GREMLIN Database
CZCD - Cadmium, cobalt and zinc/H(+)-K(+) antiporter
UniProt: O07084 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (278)
Sequences: 10370 (7236)
Seq/√Len: 434.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_W182_L3.4411.00
193_R197_N3.0791.00
204_H209_G2.9081.00
249_C283_I2.8651.00
233_H250_H2.7821.00
223_I249_C2.7471.00
222_T276_K2.7341.00
220_I224_E2.5521.00
31_G120_I2.3591.00
100_Y104_E2.3031.00
29_A44_A2.2831.00
99_I185_I2.2731.00
223_I269_I2.1921.00
69_N76_Y2.1631.00
271_H275_H2.1211.00
139_G148_R2.0941.00
230_Q254_D2.0691.00
88_G199_T2.0391.00
226_T272_E2.0261.00
218_D276_K2.0061.00
79_F207_M1.9931.00
119_T123_I1.9901.00
200_K204_H1.9801.00
217_S221_R1.9791.00
32_G41_L1.9401.00
258_T261_E1.9271.00
11_K65_E1.8871.00
118_L165_I1.8361.00
99_I188_A1.8321.00
255_D260_S1.8291.00
222_T272_E1.8081.00
72_K76_Y1.7681.00
169_I173_F1.7611.00
226_T269_I1.7571.00
216_V237_I1.7491.00
104_E108_N1.7411.00
263_E284_Q1.7301.00
226_T268_K1.7281.00
261_E264_N1.7181.00
78_R208_E1.7171.00
251_A269_I1.7101.00
136_M140_D1.6971.00
272_E276_K1.6871.00
30_I34_L1.6871.00
15_L19_I1.6561.00
264_N268_K1.6531.00
185_I189_I1.6131.00
11_K62_T1.6081.00
98_I184_S1.6031.00
96_L100_Y1.5971.00
55_M59_I1.5971.00
196_Y200_K1.5891.00
189_I193_R1.5751.00
231_N252_V1.5401.00
259_I262_S1.5321.00
29_A33_F1.5211.00
167_A183_A1.4991.00
212_E215_D1.4801.00
137_S141_T1.4751.00
46_H153_H1.4741.00
262_S285_M1.4681.00
148_R201_D1.4641.00
15_L58_L1.4611.00
115_T172_I1.4411.00
103_I107_S1.4311.00
20_M127_V1.4311.00
169_I172_I1.4301.00
218_D222_T1.4181.00
129_L133_W1.4021.00
233_H286_E1.4011.00
163_G183_A1.3901.00
118_L172_I1.3901.00
97_Y100_Y1.3891.00
22_T51_S1.3891.00
102_A184_S1.3751.00
74_F248_S1.3661.00
197_N200_K1.3491.00
255_D289_A1.3441.00
237_I247_L1.3271.00
170_L174_F1.3251.00
268_K272_E1.3231.00
136_M151_Y1.3131.00
28_E47_M1.2971.00
178_W181_P1.2781.00
16_I134_I1.2691.00
266_L270_E1.2671.00
122_I126_V1.2651.00
122_I165_I1.2581.00
250_H286_E1.2581.00
221_R225_G1.2391.00
224_E231_N1.2391.00
253_V265_I1.2351.00
211_P237_I1.2341.00
69_N72_K1.2241.00
208_E246_A1.2151.00
253_V259_I1.2051.00
215_D218_D1.1971.00
125_L165_I1.1961.00
266_L284_Q1.1941.00
32_G44_A1.1911.00
60_A83_A1.1901.00
113_A117_M1.1891.00
95_S192_L1.1831.00
217_S220_I1.1741.00
226_T265_I1.1721.00
133_W137_S1.1701.00
118_L169_I1.1701.00
236_H280_H1.1691.00
126_V130_L1.1681.00
106_F181_P1.1641.00
25_M48_L1.1631.00
270_E274_E1.1521.00
92_I195_G1.1511.00
118_L168_A1.1461.00
38_L102_A1.1451.00
273_L278_I1.1391.00
63_L79_F1.1371.00
150_A153_H1.1311.00
72_K204_H1.1291.00
228_G261_E1.1271.00
263_E266_L1.1251.00
170_L179_A1.1241.00
235_L249_C1.1201.00
130_L133_W1.1161.00
20_M131_V1.1101.00
19_I23_G1.1021.00
116_G119_T1.0971.00
263_E287_T1.0941.00
56_V83_A1.0861.00
247_L278_I1.0841.00
106_F178_W1.0761.00
24_Y28_E1.0721.00
101_E104_E1.0711.00
18_F51_S1.0701.00
219_I273_L1.0691.00
176_W179_A1.0661.00
233_H252_V1.0651.00
119_T122_I1.0641.00
218_D221_R1.0601.00
