GREMLIN Database
LUTB - Lactate utilization protein B
UniProt: O07021 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (456)
Sequences: 1365 (768)
Seq/√Len: 35.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
460_S468_D5.5361.00
77_V82_G4.6691.00
95_S99_D4.6031.00
73_L292_L4.0851.00
99_D103_K4.0831.00
98_R129_E3.9091.00
101_I202_I3.8791.00
60_Q312_Q3.8571.00
74_A78_A3.8561.00
53_S376_K3.5741.00
125_V129_E3.5281.00
202_I237_I3.4401.00
106_G202_I3.4271.00
82_G290_F3.4241.00
77_V292_L3.4071.00
72_Q75_E3.2051.00
76_N79_K3.2021.00
77_V290_F3.1511.00
101_I237_I3.1171.00
104_K289_E3.0991.00
216_S274_A3.0641.00
378_P381_E3.0101.00
98_R125_V2.8961.00
91_E95_S2.8791.00
97_I293_V2.8721.00
104_K235_T2.8191.00
117_T239_V2.8191.00
55_S258_M2.7741.00
85_Y96_Y2.7501.00
65_N68_F2.7361.00
146_D161_K2.7141.00
61_H69_Y2.7071.00
310_V342_I2.6401.00
110_V136_T2.5921.00
370_S380_H2.5711.00
344_A383_L2.5631.00
149_D161_K2.5361.00
56_E312_Q2.5171.00
146_D169_V2.4871.00
460_S465_W2.4091.00
100_V235_T2.3851.00
345_V379_L2.3691.00
195_K199_E2.3260.99
345_V382_L2.3240.99
82_G292_L2.3100.99
211_I246_V2.3010.99
242_M294_I2.2820.99
234_K288_E2.2780.99
61_H65_N2.2760.99
106_G237_I2.2620.99
306_E385_K2.2420.99
216_S276_T2.2300.99
210_A240_M2.2170.99
363_S379_L2.1750.99
88_K92_E2.1500.99
168_D172_E2.1490.99
71_G75_E2.1330.99
201_D234_K2.1170.99
110_V200_A2.1080.99
62_V69_Y2.0940.99
132_E196_K2.0650.99
211_I252_F2.0500.99
207_C240_M2.0070.98
73_L210_A1.9930.98
49_E376_K1.9870.98
107_K201_D1.9780.98
53_S57_E1.9670.98
73_L77_V1.9590.98
63_L312_Q1.9060.98
20_N165_Q1.8920.98
85_Y291_H1.8840.98
103_K289_E1.8800.98
179_T184_E1.8540.97
92_E95_S1.8410.97
102_Q129_E1.8140.97
164_E180_E1.7750.97
112_S226_G1.7680.96
116_V295_V1.7660.96
302_I349_L1.7560.96
58_I254_V1.7520.96
120_I239_V1.7500.96
363_S383_L1.7490.96
83_H289_E1.7410.96
109_I204_I1.7340.96
410_L414_S1.7270.96
320_I339_S1.7140.96
248_S251_E1.7110.96
56_E309_S1.6850.95
181_K184_E1.6820.95
213_D248_S1.6680.95
96_Y100_V1.6630.95
205_T230_S1.6620.95
309_S382_L1.6590.95
218_S274_A1.6530.95
101_I106_G1.6410.95
443_G446_K1.6390.95
89_T92_E1.5950.94
87_A96_Y1.5940.94
62_V245_I1.5880.94
423_K464_D1.5720.93
344_A363_S1.5650.93
109_I131_C1.5420.93
72_Q76_N1.5050.92
74_A86_F1.4970.91
65_N69_Y1.4740.91
183_E187_M1.4490.90
240_M294_I1.4260.89
465_W469_R1.4060.89
59_R244_R1.4030.88
138_L189_A1.4010.88
