CZCD - BACSU - GREMLIN Contacts

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CZCD - Cadmium, cobalt and zinc/H(+)-K(+) antiporter

UniProt:	O07084	Sequences: MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDAGHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEAIERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLGSVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSDIIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHKGITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	311 (278)
Sequences:	10370 (7236)
Seq/√Len:	434.0

ECOLI - ZITB FIEF
BACSU - CZCD YEAB YDFM YDBO
HALSA - Q9HP06
SULSO - Q97WH2 Q97WI8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
178_W	182_L	3.441	1.00
193_R	197_N	3.079	1.00
204_H	209_G	2.908	1.00
249_C	283_I	2.865	1.00
233_H	250_H	2.782	1.00
223_I	249_C	2.747	1.00
222_T	276_K	2.734	1.00
220_I	224_E	2.552	1.00
31_G	120_I	2.359	1.00
100_Y	104_E	2.303	1.00
29_A	44_A	2.283	1.00
99_I	185_I	2.273	1.00
223_I	269_I	2.192	1.00
69_N	76_Y	2.163	1.00
271_H	275_H	2.121	1.00
139_G	148_R	2.094	1.00
230_Q	254_D	2.069	1.00
88_G	199_T	2.039	1.00
226_T	272_E	2.026	1.00
218_D	276_K	2.006	1.00
79_F	207_M	1.993	1.00
119_T	123_I	1.990	1.00
200_K	204_H	1.980	1.00
217_S	221_R	1.979	1.00
32_G	41_L	1.940	1.00
258_T	261_E	1.927	1.00
11_K	65_E	1.887	1.00
118_L	165_I	1.836	1.00
99_I	188_A	1.832	1.00
255_D	260_S	1.829	1.00
222_T	272_E	1.808	1.00
72_K	76_Y	1.768	1.00
169_I	173_F	1.761	1.00
226_T	269_I	1.757	1.00
216_V	237_I	1.749	1.00
104_E	108_N	1.741	1.00
263_E	284_Q	1.730	1.00
226_T	268_K	1.728	1.00
261_E	264_N	1.718	1.00
78_R	208_E	1.717	1.00
251_A	269_I	1.710	1.00
136_M	140_D	1.697	1.00
272_E	276_K	1.687	1.00
30_I	34_L	1.687	1.00
15_L	19_I	1.656	1.00
264_N	268_K	1.653	1.00
185_I	189_I	1.613	1.00
11_K	62_T	1.608	1.00
98_I	184_S	1.603	1.00
96_L	100_Y	1.597	1.00
55_M	59_I	1.597	1.00
196_Y	200_K	1.589	1.00
189_I	193_R	1.575	1.00
231_N	252_V	1.540	1.00
259_I	262_S	1.532	1.00
29_A	33_F	1.521	1.00
167_A	183_A	1.499	1.00
212_E	215_D	1.480	1.00
137_S	141_T	1.475	1.00
46_H	153_H	1.474	1.00
262_S	285_M	1.468	1.00
148_R	201_D	1.464	1.00
15_L	58_L	1.461	1.00
115_T	172_I	1.441	1.00
103_I	107_S	1.431	1.00
20_M	127_V	1.431	1.00
169_I	172_I	1.430	1.00
218_D	222_T	1.418	1.00
129_L	133_W	1.402	1.00
233_H	286_E	1.401	1.00
163_G	183_A	1.390	1.00
118_L	172_I	1.390	1.00
97_Y	100_Y	1.389	1.00
22_T	51_S	1.389	1.00
102_A	184_S	1.375	1.00
74_F	248_S	1.366	1.00
197_N	200_K	1.349	1.00
255_D	289_A	1.344	1.00
237_I	247_L	1.327	1.00
170_L	174_F	1.325	1.00
268_K	272_E	1.323	1.00
136_M	151_Y	1.313	1.00
28_E	47_M	1.297	1.00
178_W	181_P	1.278	1.00
16_I	134_I	1.269	1.00
266_L	270_E	1.267	1.00