77_K244_L1.0541.00
71_N76_Y1.0491.00
130_L134_I1.0481.00
162_V166_L1.0481.00
270_E284_Q1.0451.00
138_G141_T1.0421.00
256_Q260_S1.0351.00
81_I205_I1.0351.00
259_I285_M1.0321.00
262_S266_L1.0301.00
25_M44_A1.0281.00
213_N217_S1.0221.00
12_K16_I1.0201.00
92_I196_Y1.0191.00
247_L281_V1.0191.00
99_I103_I1.0181.00
57_A149_G1.0181.00
133_W136_M1.0151.00
88_G198_V1.0131.00
266_L285_M1.0131.00
260_S264_N1.0121.00
225_G272_E1.0021.00
25_M29_A1.0001.00
208_E240_I0.9951.00
24_Y127_V0.9931.00
62_T65_E0.9891.00
29_A41_L0.9861.00
138_G142_K0.9851.00
219_I237_I0.9841.00
92_I192_L0.9831.00
222_T225_G0.9761.00
63_L66_K0.9751.00
17_S131_V0.9721.00
151_Y155_I0.9711.00
171_I174_F0.9691.00
114_T117_M0.9491.00
43_D161_S0.9441.00
38_L105_R0.9421.00
18_F55_M0.9421.00
106_F185_I0.9381.00
89_A93_L0.9371.00
82_L207_M0.9361.00
18_F58_L0.9351.00
267_R271_H0.9351.00
43_D46_H0.9331.00
253_V262_S0.9311.00
71_N209_G0.9311.00
113_A116_G0.9301.00
73_T210_T0.9241.00
26_I30_I0.9201.00
132_A151_Y0.9161.00
102_A185_I0.9141.00
121_S165_I0.9081.00
240_I246_A0.9061.00
57_A146_N0.9041.00
38_L184_S0.8941.00
59_I63_L0.8901.00
234_D280_H0.8901.00
103_I185_I0.8871.00
33_F41_L0.8861.00
221_R224_E0.8861.00
229_I251_A0.8831.00
211_P214_I0.8801.00
228_G265_I0.8801.00
101_E105_R0.8771.00
274_E279_T0.8731.00
211_P245_N0.8611.00
230_Q288_E0.8601.00
273_L281_V0.8561.00
272_E275_H0.8531.00
205_I239_S0.8511.00
210_T216_V0.8501.00
220_I232_I0.8481.00
222_T226_T0.8381.00
22_T26_I0.8361.00
234_D250_H0.8351.00
129_L155_I0.8281.00
216_V220_I0.8271.00
97_Y101_E0.8261.00
253_V285_M0.8241.00
208_E238_W0.8211.00
27_I123_I0.8161.00
80_E144_N0.8131.00
252_V288_E0.8131.00
46_H50_D0.8131.00
266_L283_I0.8131.00
267_R270_E0.8121.00
223_I232_I0.8091.00
132_A136_M0.8051.00
92_I96_L0.8041.00
139_G151_Y0.8021.00
49_S94_I0.8011.00
228_G268_K0.7951.00
224_E232_I0.7941.00
104_E107_S0.7931.00
262_S265_I0.7921.00
25_M51_S0.7911.00
167_A179_A0.7891.00
232_I235_L0.7871.00
232_I249_C0.7851.00
263_E286_E0.7821.00
182_L186_I0.7811.00
38_L101_E0.7801.00
85_V199_T0.7801.00
13_V134_I0.7781.00
131_V154_V0.7781.00
153_H157_D0.7731.00
27_I120_I0.7701.00
168_A172_I0.7661.00
78_R238_W0.7631.00
124_G128_N0.7561.00
37_S180_D0.7531.00
118_L122_I0.7501.00
21_I47_M0.7491.00
156_S194_S0.7471.00
136_M139_G0.7411.00
268_K271_H0.7391.00
269_I283_I0.7391.00
74_F238_W0.7381.00
236_H248_S0.7361.00
215_D245_N0.7341.00
211_P215_D0.7311.00
183_A187_V0.7291.00
125_L162_V0.7211.00
128_N131_V0.7191.00
93_L100_Y0.7181.00
33_F44_A0.7171.00
29_A48_L0.7151.00
28_E44_A0.7141.00
264_N267_R0.7131.00
179_A183_A0.7121.00
132_A155_I0.7111.00
219_I247_L0.7101.00
17_S135_M0.7071.00
85_V89_A0.7051.00
265_I269_I0.6991.00
145_L205_I0.6981.00
228_G254_D0.6961.00
137_S140_D0.6941.00
82_L86_I0.6941.00
39_A183_A0.6911.00
59_I62_T0.6911.00
239_S245_N0.6901.00
131_V135_M0.6891.00
11_K58_L0.6851.00
104_E110_P0.6841.00
25_M47_M0.6831.00
134_I138_G0.6821.00
152_L155_I0.6781.00
223_I251_A0.6781.00
284_Q287_T0.6761.00