461_R464_D1.3950.88
442_P449_T1.3640.87
56_E60_Q1.3560.87
67_D71_G1.3560.87
56_E376_K1.3520.86
279_K283_E1.3500.86
239_V293_V1.3490.86
34_L156_A1.3350.86
429_M457_P1.3320.86
235_T289_E1.3300.86
210_A294_I1.3200.85
170_F189_A1.3150.85
125_V128_K1.3090.85
189_A193_L1.3090.85
305_T389_N1.3060.85
26_A162_N1.3010.84
240_M292_L1.2990.84
53_S56_E1.2920.84
97_I120_I1.2920.84
96_Y291_H1.2720.83
155_V317_A1.2720.83
141_Y192_I1.2690.83
94_S120_I1.2640.83
347_S356_Y1.2580.82
202_I235_T1.2570.82
117_T204_I1.2460.82
385_K388_Q1.2460.82
307_F389_N1.2430.81
438_I442_P1.2360.81
246_V252_F1.2360.81
142_I170_F1.2330.81
70_L86_F1.2310.81
408_F412_A1.2300.81
98_R102_Q1.2260.81
127_E147_D1.2220.80
309_S312_Q1.2040.79
146_D149_D1.1980.79
304_G308_Q1.1890.78
17_G23_M1.1790.78
217_V290_F1.1740.78
370_S376_K1.1720.77
407_A410_L1.1710.77
95_S125_V1.1700.77
405_M408_F1.1690.77
156_A159_L1.1680.77
161_K169_V1.1630.77
171_K177_Q1.1610.77
75_E79_K1.1550.76
410_L417_L1.1510.76
411_G421_G1.1410.75
185_L189_A1.1370.75
414_S417_L1.1280.75
22_F162_N1.1270.75
263_A317_A1.1240.74
218_S252_F1.1130.74
217_V238_T1.1120.74
73_L245_I1.1040.73
120_I295_V1.1030.73
418_Y422_S1.1020.73
116_V240_M1.1010.73
209_F252_F1.0980.73
147_D173_R1.0900.72
59_R255_L1.0830.72
365_L383_L1.0790.71
86_F294_I1.0710.71
108_K196_K1.0670.70
187_M191_A1.0650.70
419_K463_R1.0630.70
174_L188_H1.0560.70
122_L126_L1.0550.70
255_L375_V1.0530.69
220_V256_V1.0510.69
227_R231_T1.0370.68
94_S295_V1.0360.68
345_V363_S1.0290.68
76_N213_D1.0290.68
85_Y92_E1.0250.67
221_T227_R1.0110.66
159_L317_A1.0030.66
47_N50_E0.9970.65
73_L76_N0.9960.65
139_G156_A0.9940.65
100_V104_K0.9890.64
101_I204_I0.9850.64
464_D468_D0.9850.64
121_N150_P0.9830.64
222_N317_A0.9800.64
407_A450_Q0.9790.64
147_D150_P0.9740.63
460_S464_D0.9730.63
433_T456_A0.9730.63
62_V65_N0.9720.63
465_W468_D0.9710.63
17_G20_N0.9680.63
266_Q270_S0.9680.63
64_E308_Q0.9640.62
93_A120_I0.9630.62
217_V240_M0.9600.62
106_G201_D0.9580.62
138_L186_V0.9570.62
135_E338_Y0.9560.62
80_R277_G0.9550.62
15_S19_D0.9520.61
415_L419_K0.9520.61
122_L204_I0.9480.61
97_I239_V0.9480.61
170_F185_L0.9450.61
114_S117_T0.9440.61
112_S219_L0.9440.61
207_C210_A0.9370.60
207_C244_R0.9330.60
239_V295_V0.9320.60
429_M432_F0.9290.60
460_S469_R0.9280.59
351_G356_Y0.9230.59
73_L290_F0.9210.59
307_F382_L0.9210.59
189_A266_Q0.9180.59
80_R276_T0.9110.58
205_T236_Q0.9050.58