122_I	126_V	1.265	1.00
122_I	165_I	1.258	1.00
250_H	286_E	1.258	1.00
221_R	225_G	1.239	1.00
224_E	231_N	1.239	1.00
253_V	265_I	1.235	1.00
211_P	237_I	1.234	1.00
69_N	72_K	1.224	1.00
208_E	246_A	1.215	1.00
253_V	259_I	1.205	1.00
215_D	218_D	1.197	1.00
125_L	165_I	1.196	1.00
266_L	284_Q	1.194	1.00
32_G	44_A	1.191	1.00
60_A	83_A	1.190	1.00
113_A	117_M	1.189	1.00
95_S	192_L	1.183	1.00
217_S	220_I	1.174	1.00
226_T	265_I	1.172	1.00
133_W	137_S	1.170	1.00
118_L	169_I	1.170	1.00
236_H	280_H	1.169	1.00
126_V	130_L	1.168	1.00
106_F	181_P	1.164	1.00
25_M	48_L	1.163	1.00
270_E	274_E	1.152	1.00
92_I	195_G	1.151	1.00
118_L	168_A	1.146	1.00
38_L	102_A	1.145	1.00
273_L	278_I	1.139	1.00
63_L	79_F	1.137	1.00
150_A	153_H	1.131	1.00
72_K	204_H	1.129	1.00
228_G	261_E	1.127	1.00
263_E	266_L	1.125	1.00
170_L	179_A	1.124	1.00
235_L	249_C	1.120	1.00
130_L	133_W	1.116	1.00
20_M	131_V	1.110	1.00
19_I	23_G	1.102	1.00
116_G	119_T	1.097	1.00
263_E	287_T	1.094	1.00
56_V	83_A	1.086	1.00
247_L	278_I	1.084	1.00
106_F	178_W	1.076	1.00
24_Y	28_E	1.072	1.00
101_E	104_E	1.071	1.00
18_F	51_S	1.070	1.00
219_I	273_L	1.069	1.00
176_W	179_A	1.066	1.00
233_H	252_V	1.065	1.00
119_T	122_I	1.064	1.00
218_D	221_R	1.060	1.00
77_K	244_L	1.054	1.00
71_N	76_Y	1.049	1.00
130_L	134_I	1.048	1.00
162_V	166_L	1.048	1.00
270_E	284_Q	1.045	1.00
138_G	141_T	1.042	1.00
256_Q	260_S	1.035	1.00
81_I	205_I	1.035	1.00
259_I	285_M	1.032	1.00
262_S	266_L	1.030	1.00
25_M	44_A	1.028	1.00
213_N	217_S	1.022	1.00
12_K	16_I	1.020	1.00
92_I	196_Y	1.019	1.00
247_L	281_V	1.019	1.00
99_I	103_I	1.018	1.00
57_A	149_G	1.018	1.00
133_W	136_M	1.015	1.00
88_G	198_V	1.013	1.00
266_L	285_M	1.013	1.00
260_S	264_N	1.012	1.00
225_G	272_E	1.002	1.00
25_M	29_A	1.000	1.00
208_E	240_I	0.995	1.00
24_Y	127_V	0.993	1.00
62_T	65_E	0.989	1.00
29_A	41_L	0.986	1.00
138_G	142_K	0.985	1.00
219_I	237_I	0.984	1.00
92_I	192_L	0.983	1.00
222_T	225_G	0.976	1.00
63_L	66_K	0.975	1.00
17_S	131_V	0.972	1.00
151_Y	155_I	0.971	1.00
171_I	174_F	0.969	1.00
114_T	117_M	0.949	1.00
43_D	161_S	0.944	1.00
38_L	105_R	0.942	1.00
18_F	55_M	0.942	1.00
106_F	185_I	0.938	1.00
89_A	93_L	0.937	1.00
82_L	207_M	0.936	1.00
18_F	58_L	0.935	1.00
267_R	271_H	0.935	1.00
43_D	46_H	0.933	1.00
253_V	262_S	0.931	1.00
71_N	209_G	0.931	1.00
113_A	116_G	0.930	1.00
73_T	210_T	0.924	1.00
26_I	30_I	0.920	1.00
132_A	151_Y	0.916	1.00
102_A	185_I	0.914	1.00
121_S	165_I	0.908	1.00
240_I	246_A	0.906	1.00
57_A	146_N	0.904	1.00
38_L	184_S	0.894	1.00
59_I	63_L	0.890	1.00
234_D	280_H	0.890	1.00
103_I	185_I	0.887	1.00
33_F	41_L	0.886	1.00
221_R	224_E	0.886	1.00
229_I	251_A	0.883	1.00
211_P	214_I	0.880	1.00
228_G	265_I	0.880	1.00
101_E	105_R	0.877	1.00
