GREMLIN Database
YVFS - Putative transport permease YvfS
UniProt: O07017 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 245 (234)
Sequences: 20465 (14143)
Seq/√Len: 924.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_W206_G5.1451.00
9_I13_K4.0621.00
153_L234_L3.5101.00
143_G203_F3.2631.00
114_T137_G3.1341.00
7_Q100_A3.0681.00
5_Q9_I2.9101.00
11_E101_Q2.5921.00
145_L228_M2.5891.00
93_P96_I2.5531.00
49_A52_A2.4221.00
146_P228_M2.4191.00
8_S103_I2.3971.00
13_K16_L2.2631.00
189_D193_S2.2511.00
218_W222_L2.2251.00
219_K223_I2.2071.00
222_L226_A2.1791.00
142_F225_I2.1781.00
8_S107_V2.0921.00
192_Q196_Q2.0711.00
233_L237_Y2.0421.00
227_Y231_F2.0171.00
16_L19_K1.9671.00
223_I226_A1.9161.00
195_G201_Y1.8981.00
118_L122_I1.8601.00
189_D192_Q1.8521.00
153_L238_I1.8151.00
184_F195_G1.7901.00
135_M210_L1.7841.00
159_K162_T1.7671.00
119_F123_I1.7381.00
153_L231_F1.7351.00
149_A228_M1.7121.00
158_R166_I1.7081.00
38_N41_N1.6871.00
110_V141_L1.6681.00
190_M193_S1.6471.00
202_H220_N1.6461.00
230_L234_L1.6311.00
146_P231_F1.6001.00
140_I203_F1.5911.00
223_I227_Y1.5861.00
219_K222_L1.5851.00
193_S197_W1.5691.00
196_Q202_H1.5641.00
149_A232_M1.5471.00
154_I158_R1.5421.00
226_A230_L1.5341.00
10_A78_E1.5151.00
139_W221_I1.4931.00
228_M232_M1.4871.00
209_E213_G1.4641.00
205_S220_N1.4441.00
8_S100_A1.4361.00
134_M138_L1.4111.00
100_A104_G1.4031.00
193_S196_Q1.3751.00
142_F221_I1.3731.00
196_Q201_Y1.3511.00
143_G147_F1.3341.00
12_M16_L1.3321.00
156_L238_I1.3281.00
221_I225_I1.3241.00
95_H99_S1.3111.00
78_E101_Q1.3081.00
106_S141_L1.3081.00
139_W210_L1.2821.00
146_P224_L1.2681.00
142_F228_M1.2681.00
80_S160_V1.2531.00
138_L221_I1.2381.00
37_T123_I1.2311.00
205_S209_E1.2301.00
42_T45_P1.2191.00
5_Q8_S1.2151.00
109_H144_A1.2131.00
41_N44_V1.2071.00
129_S132_E1.2071.00
32_F36_F1.2021.00
117_F136_S1.1901.00
40_V43_N1.1801.00
146_P227_Y1.1781.00
101_Q105_Q1.1721.00
158_R162_T1.1661.00
135_M138_L1.1661.00
205_S216_P1.1641.00
12_M104_G1.1591.00
28_M32_F1.1481.00
23_L27_I1.1441.00
174_L198_L1.1361.00
225_I229_M1.1311.00
106_S145_L1.1231.00
13_K17_R1.1221.00
30_I119_F1.1221.00
234_L237_Y1.1141.00
180_M204_G1.1111.00
52_A55_L1.1071.00
157_M238_I1.1071.00
55_L58_M1.1021.00
164_A168_N1.1011.00
234_L238_I1.0971.00
127_A132_E1.0961.00
50_W53_H1.0901.00
72_G163_A1.0851.00
202_H206_G1.0851.00
169_V173_L1.0811.00
187_M192_Q1.0751.00
153_L235_S1.0741.00
192_Q195_G1.0741.00
135_M217_T1.0691.00
134_M137_G1.0661.00
230_L233_L1.0651.00
149_A231_F1.0631.00
201_Y205_S1.0591.00
220_N224_L1.0361.00