37_R339_S0.9040.57
171_K178_H0.9010.57
149_D169_V0.8890.56
399_I402_K0.8890.56
422_S461_R0.8880.56
203_G233_P0.8870.56
256_V272_I0.8860.56
154_I339_S0.8860.56
306_E389_N0.8810.55
58_I62_V0.8800.55
209_F375_V0.8770.55
123_N366_C0.8730.55
124_E127_E0.8700.55
90_A94_S0.8700.55
370_S378_P0.8700.55
134_V196_K0.8690.54
80_R278_P0.8650.54
121_N124_E0.8650.54
124_E128_K0.8650.54
65_N247_P0.8640.54
161_K165_Q0.8640.54
114_S239_V0.8620.54
50_E53_S0.8600.54
411_G417_L0.8600.54
167_R171_K0.8590.54
67_D303_L0.8560.53
182_P186_V0.8560.53
99_D293_V0.8550.53
423_K439_S0.8510.53
367_A383_L0.8500.53
205_T227_R0.8500.53
38_R372_A0.8450.52
260_T272_I0.8450.52
69_Y247_P0.8440.52
95_S103_K0.8430.52
39_L43_E0.8430.52
421_G424_W0.8420.52
117_T122_L0.8410.52
97_I204_I0.8400.52
462_F466_F0.8390.52
329_V333_S0.8350.51
70_L74_A0.8320.51
322_V339_S0.8300.51
155_V269_T0.8290.51
73_L211_I0.8230.50
98_R106_G0.8150.50
79_K90_A0.8150.50
193_L266_Q0.8130.50
100_V106_G0.8130.50
36_T40_E0.8120.49
117_T123_N0.8110.49
106_G235_T0.8100.49
379_L383_L0.8090.49
305_T308_Q0.8070.49
55_S375_V0.8060.49
426_P464_D0.8030.49
363_S367_A0.8010.49
402_K406_K0.7970.48
69_Y72_Q0.7930.48
337_I347_S0.7910.48
407_A411_G0.7890.47
412_A418_Y0.7860.47
83_H103_K0.7830.47
308_Q379_L0.7820.47
207_C294_I0.7810.47
370_S381_E0.7810.47
27_V327_R0.7810.47
347_S351_G0.7800.47
125_V293_V0.7790.47
41_A265_G0.7770.46
39_L372_A0.7750.46
68_F72_Q0.7710.46
111_K366_C0.7700.46
207_C238_T0.7700.46
118_E123_N0.7670.46
207_C292_L0.7670.46
158_A166_I0.7650.45
134_V199_E0.7650.45
348_P448_W0.7610.45
210_A245_I0.7590.45
230_S275_L0.7570.45
108_K199_E0.7540.44
249_F274_A0.7540.44
385_K389_N0.7530.44
364_S371_E0.7520.44
439_S442_P0.7520.44
128_K293_V0.7510.44
211_I248_S0.7510.44
17_G246_V0.7500.44
90_A120_I0.7480.44
146_D166_I0.7480.44
166_I258_M0.7470.44
139_G222_N0.7400.43
227_R275_L0.7400.43
63_L66_L0.7400.43
123_N266_Q0.7390.43
219_L275_L0.7380.43
100_V105_N0.7370.43
101_I235_T0.7360.43
442_P446_K0.7340.43
86_F244_R0.7330.43
310_V345_V0.7320.43
341_P448_W0.7320.43
440_K446_K0.7310.42
227_R230_S0.7290.42
10_F362_A0.7290.42
175_D180_E0.7270.42
85_Y100_V0.7270.42
20_N23_M0.7240.42
108_K132_E0.7240.42
49_E53_S0.7240.42
61_H248_S0.7240.42
395_G402_K0.7240.42
38_R263_A0.7220.42
74_A244_R0.7220.42
302_I310_V0.7200.42
143_L149_D0.7200.42
439_S443_G0.7190.41
71_G86_F0.7170.41
353_Y390_I0.7170.41
