GREMLIN Database
LUTA - Lactate utilization protein A
UniProt: O07020 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (219)
Sequences: 7551 (4702)
Seq/√Len: 317.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_K160_Q3.6581.00
24_E236_N3.6581.00
21_A233_E3.6371.00
130_K162_T3.3221.00
115_V151_K3.2441.00
110_L232_A3.1541.00
51_Y54_D2.9211.00
108_Y116_N2.8211.00
74_S80_T2.6681.00
203_V229_M2.5201.00
41_C79_C2.4741.00
129_T203_V2.4311.00
22_T75_P2.3271.00
22_T110_L2.2681.00
17_N233_E2.2291.00
166_G195_C2.1671.00
135_T150_M2.1601.00
164_L196_V2.1371.00
165_P198_E2.1151.00
189_V218_R2.1121.00
205_I234_V2.1061.00
150_M163_E2.0631.00
11_V19_G2.0011.00
3_V113_F1.9641.00
5_L75_P1.8961.00
9_C41_C1.8571.00
31_C113_F1.8511.00
151_K154_S1.8281.00
84_R112_D1.8141.00
150_M154_S1.7921.00
59_M86_Y1.7741.00
18_V233_E1.7521.00
129_T202_E1.7391.00
42_C79_C1.7331.00
194_E198_E1.6901.00
71_Y106_K1.6501.00
56_K60_K1.6321.00
47_Y82_M1.6261.00
132_T164_L1.5901.00
189_V214_N1.5751.00
9_C79_C1.5701.00
40_I61_R1.5511.00
116_N148_E1.5431.00
131_A159_L1.5101.00
186_E218_R1.5091.00
71_Y108_Y1.4961.00
103_L107_T1.4891.00
108_Y113_F1.4801.00
130_K202_E1.4791.00
108_Y112_D1.4531.00
195_C198_E1.4521.00
23_V33_V1.4361.00
131_A234_V1.4331.00
76_S208_D1.4301.00
60_K64_E1.4171.00
153_L205_I1.3681.00
140_T146_R1.3651.00
182_A186_E1.3581.00
131_A205_I1.3391.00
189_V193_V1.3141.00
64_E67_Q1.3091.00
28_R236_N1.2971.00
80_T143_L1.2951.00
4_S70_E1.2871.00
190_D194_E1.2631.00
128_H160_Q1.2631.00
147_K151_K1.2481.00
61_R65_T1.2411.00
133_L149_P1.2401.00
21_A236_N1.2271.00
74_S83_F1.2191.00
166_G191_E1.2131.00
171_C211_C1.2041.00
112_D148_E1.1981.00
112_D116_N1.1941.00
80_T107_T1.1881.00
132_T199_T1.1841.00
22_T26_L1.1801.00
73_V113_F1.1781.00
71_Y113_F1.1751.00
27_E33_V1.1741.00
62_M83_F1.1721.00
23_V27_E1.1711.00
145_V148_E1.1681.00
44_Q78_S1.1661.00
9_C42_C1.1641.00
31_C117_V1.1581.00
25_L235_L1.1521.00
196_V204_L1.1401.00
20_K24_E1.1371.00
46_A54_D1.1351.00
229_M233_E1.1261.00
4_S69_S1.1251.00
166_G169_N1.1231.00
207_A231_I1.1221.00
8_T76_S1.1151.00
156_V159_L1.1121.00
111_T231_I1.1091.00
112_D145_V1.0981.00
59_M90_F1.0951.00
131_A203_V1.0931.00
34_D69_S1.0851.00
194_E197_E1.0801.00
36_P39_Q1.0791.00
154_S161_F1.0781.00
219_L228_V1.0751.00
72_V103_L1.0611.00
25_L236_N1.0561.00
7_V39_Q1.0511.00
3_V31_C1.0491.00
7_V35_F1.0201.00
193_V219_L1.0171.00
113_F117_V1.0011.00
24_E28_R1.0001.00
229_M234_V0.9811.00
44_Q48_N0.9781.00
114_I235_L0.9751.00
206_G212_L0.9671.00
3_V73_V0.9571.00
55_A82_M0.9561.00
151_K155_H0.9521.00
19_G23_V0.9501.00
167_K195_C0.9431.00
87_P104_A0.9411.00
25_L110_L0.9411.00
132_T196_V0.9401.00
136_S206_G0.9361.00
147_K150_M0.9341.00
116_N120_V0.9261.00
165_P195_C0.9161.00
128_H158_G0.9141.00
58_A62_M0.9111.00
196_V226_V0.9041.00
153_L159_L0.9041.00
204_L215_I0.9001.00
119_G151_K0.8991.00
147_K168_H0.8921.00
90_F93_D0.8851.00
17_N20_K0.8811.00
127_L159_L0.8801.00
49_S176_T0.8771.00
7_V19_G0.8751.00
132_T201_A0.8711.00
187_Q190_D0.8701.00
110_L114_I0.8671.00
183_Q187_Q0.8671.00
63_I67_Q0.8631.00
59_M89_L0.8581.00
182_A217_G0.8571.00
115_V119_G0.8511.00
15_Q18_V0.8501.00
5_L22_T0.8481.00
16_T20_K0.8441.00
5_L19_G0.8401.00
60_K93_D0.8351.00
25_L232_A0.8351.00
115_V148_E0.8331.00
108_Y117_V0.8321.00
62_M65_T0.8131.00
81_T142_L0.8081.00
53_H56_K0.8071.00
48_N78_S0.8031.00
54_D58_A0.8021.00
176_T180_K0.8021.00
130_K200_G0.8021.00
46_A58_A0.8001.00
117_V120_V0.8001.00
23_V35_F0.7991.00
26_L31_C0.7961.00
5_L11_V0.7951.00
47_Y55_A0.7931.00
