GREMLIN Database
YRDC - Uncharacterized isochorismatase family protein YrdC
UniProt: O07081 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 187 (161)
Sequences: 10080 (6938)
Seq/√Len: 546.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_E101_K3.4561.00
51_Q84_T2.8821.00
107_T132_D2.8131.00
97_E131_F2.7511.00
40_W45_W2.7351.00
89_S125_M2.6121.00
33_I111_T2.4401.00
5_K107_T2.4271.00
97_E129_L2.4031.00
12_V33_I2.3221.00
36_I136_I2.3051.00
107_T134_Y2.2871.00
110_I123_T2.2211.00
15_A67_G2.0341.00
95_N99_F1.9861.00
4_K106_T1.9821.00
126_S133_T1.9481.00
120_S124_R1.9261.00
83_I99_F1.9071.00
90_S122_T1.8691.00
32_N139_A1.8641.00
166_L171_A1.8641.00
14_K66_E1.8411.00
6_A105_I1.8401.00
48_I99_F1.8131.00
39_L43_K1.7971.00
32_N35_K1.7711.00
41_R80_E1.6651.00
14_K72_E1.6361.00
5_K109_V1.5951.00
17_D71_K1.5731.00
137_S173_I1.5471.00
109_V136_I1.5451.00
81_V99_F1.5241.00
40_W109_V1.5181.00
9_I37_L1.5161.00
66_E69_A1.5121.00
50_I90_S1.5041.00
137_S175_T1.4631.00
25_N28_K1.4271.00
46_T103_N1.4181.00
34_S38_E1.4141.00
9_I111_T1.4101.00
115_T140_T1.3971.00
108_V126_S1.3891.00
116_P142_A1.3811.00
63_P84_T1.3721.00
119_V135_L1.3451.00
53_T68_F1.3281.00
99_F103_N1.3071.00
34_S73_I1.3031.00
110_I122_T1.3021.00
125_M129_L1.2821.00
8_I110_I1.2801.00
9_I12_V1.2631.00
98_E102_L1.2561.00
135_L140_T1.2551.00
29_A33_I1.2521.00
145_M160_N1.2391.00
101_K131_F1.2241.00
10_V118_C1.2181.00
38_E42_E1.2021.00
53_T84_T1.1961.00
51_Q70_I1.1911.00
7_L40_W1.1761.00
31_E73_I1.1551.00
37_L41_R1.1371.00
160_N164_A1.1211.00
109_V134_Y1.0991.00
36_I139_A1.0931.00
14_K69_A1.0841.00
37_L49_Y1.0651.00
9_I33_I1.0631.00
51_Q82_I1.0411.00
32_N138_D1.0351.00
99_F102_L1.0261.00
121_T124_R1.0261.00
157_T160_N1.0241.00
123_T135_L1.0091.00
159_H163_L1.0011.00
62_H65_N0.9981.00
115_T163_L0.9831.00
35_K39_L0.9781.00
5_K45_W0.9741.00
108_V133_T0.9711.00
70_I82_I0.9711.00
100_L131_F0.9611.00
39_L42_E0.9581.00
95_N98_E0.9481.00
77_M80_E0.9471.00
115_T142_A0.9301.00
120_S162_S0.9141.00
115_T159_H0.9081.00
6_A48_I0.9051.00
53_T63_P0.9041.00
29_A141_A0.9031.00
49_Y76_P0.8981.00
136_I174_L0.8981.00
11_D85_K0.8941.00
12_V113_L0.8881.00
36_I111_T0.8861.00
14_K18_D0.8831.00
120_S165_T0.8821.00
69_A75_K0.8741.00
111_T139_A0.8701.00
137_S163_L0.8681.00
35_K38_E0.8641.00
92_I129_L0.8621.00
34_S76_P0.8571.00
38_E77_M0.8521.00
136_I139_A0.8481.00
49_Y70_I0.8471.00
87_V130_G0.8381.00
87_V93_G0.8381.00
6_A100_L0.8381.00
55_D63_P0.8331.00
8_I96_L0.8271.00
91_F126_S0.8201.00
90_S96_L0.8181.00
76_P80_E0.8171.00
30_E34_S0.8141.00
123_T166_L0.8071.00
144_G157_T0.7971.00
46_T105_I0.7951.00
33_I139_A0.7951.00
37_L47_V0.7901.00
142_A159_H0.7901.00
134_Y174_L0.7881.00