139_G266_Q0.7150.41
155_V263_A0.7130.41
73_L216_S0.7120.41
62_V237_I0.7110.41
444_P447_N0.7100.41
168_D171_K0.7040.40
166_I337_I0.7040.40
67_D300_S0.7000.40
163_K422_S0.6990.40
18_I24_R0.6960.40
230_S238_T0.6950.39
312_Q382_L0.6920.39
123_N197_F0.6920.39
166_I269_T0.6920.39
268_L272_I0.6910.39
89_T273_T0.6900.39
167_R180_E0.6870.39
78_A83_H0.6870.39
12_E16_Q0.6830.38
101_I125_V0.6820.38
16_Q470_E0.6820.38
348_P359_L0.6820.38
93_A239_V0.6820.38
139_G236_Q0.6810.38
388_Q392_E0.6800.38
76_N80_R0.6780.38
450_Q469_R0.6780.38
27_V328_H0.6760.38
365_L448_W0.6740.38
327_R368_A0.6730.38
30_A156_A0.6720.38
391_V395_G0.6690.37
179_T368_A0.6690.37
86_F242_M0.6680.37
70_L348_P0.6680.37
72_Q79_K0.6670.37
204_I228_L0.6660.37
406_K467_A0.6660.37
252_F255_L0.6640.37
421_G440_K0.6640.37
123_N264_V0.6630.37
33_R156_A0.6630.37
318_A377_I0.6620.37
111_K123_N0.6620.37
193_L264_V0.6610.37
23_M165_Q0.6610.37
460_S471_T0.6600.37
167_R179_T0.6600.37
238_T292_L0.6590.37
423_K461_R0.6590.37
421_G445_L0.6580.36
345_V372_A0.6570.36
56_E382_L0.6540.36
155_V333_S0.6540.36
309_S356_Y0.6540.36
189_A332_H0.6540.36
122_L193_L0.6520.36
61_H68_F0.6520.36
256_V260_T0.6510.36
110_V229_V0.6500.36
172_E191_A0.6500.36
416_S420_M0.6490.36
59_R302_I0.6490.36
38_R42_A0.6490.36
156_A269_T0.6480.36
18_I143_L0.6480.36
392_E395_G0.6470.36
155_V159_L0.6470.36
360_P363_S0.6470.36
104_K234_K0.6470.36
166_I400_S0.6450.35
177_Q184_E0.6430.35
416_S419_K0.6430.35
105_N130_G0.6430.35
28_S32_E0.6400.35
264_V346_L0.6400.35
73_L368_A0.6390.35
16_Q411_G0.6390.35
152_S332_H0.6380.35
127_E293_V0.6380.35
68_F75_E0.6360.35
166_I357_K0.6340.35
118_E149_D0.6340.35
209_F255_L0.6330.34
95_S105_N0.6330.34
112_S139_G0.6310.34
287_P341_P0.6310.34
58_I470_E0.6290.34
9_A12_E0.6280.34
408_F418_Y0.6250.34
445_L455_P0.6230.34
252_F401_E0.6220.34
134_V166_I0.6220.34
107_K132_E0.6210.34
409_G413_S0.6210.34
430_T457_P0.6200.33
416_S450_Q0.6170.33
301_N304_G0.6170.33
59_R368_A0.6170.33
70_L245_I0.6160.33
98_R293_V0.6150.33
423_K431_P0.6140.33
186_V189_A0.6140.33
127_E132_E0.6110.33
49_E52_R0.6100.33
239_V366_C0.6090.33
116_V241_G0.6080.33
230_S236_Q0.6080.33
421_G470_E0.6060.32
278_P283_E0.6060.32
75_E78_A0.6060.32
222_N266_Q0.6050.32
203_G229_V0.6050.32
135_E207_C0.6050.32
339_S379_L0.6030.32
262_S374_P0.6030.32
38_R262_S0.6020.32
351_G355_D0.6020.32
221_T273_T0.6020.32
171_K176_Y0.6010.32