274_E	279_T	0.873	1.00
211_P	245_N	0.861	1.00
230_Q	288_E	0.860	1.00
273_L	281_V	0.856	1.00
272_E	275_H	0.853	1.00
205_I	239_S	0.851	1.00
210_T	216_V	0.850	1.00
220_I	232_I	0.848	1.00
222_T	226_T	0.838	1.00
22_T	26_I	0.836	1.00
234_D	250_H	0.835	1.00
129_L	155_I	0.828	1.00
216_V	220_I	0.827	1.00
97_Y	101_E	0.826	1.00
253_V	285_M	0.824	1.00
208_E	238_W	0.821	1.00
27_I	123_I	0.816	1.00
80_E	144_N	0.813	1.00
252_V	288_E	0.813	1.00
46_H	50_D	0.813	1.00
266_L	283_I	0.813	1.00
267_R	270_E	0.812	1.00
223_I	232_I	0.809	1.00
132_A	136_M	0.805	1.00
92_I	96_L	0.804	1.00
139_G	151_Y	0.802	1.00
49_S	94_I	0.801	1.00
228_G	268_K	0.795	1.00
224_E	232_I	0.794	1.00
104_E	107_S	0.793	1.00
262_S	265_I	0.792	1.00
25_M	51_S	0.791	1.00
167_A	179_A	0.789	1.00
232_I	235_L	0.787	1.00
232_I	249_C	0.785	1.00
263_E	286_E	0.782	1.00
182_L	186_I	0.781	1.00
38_L	101_E	0.780	1.00
85_V	199_T	0.780	1.00
13_V	134_I	0.778	1.00
131_V	154_V	0.778	1.00
153_H	157_D	0.773	1.00
27_I	120_I	0.770	1.00
168_A	172_I	0.766	1.00
78_R	238_W	0.763	1.00
124_G	128_N	0.756	1.00
37_S	180_D	0.753	1.00
118_L	122_I	0.750	1.00
21_I	47_M	0.749	1.00
156_S	194_S	0.747	1.00
136_M	139_G	0.741	1.00
268_K	271_H	0.739	1.00
269_I	283_I	0.739	1.00
74_F	238_W	0.738	1.00
236_H	248_S	0.736	1.00
215_D	245_N	0.734	1.00
211_P	215_D	0.731	1.00
183_A	187_V	0.729	1.00
125_L	162_V	0.721	1.00
128_N	131_V	0.719	1.00
93_L	100_Y	0.718	1.00
33_F	44_A	0.717	1.00
29_A	48_L	0.715	1.00
28_E	44_A	0.714	1.00
264_N	267_R	0.713	1.00
179_A	183_A	0.712	1.00
132_A	155_I	0.711	1.00
219_I	247_L	0.710	1.00
17_S	135_M	0.707	1.00
85_V	89_A	0.705	1.00
265_I	269_I	0.699	1.00
145_L	205_I	0.698	1.00
228_G	254_D	0.696	1.00
137_S	140_D	0.694	1.00
82_L	86_I	0.694	1.00
39_A	183_A	0.691	1.00
59_I	62_T	0.691	1.00
239_S	245_N	0.690	1.00
131_V	135_M	0.689	1.00
11_K	58_L	0.685	1.00
104_E	110_P	0.684	1.00
25_M	47_M	0.683	1.00
134_I	138_G	0.682	1.00
152_L	155_I	0.678	1.00
223_I	251_A	0.678	1.00
284_Q	287_T	0.676	1.00
190_L	194_S	0.674	1.00
13_V	138_G	0.673	1.00
149_G	198_V	0.672	1.00
64_A	80_E	0.671	1.00
61_F	146_N	0.670	1.00
13_V	137_S	0.669	1.00
32_G	35_T	0.668	1.00
85_V	202_S	0.665	1.00
46_H	91_L	0.665	1.00
53_S	57_A	0.664	1.00
269_I	272_E	0.661	1.00
262_S	287_T	0.660	1.00
145_L	201_D	0.659	1.00
278_I	281_V	0.658	1.00
204_H	212_E	0.658	1.00
73_T	236_H	0.657	1.00
255_D	288_E	0.656	0.99
84_A	146_N	0.656	0.99
214_I	237_I	0.655	0.99
135_M	150_A	0.654	0.99
148_R	152_L	0.654	0.99
53_S	90_A	0.649	0.99
274_E	281_V	0.646	0.99
17_S	154_V	0.646	0.99
239_S	243_G	0.645	0.99
270_E	281_V	0.645	0.99
105_R	110_P	0.642	0.99
48_L	52_I	0.641	0.99
21_I	50_D	0.641	0.99
271_H	274_E	0.640	0.99
210_T	237_I	0.638	0.99