202_H223_I1.0351.00
118_L121_A1.0281.00
33_Y116_I1.0231.00
184_F192_Q1.0231.00
150_L170_L1.0111.00
204_G208_W1.0041.00
171_Y175_A1.0041.00
184_F201_Y0.9901.00
199_P203_F0.9841.00
76_V80_S0.9761.00
8_S12_M0.9741.00
39_V43_N0.9741.00
98_L236_K0.9701.00
77_Q80_S0.9671.00
8_S104_G0.9651.00
6_K9_I0.9611.00
92_L97_Y0.9571.00
49_A53_H0.9531.00
40_V44_V0.9461.00
78_E83_W0.9381.00
184_F196_Q0.9371.00
218_W221_I0.9251.00
131_F134_M0.9231.00
11_E104_G0.9211.00
222_L225_I0.9211.00
168_N172_M0.9201.00
225_I228_M0.9171.00
98_L235_S0.9161.00
198_L201_Y0.9141.00
138_L142_F0.9121.00
55_L120_G0.9101.00
202_H205_S0.9101.00
140_I207_A0.9091.00
173_L176_L0.9021.00
56_M61_F0.8971.00
114_T118_L0.8961.00
133_W137_G0.8951.00
19_K22_V0.8851.00
216_P219_K0.8831.00
102_M232_M0.8651.00
15_V25_S0.8651.00
162_T165_G0.8621.00
83_W86_F0.8611.00
50_W54_Y0.8551.00
11_E14_R0.8551.00
220_N223_I0.8511.00
150_L231_F0.8491.00
227_Y230_L0.8431.00
231_F235_S0.8401.00
215_S219_K0.8361.00
48_R52_A0.8321.00
41_N123_I0.8301.00
161_E165_G0.8281.00
236_K239_R0.8271.00
60_V200_S0.8221.00
15_V108_I0.8191.00
149_A235_S0.8191.00
86_F89_L0.8181.00
63_V68_I0.8181.00
144_A148_L0.8171.00
190_M194_I0.8161.00
110_V114_T0.8161.00
18_N21_F0.8161.00
208_W212_R0.8111.00
12_M107_V0.8021.00
58_M61_F0.7921.00
78_E85_A0.7921.00
57_S63_V0.7871.00
58_M63_V0.7761.00
145_L149_A0.7711.00
96_I100_A0.7581.00
115_V118_L0.7531.00
118_L133_W0.7511.00
62_S65_G0.7501.00
210_L217_T0.7501.00
103_I107_V0.7471.00
11_E105_Q0.7441.00
236_K240_R0.7441.00
203_F206_G0.7431.00
95_H236_K0.7421.00
137_G141_L0.7421.00
50_W55_L0.7381.00
59_T62_S0.7351.00
216_P220_N0.7251.00
7_Q96_I0.7241.00
86_F90_T0.7231.00
131_F135_M0.7211.00
113_I141_L0.7181.00
120_G136_S0.7081.00
132_E135_M0.7081.00
188_P192_Q0.7071.00
224_L227_Y0.7061.00
60_V68_I0.6991.00
232_M236_K0.6981.00
86_F91_P0.6971.00
136_S207_A0.6971.00
229_M233_L0.6951.00
105_Q109_H0.6881.00
83_W87_I0.6871.00
73_I76_V0.6841.00
57_S60_V0.6821.00
125_D129_S0.6811.00
76_V163_A0.6811.00
224_L228_M0.6801.00
152_T155_G0.6801.00
125_D128_L0.6791.00
61_F65_G0.6791.00
151_G155_G0.6771.00
223_I231_F0.6771.00
154_I170_L0.6711.00
51_E55_L0.6691.00
41_N45_P0.6681.00
20_Y24_W0.6671.00
34_Y38_N0.6671.00
167_S171_Y0.6591.00
152_T156_L0.6591.00
122_I128_L0.6591.00
179_G183_P0.6561.00
142_F224_L0.6551.00
58_M62_S0.6541.00
113_I140_I0.6501.00
107_V110_V0.6501.00
29_P33_Y0.6491.00
177_G191_M0.6471.00
168_N173_L0.6411.00
60_V63_V0.6401.00
182_M186_V0.6351.00
165_G168_N0.6341.00
102_M148_L0.6321.00
55_L66_S0.6321.00