115_M151_P0.6010.32
203_G279_K0.6000.32
176_Y188_H0.5990.32
99_D102_Q0.5990.32
22_F165_Q0.5980.32
73_L259_L0.5980.32
31_Q221_T0.5970.32
75_E103_K0.5970.32
10_F237_I0.5940.31
15_S99_D0.5940.31
149_D173_R0.5940.31
130_G295_V0.5930.31
30_A221_T0.5930.31
12_E15_S0.5930.31
277_G338_Y0.5920.31
362_A365_L0.5910.31
238_T379_L0.5890.31
60_Q63_L0.5890.31
367_A380_H0.5890.31
354_D396_R0.5880.31
69_Y378_P0.5870.31
442_P458_H0.5860.31
98_R104_K0.5860.31
62_V249_F0.5860.31
94_S122_L0.5860.31
334_Y348_P0.5850.31
28_S274_A0.5840.31
349_L386_H0.5820.31
204_I239_V0.5810.30
112_S155_V0.5810.30
354_D456_A0.5800.30
197_F228_L0.5800.30
312_Q356_Y0.5800.30
227_R401_E0.5790.30
348_P360_P0.5790.30
71_G74_A0.5780.30
461_R469_R0.5770.30
334_Y350_L0.5760.30
189_A346_L0.5750.30
168_D178_H0.5740.30
378_P412_A0.5740.30
40_E172_E0.5740.30
345_V348_P0.5730.30
100_V204_I0.5720.30
26_A229_V0.5720.30
73_L238_T0.5700.30
404_A407_A0.5700.30
94_S185_L0.5700.30
23_M162_N0.5690.30
216_S249_F0.5690.30
442_P457_P0.5690.30
252_F274_A0.5680.30
54_L105_N0.5680.30
32_E327_R0.5670.29
25_G29_G0.5670.29
109_I202_I0.5660.29
170_F321_N0.5660.29
30_A37_R0.5650.29
70_L300_S0.5640.29
337_I404_A0.5640.29
59_R386_H0.5630.29
47_N257_S0.5620.29
98_R101_I0.5620.29
79_K424_W0.5620.29
205_T226_G0.5620.29
174_L182_P0.5620.29
266_Q366_C0.5620.29
112_S221_T0.5610.29
241_G342_I0.5610.29
83_H245_I0.5600.29
62_V396_R0.5600.29
52_R174_L0.5600.29
396_R404_A0.5590.29
112_S252_F0.5590.29
102_Q105_N0.5580.29
189_A264_V0.5580.29
410_L447_N0.5580.29
12_E36_T0.5580.29
167_R178_H0.5580.29
309_S409_G0.5570.29
143_L146_D0.5570.29
74_A300_S0.5570.29
294_I303_L0.5570.29
73_L294_I0.5560.29
279_K288_E0.5560.29
140_E331_G0.5540.29
341_P379_L0.5540.29
209_F334_Y0.5540.29
293_V428_A0.5540.29
166_I185_L0.5530.28
427_A430_T0.5520.28
154_I322_V0.5510.28
53_S121_N0.5510.28
293_V431_P0.5500.28
117_T462_F0.5500.28
135_E229_V0.5490.28
218_S238_T0.5490.28
171_K175_D0.5490.28
277_G367_A0.5480.28
428_A441_G0.5480.28
41_A261_R0.5480.28
449_T454_F0.5480.28
428_A439_S0.5480.28
90_A298_G0.5470.28
200_A233_P0.5460.28
450_Q468_D0.5460.28
58_I246_V0.5450.28
363_S366_C0.5450.28
300_S410_L0.5450.28
185_L382_L0.5450.28
70_L242_M0.5440.28
310_V346_L0.5440.28
214_T276_T0.5440.28
156_A163_K0.5430.28
161_K431_P0.5430.28
49_E345_V0.5430.28
311_L375_V0.5430.28
168_D177_Q0.5430.28
8_D199_E0.5420.28
101_I131_C0.5420.28
