371.00
5_I30_L2.6031.00
30_L116_Y2.5241.00
5_I109_I2.5131.00
132_N282_R2.4811.00
5_I116_Y2.4791.00
240_K244_K2.4631.00
256_A263_I2.4371.00
258_K263_I2.3291.00
110_K115_E2.2791.00
137_S256_A2.2211.00
162_N186_Y2.2201.00
162_N271_E2.1491.00
12_A315_I2.1241.00
263_I269_T2.1011.00
28_I92_Q2.0721.00
162_N183_R2.0691.00
107_F111_T1.9961.00
118_T121_L1.9731.00
105_N311_G1.9481.00
255_I265_K1.9411.00
120_N311_G1.8941.00
5_I28_I1.8571.00
108_L117_Q1.8561.00
164_L262_I1.8451.00
188_A270_L1.8381.00
258_K269_T1.8361.00
122_V315_I1.8231.00
130_T284_P1.8201.00
130_T286_C1.8151.00
72_S75_E1.8041.00
295_D299_R1.7981.00
111_T116_Y1.7931.00
161_G273_N1.7881.00
253_R265_K1.7791.00
26_K90_P1.7601.00
5_I118_T1.7521.00
102_K309_V1.7261.00
99_S110_K1.6741.00
251_K268_S1.6601.00
130_T282_R1.6521.00
255_I263_I1.6481.00
163_V179_L1.6051.00
190_S253_R1.5671.00
252_K266_D1.5541.00
111_T114_E1.5521.00
81_K85_K1.5411.00
17_G29_I1.5161.00
96_E112_N1.5161.00
6_V17_G1.5051.00
4_T122_V1.4961.00
78_A82_K1.4921.00
141_S259_Q1.4811.00
186_Y272_V1.4751.00
335_A339_V1.4681.00
3_D28_I1.4331.00
100_V121_L1.4291.00
99_S102_K1.4101.00
9_A31_D1.4031.00
186_Y249_I1.3891.00
19_Y22_Q1.3801.00
173_A187_L1.3771.00
287_W290_I1.3721.00
135_S139_D1.3621.00
166_V275_I1.3621.00
6_V13_G1.3461.00
309_V312_L1.3371.00
257_A275_I1.3371.00
313_Y341_Q1.3281.00
28_I116_Y1.3201.00
92_Q95_T1.3131.00
101_L104_K1.3061.00
264_F270_L1.2981.00
148_H151_Q1.2931.00
125_T318_P1.2871.00
102_K105_N1.2861.00
330_G334_D1.2791.00
98_I112_N1.2711.00
120_N313_Y1.2711.00
34_H94_R1.2631.00
97_V102_K1.2631.00
300_I318_P1.2611.00
92_Q114_E1.2571.00
160_Y183_R1.2521.00
95_T113_R1.2501.00
302_H319_W1.2421.00
35_E81_K1.2361.00
327_L330_G1.2291.00
168_G189_C1.2091.00
101_L108_L1.2081.00
102_K312_L1.2051.00
82_K85_K1.1891.00
242_A245_Q1.1891.00
124_A315_I1.1851.00
163_V183_R1.1831.00
176_A187_L1.1781.00
193_L236_G1.1731.00
4_T25_Q1.1661.00
16_I315_I1.1621.00
95_T111_T1.1531.00
165_V176_A1.1501.00
172_G189_C1.1371.00
12_A331_V1.1361.00
164_L270_L1.1351.00
146_Q277_W1.1331.00
75_E78_A1.1321.00
7_I123_I1.1311.00
19_Y340_K1.1261.00
180_S184_V1.1261.00
101_L110_K1.1161.00
327_L331_V1.1091.00
295_D301_I1.1031.00
260_N271_E1.0891.00
77_V81_K1.0791.00
168_G194_V1.0741.00
252_K264_F1.0631.00
331_V334_D1.0631.00
30_L111_T1.0611.00
164_L275_I1.0551.00
78_A81_K1.0491.00
97_V105_N1.0481.00
302_H314_F1.0451.00
258_K261_E1.0401.00
138_K141_S1.0391.00
242_A246_K1.0361.00
19_Y23_S1.0311.00
294_L301_I1.0271.00
20_L25_Q1.0241.00
288_I291_K1.0241.00
95_T114_E1.0221.00
30_L97_V1.0211.00
150_S153_K1.0201.00
186_Y270_L1.0111.00
337_Y341_Q1.0081.00
163_V274_N1.0071.00
55_Y58_L1.0061.00
30_L92_Q1.0011.00
180_S248_I0.9901.00
338_I341_Q0.9871.00
286_C289_N0.9851.00
327_L334_D0.9811.00
106_Y117_Q0.9811.00
241_H244_K0.9781.00
4_T120_N0.9721.00
302_H306_V0.9711.00
83_Y87_F0.9671.00
233_P237_H0.9581.00
149_S175_I0.9581.00