46_D49_A0.6291.00
57_S208_W0.6291.00
121_A125_D0.6271.00
99_S103_I0.6241.00
188_P191_M0.6221.00
34_Y119_F0.6221.00
184_F187_M0.6211.00
203_F224_L0.6201.00
228_M231_F0.6191.00
88_R94_D0.6191.00
30_I34_Y0.6181.00
154_I167_S0.6181.00
207_A211_V0.6141.00
233_L236_K0.6141.00
139_W203_F0.6141.00
117_F137_G0.6111.00
10_A14_R0.6111.00
178_G201_Y0.6101.00
62_S66_S0.6101.00
86_F112_S0.6091.00
72_G75_M0.6091.00
97_Y239_R0.6041.00
84_A88_R0.6031.00
34_Y123_I0.6011.00
55_L63_V0.6001.00
154_I157_M0.5991.00
56_M60_V0.5981.00
160_V167_S0.5981.00
46_D53_H0.5981.00
155_G174_L0.5971.00
231_F234_L0.5951.00
135_M206_G0.5931.00
56_M59_T0.5921.00
158_R163_A0.5911.00
183_P187_M0.5891.00
135_M139_W0.5871.00
107_V111_L0.5861.00
86_F92_L0.5841.00
63_V66_S0.5821.00
37_T41_N0.5821.00
155_G163_A0.5751.00
162_T166_I0.5751.00
10_A86_F0.5741.00
102_M149_A0.5711.00
9_I12_M0.5701.00
106_S148_L0.5691.00
31_A36_F0.5691.00
119_F122_I0.5691.00
117_F121_A0.5661.00
196_Q205_S0.5641.00
79_R84_A0.5611.00
11_E79_R0.5601.00
206_G220_N0.5601.00
229_M232_M0.5591.00
40_V45_P0.5571.00
87_I90_T0.5571.00
57_S61_F0.5551.00
76_V79_R0.5541.00
105_Q152_T0.5541.00
57_S211_V0.5491.00
202_H227_Y0.5441.00
28_M173_L0.5431.00
186_V189_D0.5411.00
58_M65_G0.5401.00
151_G177_G0.5401.00
27_I31_A0.5401.00
105_Q148_L0.5401.00
114_T117_F0.5391.00
231_F236_K0.5371.00
237_Y240_R0.5341.00
10_A83_W0.5341.00
80_S83_W0.5331.00
82_G85_A0.5321.00
86_F151_G0.5291.00
156_L235_S0.5271.00
105_Q156_L0.5261.00
111_L114_T0.5221.00
161_E164_A0.5211.00
29_P35_F0.5191.00
187_M195_G0.5171.00
217_T220_N0.5161.00
108_I112_S0.5151.00
15_V104_G0.5151.00
153_L157_M0.5131.00
177_G182_M0.5131.00
151_G179_G0.5111.00
210_L213_G0.5091.00
197_W202_H0.5091.00
141_L145_L0.5081.00
140_I144_A0.5081.00
38_N123_I0.5081.00
38_N44_V0.5071.00
219_K226_A0.5051.00
153_L156_L0.5031.00
38_N42_T0.5031.00
66_S70_T0.5021.00
150_L153_L0.5021.00
63_V67_S0.5021.00
195_G198_L0.5011.00
7_Q92_L0.5011.00
168_N171_Y0.5011.00
58_M66_S0.5011.00
226_A233_L0.5001.00
30_I115_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2a65A 2 0.3469 13.4 0.927 Contact Map
2rddB 1 0.1224 6 0.937 Contact Map
2wswA 3 0.6653 4.3 0.941 Contact Map
2ks1B 1 0.1673 4.3 0.942 Contact Map
3qbgA 3 0.2 3.4 0.944 Contact Map
2gsmB 1 0.2367 2.8 0.947 Contact Map
4lz6A 1 0.849 2.7 0.947 Contact Map
2m20A 2 0.1306 2.7 0.947 Contact Map
2ksdA 1 0.2571 2.6 0.947 Contact Map
2jwaA 2 0.1592 2.6 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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