30_I	33_F	0.636	0.99
266_L	269_I	0.635	0.99
71_N	204_H	0.634	0.99
82_L	203_I	0.634	0.99
52_I	55_M	0.633	0.99
132_A	154_V	0.632	0.99
129_L	158_M	0.631	0.99
93_L	97_Y	0.631	0.99
84_A	198_V	0.629	0.99
17_S	54_L	0.627	0.99
186_I	190_L	0.627	0.99
229_I	232_I	0.626	0.99
19_I	22_T	0.624	0.99
102_A	188_A	0.619	0.99
127_V	131_V	0.618	0.99
261_E	268_K	0.617	0.99
121_S	124_G	0.612	0.99
143_N	277_G	0.610	0.99
58_L	62_T	0.607	0.99
95_S	195_G	0.606	0.99
110_P	113_A	0.605	0.99
88_G	202_S	0.601	0.99
170_L	173_F	0.601	0.99
28_E	43_D	0.599	0.99
251_A	285_M	0.599	0.99
17_S	150_A	0.598	0.99
193_R	196_Y	0.597	0.99
273_L	283_I	0.593	0.99
248_S	280_H	0.591	0.99
15_L	18_F	0.589	0.99
131_V	134_I	0.589	0.99
11_K	15_L	0.586	0.99
211_P	216_V	0.585	0.99
111_K	177_G	0.584	0.99
54_L	150_A	0.581	0.99
263_E	267_R	0.579	0.99
36_N	110_P	0.578	0.99
235_L	247_L	0.576	0.99
128_N	154_V	0.572	0.99
135_M	154_V	0.568	0.99
139_G	142_K	0.567	0.99
164_A	167_A	0.561	0.98
38_L	41_L	0.561	0.98
79_F	83_A	0.560	0.98
256_Q	261_E	0.560	0.98
53_S	153_H	0.559	0.98
84_A	202_S	0.552	0.98
226_T	229_I	0.551	0.98
159_L	162_V	0.550	0.98
102_A	181_P	0.549	0.98
140_D	148_R	0.549	0.98
72_K	209_G	0.548	0.98
114_T	172_I	0.547	0.98
222_T	269_I	0.546	0.98
155_I	159_L	0.544	0.98
227_E	268_K	0.542	0.98
128_N	135_M	0.542	0.98
163_G	187_V	0.542	0.98
171_I	179_A	0.542	0.98
148_R	151_Y	0.540	0.98
16_I	19_I	0.540	0.98
190_L	193_R	0.536	0.98
153_H	156_S	0.536	0.98
35_T	116_G	0.534	0.98
247_L	279_T	0.533	0.98
14_L	18_F	0.532	0.98
93_L	96_L	0.530	0.98
251_A	283_I	0.528	0.98
268_K	275_H	0.527	0.98
14_L	57_A	0.524	0.98
101_E	185_I	0.523	0.98
223_I	229_I	0.523	0.98
24_Y	27_I	0.522	0.98
128_N	153_H	0.522	0.98
66_K	76_Y	0.521	0.97
62_T	66_K	0.520	0.97
183_A	186_I	0.519	0.97
160_G	167_A	0.519	0.97
203_I	207_M	0.517	0.97
21_I	51_S	0.517	0.97
67_K	76_Y	0.517	0.97
125_L	129_L	0.517	0.97
174_F	179_A	0.516	0.97
85_V	206_L	0.513	0.97
18_F	54_L	0.511	0.97
188_A	195_G	0.510	0.97
10_N	61_F	0.507	0.97
56_V	86_I	0.507	0.97
210_T	239_S	0.506	0.97
94_I	98_I	0.504	0.97
10_N	142_K	0.504	0.97
29_A	45_G	0.502	0.97
112_V	115_T	0.502	0.97
123_I	127_V	0.501	0.97
106_F	182_L	0.500	0.97
68_A	76_Y	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3j1zP	8	0.9389	100	0.143	Contact Map
3h90A	3	0.9035	100	0.177	Contact Map
2zztA	2	0.254	99.6	0.754	Contact Map
3bypA	2	0.254	99.5	0.776	Contact Map
3w61A	2	0.2508	99.3	0.799	Contact Map
2wkbA	3	0.3408	48.9	0.946	Contact Map
3b9wA	3	0.6463	37.9	0.949	Contact Map
3cq1A	2	0.3151	37.7	0.949	Contact Map
1mhsA	2	0.7203	26.8	0.953	Contact Map
3ncqA	4	0.3087	26.6	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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