9_A464_D0.5420.28
303_L348_P0.5410.28
92_E99_D0.5410.28
16_Q464_D0.5410.28
122_L264_V0.5400.28
414_S421_G0.5400.28
112_S229_V0.5400.28
341_P365_L0.5390.27
65_N107_K0.5380.27
123_N332_H0.5380.27
55_S466_F0.5380.27
93_A293_V0.5380.27
401_E405_M0.5360.27
219_L462_F0.5360.27
221_T287_P0.5360.27
32_E274_A0.5360.27
25_G105_N0.5350.27
166_I184_E0.5340.27
430_T433_T0.5340.27
239_V246_V0.5330.27
52_R376_K0.5330.27
150_P293_V0.5320.27
292_L466_F0.5320.27
440_K450_Q0.5310.27
115_M332_H0.5310.27
185_L342_I0.5300.27
142_I145_I0.5300.27
141_Y266_Q0.5300.27
450_Q456_A0.5300.27
152_S291_H0.5290.27
166_I420_M0.5280.27
336_S351_G0.5280.27
50_E461_R0.5280.27
362_A383_L0.5270.27
104_K237_I0.5260.27
445_L454_F0.5260.27
45_L82_G0.5240.26
302_I350_L0.5230.26
12_E406_K0.5230.26
228_L231_T0.5230.26
102_Q250_S0.5230.26
95_S467_A0.5220.26
417_L420_M0.5220.26
26_A219_L0.5220.26
429_M456_A0.5210.26
407_A424_W0.5210.26
363_S370_S0.5200.26
214_T218_S0.5200.26
348_P363_S0.5200.26
166_I430_T0.5190.26
149_D332_H0.5190.26
363_S380_H0.5190.26
12_E97_I0.5190.26
159_L366_C0.5190.26
51_W294_I0.5180.26
73_L289_E0.5170.26
24_R27_V0.5160.26
115_M118_E0.5150.26
62_V268_L0.5150.26
143_L361_Y0.5130.26
140_E154_I0.5120.26
378_P382_L0.5120.26
51_W220_V0.5120.26
88_K420_M0.5110.26
403_L406_K0.5110.26
185_L291_H0.5100.26
336_S347_S0.5090.25
73_L240_M0.5080.25
79_K357_K0.5080.25
118_E266_Q0.5080.25
245_I461_R0.5070.25
69_Y385_K0.5070.25
59_R94_S0.5070.25
183_E337_I0.5060.25
51_W328_H0.5060.25
367_A457_P0.5060.25
156_A266_Q0.5050.25
112_S222_N0.5040.25
334_Y365_L0.5040.25
122_L346_L0.5040.25
398_P417_L0.5040.25
135_E203_G0.5030.25
60_Q64_E0.5030.25
163_K400_S0.5030.25
23_M135_E0.5030.25
207_C217_V0.5030.25
173_R176_Y0.5030.25
40_E393_K0.5030.25
163_K404_A0.5030.25
382_L385_K0.5020.25
9_A16_Q0.5020.25
146_D332_H0.5010.25
110_V172_E0.5000.25
384_L388_Q0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cf4A 2 0.8476 100 0.746 Contact Map
2g40A 2 0.3361 100 0.8 Contact Map
2h88B 1 0.4468 99.6 0.916 Contact Map
1kf6B 1 0.4656 99.5 0.923 Contact Map
4ysxB 1 0.4593 99.5 0.925 Contact Map
2wdqB 1 0.4447 99.4 0.926 Contact Map
2bs2B 1 0.4342 99.3 0.931 Contact Map
4p6vA 1 0.5846 98.8 0.944 Contact Map
3c8yA 1 0.5658 98.5 0.95 Contact Map
1gteA 4 0.7411 98.4 0.951 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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