164_L167_K0.7821.00
139_M145_V0.7751.00
3_V33_V0.7751.00
4_S66_F0.7711.00
117_V121_E0.7701.00
20_K23_V0.7640.99
58_A61_R0.7600.99
78_S208_D0.7530.99
74_S107_T0.7520.99
127_L203_V0.7500.99
15_Q209_C0.7500.99
119_G155_H0.7500.99
190_D218_R0.7500.99
24_E27_E0.7470.99
133_L161_F0.7430.99
197_E225_N0.7390.99
91_Q105_D0.7350.99
18_V21_A0.7330.99
139_M207_A0.7320.99
54_D57_K0.7280.99
204_L226_V0.7280.99
65_T68_D0.7220.99
126_T158_G0.7210.99
205_I231_I0.7180.99
78_S138_H0.7170.99
148_E151_K0.7160.99
173_F178_S0.7140.99
81_T85_E0.7120.99
80_T84_R0.7120.99
129_T159_L0.7110.99
193_V197_E0.7070.99
136_S139_M0.7070.99
183_Q186_E0.7050.99
114_I118_L0.7030.99
11_V75_P0.7020.99
70_E106_K0.6980.99
132_T204_L0.6940.99
27_E32_E0.6900.99
186_E190_D0.6880.99
55_A59_M0.6860.99
135_T146_R0.6850.99
22_T232_A0.6850.99
47_Y52_V0.6830.99
57_K60_K0.6780.99
61_R64_E0.6760.99
163_E167_K0.6760.99
78_S210_G0.6730.99
114_I152_L0.6690.99
29_L117_V0.6690.99
191_E194_E0.6660.99
76_S79_C0.6570.98
85_E142_L0.6570.98
147_K154_S0.6550.98
173_F210_G0.6530.98
39_Q66_F0.6520.98
136_S208_D0.6500.98
215_I219_L0.6470.98
8_T208_D0.6450.98
26_L110_L0.6430.98
57_K61_R0.6370.98
62_M86_Y0.6340.98
4_S36_P0.6320.98
25_L152_L0.6250.98
22_T73_V0.6250.98
196_V215_I0.6230.98
133_L150_M0.6210.98
212_L228_V0.6160.98
17_N21_A0.6130.98
178_S185_S0.6120.97
11_V18_V0.6110.97
123_V155_H0.6100.97
115_V152_L0.6090.97
38_G69_S0.6090.97
135_T163_E0.6080.97
83_F103_L0.6060.97
27_E31_C0.6060.97
233_E236_N0.6060.97
197_E201_A0.6050.97
154_S158_G0.6040.97
15_Q212_L0.6020.97
119_G122_D0.6010.97
78_S173_F0.5990.97
55_A89_L0.5980.97
84_R143_L0.5920.97
193_V215_I0.5910.97
219_L226_V0.5890.97
85_E88_H0.5890.97
71_Y74_S0.5890.97
128_H159_L0.5860.97
153_L161_F0.5820.97
66_F72_V0.5820.97
216_G227_K0.5800.97
177_F188_M0.5790.97
111_T149_P0.5780.96
192_K195_C0.5780.96
137_C170_C0.5760.96
168_H192_K0.5750.96
86_Y89_L0.5740.96
5_L33_V0.5740.96
15_Q213_M0.5720.96
111_T207_A0.5700.96
215_I228_V0.5700.96
106_K116_N0.5690.96
190_D197_E0.5670.96
64_E68_D0.5660.96
204_L219_L0.5640.96
150_M161_F0.5610.96
21_A25_L0.5600.96
124_G127_L0.5600.96
77_G207_A0.5580.96
145_V149_P0.5560.96
88_H91_Q0.5550.96
135_T140_T0.5530.95
126_T129_T0.5520.95
161_F164_L0.5520.95
12_D19_G0.5510.95
48_N210_G0.5500.95
52_V56_K0.5470.95
72_V83_F0.5460.95
132_T162_T0.5450.95
135_T148_E0.5430.95
111_T115_V0.5430.95
179_V212_L0.5420.95
138_H214_N0.5410.95
152_L235_L0.5400.95
137_C211_C0.5400.95
80_T109_E0.5400.95
4_S72_V0.5390.95
6_F66_F0.5380.95
201_A226_V0.5380.95
75_P110_L0.5380.95
126_T159_L0.5340.95
231_I235_L0.5330.95
6_F83_F0.5330.95
132_T161_F0.5320.94
204_L228_V0.5320.94
45_P79_C0.5310.94
203_V227_K0.5300.94
4_S34_D0.5250.94
38_G65_T0.5230.94
125_A129_T0.5210.94
150_M167_K0.5190.94
6_F42_C0.5190.94
3_V71_Y0.5180.94
125_A128_H0.5160.94
133_L153_L0.5150.93
118_L152_L0.5150.93
135_T167_K0.5140.93
177_F185_S0.5140.93
156_V234_V0.5100.93
133_L207_A0.5080.93
77_G136_S0.5070.93
189_V215_I0.5050.93
173_F214_N0.5040.93
135_T149_P0.5000.92
118_L121_E0.5000.92
139_M206_G0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.9328 100 0.311 Contact Map
3cf4A 2 0.7731 100 0.565 Contact Map
3c8yA 1 0.895 98.4 0.836 Contact Map
2eq5A 2 0.4286 73.4 0.93 Contact Map
2gzmA 3 0.4244 73 0.93 Contact Map
2jfnA 1 0.8529 72 0.931 Contact Map
2jfzA 2 0.4118 70.4 0.931 Contact Map
3qvlA 3 0.8445 63.2 0.935 Contact Map
3outA 5 0.4286 62.4 0.935 Contact Map
1b73A 2 0.4118 56.3 0.937 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.