10_V110_I0.7851.00
56_K59_S0.7771.00
66_E72_E0.7721.00
48_I103_N0.7691.00
106_T132_D0.7651.00
4_K107_T0.7551.00
110_I119_V0.7551.00
48_I81_V0.7501.00
132_D172_T0.7491.00
72_E75_K0.7471.00
30_E71_K0.7411.00
49_Y79_E0.7381.00
157_T161_I0.7361.00
38_E75_K0.7321.00
16_F118_C0.7311.00
14_K71_K0.7261.00
125_M128_N0.7251.00
41_R77_M0.7241.00
31_E35_K0.7221.00
163_L173_I0.7221.00
81_V103_N0.7201.00
113_L141_A0.7141.00
28_K31_E0.7091.00
76_P82_I0.7071.00
31_E34_S0.7071.00
34_S75_K0.7051.00
46_T99_F0.7051.00
110_I133_T0.7021.00
29_A113_L0.7021.00
49_Y80_E0.7011.00
12_V71_K0.6851.00
140_T159_H0.6831.00
22_G27_V0.6821.00
157_T164_A0.6751.00
116_P165_T0.6711.00
161_I165_T0.6701.00
123_T133_T0.6701.00
114_T142_A0.6591.00
37_L40_W0.6541.00
41_R79_E0.6541.00
116_P143_F0.6521.00
18_D27_V0.6511.00
9_I49_Y0.6511.00
162_S165_T0.6451.00
26_N113_L0.6441.00
158_I162_S0.6441.00
24_R141_A0.6421.00
4_K104_E0.6411.00
158_I161_I0.6411.00
7_L36_I0.6351.00
158_I164_A0.6351.00
71_K74_V0.6341.00
36_I109_V0.6331.00
17_D30_E0.6301.00
51_Q68_F0.6271.00
65_N68_F0.6261.00
98_E101_K0.6241.00
121_T170_F0.6221.00
162_S166_L0.6151.00
92_I128_N0.6141.00
144_G158_I0.6141.00
15_A61_F0.6141.00
52_H61_F0.6071.00
92_I125_M0.6051.00
41_R47_V0.6041.00
37_L80_E0.5971.00
19_K22_G0.5941.00
114_T117_H0.5931.00
57_P60_L0.5911.00
12_V29_A0.5901.00
41_R49_Y0.5881.00
7_L111_T0.5881.00
48_I83_I0.5861.00
89_S128_N0.5820.99
55_D86_T0.5800.99
40_W46_T0.5740.99
88_N122_T0.5720.99
159_H162_S0.5720.99
13_Q51_Q0.5720.99
49_Y74_V0.5710.99
46_T81_V0.5690.99
114_T143_F0.5680.99
140_T163_L0.5660.99
49_Y82_I0.5660.99
7_L37_L0.5630.99
164_A168_D0.5590.99
109_V138_D0.5590.99
119_V140_T0.5560.99
133_T136_I0.5540.99
58_H61_F0.5520.99
36_I40_W0.5490.99
24_R28_K0.5470.99
30_E74_V0.5460.99
88_N128_N0.5430.99
64_K69_A0.5410.99
51_Q69_A0.5410.99
161_I164_A0.5400.99
60_L65_N0.5390.99
100_L105_I0.5250.99
13_Q50_I0.5230.99
18_D66_E0.5220.99
137_S167_H0.5200.99
28_K32_N0.5190.99
134_Y172_T0.5160.99
83_I95_N0.5150.99
164_A167_H0.5150.99
76_P79_E0.5130.99
12_V74_V0.5110.99
17_D26_N0.5100.99
88_N127_G0.5100.99
86_T95_N0.5090.99
30_E73_I0.5050.99
61_F67_G0.5040.99
117_H143_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mcwA 2 1 100 0.165 Contact Map
3oqpA 2 0.9893 100 0.174 Contact Map
4l07A 4 0.9412 100 0.175 Contact Map
3irvA 2 1 100 0.176 Contact Map
3lqyA 2 0.9519 100 0.18 Contact Map
1nbaA 4 0.9412 100 0.182 Contact Map
3ot4A 4 0.9251 100 0.183 Contact Map
3hb7A 3 0.9251 100 0.19 Contact Map
3hu5A 3 0.9198 100 0.194 Contact Map
2fq1A 2 0.9412 100 0.197 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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