123_I318_P0.9571.00
99_S104_K0.9511.00
241_H245_Q0.9501.00
79_Y82_K0.9461.00
73_K80_L0.9391.00
147_L274_N0.9381.00
240_K250_L0.9371.00
97_V109_I0.9241.00
166_V279_T0.9191.00
238_E241_H0.9181.00
314_F318_P0.9181.00
23_S340_K0.9161.00
36_V93_L0.9091.00
20_L339_V0.9021.00
296_Q301_I0.8961.00
16_I338_I0.8911.00
315_I338_I0.8841.00
326_A330_G0.8831.00
106_Y111_T0.8781.00
181_K246_K0.8721.00
103_I108_L0.8721.00
52_S55_Y0.8681.00
82_K86_K0.8681.00
237_H240_K0.8671.00
121_L312_L0.8631.00
18_Y22_Q0.8621.00
333_N336_E0.8581.00
300_I314_F0.8531.00
98_I110_K0.8471.00
306_V319_W0.8421.00
3_D25_Q0.8391.00
166_V277_W0.8351.00
107_F309_V0.8321.00
325_S330_G0.8291.00
150_S154_N0.8281.00
158_L183_R0.8171.00
156_K159_A0.8171.00
151_Q154_N0.8151.00
141_S145_N0.8141.00
134_P279_T0.8101.00
244_K249_I0.8011.00
19_Y336_E0.7991.00
99_S105_N0.7991.00
303_H306_V0.7961.00
17_G27_F0.7951.00
188_A251_K0.7931.00
9_A36_V0.7931.00
21_K27_F0.7901.00
28_I118_T0.7881.00
252_K265_K0.7871.00
325_S328_L0.7861.00
92_Q116_Y0.7821.00
61_M86_K0.7811.00
134_P139_D0.7801.00
84_V89_I0.7791.00
148_H152_Y0.7761.00
6_V16_I0.7761.00
3_D117_Q0.7751.00
84_V87_F0.7681.00
301_I305_G0.7601.00
331_V335_A0.7581.00
147_L151_Q0.7551.00
152_Y155_S0.7551.00
134_P277_W0.7501.00
161_G184_V0.7501.00
17_G89_I0.7491.00
3_D118_T0.7491.00
162_N272_V0.7461.00
239_L243_I0.7441.00
325_S334_D0.7431.00
110_K113_R0.7401.00
172_G190_S0.7381.00
80_L84_V0.7361.00
77_V80_L0.7361.00
272_V275_I0.7321.00
141_S144_I0.7321.00
97_V104_K0.7311.00
149_S152_Y0.7291.00
235_F238_E0.7281.00
147_L155_S0.7261.00
189_C192_K0.7251.00
99_S290_I0.7251.00
75_E79_Y0.7241.00
16_I335_A0.7201.00
91_I94_R0.7181.00
107_F312_L0.7181.00
161_G274_N0.7161.00
121_L311_G0.7161.00
51_T54_M0.7151.00
51_T55_Y0.7151.00
9_A29_I0.7141.00
74_N78_A0.7131.00
314_F319_W0.7101.00
95_T98_I0.7091.00
30_L118_T0.7091.00
133_I148_H0.7091.00
133_I277_W0.7071.00
307_S314_F0.7011.00
293_V300_I0.7001.00
163_V276_I0.6981.00
306_V337_Y0.6961.00
71_P75_E0.6951.00
122_V338_I0.6941.00
13_G17_G0.6931.00
251_K270_L0.6921.00
141_S256_A0.6891.00
80_L83_Y0.6891.00
6_V29_I0.6851.00
107_F311_G0.6831.00
20_L27_F0.6811.00
242_A247_E0.6811.00
139_D277_W0.6801.00
243_I250_L0.6771.00
73_K77_V0.6741.00
327_L332_G0.6721.00
328_L334_D0.6711.00
193_L233_P0.6671.00
326_A329_Q0.6661.00
238_E242_A0.6661.00
132_N279_T0.6631.00
3_D116_Y0.6631.00
123_I288_I0.6631.00
51_T56_S0.6621.00
28_I90_P0.6621.00
325_S329_Q0.6611.00
101_L105_N0.6611.00
59_P62_H0.6601.00
254_V257_A0.6601.00
133_I140_L0.6591.00
152_Y179_L0.6541.00
188_A264_F0.6531.00
293_V309_V0.6531.00
257_A262_I0.6531.00
237_H241_H0.6521.00
99_S103_I0.6521.00
243_I246_K0.6521.00
329_Q333_N0.6511.00
25_Q119_K0.6501.00
326_A334_D0.6501.00
149_S154_N0.6491.00
152_Y178_E0.6481.00
264_F268_S0.6481.00
74_N77_V0.6461.00
264_F267_S0.6451.00
147_L152_Y0.6451.00
102_K107_F0.6441.00
327_L335_A0.6441.00
287_W291_K0.6421.00