190_L194_S0.6741.00
13_V138_G0.6731.00
149_G198_V0.6721.00
64_A80_E0.6711.00
61_F146_N0.6701.00
13_V137_S0.6691.00
32_G35_T0.6681.00
85_V202_S0.6651.00
46_H91_L0.6651.00
53_S57_A0.6641.00
269_I272_E0.6611.00
262_S287_T0.6601.00
145_L201_D0.6591.00
278_I281_V0.6581.00
204_H212_E0.6581.00
73_T236_H0.6571.00
255_D288_E0.6560.99
84_A146_N0.6560.99
214_I237_I0.6550.99
135_M150_A0.6540.99
148_R152_L0.6540.99
53_S90_A0.6490.99
274_E281_V0.6460.99
17_S154_V0.6460.99
239_S243_G0.6450.99
270_E281_V0.6450.99
105_R110_P0.6420.99
48_L52_I0.6410.99
21_I50_D0.6410.99
271_H274_E0.6400.99
210_T237_I0.6380.99
30_I33_F0.6360.99
266_L269_I0.6350.99
71_N204_H0.6340.99
82_L203_I0.6340.99
52_I55_M0.6330.99
132_A154_V0.6320.99
129_L158_M0.6310.99
93_L97_Y0.6310.99
84_A198_V0.6290.99
17_S54_L0.6270.99
186_I190_L0.6270.99
229_I232_I0.6260.99
19_I22_T0.6240.99
102_A188_A0.6190.99
127_V131_V0.6180.99
261_E268_K0.6170.99
121_S124_G0.6120.99
143_N277_G0.6100.99
58_L62_T0.6070.99
95_S195_G0.6060.99
110_P113_A0.6050.99
88_G202_S0.6010.99
170_L173_F0.6010.99
28_E43_D0.5990.99
251_A285_M0.5990.99
17_S150_A0.5980.99
193_R196_Y0.5970.99
273_L283_I0.5930.99
248_S280_H0.5910.99
15_L18_F0.5890.99
131_V134_I0.5890.99
11_K15_L0.5860.99
211_P216_V0.5850.99
111_K177_G0.5840.99
54_L150_A0.5810.99
263_E267_R0.5790.99
36_N110_P0.5780.99
235_L247_L0.5760.99
128_N154_V0.5720.99
135_M154_V0.5680.99
139_G142_K0.5670.99
164_A167_A0.5610.98
38_L41_L0.5610.98
79_F83_A0.5600.98
256_Q261_E0.5600.98
53_S153_H0.5590.98
84_A202_S0.5520.98
226_T229_I0.5510.98
159_L162_V0.5500.98
102_A181_P0.5490.98
140_D148_R0.5490.98
72_K209_G0.5480.98
114_T172_I0.5470.98
222_T269_I0.5460.98
155_I159_L0.5440.98
227_E268_K0.5420.98
128_N135_M0.5420.98
163_G187_V0.5420.98
171_I179_A0.5420.98
148_R151_Y0.5400.98
16_I19_I0.5400.98
190_L193_R0.5360.98
153_H156_S0.5360.98
35_T116_G0.5340.98
247_L279_T0.5330.98
14_L18_F0.5320.98
93_L96_L0.5300.98
251_A283_I0.5280.98
268_K275_H0.5270.98
14_L57_A0.5240.98
101_E185_I0.5230.98
223_I229_I0.5230.98
24_Y27_I0.5220.98
128_N153_H0.5220.98
66_K76_Y0.5210.97
62_T66_K0.5200.97
183_A186_I0.5190.97
160_G167_A0.5190.97
203_I207_M0.5170.97
21_I51_S0.5170.97
67_K76_Y0.5170.97
125_L129_L0.5170.97
174_F179_A0.5160.97
85_V206_L0.5130.97
18_F54_L0.5110.97
188_A195_G0.5100.97
10_N61_F0.5070.97
56_V86_I0.5070.97
210_T239_S0.5060.97
94_I98_I0.5040.97
10_N142_K0.5040.97
29_A45_G0.5020.97
112_V115_T0.5020.97
123_I127_V0.5010.97
106_F182_L0.5000.97
68_A76_Y0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 0.9389 100 0.143 Contact Map
3h90A 3 0.9035 100 0.177 Contact Map
2zztA 2 0.254 99.6 0.754 Contact Map
3bypA 2 0.254 99.5 0.776 Contact Map
3w61A 2 0.2508 99.3 0.799 Contact Map
2wkbA 3 0.3408 48.9 0.946 Contact Map
3b9wA 3 0.6463 37.9 0.949 Contact Map
3cq1A 2 0.3151 37.7 0.949 Contact Map
1mhsA 2 0.7203 26.8 0.953 Contact Map
3ncqA 4 0.3087 26.6 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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