327_L333_N0.6401.00
175_I278_A0.6391.00
76_I80_L0.6391.00
21_K89_I0.6381.00
136_I139_D0.6371.00
188_A272_V0.6331.00
161_G183_R0.6331.00
256_A259_Q0.6321.00
175_I276_I0.6301.00
334_D337_Y0.6281.00
7_I125_T0.6281.00
306_V338_I0.6261.00
52_S56_S0.6261.00
328_L331_V0.6251.00
90_P94_R0.6241.00
329_Q332_G0.6221.00
144_I147_L0.6201.00
98_I102_K0.6171.00
187_L250_L0.6151.00
261_E269_T0.6141.00
146_Q257_A0.6141.00
239_L242_A0.6131.00
127_P281_F0.6131.00
301_I308_P0.6121.00
123_I312_L0.6111.00
149_S153_K0.6081.00
294_L300_I0.6071.00
83_Y86_K0.6061.00
133_I139_D0.6041.00
255_I258_K0.6031.00
9_A13_G0.6021.00
333_N337_Y0.6001.00
285_L318_P0.5991.00
56_S59_P0.5991.00
176_A248_I0.5981.00
295_D320_Q0.5951.00
158_L161_G0.5941.00
188_A252_K0.5941.00
151_Q155_S0.5921.00
175_I178_E0.5921.00
164_L186_Y0.5921.00
176_A185_T0.5911.00
145_N149_S0.5901.00
336_E340_K0.5891.00
29_I91_I0.5891.00
4_T339_V0.5881.00
157_Q160_Y0.5821.00
36_V91_I0.5811.00
79_Y83_Y0.5801.00
13_G124_A0.5771.00
108_L111_T0.5771.00
26_K119_K0.5761.00
189_C196_F0.5741.00
138_K256_A0.5721.00
251_K264_F0.5701.00
177_V181_K0.5691.00
180_S247_E0.5681.00
244_K250_L0.5681.00
166_V254_V0.5681.00
15_S335_A0.5671.00
255_I267_S0.5631.00
6_V124_A0.5621.00
53_R56_S0.5611.00
245_Q248_I0.5611.00
95_T99_S0.5611.00
52_S57_S0.5591.00
149_S155_S0.5591.00
328_L332_G0.5591.00
7_I97_V0.5581.00
96_E99_S0.5571.00
285_L294_L0.5571.00
193_L240_K0.5551.00
123_I287_W0.5541.00
137_S140_L0.5531.00
97_V111_T0.5531.00
73_K76_I0.5511.00
80_L87_F0.5491.00
21_K90_P0.5491.00
70_F73_K0.5471.00
233_P236_G0.5471.00
97_V103_I0.5461.00
150_S155_S0.5461.00
67_K70_F0.5451.00
56_S60_G0.5431.00
15_S332_G0.5431.00
76_I79_Y0.5431.00
15_S19_Y0.5411.00
332_G335_A0.5391.00
139_D146_Q0.5381.00
262_I265_K0.5361.00
132_N135_S0.5361.00
53_R57_S0.5341.00
249_I268_S0.5321.00
326_A331_V0.5321.00
178_E182_E0.5311.00
243_I247_E0.5311.00
330_G333_N0.5281.00
329_Q334_D0.5271.00
180_S246_K0.5211.00
16_I20_L0.5211.00
189_C250_L0.5211.00
30_L95_T0.5201.00
13_G16_I0.5201.00
325_S331_V0.5181.00
294_L297_E0.5181.00
159_A182_E0.5181.00
332_G336_E0.5171.00
257_A261_E0.5151.00
169_G280_G0.5151.00
58_L61_M0.5141.00
13_G29_I0.5141.00
94_R98_I0.5101.00
289_N292_G0.5071.00
92_Q99_S0.5061.00
145_N259_Q0.5051.00
236_G240_K0.5041.00
57_S60_G0.5041.00
54_M58_L0.5021.00
144_I152_Y0.5021.00
79_Y86_K0.5021.00
6_V27_F0.5011.00
305_G341_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c5oA 5 0.9362 100 0.285 Contact Map
4usrA 1 0.9884 100 0.288 Contact Map
4usqA 3 0.971 100 0.293 Contact Map
3uoxA 2 0.9826 100 0.3 Contact Map
4rg3A 1 0.9884 100 0.304 Contact Map
1w4xA 1 0.9971 100 0.309 Contact Map
4ap3A 1 0.9884 100 0.319 Contact Map
2xveA 2 0.8551 100 0.326 Contact Map
2gv8A 2 0.8493 100 0.344 Contact Map
3lzwA 2 0.8464 100 0.361 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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